Article ; Online: Tratamiento de hipoparatiroidismo con parathormona recombinante humana [rhPTH(1-84)].
2020 Volume 80, Issue 3, Page(s) 289–291
Abstract: Hypoparathyroidism (HypoPT) is a rare disease characterized by low calcium and inappropriately low circulating parathormone levels. We present the case of a 25-year-old high-performance athlete male, with history of HypoPT after total thyroidectomy for ... ...
| Title translation | Hypoparathyroidism treated with recombinant human parathyroid hormone [rhPTH(1-84)]. | |||||
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| Abstract | Hypoparathyroidism (HypoPT) is a rare disease characterized by low calcium and inappropriately low circulating parathormone levels. We present the case of a 25-year-old high-performance athlete male, with history of HypoPT after total thyroidectomy for papillary thyroid carcinoma (T3 N1b M0) two years before, who was referred to our clinic for symptomatic hypocalcemia. The patient reported serum calcium average levels of 7mg%, presented symptoms of hypocalcemia at rest and had multiple hospital admissions. First, standard treatment was optimized by calcium supplementation up to 12g/d and active vitamin D, not showing clinical or biochemical improvement. Malabsorption and complications of chronic HypoPT were ruled out. The 36-Item Short Form Health Survey (SF-36) demonstrated an impaired quality of life (QoL). Full-length recombinant human parathyroid hormone [rhPTH(1-84)] therapy was started with 50υg/d subcutaneous, and later adjusted to 75υg/d and the oral treatment gradually decreased. Currently, he is asymptomatic, with serum calcium levels above 9mg%, without receiving oral medication. He performs sports activity and shows marked improvement in quality of life according to SF-36 questionnaire. |
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| MeSH term(s) | Adult ; Calcitriol/therapeutic use ; Calcium-Regulating Hormones and Agents/therapeutic use ; Hormone Replacement Therapy/methods ; Humans ; Hypoparathyroidism/drug therapy ; Hypoparathyroidism/etiology ; Male ; Parathyroid Hormone/therapeutic use ; Thyroid Cancer, Papillary/complications ; Thyroid Cancer, Papillary/surgery ; Thyroid Neoplasms/complications ; Thyroid Neoplasms/surgery ; Thyroidectomy/adverse effects ; Vitamin D/therapeutic use | |||||
| Chemical Substances | Calcium-Regulating Hormones and Agents ; Parathyroid Hormone ; Vitamin D (1406-16-2) ; Calcitriol (FXC9231JVH) | |||||
| Language | Spanish | |||||
| Publishing date | 2020-05-13 | |||||
| Publishing country | Argentina | |||||
| Document type | Case Reports | |||||
| ZDB-ID | 411586-7 | |||||
| ISSN | 1669-9106 ; 0025-7680 ; 0325-951X | |||||
| ISSN (online) | 1669-9106 | |||||
| ISSN | 0025-7680 ; 0325-951X | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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