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  1. Article: Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men.

    Hugo Perez, B S

    Medical hypotheses

    2003  Volume 62, Issue 1, Page(s) 112–115

    Abstract: Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (AGA). Testosterone is converted to DHT by the enzyme ... ...

    Abstract Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (AGA). Testosterone is converted to DHT by the enzyme 5alpha-reductase. Finasateride a 5alpha-reducase inhibitor blocks the production of DHT and is currently used to treat AGA. The inhibition is not complete but a reduction of DHT systemically and in the scalp is accomplished. Ketoconazole has been clinically shown to be effective in the treatment of AGA. In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat AGA.
    MeSH term(s) Administration, Oral ; Administration, Topical ; Alopecia/drug therapy ; Antifungal Agents/administration & dosage ; Chemotherapy, Adjuvant/methods ; Clinical Trials as Topic ; Drug Therapy, Combination ; Enzyme Inhibitors/administration & dosage ; Evidence-Based Medicine/methods ; Finasteride/administration & dosage ; Hair Preparations ; Humans ; Ketoconazole/administration & dosage ; Male ; Treatment Outcome
    Chemical Substances Antifungal Agents ; Enzyme Inhibitors ; Hair Preparations ; Finasteride (57GNO57U7G) ; Ketoconazole (R9400W927I)
    Language English
    Publishing date 2003-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/s0306-9877(03)00264-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Morphological observations of turkey (Meleagris gallopavo) spermiophages maintained in tissue culture.

    Perez, B S / Derrick, F C / Korn, N / Thurston, R J

    Poultry science

    1994  Volume 73, Issue 10, Page(s) 1597–1606

    Abstract: Spermiophages were isolated from turkey semen using Percoll gradient centrifugation, cultured in Roswell Park Memorial Institute 1640 medium at room temperature, and characterized by transmission electron microscopy. After 1 to 2 h, the cells enlarged ... ...

    Abstract Spermiophages were isolated from turkey semen using Percoll gradient centrifugation, cultured in Roswell Park Memorial Institute 1640 medium at room temperature, and characterized by transmission electron microscopy. After 1 to 2 h, the cells enlarged and developed numerous motile mitochondria. Over time, the mitochondria appeared to increase in number and were released into the extracellular medium. Few mitochondria were observed in spermiophages from fresh semen. However, there was an apparent increase in the number and size of mitochondria after Percoll isolation, which was more pronounced in cultured spermiophages. Over a period of 3 h in culture, many spermiophages became engorged with mitochondria, which subsequently appeared to be released as blebs pinched off from the surface. The release of mitochondria resulted in spermiophages with large, empty vacuoles, although their remaining cytoplasm was engorged with mitochondria. Many free mitochondria were present in the medium. The results of the current research suggest that isolating and culturing turkey spermiophages elicit mitochondrial biogenesis, which proceeds unabated until the cells are engorged with and release numerous mitochondria. This may be due to conditions under which the spermiophages were cultured or to nonhistocompatibility of these cells in pooled semen.
    MeSH term(s) Animals ; Macrophages/ultrastructure ; Male ; Microscopy, Electron ; Mitochondria/ultrastructure ; Semen/cytology ; Turkeys
    Language English
    Publishing date 1994-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.3382/ps.0731597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Morphological observations of turkey (Meleagris gallopavo) spermiophages maintained in tissue culture

    Perez, B.S / Derrick, F.C. Jr / Korn, N / Thurston, R.J

    Poultry science. Oct 1994. v. 73 (10)

    1994  

    Abstract: Spermiophages were isolated from turkey semen using Percoll gradient centrifugation, cultured in Roswell Park Memorial Institute 1640 medium at room temperature, and characterized by transmission electron microscopy. After 1 to 2 h, the cells enlarged ... ...

    Abstract Spermiophages were isolated from turkey semen using Percoll gradient centrifugation, cultured in Roswell Park Memorial Institute 1640 medium at room temperature, and characterized by transmission electron microscopy. After 1 to 2 h, the cells enlarged and developed numerous motile mitochondria. Over time, the mitochondria appeared to increase in number and were released into the extracellular medium. Few mitochondria were observed in spermiophages from fresh semen. However, there was an apparent increase in the number and size of mitochondria after Percoll isolation, which was more pronounced in cultured spermiophages. Over a period of 3 h in culture, many spermiophages became engorged with mitochondria, which subsequently appeared to be released as blebs pinched off from the surface. The release of mitochondria resulted in spermiophages with large, empty vacuoles, although their remaining cytoplasm was engorged with mitochondria. Many free mitochondria were present in the medium. The results of the current research suggest that isolating and culturing turkey spermiophages elicit mitochondrial biogenesis, which proceeds unabated until the cells are engorged with and release numerous mitochondria. This may be due to conditions under which the spermiophages were cultured or to nonhistocompatibility of these cells in pooled semen.
    Keywords turkeys ; semen ; mitochondria ; phagocytes ; cell culture ; microscopy ; electron microscopy
    Language English
    Dates of publication 1994-10
    Size p. 1597-1606.
    Document type Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Isolation and characterization of mitochondria from turkey spermatozoa.

    McLean, D J / Korn, N / Perez, B S / Thurston, R J

    Journal of andrology

    1993  Volume 14, Issue 6, Page(s) 433–438

    Abstract: A procedure was developed to rapidly isolate functional, intact mitochondria from turkey spermatozoa. Semen was collected from turkeys, pooled, and centrifuged to remove spermiophages and other cells. The sperm cells were then mechanically disrupted with ...

    Abstract A procedure was developed to rapidly isolate functional, intact mitochondria from turkey spermatozoa. Semen was collected from turkeys, pooled, and centrifuged to remove spermiophages and other cells. The sperm cells were then mechanically disrupted with a Dounce homogenizer, sonicated, and centrifuged using a discontinuous Percoll gradient. Electron microscopy revealed morphologically intact mitochondria. The isolated mitochondria exhibited cytochrome oxidase activity, oxygen consumption, and were stained by rhodamine 123, a fluorescent stain specific for functional mitochondria in eukaryotic cells. Mitochondrial DNA (mtDNA) was isolated and purified, and the genome was determined to be 16.457 +/- 0.07 kbp. Restriction fragment patterns were identified using the endonucleases EcoR1, HindIII, and BamH1. Mitochondrial DNA was also purified from turkey liver and testis, and no differences in the restriction enzyme patterns were found between somatic and germ cell mtDNA. It is concluded that mitochondria can be isolated from spermatozoa for metabolic or genetic study.
    MeSH term(s) Animals ; Cell Fractionation/methods ; DNA Restriction Enzymes ; DNA, Mitochondrial/isolation & purification ; Male ; Mitochondria/ultrastructure ; Spermatozoa/ultrastructure ; Turkeys
    Chemical Substances DNA, Mitochondrial ; DNA Restriction Enzymes (EC 3.1.21.-)
    Language English
    Publishing date 1993-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604624-1
    ISSN 1939-4640 ; 0196-3635
    ISSN (online) 1939-4640
    ISSN 0196-3635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Global attitudes in the management of acute appendicitis during COVID-19 pandemic

    Ielpo, B. / Podda, M. / Pellino, G. / Pata, F. / Caruso, R. / Gravante, G. / Di Saverio, S. / Gallo, G. / Lui, R. / Orengia, A. / Chowdary, A. / Kulkarni, A. / Kuvvetli, A. / Navarro, A. / Pisanu, A. / Smith, A. / Ibiricu, A. C. / Nacion, A. J. D. / Alsaleh, A. /
    Alhazmi, A. / Elmabri, A. / Wani, A. / Rencuzogullari, A. / Lasarte, A. S. / Rubio, A. V. / Bavikatte, A. / Kumar, A. / Jamiri, A. -R. / Padilla, A. M. A. / Cacurri, A. / de San Ildefonso, A. / Porcu, A. / Sartori, A. / Rocca, A. / Yanez, A. P. / Becaria, A. / Solis-Pena, A. / Sretenovic, A. / Urbistondo, A. / Bandin, A. / Najar, A. / De Luca, A. / Boddy, A. / Charalabopoulos, A. / Tzivanakis, A. / Amendola, A. / de Velasco, A. R. -G. / Yildirim, A. C. / Frontali, A. / Toure, A. O. / Garcia-Granero, A. / Roldan, A. M. / Larrainzar, A. S. / Ratnayake, A. S. / Gonzalez-Ganso, A. M. / Minaya-Bravo, A. M. / Das, A. / Bondurri, A. / Costanzi, A. / Lucchi, A. / Mazzari, A. / Musig, A. / Peloso, A. / Piano, A. / Police, A. / Mihailescu, A. / Pouy, A. / Romano, A. / Iossa, A. / Leonetti, A. C. / Guariniello, A. / Isaac, A. / Bovi, A. P. D. / Chessa, A. / Tromba, A. / Martinez, A. A. / Brillantino, A. / Caira, A. / Castaldi, A. / Ferronetti, A. / Giuliani, A. / Prestera, A. / la Medina, A. R. -D. / Tarasconi, A. / Tornambe, A. / Picciariello, A. / Ioannidis, A. / Leppaniemi, A. / Khan, A. / Rashid, A. / Perez-Sanchez, A. L. E. / Mittal, A. / Mitul, A. R. / Mehraj, A. / Laharwal, A. / Dorisme, A. / Marinis, A. / Iqbal, A. / Moncada, A. / Braccio, B. / Alkhafaji, B. / de Andres Asenjo, B. / Martin-Perez, B. / Perez, B. S. / Creavin, B. / Cali, B. / Pascotto, B. / Stubbs, B. / Retes, B. Z. / Jovanovic, B. / Goh, B. K. P. / Sensi, B. / Biddau, C. / Gazia, C. / Vallicelli, C. / Fagundes, C. A. / Santacruz, C. C. / Chirico, C. / Diaz, C. J. G. / Petrola, C. / Rodriguez, C. S. / Benitez, C. Y. / Dammaro, C. / Faro, C. L. / Reinke, C. / Paez, C. D. / Oliva, C. / Paranjape, C. / Thomas, C. / Chia, C. F. / Kong, C. K. / De Lucia, C. / Chao, C. O. / Arcudi, C. / Guerci, C. / Chia, C. / Parise, C. / Folliero, C. / Varela, C. / Ferguson, D. M. / Camacho, D. / Popowich, D. / Lima, D. S. / Rega, D. / Delogu, D. / Zigiotto, D. / Vinci, D. / D'Antonio, D. / Parini, D. / Merlini, D. A. / Zimmerman, D. D. E. / Moro-Valdezate, D. / Pertile, D. / Giusti, D. M. / Keller, D. S. / Tarik, D. / Kalivaci, D. / Mazingi, D. / Maldonado-Pintado, D. G. / Sasia, D. / Linardoutsos, D. / Osilli, D. / Murrone, D. / Russello, D. / Rodas, E. / Roa, E. A. A. / Ricciardi, E. / Rosso, E. / Saladino, E. / Flores-Villalba, E. / Ajs, E. R. / Smith-Singares, E. / Baili, E. / Kouroumpas, E. / Bourmpouteli, E. / Douka, E. / Martin-Perez, E. / Guaitoli, E. / Samadov, E. / Francone, E. / Vaterlini, E. / Morales, E. / Pena, E. / Zhao, E. / Andres, E. D. P. / Benzoni, E. / Erdas, E. / Pinotti, E. / Colas-Ruiz, E. / Aytac, E. / Laterza, E. / Agastra, E. / Foianini, E. / Moscoso, E. / Laviano, E. / Marra, E. / Cardamone, E. / Licardie, E. / Mpaili, E. / Pinna, E. / Varo, E. / Navarro, F. M. / Marino, F. / Medas, F. / Romano, F. / Maraska, F. / Saliu, F. / Madrid, F. / Rosa, F. / Mastella, F. / Gheza, F. / Luvisetto, F. / Alconchel, F. / Vieira, F. M. / Pareja, F. / Agresta, F. / Luna, F. / Bonilla, F. / Cordera, F. / Burdio, F. / Mendoza-Moreno, F. / Flores, F. M. / Aranda, F. P. / Taylor, F. / Ramos, F. L. / Fernandes, F. / Tropeano, F. P. / Balestra, F. / Bianco, F. / Ceci, F. / Colombo, F. / Di Marzo, F. / Ferrara, F. / Lancellotti, F. / Lazzarin, F. / Litta, F. / Martini, F. / Pizza, F. / Roscio, F. / Virdis, F. / Antona, F. B. / Ramirez, F. C. / Fernandez, F. M. / Llinares, F. O. / Quezada, F. / Schlottmann, F. / Herrera-Almario, G. / Massaferro, G. / Bislenghi, G. / van Ramshorst, G. / Luglio, G. / Bointas, G. / Kampouroglou, G. / Papadopoulos, G. / Manrique, G. A. / Calini, G. / Nastri, G. / Formisano, G. / Galiffa, G. / Palini, G. M. / Colucci, G. / Pagano, G. / Vanni, G. / Pattacini, G. C. / De Paola, G. / Lisi, G. / Partida, G. / Bellanova, G. / De Nobili, G. / Necchi, G. S. / Sinibaldi, G. / Tebala, G. / Bagaglini, G. / Izzo, G. / Argenio, G. / Brisinda, G. / Candilio, G. / Di Grezia, G. / Esposito, G. / Faillace, G. / Frazzetta, G. / La Gumina, G. / Nigri, G. / Romeo, G. / Amatriain, G. C. / Ortega, G. / Martin-Martin, G. / Stavrou, G. A. / Gunadi, / Ugon, G. A. / Machain, G. / Marcucci, G. / Martinez-Mier, G. / Machain, G. M. / Nari, G. / Calvo, H. / Fathy, H. / Hamilto, / Ahmed, H. / Faraj, H. / Nava, H. / Macias, H. O. / Nikaj, H. / Solano, H. / Khan, H. A. / Alarcon, H. S. / Ebied, H. / Giani, I. / Ateca, I. V. / Neri, I. / Roman, I. A. S. / Fidoshev, I. / Rodriguez, I. M. / Negoi, I. / Ortega, I. / Bernescu, I. / Russo, I. S. / Rodriguez, I. V. / Palomares, I. / Baltazar, I. / Torrejimeno, I. J. / Jurado, I. M. C. / Reccia, I. / Hussain, I. / Toledo, I. B. / Mora-Guzman, I. / Dogaru, I. / Romic, I. / Balciscueta, I. / Kenington, J. C. / Sagolsem, J. / Jang, J. Y. / Olivier, J. / Lammel-Lindemann, J. / Dziakova, J. / Villavicencio, J. I. R. / Salinas, J. / Parreira, J. P. J. G. / Jovanovic, / Perez, J. R. / Reyes, J. A. S. / Luque, J. A. M. / Mak, J. / Rodriguez, J. S. / Kok, J. H. H. / Krook, J. / Diaz-Elizondo, J. A. / Castell, J. / Garcia-Flores, J. E. / Navalon, J. M. J. / Rodrigues, J. M. S. / Pereira, J. / Gomez, J. T. C. / Luque, J. B. / del Olmo, J. C. M. / Salamea, J. C. / Olivier, J. F. C. / Laina, J. L. B. / Ordonez, J. M. / Gutierrez, J. / Abba, J. / Sofi, J. A. / Sherafgan, K. / Sahnan, K. / Yanaga, K. / Beatson, K. / Asim, L. / Alvarez, L. / Siragusa, L. / Farber, L. / Ong, L. / Athanasios, L. / Garcia-Bruna, L. / De Martino, L. / Ferrario, L. / Giordano, L. / Gordini, L. / Pio, L. / Ponchietti, L. / Moletta, L. / Curella, L. / Poggi, L. / Taglietti, L. / Bonavina, L. / Conti, L. / Goffredi, L. / Ruiz, L. A. G. / Barrionuevo, L. / Fregoso, L. E. / Cabrera, L. F. / Rodriguez, L. G. / Grande, L. / Osoria, L. G. / Gonzalez, L. J. K. / Sanchez-Guillen, L. / Tallon-Aguilar, L. / Tresierra, L. / Giavarini, L. / Hasabelnabi, M. / Odovic, M. / Uemura, M. / Khan, M. / Artiles-Armas, M. / David, M. / Di Martino, M. / Spampinato, M. G. / Ribeiro, M. A. F. / Viola, M. / Angrisani, M. / Calussi, M. / Cannistra, M. / Catarci, M. / Cereda, M. / Conte, M. / Giordano, M. / Pellicciaro, M. / Marino, M. V. / Vaterlini, M. E. / Jimenez, M. F. / Lolli, M. G. / Bellini, M. I. / Lemma, M. / Chiarello, M. M. / Nicola, M. / Arrigo, M. / Mejia, M. C. / Manrique, M. M. / Rodriguez-Lopez, M. / Serradilla-Martin, M. / Lara, M. Z. / Martinez, M. / Bagnall, M. / Peter, M. / Lara, M. C. / Gomez, M. J. / Paniagua-Garcia-Senorans, M. / Gonzalez, M. P. / Rutegard, M. / Salo, M. / Franceschilli, M. / Silveri, M. / Veroux, M. / Pezzulo, M. / Nardi, M. / Rottoli, M. / Tolonen, M. / Ciro, M. P. / Zuluagua, M. / Cannavo, M. / Cervellera, M. / Iacobone, M. / Montuori, M. / Dominguez, M. G. / Bingol-Kologlu, M. / Tahir, M. / Lim, M. / Wilson, M. S. / Wilson, M. / Campanelli, M. / Bisaccia, M. / De Rosa, M. / Maruccia, M. / Paterno, M. / Pisano, M. / Torre, M. / Trevino, M. / Zuolo, M. / Hernandez Bartolome, M. A. / Farina, M. / Pera, M. / Calvo, M. P. / Sotelo, M. / Thway, M. M. / Hassan, M. / Hassan, M. S. E. / Azfar, M. / Bouhuwaish, M. / Taha, M. / Zaieem, M. / Korkoman, M. / Guraieb, M. / Shalaby, M. / Raza, M. A. / Younis, M. U. / Elhadi, M. / Ali, M. Z. / Quazi, N. / Dudi-Venkata, N. N. / Alselaim, N. / Loria, N. / Ramirez, N. V. / Than, N. W. / Smart, N. / Trelles, N. / Pinto, N. / Allievi, N. / Petrucciani, N. / Antonacci, N. / Cillara, N. / Gica, N. / Cristiana, N. D. / Krystek, N. / Falco, N. / Pecorelli, N. / Tamini, N. / Dallas, N. A. / Machairas, N. / Brito, N. / Fieturi, N. A. / Ortega, N. / Mercado, O. A. / Irkorucu, O. / Alsherif, O. / Valles, O. / Ioannidis, O. / Palmas, O. H. / Palmas, O. I. H. / Guadarrama, O. S. / Bozbiyik, O. / Omelanczuk, P. / Ottolino, P. / Rodrigues, P. / Ruiz, P. / Campenni, P. / Chiarade, P. / Olivares, P. P. / Baroffio, P. / Panaccio, P. / Wintringer, P. / Di Fronzo, P. / Talento, P. / Favoriti, P. / Sendino, P. / Marsanic, P. / Mifsut, P. / Andrade, P. / Ajawin, P. / Abadia-Barno, P. / Castaneda, P. A. N. / Arevalos, P. O. S. / Bellver, P. P. / Koh, P. S. / Souza, P. / Major, P. / Bali, R. S. / Khattar, R. M. / Melo, R. B. / Ebrahiminia, R. / Azar, R. / Murga, R. L. / Pirolo, R. / Brady, R. / Davies, R. J. / Dholakia, R. / Rattan, R. / Singhal, R. / Lim, R. / Angelico, R. / Isernia, R. M. / Tutino, R. / Faccincani, R. / Peltrini, R. / Carrera-Ceron, R. / Tejos, R. / Kashyap, R. / Fajardo, R. / Lozito, R. / Pareja, R. M. / Garbarino, S. / Morales-Conde, S. / Benli, S. / Mansour, S. / Flores, S. / Suarez, S. L. / Ben, S. L. / Fuentes, S. / Napetti, S. / de Guzman, S. O. / Awad, S. / Weckmann Lujan, S. A. / Gentilli, S. / Grimaldi, S. / Pizarro, S. O. / Tayar, S. / Nabi, S. / Chan, S. M. / Junaid, S. / Rojas, S. / Monetti, S. / Garcia, S. / Salvans, S. / Tenconi, S. / Shaw, S. / Santoni, S. / Parra, S. A. / Cardenas, S. / Perez-Bertolez, S. / Chiappetta, S. / Dessureault, S. / Delis, S. / Bonapasta, S. A. / Rausei, S. / Scaringi, S. / Keswani, S. / Ali, S. M. / Cetinkunar, S. / Fung, T. L. D. / Rawashdeh, T. / Lopez, T. N. / De Campos, T. / Duque, T. C. / Perra, T. / Liakakos, T. / Daskalakis, T. / Barnes, T. / Koeter, T. / Zalla, T. / Gonzalez, T. E. / Elosua, T. / Campagnaro, T. / Brown, T. / Luoto, T. / Oumar, T. A. / Giustizieri, U. / Grossi, U. / Bracale, U. / Rivas, U. / Sosa, V. / Testa, V. / Andriola, V. / Tonini, V. / Balassone, V. / Celentano, V. / Progno, V. / Raju, V. / Carroni, V. / Cavallaro, V. / Katta, V. R. / De Simone, V. / Romaguera, V. P. / Orozco, V. H. G. / Luraschi, V. / Rachkov, V. / Turrado-L, V. / Visag-Castillo, V. / Dowling, V. / Graham, V. / Papagni, V. / Vigorita, V. / Fonseca, V. C. / Carneros, V. J. / Bellato, V. / Goncalves, W. / Powers, W. F. / Grigg, W. / Bechstein, W. O. / Lim, Y. B. / Altinel, Y. / Golubovic, Z. / Balciscueta, Z.

    ACIE Appy Study

    2020  

    Abstract: Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a ... ...

    Abstract Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a snapshot of worldwide approaches to appendicitis. Methods: The Association of Italian Surgeons in Europe designed an online survey to assess the current attitude of surgeons globally regarding the management of patients with acute appendicitis during the pandemic. Questions were divided into baseline information, hospital organization and screening, personal protective equipment, management and surgical approach, and patient presentation before versus during the pandemic. Results: Of 744 answers, 709 (from 66 countries) were complete and were included in the analysis. Most hospitals were treating both patients with and those without COVID. There was variation in screening indications and modality used, with chest X-ray plus molecular testing (PCR) being the commonest (19·8 per cent). Conservative management of complicated and uncomplicated appendicitis was used by 6·6 and 2·4 per cent respectively before, but 23·7 and 5·3 per cent, during the pandemic (both P < 0·001). One-third changed their approach from laparoscopic to open surgery owing to the popular (but evidence-lacking) advice from expert groups during the initial phase of the pandemic. No agreement on how to filter surgical smoke plume during laparoscopy was identified. There was an overall reduction in the number of patients admitted with appendicitis and one-third felt that patients who did present had more severe appendicitis than they usually observe. Conclusion: Conservative management of mild appendicitis has been possible during the pandemic. The fact that some surgeons switched to open appendicectomy may reflect the poor guidelines that emanated in the early phase of SARS-CoV-2.
    Keywords covid19
    Subject code 610
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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