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  1. Book: Practical applications of recent data in breast cancer

    Perez, Edith A.

    an update on optimizing cytotoxic regimens for advanced and early-stage breast cancer

    (Clinical breast cancer ; 10, Suppl. 2)

    2010  

    Series title Clinical breast cancer ; 10, Suppl. 2
    Collection
    Language English
    Size S49 S. : Ill., graph. Darst.
    Publisher CIG Media Group
    Publishing place Dallas, Tex
    Publishing country United States
    Document type Book
    HBZ-ID HT016529556
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Advances in combination chemotherapy in metastatic breast cancer

    Perez, Edith A.

    (EJC Supplements ; 3,5)

    2005  

    Author's details guest ed.: Edith A. Perez
    Series title EJC Supplements ; 3,5
    European journal of cancer
    Collection European journal of cancer
    Language English
    Size 21 S. : Ill., graph. Darst.
    Publisher Pergamon Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014597732
    Database Catalogue ZB MED Medicine, Health

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  3. Book: Treating the whole patient with breast or ovarian cancer: strategies for assessing and managing complications

    Perez, Edith A.

    (Seminars in oncology nursing ; 19,4, Suppl. 2)

    2003  

    Author's details Edith A. Perez ..., guest ed
    Series title Seminars in oncology nursing ; 19,4, Suppl. 2
    Collection
    Language English
    Size 41 S. : graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT013898519
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  4. Book: Evolving treatment options for patients with metastatic breast cancer

    Cristofanilli, Massimo / Perez, Edith A.

    (Seminars in oncology ; 33,3, Suppl. 9)

    2006  

    Author's details Edith A. Perez ..., guest ed. Contributors Massimo Cristofanilli
    Series title Seminars in oncology ; 33,3, Suppl. 9
    Collection
    Language English
    Size S28 S. : graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT014798149
    Database Catalogue ZB MED Medicine, Health

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  5. Book: From tamoxifen to letrozole

    Brufsky, Adam / Perez, Edith A.

    changing paradigms for the treatment of hormone-sensitive breast cancer

    (Seminars in oncology ; 33,2, Suppl. 7)

    2006  

    Author's details Edith A. Perez ... guest ed. Contributors Adam Brufsky
    Series title Seminars in oncology ; 33,2, Suppl. 7
    Collection
    Language English
    Size S25 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT014768228
    Database Catalogue ZB MED Medicine, Health

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  6. Book: New developments in metastatic breast cancer

    Perez, Edith A. / Rugo, Hope S. / Vahdat, Linda T.

    integrating recent data into clinical practice

    (Clinical advances in hematology & oncology ; 11,10, Suppl. 16 : Clinical roundtable monograph)

    2013  

    Author's details moderator Edith A. Perez ; discussants Hope S. Rugo ; Linda T. Vahdat
    Series title Clinical advances in hematology & oncology ; 11,10, Suppl. 16 : Clinical roundtable monograph
    Collection
    Language English
    Size 18 S. : Ill., graph. Darst.
    Publisher Millennium Med. Publ
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT018176607
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: Treatment strategies for advanced hormone receptor-positive and human epidermal growth factor 2-negative breast cancer: the role of treatment order.

    Perez, Edith A

    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

    2016  Volume 24, Page(s) 13–22

    Abstract: Although survival rates among patients with breast cancer have improved in recent years, those diagnosed with advanced disease with distant metastasis face a 5-year survival rate of less than 25%, making the management of these patients an area still in ... ...

    Abstract Although survival rates among patients with breast cancer have improved in recent years, those diagnosed with advanced disease with distant metastasis face a 5-year survival rate of less than 25%, making the management of these patients an area still in significant need of continued research. Selecting the optimal treatment order from among the variety of currently available therapy options presents a relevant challenge for medical oncologists. With the understanding that the majority of patients with breast cancer and those who succumb to this disease have HR-positive disease, this review will focus on treatment options and treatment order in patients with HR-positive advanced breast cancer. While endocrine therapy is considered the preferred treatment for first-line therapy in HR-positive/HER2-negative breast cancer, selection of the specific agent depends on the menopausal status of the patient. Palbociclib, a cyclin-dependent kinase (CDK) 4/6 inhibitor, is also recommended as first-line treatment in patients with ER-positive/HER2-negative disease. In patients with endocrine therapy-resistant disease, specific strategies include sequencing of other antiestrogen receptor agents, or agents that target other molecular pathways. Future treatment strategies for patients with primary or secondary resistance to endocrine therapy for advanced disease are discussed. These strategies include first-line therapy with high-dose fulvestrant or everolimus (in combination with exemestane or letrozole or with other endocrine therapies), use of the PI3K inhibitors (e.g., buparlisib, alpelisib, pictilisib, taselisib), entinostat, CDK 4/6 inhibitors (e.g., palbociclib, ribociclib, abemaciclib), and novel selective estrogen receptor degradation agents that may enhance the targeting of acquired mutations in the ESR1 gene.
    MeSH term(s) Antineoplastic Agents, Hormonal/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Drug Administration Schedule ; Female ; Humans ; Neoplasm Staging ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/antagonists & inhibitors ; Receptors, Estrogen/metabolism
    Chemical Substances Antineoplastic Agents, Hormonal ; Receptors, Estrogen ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2016-01
    Publishing country Scotland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1474513-6
    ISSN 1532-2084 ; 1368-7646
    ISSN (online) 1532-2084
    ISSN 1368-7646
    DOI 10.1016/j.drup.2015.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Current treatment options for metastatic breast cancer: what now?

    Rugo, Hope S. / O'Shaughnessy, Joyce / Perez, Edith A.

    (Clinical advances in hematology & oncology ; 9,11, Suppl. 25 : Clinical roundtable monograph)

    2011  

    Author's details moderator Hope S. Rugo. Discussants Joyce A. O'Shaughnessy ; Edith A. Perez
    Series title Clinical advances in hematology & oncology ; 9,11, Suppl. 25 : Clinical roundtable monograph
    Collection
    Language English
    Size 15 S. : Ill.
    Publisher Millennium Med. Publ
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT017150031
    Database Catalogue ZB MED Medicine, Health

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  9. Book ; Conference proceedings: Recent advances in the treatment of breast cancer

    Perez, Edith A. / Burstein, Harold J. / Hudis, Clifford A.

    highlights from the 2010 San Antonio Breast Cancer Symposium

    (Clinical advances in hematology & oncology ; 9,5, Suppl. 11)

    2011  

    Event/congress San Antonio Breast Cancer Symposium (33, 2010, SanAntonioTex.)
    Author's details moderator Edith Perez ; discussants Harold J. Burstein ; Clifford Hudis
    Series title Clinical advances in hematology & oncology ; 9,5, Suppl. 11
    Collection
    Language English
    Size 15 S.
    Publisher Millennium Med. Publ
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016884063
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  10. Article ; Conference proceedings: Highlights in breast cancer from the 2014 American Society of Clinical Oncology® annual meeting.

    Perez, Edith A

    Clinical advances in hematology & oncology : H&O

    2014  Volume 12, Issue 7, Page(s) 451–453

    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/therapy ; Female ; Humans
    Language English
    Publishing date 2014-07
    Publishing country United States
    Document type Congresses
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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