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Article: Seroprevalence for Measles, Varicella, Mumps and Rubella in the Trainee Obstetric Population: A Survey in Southern Italy.

Perfetto, Brunella / Paduano, Giovanna / Grimaldi, Elena / Sansone, Vincenza / Donnarumma, Giovanna / Di Giuseppe, Gabriella

Vaccines

2024 Volume 12, Issue 3

Abstract: Background: Despite the efforts of the World Health Organization, some childhood viral diseases, for which there is already an effective vaccine, have not yet been eradicated. Among these, we find varicella, mumps, measles, and rubella, which although ... ...

Abstract	Background: Despite the efforts of the World Health Organization, some childhood viral diseases, for which there is already an effective vaccine, have not yet been eradicated. Among these, we find varicella, mumps, measles, and rubella, which although in most cases have a benign course, can in some cases be responsible for infectious outbreaks, especially in nosocomial settings. The aim of this study was to verify the immunological situation of a cohort of trainee obstetricians in Campania regarding varicella, mumps, measles, and rubella to be used as an example for the evaluation of possible preventive strategies to avoid infectious outbreaks. Methods: All the samples collected and sent to the laboratory were eligible for analysis and have been included in the study. Specific IgG for varicella, measles, mumps, and rubella were assayed on serum samples taken from 517 trainee obstetricians using the enzyme-linked immunosorbent assay (ELISA) technique. The seropositivity results were statistically analyzed by correlating them to age group and gender. Results: The results obtained show that a percentage of trainee obstetricians tested do not have an effective immunological coverage against at least one of the vaccine-preventable diseases considered, especially for mumps. Conclusions: Therefore, it is proposed to extend surveillance to other professionals in contact with frail patients and increase awareness of vaccination campaigns.
Language	English
Publishing date	2024-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines12030335
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Article ; Online: Antimicrobial peptide human β-defensin-2 improves <i>in vitro</i> cellular viability and reduces pro-inflammatory effects induced by enteroinvasive <i>Escherichia coli</i> in Caco-2 cells by inhibiting invasion and virulence factors' expression.

Fusco, Alessandra / Savio, Vittoria / Perfetto, Brunella / Mattina, Roberto / Donnarumma, Giovanna

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 1009415

Abstract: ... Escherichia coli ... is one of the commensal species most represented in the intestinal microbiota. However, there are some strains that can acquire new virulence factors that enable them to adapt to new intestinal niches. These include enteroinvasive ...

Abstract	Escherichia coli is one of the commensal species most represented in the intestinal microbiota. However, there are some strains that can acquire new virulence factors that enable them to adapt to new intestinal niches. These include enteroinvasive E. coli (EIEC) that is responsible for the bacillary dysentery that causes severe diarrheal symptoms in both children and adults. Due to the increasing onset of antibiotic resistance phenomena, scientific research is focused on the study of other therapeutic approaches for the treatment of bacterial infections. A promising alternative could be represented by antimicrobial peptides (AMPs), that have received widespread attention due to their broad antimicrobial spectrum and low incidence of bacterial resistance. AMPs modulate the immune defenses of the host and regulate the composition of microbiota and the renewal of the intestinal epithelium. With the aim to investigate an alternative therapeutic approach, especially in the case of antibiotic resistance, in this work we created a line of intestinal epithelial cells able to express high concentrations of AMP human β-defensin-2 (HBD-2) in order to test its ability to interfere with the pathogenicity mechanisms of EIEC. The results showed that HBD-2 is able to significantly reduce the expression of the proinflammatory cytokines by intestinal epithelial cells, the invasiveness ability of EIEC and the expression of invasion-associated genes.
MeSH term(s)	Child ; Humans ; Antimicrobial Peptides ; beta-Defensins/pharmacology ; Caco-2 Cells ; Diarrhea/microbiology ; Escherichia coli/genetics ; Virulence Factors/genetics
Chemical Substances	Antimicrobial Peptides ; beta-Defensins ; Virulence Factors ; DEFB4A protein, human
Language	English
Publishing date	2022-10-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.1009415
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Article ; Online: Regulatory Ability of

Fusco, Alessandra / Perfetto, Brunella / Savio, Vittoria / Chiaromonte, Adriana / Torelli, Giovanna / Donnarumma, Giovanna / Baroni, Adone

Journal of fungi (Basel, Switzerland)

2023 Volume 9, Issue 12

Abstract: The skin serves as the first barrier against pathogen attacks, thanks to its multifunctional microbial community. ...

Abstract	The skin serves as the first barrier against pathogen attacks, thanks to its multifunctional microbial community.
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof9121153
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Article ; Online: Q-switched Nd:YAG laser protects human keratinocytes from oxidative stress and inflammation via AhR-Nrf2 pathway.

Fusco, Alessandra / Savio, Vittoria / Perfetto, Brunella / Donniacuo, Maria / Shadrina, Elena / Donnarumma, Giovanna / Baroni, Adone

Lasers in medical science

2023 Volume 39, Issue 1, Page(s) 7

Abstract: In recent years, some treatments for esthetic and pathologic skin conditions have increasingly been based on the use of non-ablative neodymium-doped yttrium aluminum garnet (Nd:YAG) laser due to its greater penetration ability than other types of lasers, ...

Abstract	In recent years, some treatments for esthetic and pathologic skin conditions have increasingly been based on the use of non-ablative neodymium-doped yttrium aluminum garnet (Nd:YAG) laser due to its greater penetration ability than other types of lasers, few contraindications, minimal side effects, no damage for epidermidis and the rapid recovery of the treated patients. The skin is frequently exposed to many stressors such as radiation, toxic substances, metabolites, foods, mechanical insults, and allergen exposition that cause oxidative damage and have a decisive influence on the aging process. The imbalance between reactive oxygen species, reactive nitrogen species, and the malfunctioning of the antioxidant defense system promotes the establishment of an excessive inflammatory process, which can induce various diseases including cancer and neurodegenerative disorders. The present study investigated the cytoprotective function of Q-switched Nd:YAG laser against stress aging and cell injury in HaCaT cells. We evaluated the effect of the laser on antioxidant defenses, inflammation, metalloproteinases' expression, and the AhR-Nrf2 pathway. Q-switched Nd:YAG is able to upregulate the AhR pathway and the expression of IL-6 and TGF-β, which are involved in wound repair process, and to downregulate the expression of MMP-2 and 9, so preventing the collagen degradation. Q-switched Nd:YAG can stimulate the cellular antioxidant defenses by activating the AhR-Nrf2 system.
MeSH term(s)	Humans ; Lasers, Solid-State/therapeutic use ; NF-E2-Related Factor 2 ; Antioxidants ; Keratinocytes/radiation effects ; Inflammation/radiotherapy ; Inflammation/pathology ; Oxidative Stress
Chemical Substances	NF-E2-Related Factor 2 ; Antioxidants
Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-023-03953-5
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Article ; Online: Antimicrobial Peptides Human Beta-Defensin-2 and -3 Protect the Gut During

Fusco, Alessandra / Savio, Vittoria / Donniacuo, Maria / Perfetto, Brunella / Donnarumma, Giovanna

Frontiers in cellular and infection microbiology

2021 Volume 11, Page(s) 666900

Abstract: The intestinal mucosa is composed of a monolayer of epithelial cells, which is highly polarized and firmly united to each other thanks to the presence of proteins complexes, called Tight junctions (TJs). Alteration of the mucus layer and TJs causes an ... ...

Abstract	The intestinal mucosa is composed of a monolayer of epithelial cells, which is highly polarized and firmly united to each other thanks to the presence of proteins complexes, called Tight junctions (TJs). Alteration of the mucus layer and TJs causes an increase in intestinal permeability, which can lead to a microbial translocation and systemic disorders.
MeSH term(s)	Candida albicans ; Candidiasis ; Humans ; Intestinal Mucosa ; Pore Forming Cytotoxic Proteins ; beta-Defensins
Chemical Substances	Pore Forming Cytotoxic Proteins ; beta-Defensins
Language	English
Publishing date	2021-06-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.666900
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Article ; Online: Long-Term Neuromodulatory Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Plasmatic Matrix Metalloproteinases (MMPs) Levels and Visuospatial Abilities in Mild Cognitive Impairment (MCI).

Cirillo, Giovanni / Pepe, Roberta / Siciliano, Mattia / Ippolito, Domenico / Ricciardi, Dario / de Stefano, Manuela / Buonanno, Daniela / Atripaldi, Danilo / Abbadessa, Salvatore / Perfetto, Brunella / Sharbafshaaer, Minoo / Sepe, Giovanna / Bonavita, Simona / Iavarone, Alessandro / Todisco, Vincenzo / Papa, Michele / Tedeschi, Gioacchino / Esposito, Sabrina / Trojsi, Francesca

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that is used against cognitive impairment in mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, the neurobiological mechanisms underlying ... ...

Abstract	Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that is used against cognitive impairment in mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, the neurobiological mechanisms underlying the rTMS therapeutic effects are still only partially investigated. Maladaptive plasticity, glial activation, and neuroinflammation, including metalloproteases (MMPs) activation, might represent new potential targets of the neurodegenerative process and progression from MCI to AD. In this study, we aimed to evaluate the effects of bilateral rTMS over the dorsolateral prefrontal cortex (DLPFC) on plasmatic levels of MMP1, -2, -9, and -10; MMPs-related tissue inhibitors TIMP1 and TIMP2; and cognitive performances in MCI patients. Patients received high-frequency (10 Hz) rTMS (MCI-TMS,
MeSH term(s)	Humans ; Transcranial Magnetic Stimulation/methods ; Matrix Metalloproteinase 1 ; Cognitive Dysfunction/psychology ; Alzheimer Disease/therapy ; Matrix Metalloproteinases ; Prefrontal Cortex
Chemical Substances	Matrix Metalloproteinase 1 (EC 3.4.24.7) ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2023-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043231
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Article ; Online: Use of MALDI-TOF MS to Discriminate between Biofilm-Producer and Non-Producer Strains of

Caputo, Pina / Di Martino, Maria Chiara / Perfetto, Brunella / Iovino, Francesco / Donnarumma, Giovanna

International journal of environmental research and public health

2018 Volume 15, Issue 8

Abstract: For the management of Staphylococci coagulase-negative infection, often related to biofilm formation, rapid and accurate identification is necessary in choosing a correct antibiotic therapy. Matrix-assisted laser desorption ionization time-of-flight ( ... ...

Abstract	For the management of Staphylococci coagulase-negative infection, often related to biofilm formation, rapid and accurate identification is necessary in choosing a correct antibiotic therapy. Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) is becoming increasingly important for bacterial identification over traditional methods. Our aim was to validate the use of MALDI to discriminate
MeSH term(s)	Biofilms/growth & development ; Humans ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Staphylococcal Infections/microbiology ; Staphylococcus epidermidis/classification ; Staphylococcus epidermidis/growth & development
Language	English
Publishing date	2018-08-09
Publishing country	Switzerland
Document type	Journal Article
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph15081695
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Article ; Online: Q-switched 1064 nm Nd-Yag nanosecond laser effects on skin barrier function and on molecular rejuvenation markers in keratinocyte-fibroblasts interaction.

De Filippis, Anna / Perfetto, Brunella / Guerrera, Luigi Pio / Oliviero, Giovanni / Baroni, Adone

Lasers in medical science

2018 Volume 34, Issue 3, Page(s) 595–605

Abstract: Skin represents an interface between internal and external environment; it protects human body by regulating the water loss and the maintenance of body temperature, defending against irritant and pathogen agents, and against physical, chemical, and UV ... ...

Abstract	Skin represents an interface between internal and external environment; it protects human body by regulating the water loss and the maintenance of body temperature, defending against irritant and pathogen agents, and against physical, chemical, and UV damage. It provides to essential physiological functions, such as the important antioxidant defense capacity; its protective/defensive function is performed by a high number of proteins, and shows important functions in maintenance of skin barrier homeostasis. Keratinocytes and fibroblasts play a pivotal role to determine or prevent skin aging in response to intrinsic or extrinsic stimuli, modulating cytokines and several biochemical factors. Non-ablative technologies are playing an increasing role in the management of skin aging, inducing a dermal remodeling without a visible epidermal damage. The objective of this study was to evaluate the effect of Q-switched 1064 Nd-YAG laser (Medlite Conbio C6 Nd-YAG laser, Cynosure USA) in skin barrier function, analyzing the constituents which are strongly altered in aging skin. Particularly, we evaluated the expression of filaggrin, TGase, HSP70, and aquaporins, on HaCaT cells. The expression of proinflammatory cytokines has been investigated too.As a second step of the study, we analyzed the modulation of the rejuvenation molecular markers on human skin fibroblasts (HDFs) stimulated with keratinocytes conditioned medium (KCM).Our results demonstrated that Q-switched 1064 nm Nd:YAG laser acts on the skin barrier function, increasing the expression of aquaporins, filaggrin, TGase, and HSP70, modulating the proinflammatory cytokines. In fibroblasts stimulated with keratinocytes conditioned medium (KCM) and irradiated with Q-switched 1064 nm Nd:YAG laser, we can observe a reduction of MMP-1 and an increase in procollagen, collagen type I, and elastin. Our results highlight that Q-switched 1064 nm Nd:YAG laser treatment could represent an effective weapon to fight skin aging.
MeSH term(s)	Biomarkers/metabolism ; Cell Communication/radiation effects ; Cell Line ; Cell Survival/radiation effects ; Cytokines/genetics ; Cytokines/metabolism ; Fibroblasts/cytology ; Fibroblasts/radiation effects ; Gene Expression Regulation/radiation effects ; Humans ; Inflammation Mediators/metabolism ; Keratinocytes/cytology ; Keratinocytes/radiation effects ; Lasers, Solid-State/therapeutic use ; Rejuvenation ; Skin/radiation effects ; Skin Aging/radiation effects ; Water
Chemical Substances	Biomarkers ; Cytokines ; Inflammation Mediators ; Water (059QF0KO0R)
Language	English
Publishing date	2018-10-01
Publishing country	England
Document type	Journal Article
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-018-2635-1
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Article ; Online: Correction to: Effect of 1064-nm Q-switched Nd:YAG laser on invasiveness and innate immune response in keratinocytes infected with Candida albicans.

Baroni, Adone / De Filippis, Anna / Oliviero, Giovanni / Fusco, Alessandra / Perfetto, Brunella / Buommino, Elisabetta / Donnarumma, Giovanna

Lasers in medical science

2018 Volume 33, Issue 3, Page(s) 691

Abstract: In the published online version of the article, the authors' given and family names were incorrectly captured. The corrected names are shown in the author group section above. ...

Abstract	In the published online version of the article, the authors' given and family names were incorrectly captured. The corrected names are shown in the author group section above.
Language	English
Publishing date	2018
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-018-2448-2
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Article ; Online: Effect of 1064-nm Q-switched Nd:YAG laser on invasiveness and innate immune response in keratinocytes infected with Candida albicans.

Baroni, Adone / De Filippis, Anna / Oliviero, Giovanni / Fusco, Alessandra / Perfetto, Brunella / Buommino, Elisabetta / Donnarumma, Giovanna

Lasers in medical science

2018 Volume 33, Issue 5, Page(s) 941–948

Abstract: Candida albicans is an opportunistic pathogen commensal in the oral cavity, vagina, and healthy skin. Common therapeutic options for fungal infections are topical or systemic antifungal drugs. Recently, in cutaneous pathologies, lasers and light-based ... ...

Abstract	Candida albicans is an opportunistic pathogen commensal in the oral cavity, vagina, and healthy skin. Common therapeutic options for fungal infections are topical or systemic antifungal drugs. Recently, in cutaneous pathologies, lasers and light-based treatments have emerged showing few contraindications and minimal side effects. The Q-switched (Nd-YAG) laser at a wavelength of 1064 nm has been shown to be useful in dermatology, dentistry, and some other medical specialties. It is used to treat onychomycoses, warts, and wounds and in some other treatments. We analyzed the effect of Q-switched (Nd-YAG) laser 1064 nm on human keratinocytes infected with C. albicans. In particular, we evaluated the effect of laser on invasiveness of C. albicans and on inflammatory and protective response of HaCaT cells infected. The results obtained did not show inhibitory, fungicidal, or fungistatic effects of laser on yeast; in addition, laser did not affect HaCaT vitality. HaCaT cells infected with C. albicans and irradiated with laser showed a reduction of invasiveness of TNF-α and IL8 gene expression and an increase of immunomodulatory cytokines such as TGFβ. Furthermore, laser induces a significant over-expression of HSP70B (heat shock protein) and of HBD-2 (Human β defensin-2) in HaCaT infected with C. albicans, compared to the untreated control. The use of Q-switched Nd:YAG laser in skin mycosis caused by C. albicans reduces yeast invasiveness in keratinocytes, downregulates inflammatory activities, and facilitates cytoprotection and antimicrobial defense. Our results offer a promising therapeutic strategy in the management of skin candidiasis, also in combination with conventional therapies.
MeSH term(s)	Candida albicans/radiation effects ; Cell Line ; Cell Survival/radiation effects ; Female ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Humans ; Immunity, Innate/radiation effects ; Inflammation/pathology ; Keratinocytes/immunology ; Keratinocytes/microbiology ; Keratinocytes/pathology ; Keratinocytes/radiation effects ; Lasers, Solid-State/therapeutic use ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Up-Regulation/radiation effects ; beta-Defensins/genetics ; beta-Defensins/metabolism
Chemical Substances	HSP70 Heat-Shock Proteins ; RNA, Messenger ; beta-Defensins
Language	English
Publishing date	2018-07
Publishing country	England
Document type	Journal Article
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-017-2407-3
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