LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: Systems Biology Approach to Investigate Biomarkers, Boron-10 Carriers, and Mechanisms Useful for Improving Boron Neutron Capture Therapy.

    Perico, Davide / Di Silvestre, Dario / Imamichi, Shoji / Sanada, Yu / Masutani, Mitsuko / Mauri, Pier Luigi

    Cancer biotherapy & radiopharmaceuticals

    2022  Volume 38, Issue 3, Page(s) 152–159

    Abstract: Systems biology approach, carried out with high-throughput omics technologies, has become a fundamental aspect of the study of complex diseases like cancer. It can molecularly characterize subjects, physiopathological conditions, and interactions, ... ...

    Abstract Systems biology approach, carried out with high-throughput omics technologies, has become a fundamental aspect of the study of complex diseases like cancer. It can molecularly characterize subjects, physiopathological conditions, and interactions, allowing a precise description, to reach personalized medicine. In particular, proteomics, typically performed with liquid chromatography coupled to mass spectrometry, is a powerful tool for systems biology, giving the possibility to perform diagnosis, patient stratification, and prediction of therapy effects. Boron Neutron Capture Therapy (BNCT) is a selective antitumoral radiotherapy based on a nuclear reaction that occurs when Boron-10 (
    MeSH term(s) Humans ; Boron ; Boron Neutron Capture Therapy/methods ; Systems Biology ; Glioma/drug therapy ; Boron Compounds/therapeutic use
    Chemical Substances Boron-10 ; Boron (N9E3X5056Q) ; Boron Compounds
    Language English
    Publishing date 2022-10-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1315649-4
    ISSN 1557-8852 ; 1084-9785
    ISSN (online) 1557-8852
    ISSN 1084-9785
    DOI 10.1089/cbr.2022.0053
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1896: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Proteomic Characterization of SAS Cell-Derived Extracellular Vesicles in Relation to Both BPA and Neutron Irradiation Doses.

    Perico, Davide / Tong, Ying / Chen, Lichao / Imamichi, Shoji / Sanada, Yu / Ishiai, Masamichi / Suzuki, Minoru / Masutani, Mitsuko / Mauri, Pierluigi

    Cells

    2023  Volume 12, Issue 12

    Abstract: Boron neutron capture therapy (BNCT) is a selective radiotherapy based on nuclear reaction that occurs ... ...

    Abstract Boron neutron capture therapy (BNCT) is a selective radiotherapy based on nuclear reaction that occurs when
    MeSH term(s) Boron Compounds/therapeutic use ; Proteomics ; Tandem Mass Spectrometry ; Boron Neutron Capture Therapy/methods ; Neutrons ; Extracellular Vesicles
    Chemical Substances Boron Compounds
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12121562
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Interaction of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicases DDX1 and DDX3X Modulates Their Activities on Double-Stranded RNA.

    Lodola, Camilla / Secchi, Massimiliano / Sinigiani, Virginia / De Palma, Antonella / Rossi, Rossana / Perico, Davide / Mauri, Pier Luigi / Maga, Giovanni

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: The nucleocapsid protein Np of SARS-CoV-2 is involved in the replication, transcription, and packaging of the viral genome, but it also plays a role in the modulation of the host cell innate immunity and inflammation response. Ectopic expression of Np ... ...

    Abstract The nucleocapsid protein Np of SARS-CoV-2 is involved in the replication, transcription, and packaging of the viral genome, but it also plays a role in the modulation of the host cell innate immunity and inflammation response. Ectopic expression of Np alone was able to induce significant changes in the proteome of human cells. The cellular RNA helicase DDX1 was among the proteins whose levels were increased by Np expression. DDX1 and its related helicase DDX3X were found to physically interact with Np and to increase 2- to 4-fold its affinity for double-stranded RNA in a helicase-independent manner. Conversely, Np inhibited the RNA helicase activity of both proteins. These functional interactions among Np and DDX1 and DDX3X highlight novel possible roles played by these host RNA helicases in the viral life cycle.
    MeSH term(s) Humans ; RNA Helicases ; RNA, Double-Stranded ; SARS-CoV-2 ; COVID-19 ; Nucleocapsid Proteins ; DEAD-box RNA Helicases/genetics
    Chemical Substances RNA Helicases (EC 3.6.4.13) ; RNA, Double-Stranded ; Nucleocapsid Proteins ; DDX3X protein, human (EC 3.6.1.-) ; DEAD-box RNA Helicases (EC 3.6.4.13) ; DDX1 protein, human (EC 3.6.1.-)
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065784
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: A Boron Delivery Antibody (BDA) with Boronated Specific Residues: New Perspectives in Boron Neutron Capture Therapy from an In Silico Investigation.

    Rondina, Alessandro / Fossa, Paola / Orro, Alessandro / Milanesi, Luciano / De Palma, Antonella / Perico, Davide / Mauri, Pier Luigi / D'Ursi, Pasqualina

    Cells

    2021  Volume 10, Issue 11

    Abstract: Boron Neutron Capture Therapy (BNCT) is a tumor cell-selective radiotherapy based on a nuclear reaction that occurs when the isotope boron-10 ( ...

    Abstract Boron Neutron Capture Therapy (BNCT) is a tumor cell-selective radiotherapy based on a nuclear reaction that occurs when the isotope boron-10 (
    MeSH term(s) Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/genetics ; Boron/administration & dosage ; Boron Neutron Capture Therapy ; Boronic Acids/chemistry ; Computer Simulation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutation/genetics
    Chemical Substances Antibodies, Monoclonal ; Boronic Acids ; Boron (N9E3X5056Q)
    Language English
    Publishing date 2021-11-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10113225
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top