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  1. Article: Hereditary geniospasm in a mother and son treated with botulinum toxin injection: A case report.

    Perkins, Clare / Jia, Wei / Rainsbury, James / Lux, Andrew

    SAGE open medical case reports

    2021  Volume 9, Page(s) 2050313X21993593

    Abstract: Hereditary geniospasm is a rare and benign disorder that can cause distress and social embarrassment to patients. There are only a handful of possible treatment options available. Due to the rarity of the condition, practices differ across the world and ... ...

    Abstract Hereditary geniospasm is a rare and benign disorder that can cause distress and social embarrassment to patients. There are only a handful of possible treatment options available. Due to the rarity of the condition, practices differ across the world and the results are varied. These include beta-blockers, benzodiazepines and anti-epileptics. These treatments can have significant side-effects when used long term. However, botulinum toxin injections have been successfully used in a handful of cases. We report a successful botulinum treatment of hereditary geniospasm in a mother and son, with the injection protocols.
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X21993593
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  2. Article ; Online: Trends in childhood height and weight, and socioeconomic inequalities.

    Perkins, Clare / DeSousa, Eustace

    The Lancet. Public health

    2018  Volume 3, Issue 4, Page(s) e160–e161

    MeSH term(s) Adolescent ; Body Mass Index ; Child ; Humans ; Longitudinal Studies ; Socioeconomic Factors
    Language English
    Publishing date 2018-03-21
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(18)30050-1
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  3. Article ; Online: Fine-needle aspiration cytology and radiological imaging in parotid gland tumours: Our experience in 103 patients.

    Perkins, Clare / Toll, Edward / Reece, Philip

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2019  Volume 44, Issue 6, Page(s) 1124–1127

    MeSH term(s) Anatomic Landmarks/diagnostic imaging ; Biopsy, Fine-Needle ; Diagnosis, Differential ; Female ; Humans ; Male ; Neoplasm Staging ; Parotid Neoplasms/diagnostic imaging ; Parotid Neoplasms/pathology ; Retrospective Studies ; Sensitivity and Specificity
    Language English
    Publishing date 2019-10-11
    Publishing country England
    Document type Letter ; Multicenter Study
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.13410
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  4. Article ; Online: Patient perspectives on surveillance after head and neck cancer treatment: A systematic review.

    McLaren, Oliver / Perkins, Clare / Zhu, Yinan / Smith, Mary / Williams, Richard

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2021  Volume 46, Issue 6, Page(s) 1345–1353

    Abstract: Objectives: Current guidelines advise post-treatment surveillance of head and neck cancer (HNC) patients should involve scheduled appointments with a variety of practitioners. Increasing numbers of HNC survivors raise the burden to provide efficient and ...

    Abstract Objectives: Current guidelines advise post-treatment surveillance of head and neck cancer (HNC) patients should involve scheduled appointments with a variety of practitioners. Increasing numbers of HNC survivors raise the burden to provide efficient and effective care. With resource limitation, there is growing importance to identify how surveillance can be justified and optimised for survivors. This systematic review presents current evidence on patient perspectives of post-treatment HNC surveillance, aiming to inform future work putting patient priorities at the forefront of surveillance planning.
    Design: MEDLINE, Embase, the Cochrane Library, NIHR Dissemination Centre, The Kings Fund Library, Clinical Evidence, NHS Evidence and NICE Clinical Evidence were searched to identify publications regarding patient perspectives of HNC post-treatment surveillance. Studies not reporting on both surveillance and patient perspectives were excluded.
    Results: Three thousand five hundred fifty-eight citations were screened and 49 full-text articles reviewed. Sixteen studies were included in the final review. Three authors reviewed all articles prior to final analysis to ensure all met inclusion criteria. Most evidence was low quality. Study models returned included cross-sectional surveys, structured interviews and one systematic review. Overall, positive perceptions of HNC surveillance were mostly related to increased reassurance. Negative perceptions predominantly focused on anxiety and fear of recurrence, but a lack of psychological support and inadequate access to certain aspects of care were also reported.
    Conclusions: This systematic review demonstrates that patients' perceptions of surveillance after HNC are mostly positive, feeling it provides reassurance. However, several studies report unmet needs, particularly regarding managing anxiety.
    MeSH term(s) Cancer Survivors/psychology ; Head and Neck Neoplasms/psychology ; Head and Neck Neoplasms/therapy ; Humans ; Patient Satisfaction ; Quality of Life ; Survivors
    Language English
    Publishing date 2021-08-10
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.13846
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Alcohol-related harm to others in England: a cross-sectional analysis of national survey data.

    Beynon, Caryl / Bayliss, David / Mason, Jenny / Sweeney, Kate / Perkins, Clare / Henn, Clive

    BMJ open

    2019  Volume 9, Issue 5, Page(s) e021046

    Abstract: Objectives: To estimate the prevalence, the frequency and the perpetrators of alcohol-related harm to others (AHTO) and identify factors associated with experiencing harm and aggressive harm.: Design: Cross-sectional survey.: Setting: England.: ... ...

    Abstract Objectives: To estimate the prevalence, the frequency and the perpetrators of alcohol-related harm to others (AHTO) and identify factors associated with experiencing harm and aggressive harm.
    Design: Cross-sectional survey.
    Setting: England.
    Participants: Adults (general population) aged 16 and over.
    Outcome measures: Percentage of respondents who experienced harm. Socioeconomic and demographic factors associated with the outcomes. Outcomes were (1) experienced harm/did not experience harm and (2) experienced aggressive harm (physically threatened, physically hurt and forced/pressured into something sexual)/did not experience an aggressive harm (no aggressive harm plus no harm at all).
    Results: Data to support a response rate calculation were not collected; 96.3% of people surveyed completed the AHTO questions. The weighted sample was 4874; 20.1% (95% CI 18.9 to 21.4, N=980) reported experiencing harm in the previous 12 months and 4.6% (95% CI 4.0 to 5.4, N=225) reported experiencing an aggressive harm. Friends and strangers were the dominant perpetrators. Most harms (74.8%) occurred less than monthly. Factors associated with experiencing harm were: younger age (p<0.001), drinking harmfully/hazardously (p<0.001), white British (p<0.001 compared to other white groups and Asian groups and p=0.017 compared to black groups), having a disability (p<0.001), being educated (p<0.001 compared to no education) and living in private rented accommodation (p=0.004 compared with owned outright). Being in the family stage of life (defined as having children in the household) had significantly lower odds of harm (p=0.006 compared to being single), as did being retired (p<0.001 compared to being employed). Factors associated with experiencing an aggressive harm were similar.
    Conclusions: This exploratory study, using data collected through the Alcohol Toolkit Survey, shows that AHTO affects 20.1% of the population of England. Even apparently minor harms, like being kept awake, can have a negative impact on health, while aggressive harms are clearly of concern. Using a standard methodology to measure harm across studies would be advantageous. Policies that focus on alcohol must take into consideration the impact of drinking on those other than the drinker.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Aggression/psychology ; Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Alcohol Drinking/psychology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Surveys and Questionnaires ; United Kingdom/epidemiology ; Violence/psychology ; Violence/statistics & numerical data ; Young Adult
    Language English
    Publishing date 2019-05-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2017-021046
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  6. Article ; Online: National household survey of adverse childhood experiences and their relationship with resilience to health-harming behaviors in England.

    Bellis, Mark A / Hughes, Karen / Leckenby, Nicola / Perkins, Clare / Lowey, Helen

    BMC medicine

    2014  Volume 12, Page(s) 72

    Abstract: Background: Epidemiological and biomedical evidence link adverse childhood experiences (ACEs) with health-harming behaviors and the development of non-communicable disease in adults. Investment in interventions to improve early life experiences requires ...

    Abstract Background: Epidemiological and biomedical evidence link adverse childhood experiences (ACEs) with health-harming behaviors and the development of non-communicable disease in adults. Investment in interventions to improve early life experiences requires empirical evidence on levels of childhood adversity and the proportion of HHBs potentially avoided should such adversity be addressed.
    Methods: A nationally representative survey of English residents aged 18 to 69 (n = 3,885) was undertaken during the period April to July 2013. Individuals were categorized according to the number of ACEs experienced. Modeling identified the proportions of HHBs (early sexual initiation, unintended teenage pregnancy, smoking, binge drinking, drug use, violence victimization, violence perpetration, incarceration, poor diet, low levels of physical exercise) independently associated with ACEs at national population levels.
    Results: Almost half (47%) of individuals experienced at least one of the nine ACEs. Prevalence of childhood sexual, physical, and verbal abuse was 6.3%, 14.8%, and 18.2% respectively (population-adjusted). After correcting for sociodemographics, ACE counts predicted all HHBs, e.g. (0 versus 4+ ACEs, adjusted odds ratios (95% confidence intervals)): smoking 3.29 (2.54 to 4.27); violence perpetration 7.71 (4.90 to 12.14); unintended teenage pregnancy 5.86 (3.93 to 8.74). Modeling suggested that 11.9% of binge drinking, 13.6% of poor diet, 22.7% of smoking, 52.0% of violence perpetration, 58.7% of heroin/crack cocaine use, and 37.6% of unintended teenage pregnancy prevalence nationally could be attributed to ACEs.
    Conclusions: Stable and protective childhoods are critical factors in the development of resilience to health-harming behaviors in England. Interventions to reduce ACEs are available and sustainable, with nurturing childhoods supporting the adoption of health-benefiting behaviors and ultimately the provision of positive childhood environments for future generations.
    MeSH term(s) Adolescent ; Adult ; Binge Drinking/complications ; Coitus ; Crime Victims ; Diet/adverse effects ; England ; Ethnic Groups ; Female ; Health Behavior ; Health Surveys ; Humans ; Life Change Events ; Male ; Middle Aged ; Pregnancy ; Pregnancy in Adolescence ; Prevalence ; Resilience, Psychological ; Sedentary Behavior ; Smoking/adverse effects ; Substance-Related Disorders/complications ; Violence ; Young Adult
    Language English
    Publishing date 2014-05-02
    Publishing country England
    Document type Journal Article
    ISSN 1741-7015
    ISSN (online) 1741-7015
    DOI 10.1186/1741-7015-12-72
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  7. Article ; Online: Variations in risk and protective factors for life satisfaction and mental wellbeing with deprivation

    Bellis Mark A / Lowey Helen / Hughes Karen / Deacon Lynn / Stansfield Jude / Perkins Clare

    BMC Public Health, Vol 12, Iss 1, p

    a cross-sectional study

    2012  Volume 492

    Abstract: Abstract Background Improving life satisfaction (LS) and mental wellbeing (MWB) is important for better public health. Like other health issues, LS and MWB are closely related to deprivation (i.e. lack of resources). Developing public health measures ... ...

    Abstract Abstract Background Improving life satisfaction (LS) and mental wellbeing (MWB) is important for better public health. Like other health issues, LS and MWB are closely related to deprivation (i.e. lack of resources). Developing public health measures that reduce inequalities in wellbeing requires an understanding of how factors associated with high and low LS and MWB vary with deprivation. Here, we examine such variations and explore which public health measures are likely to improve wellbeing while reducing related inequalities. Methods A self-administered questionnaire measuring LS and MWB was used with a cross-sectional sample of adults from the North West of England (n = 15,228). Within deprivation tertiles, analyses examined how demographics, health status, employment, relationships and behaviours (alcohol, tobacco, physical exercise) were associated with LS and MWB. Results Deprivation was strongly related to low LS and MWB with, for instance, 17.1 % of the most deprived tertile having low LS compared to 8.9 % in the most affluent. After controlling for confounders, across all deprivation tertiles, better self-assessed health status and being in a relationship were protective against low LS and MWB. Unemployment increased risks of low LS across all tertiles but only risks of low MWB in the deprived tertile. For this tertile, South Asian ethnicity and higher levels of exercise were protective against low MWB. In the middle tertile retired individuals had a reduced risk of low MWB and an increased chance of high LS even in comparison to those in employment. Alcohol’s impact on LS was limited to the most deprived tertile where heavy drinkers were at most risk of poor outcomes. Conclusions In this study, positive outcomes for LS and MWB were strongly associated with lower deprivation and good health status. Public health measures already developed to promote these issues are likely to improve LS and MWB. Efforts to increase engagement in exercise are also likely to have positive impacts, particularly in ...
    Keywords Wellbeing ; Life satisfaction ; Deprivation ; Smoking ; Alcohol ; Physical activity ; Ethnicity ; Health ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2012-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Childhood happiness and violence: a retrospective study of their impacts on adult well-being.

    Bellis, Mark A / Hughes, Karen / Jones, Alyson / Perkins, Clare / McHale, Philip

    BMJ open

    2013  Volume 3, Issue 9, Page(s) e003427

    Abstract: Objectives: To examine the hypothesis that adult well-being is related to childhood experiences independent of current adult sociodemographic conditions.: Design: A cross-sectional, stratified, randomised sample survey using self-assessed measures of ...

    Abstract Objectives: To examine the hypothesis that adult well-being is related to childhood experiences independent of current adult sociodemographic conditions.
    Design: A cross-sectional, stratified, randomised sample survey using self-assessed measures of current well-being and retrospective measures of childhood experiences.
    Setting: Households in North West England (September 2012-March 2013).
    Participants: The individual with the next birthday in randomly selected households (n=11 500; compliance 89.6% of eligible households). Analysis was limited to those aged ≥18 years and answering all pertinent questions (n=11 157).
    Outcomes: The primary outcome was a validated multicomponent measure of mental well-being (MWB). Additional outcomes included self-assessed life satisfaction (LS), life worth and trust in others.
    Results: Adult MWB, LS, life worth and trust were all significantly related to childhood violence and happiness. Relationships remained after controlling for sociodemographics. Thus, compared with those with happy, non-violent childhoods, respondents with unhappy, violent childhoods had adjusted ORs (95% CI, significance) of 3.10 (2.59 to 3.71, p<0.001) for low MWB, 3.62 (2.99 to 4.38, p<0.001) for low LS, 4.13 (3.40 to 5.01, p<0.001) for low life worth and 2.62 (2.20 to 3.11, p<0.001) for low trust. The impact of unhappy but non-violent childhoods were smaller but significant (p<0.001). The modelled impact of childhood factors predicted, for instance, that among unemployed white men aged 25-39 years from the most deprived communities, 27% of those with happy non-violent childhoods would have low MWB rising to 53% of those with unhappy violent childhoods.
    Conclusions: Adult well-being is strongly linked to childhood experiences. The addition of well-being measures to outcomes already associated with adverse childhoods (eg, adolescent antisocial behaviour and risks of adult disease) strengthens the case for investment in interventions to improve childhood experiences. Public health systems are well placed to ensure that policy to improve adult well-being exploits the potential for this to be realised through appropriate interventions.
    Language English
    Publishing date 2013-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2013-003427
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  9. Article ; Online: Variations in risk and protective factors for life satisfaction and mental wellbeing with deprivation: a cross-sectional study.

    Bellis, Mark A / Lowey, Helen / Hughes, Karen / Deacon, Lynn / Stansfield, Jude / Perkins, Clare

    BMC public health

    2012  Volume 12, Page(s) 492

    Abstract: Background: Improving life satisfaction (LS) and mental wellbeing (MWB) is important for better public health. Like other health issues, LS and MWB are closely related to deprivation (i.e. lack of resources). Developing public health measures that ... ...

    Abstract Background: Improving life satisfaction (LS) and mental wellbeing (MWB) is important for better public health. Like other health issues, LS and MWB are closely related to deprivation (i.e. lack of resources). Developing public health measures that reduce inequalities in wellbeing requires an understanding of how factors associated with high and low LS and MWB vary with deprivation. Here, we examine such variations and explore which public health measures are likely to improve wellbeing while reducing related inequalities.
    Methods: A self-administered questionnaire measuring LS and MWB was used with a cross-sectional sample of adults from the North West of England (n = 15,228). Within deprivation tertiles, analyses examined how demographics, health status, employment, relationships and behaviours (alcohol, tobacco, physical exercise) were associated with LS and MWB.
    Results: Deprivation was strongly related to low LS and MWB with, for instance, 17.1% of the most deprived tertile having low LS compared to 8.9% in the most affluent. After controlling for confounders, across all deprivation tertiles, better self-assessed health status and being in a relationship were protective against low LS and MWB. Unemployment increased risks of low LS across all tertiles but only risks of low MWB in the deprived tertile. For this tertile, South Asian ethnicity and higher levels of exercise were protective against low MWB. In the middle tertile retired individuals had a reduced risk of low MWB and an increased chance of high LS even in comparison to those in employment. Alcohol's impact on LS was limited to the most deprived tertile where heavy drinkers were at most risk of poor outcomes.
    Conclusions: In this study, positive outcomes for LS and MWB were strongly associated with lower deprivation and good health status. Public health measures already developed to promote these issues are likely to improve LS and MWB. Efforts to increase engagement in exercise are also likely to have positive impacts, particularly in deprived communities. The development of future initiatives that address LS and MWB must take account of variations in their risk and protective factors at different levels of deprivation.
    MeSH term(s) Adolescent ; Adult ; Aged ; Cross-Sectional Studies ; Female ; Health Status Disparities ; Humans ; Male ; Mental Disorders/epidemiology ; Mental Health ; Middle Aged ; Personal Satisfaction ; Risk Factors ; Socioeconomic Factors ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2012-07-02
    Publishing country England
    Document type Journal Article
    ISSN 1471-2458
    ISSN (online) 1471-2458
    DOI 10.1186/1471-2458-12-492
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  10. Article ; Online: National five-year examination of inequalities and trends in emergency hospital admission for violence across England.

    Bellis, Mark A / Hughes, Karen / Wood, Sara / Wyke, Sacha / Perkins, Clare

    Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention

    2011  Volume 17, Issue 5, Page(s) 319–325

    Abstract: Objectives: To examine relationships between violence, age (0-74 years), and deprivation, and to explore in which communities, age groups, and gender the potential for transmission of violent tendencies between individuals is greatest.: Methods: Five ...

    Abstract Objectives: To examine relationships between violence, age (0-74 years), and deprivation, and to explore in which communities, age groups, and gender the potential for transmission of violent tendencies between individuals is greatest.
    Methods: Five year (2004/2005 to 2008/2009) ecological study of emergency admissions resulting from violence (n=170074) into all English hospitals using trend and logistic regression analyses.
    Results: Hospital admissions for violence peak as individuals achieve legal adulthood (18 years). Risks of admission increase exponentially with increasing quintile of deprivation of residence, with odds overall being 5.5 times higher in the poorest quintile compared with the richest. The greatest absolute difference in violence admissions by deprivation quintile is seen in males aged 18 (218/100 000, richest; 698/100 000, poorest). However, the highest deprivation rate ratios (quintile 5:1) are seen at ages 0-10 years in both sexes and at all ages after 40 years in males (40-58 years, females). In males aged 17-19 years, violence accounts for 20% of the entire gap between wealthiest and poorest quintiles in all cause emergency hospital admissions.
    Conclusions: Analyses identify four lifetime periods for violence: up to 10 years (prepubescent), 11-20 years (adolescence), 21-45 years (younger adults), and over 45 years (older adults). While violence is most common in adolescence, its concentration in poorer areas during prepubescence and in younger adulthood (parenting age) suggests that poorer children are exposed to much more aggressive communities. This is likely to contribute to the disproportionate escalation in violence they experience during adolescence. Effective interventions to prevent such escalations are available and need to be implemented particularly in poor communities.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Aged ; Child ; Child, Preschool ; Emergency Medical Services/utilization ; England/epidemiology ; Female ; Hospitalization/statistics & numerical data ; Hospitalization/trends ; Humans ; Infant ; Infant, Newborn ; Logistic Models ; Male ; Middle Aged ; Poverty Areas ; Risk Factors ; Violence/statistics & numerical data ; Violence/trends ; Wounds and Injuries/epidemiology ; Young Adult
    Language English
    Publishing date 2011-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1433667-4
    ISSN 1475-5785 ; 1353-8047
    ISSN (online) 1475-5785
    ISSN 1353-8047
    DOI 10.1136/ip.2010.030486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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