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  1. AU="Perkins, James A."
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  1. Book ; Online: Interviews with David Madden

    Morrow, Carol / Perkins, James A.

    2014  

    Keywords History (General) ; America
    Size 1 electronic resource (xi, 336 p.)
    Publisher Newfound Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020089356
    ISBN 098464458X ; 9780984644582
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Robbins basic pathology

    Perkins, James A. / Robbins, Stanley L. / Kumar, Vinay / Abbas, Abul K. / Aster, Jon C.

    2018  

    Title variant Basic pathology
    Author's details Vinay Kumar (MBBS, MD FRCPath), Abul K. Abbas (MBBS), Jon C. Aster (MD, PhD) ; artist: James A. Perkins (MS, MFA)
    Keywords Pathologie
    Subject Allgemeine Pathologie ; Spezielle Pathologie ; Klinische Pathologie ; Allgemeine Krankheitslehre
    Language English
    Size xiv, 935 Seiten, Illustrationen, Diagramme
    Edition Tenth edition
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT019461959
    ISBN 978-0-323-35317-5 ; 978-0-323-48054-3 ; 0-323-35317-7 ; 0-323-48054-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 1871 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  3. Article ; Online: Deltoid-Spring Ligament Reconstruction in Adult Acquired Flatfoot Deformity With Medial Peritalar Instability.

    Brodell, James D / MacDonald, Ashlee / Perkins, James A / Deland, Jonathan T / Oh, Irvin

    Foot & ankle international

    2019  Volume 40, Issue 7, Page(s) 753–761

    Abstract: Background: A spring ligament tear is commonly present in advanced stages of adult acquired flatfoot deformity (AAFD). Previous anatomic studies have demonstrated that the superficial deltoid ligament blends with the superomedial spring ligament, ... ...

    Abstract Background: A spring ligament tear is commonly present in advanced stages of adult acquired flatfoot deformity (AAFD). Previous anatomic studies have demonstrated that the superficial deltoid ligament blends with the superomedial spring ligament, forming the tibiocalcaneonavicular ligament (TCNL). Adding allograft TCNL reconstruction to osseous correction has been suggested to augment medial peritalar stability in advanced AAFD with large spring ligament tears. We aimed to investigate the clinical and radiographic outcomes of TCNL reconstruction for flexible AAFD with medial peritalar instability.
    Methods: Fourteen feet in 12 patients who underwent osseous and TCNL reconstructions for advanced AAFD (stage IIB with large spring ligament tears or stage IV) were recruited for the study. The mean postoperative follow-up was 24 (range, 12-33) months. Pre- and postoperative clinical outcomes were assessed by the Foot and Ankle Ability Measure (FAAM), SF-36, and Patient-Reported Outcomes Measurement Information System (PROMIS). Correction of forefoot abduction and the sagittal arch were measured from pre- and postoperative weightbearing radiographs.
    Results: The FAAM Activities of Daily Living improved from 69.3 to 90.1 (
    Conclusion: Considering the anatomic characteristics of the deltoid-spring ligament complex, TCNL reconstruction may play a significant role in maintaining peritalar stability when performed with osseous correction. Deltoid-spring ligament (TCNL) reconstruction is a viable surgical option for those with advanced stage AAFD with medial peritalar instability that leads to improved functional and radiographic outcomes.
    Level of evidence: Level IV, retrospective case series.
    MeSH term(s) Adult ; Aged ; Female ; Flatfoot/diagnostic imaging ; Flatfoot/surgery ; Foot Deformities, Acquired/diagnostic imaging ; Foot Deformities, Acquired/surgery ; Humans ; Joint Instability/diagnostic imaging ; Joint Instability/surgery ; Ligaments, Articular/diagnostic imaging ; Ligaments, Articular/surgery ; Male ; Middle Aged ; Radiography ; Reconstructive Surgical Procedures ; Retrospective Studies ; Surveys and Questionnaires
    Language English
    Publishing date 2019-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183283-6
    ISSN 1944-7876 ; 1071-1007
    ISSN (online) 1944-7876
    ISSN 1071-1007
    DOI 10.1177/1071100719839176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1600: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book: Robbins basic pathology

    Kumar, Vinay / Abbas, Abul K / Aster, Jon C / Perkins, James A

    2018  

    Title variant Basic pathology
    Author's details [edited by] Vinay Kumar, Abul K. Abbas, Jon C. Aster ; artist, James A. Perkins
    MeSH term(s) Pathologic Processes
    Language English
    Size p. ;, cm.
    Edition Tenth edition.
    Document type Book
    ISBN 9780323353175 ; 0323353177
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Book ; Online: Southern Writers at Century's End

    Folks, Jeffrey J / Perkins, James A

    2015  

    Abstract: Since the end of World War II, the South has experienced a greater awareness of growth and of its accompanying tensions than other regions of the United States. The rapid change that climaxed with the war in Vietnam, the Cold War, civil rights ... ...

    Abstract Since the end of World War II, the South has experienced a greater awareness of growth and of its accompanying tensions than other regions of the United States. The rapid change that climaxed with the war in Vietnam, the Cold War, civil rights demonstrations, and Watergate has forced the traditional South to come to terms with social upheaval. As the essays collected in Southern Writers at Century's End point out, southern writing: since 1975 reflects the confusion and violence that have characterized late-twentieth-century public culture.These essays consider the work of twenty-one of the fo
    Language English
    Size Online-Ressource (306 p)
    Publisher The University Press of Kentucky
    Publishing place Lexington
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780813120324 ; 0813120322
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book: Netter's biochemistry

    Ronner, Peter / Netter, Frank H / Machado, Carlos A. G / Craig, John A / Perkins, James A

    2018  

    Title variant Biochemistry
    Author's details Peter Ronner ; illustrations by Frank H. Netter ; contributing illustrators, Carlos A.G. Machado, John A. Craig, James A. Perkins
    MeSH term(s) Biochemical Phenomena ; Biochemistry
    Language English
    Size p. ;, cm.
    Document type Book
    ISBN 9781929007639 ; 1929007639
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Book: Robbins and Cotran pathologic basis of disease

    Kumar, Vinay / Abbas, Abul K / Aster, Jon C / Perkins, James A

    (Student Consult)

    2015  

    Title translation Pathologic basis of disease
    Author's details Vinay Kumar, MBBS, MD, FRCPath (Donald N. Pritzker Professor and Chairman, Department of Pathology, Biologic Sciences Division and The Pritzker School of Medicine, the University of Chicago, Chicago, Illinois), Abul K. Abbas, MBBS (Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California), Jon C. Aster, MD, PhD (Professor of Pathology, Harvard Medical School, Brigham and Women´s Hospital, Boston, Massachusetts) ; with illustrations by James A. Perkins, MS, MFA
    Series title Student Consult
    MeSH term(s) Pathologic Processes
    Keywords Pathology
    Language English
    Size xvi, 1391 Seiten, farbige Illustrationen, Diagramme
    Edition Ninth edition
    Document type Book
    Note Literaturangaben
    ISBN 9780323266161 ; 9780808924500 ; 9781455726134 ; 0323266169 ; 0808924508 ; 1455726133
    Database Friedrich Loeffler-Institute, Federal Research Institute for Animal Health

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  8. Book: Netter's essential physiology

    Mulroney, Susan E / Myers, Adam K / Netter, Frank H / Machado, Carlos A. G / Craig, John A / Perkins, James A / DaVanzo, Tiffany Slaybaugh

    2016  

    Title variant Essential physiology
    Author's details Susan E. Mulroney, Adam K. Myers ; illustrations by Frank H. Netter ; contributing illustrators, Carlos A.G. Machado, John A. Craig, James A. Perkins, Tiffany Slaybaugh DaVanzo
    MeSH term(s) Physiological Phenomena
    Language English
    Size xvi, 402 pages :, color illustrations, portraits ;, 28 cm
    Edition Second edition.
    Document type Book
    Note Includes index.
    ISBN 9780323358194 ; 0323358195
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article ; Online: Cytochromes P450 1A2 and 3A4 Catalyze the Metabolic Activation of Sunitinib.

    Amaya, Gracia M / Durandis, Rebecca / Bourgeois, David S / Perkins, James A / Abouda, Arsany A / Wines, Kahari J / Mohamud, Mohamed / Starks, Samuel A / Daniels, R Nathan / Jackson, Klarissa D

    Chemical research in toxicology

    2018  Volume 31, Issue 7, Page(s) 570–584

    Abstract: Sunitinib is a multitargeted tyrosine kinase inhibitor associated with idiosyncratic hepatotoxicity. The mechanisms of this toxicity are unknown. We hypothesized that sunitinib undergoes metabolic activation to form chemically reactive, potentially toxic ...

    Abstract Sunitinib is a multitargeted tyrosine kinase inhibitor associated with idiosyncratic hepatotoxicity. The mechanisms of this toxicity are unknown. We hypothesized that sunitinib undergoes metabolic activation to form chemically reactive, potentially toxic metabolites which may contribute to development of sunitinib-induced hepatotoxicity. The purpose of this study was to define the role of cytochrome P450 (P450) enzymes in sunitinib bioactivation. Metabolic incubations were performed using individual recombinant P450s, human liver microsomal fractions, and P450-selective chemical inhibitors. Glutathione (GSH) and dansylated GSH were used as trapping agents to detect reactive metabolite formation. Sunitinib metabolites were analyzed by liquid chromatography-tandem mass spectrometry. A putative quinoneimine-GSH conjugate (M5) of sunitinib was detected from trapping studies with GSH and dansyl-GSH in human liver microsomal incubations, and M5 was formed in an NADPH-dependent manner. Recombinant P450 1A2 generated the highest levels of defluorinated sunitinib (M3) and M5, with less formation by P450 3A4 and 2D6. P450 3A4 was the major enzyme forming the primary active metabolite N-desethylsunitinib (M1). In human liver microsomal incubations, P450 3A inhibitor ketoconazole reduced formation of M1 by 88%, while P450 1A2 inhibitor furafylline decreased generation of M5 by 62% compared to control levels. P450 2D6 and P450 3A inhibition also decreased M5 by 54 and 52%, respectively, compared to control. In kinetic assays, recombinant P450 1A2 showed greater efficiency for generation of M3 and M5 compared to that of P450 3A4 and 2D6. Moreover, M5 formation was 2.7-fold more efficient in human liver microsomal preparations from an individual donor with high P450 1A2 activity compared to a donor with low P450 1A2 activity. Collectively, these data suggest that P450 1A2 and 3A4 contribute to oxidative defluorination of sunitinib to generate a reactive, potentially toxic quinoneimine. Factors that alter P450 1A2 and 3A activity may affect patient risk for sunitinib toxicity.
    MeSH term(s) Biocatalysis ; Chromatography, High Pressure Liquid ; Cytochrome P-450 CYP1A2/chemistry ; Cytochrome P-450 CYP1A2/genetics ; Cytochrome P-450 CYP1A2/metabolism ; Cytochrome P-450 CYP3A/chemistry ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Glutathione/chemistry ; Humans ; Ketoconazole/chemistry ; Ketoconazole/metabolism ; Kinetics ; Microsomes, Liver/metabolism ; Quinones/chemistry ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Spectrophotometry, Ultraviolet ; Sunitinib/analysis ; Sunitinib/metabolism ; Tandem Mass Spectrometry
    Chemical Substances Enzyme Inhibitors ; Quinones ; Recombinant Proteins ; CYP1A2 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP1A2 (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; CYP3A4 protein, human (EC 1.14.14.55) ; Glutathione (GAN16C9B8O) ; Ketoconazole (R9400W927I) ; Sunitinib (V99T50803M)
    Language English
    Publishing date 2018-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639353-6
    ISSN 1520-5010 ; 0893-228X
    ISSN (online) 1520-5010
    ISSN 0893-228X
    DOI 10.1021/acs.chemrestox.8b00005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Book: Hochschulzugang in den USA und der Bundesrepublik Deutschland

    Perkins, James A

    (Schriftenreihe der Stiftung Volkswagenwerk ; 18)

    1981  

    Institution Deutsch-amerikanische Studiengruppe des International Council for Educational Development
    Author's details Perkins, James A. u.a. [Hrsg.]. Deutsch-amerikanische Studiengruppe des International Council for Educational Development
    Series title Schriftenreihe der Stiftung Volkswagenwerk ; 18
    Size 270 S
    Publishing place Göttingen
    Document type Book
    ISBN 3525853602 ; 9783525853603
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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