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Article: The impact of bariatric and metabolic surgery on cancer development.

Lunger, Fabian / Aeschbacher, Pauline / Nett, Philipp C / Peros, Georgios

2022 Volume 9, Page(s) 918272

Abstract: Obesity (BMI ≥ 30 kg/ ... ...

Abstract	Obesity (BMI ≥ 30 kg/m
Language	English
Publishing date	2022-07-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.918272
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Acetone compression improves lymph node yield and metastasis detection in colorectal cancer.

Schnoz, Christina / Schmid, Katrin / Ortega Sanchez, Guacimara / Schacher-Kaufmann, Sabina / Adamina, Michel / Peros, Georgios / Erdin, Dieter / Bode, Peter Karl

Clinical & experimental metastasis

2024 Volume 41, Issue 1, Page(s) 45–53

Abstract: Lymph node status is one of the most important prognostic factors in colorectal cancer, and accurate pathological nodal staging and detection of lymph node metastases is crucial for determination of post-operative management. Current guidelines, ... ...

Abstract	Lymph node status is one of the most important prognostic factors in colorectal cancer, and accurate pathological nodal staging and detection of lymph node metastases is crucial for determination of post-operative management. Current guidelines, including the TNM staging system and European Society for Medical Oncology (ESMO) guidelines, recommend examination of at least 12 lymph nodes. However, identification of an adequate number of lymph nodes can be challenging, especially in the setting of neoadjuvant treatment, which may reduce nodal size. In this study, we investigated 384 colorectal cancer resections that were processed at our department of pathology between January 2012 and December 2022, in which the number of detected lymph nodes was less than 12 subsequent to conventional preparation of mesocolic fat tissue. By means of acetone compression, lymph node harvest increased significantly (p < 0.0001), and the intended number of ≥ 12 lymph nodes was achieved in 98% of resection specimens. The number of nodal positive cases increased significantly from n = 95 (24.7%) before versus n = 131 (34.1%) after acetone compression due to additionally identified lymph node metastases (p < 0.001). In 36 patients (9.4%) initially considered as nodal negative, acetone compression led to a staging adjustment to a nodal positive category and thereby drove a recommendation to offer post-operative therapy. In conclusion, acetone compression is a reliable and useful method implementable in routine surgical pathology for the retrieval of lymph nodes in colorectal cancer specimen, allowing for an adequate lymph node sampling and an increase in nodal staging reliability.
MeSH term(s)	Humans ; Lymphatic Metastasis/pathology ; Acetone ; Reproducibility of Results ; Colorectal Neoplasms/pathology ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Neoplasm Staging ; Lymph Node Excision
Chemical Substances	Acetone (1364PS73AF)
Language	English
Publishing date	2024-01-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604952-7
ISSN	1573-7276 ; 0262-0898
ISSN (online)	1573-7276
ISSN	0262-0898
DOI	10.1007/s10585-023-10259-x
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Article ; Online: Organizing a COVID-19 triage unit: a Swiss perspective.

Peros, Georgios / Gronki, Ferda / Molitor, Nadine / Streit, Michael / Sugimoto, Kiyoshi / Karrer, Urs / Lunger, Fabian / Adamina, Michel / Breitenstein, Stefan / Lamdark, Tenzin

Emerging microbes & infections

2020 Volume 9, Issue 1, Page(s) 1506–1513

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Female ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; Switzerland ; Triage/methods
Keywords	covid19
Language	English
Publishing date	2020-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2020.1787107
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Article ; Online: Potential benefit in information providing and influence on patient anxiety and satisfaction by means of preoperative explanatory videos in total extraperitoneal inguinal hernioplasty: study protocol of a multicentre, double-blinded, randomised parallel-group controlled trial.

Lunger, Fabian / Frank, Florian / Peros, Georgios / Lunger, Alexander / Vuille-Dit-Bille, Raphael / Guglielmetti, Laura / Breitenstein, Stefan / Grieder, Felix / Ehlers, Jan / Gingert, Christian

BMJ open

2021 Volume 11, Issue 1, Page(s) e043702

Abstract: Introduction: The use of electronic media in informed consent giving has become increasingly important in recent years. Due to the easy access to information via electronical media, patients are primed in a heterogeneous manner concerning expectations ... ...

Abstract	Introduction: The use of electronic media in informed consent giving has become increasingly important in recent years. Due to the easy access to information via electronical media, patients are primed in a heterogeneous manner concerning expectations and wishes regarding surgical interventions. Inherent to its nature elective interventions are critically questioned as there is time for information gathering and reflection. In this study, we set out to investigate the effect of an educational video as a supporting element in the process of informed consent giving for one the most frequently performed interventions in general surgery, namely inguinal hernia repair. Methods and analysis: In a multicentre setup, eligible patients for primary inguinal hernia repair will be randomly assigned to one of three groups. All three groups will have a preoperative informed consent discussion with a physician in which they will eventually sign the informed consent sheet if participation is desired. Eventually, all three groups will get an online link. For two groups, the link will lead to a video with audiovisual information (an inguinal hernia video for the intervention group and a mock video for the control group). The intervention video provides basic principles of endoscopic extraperitoneal hernia repair. The second video is similar in length and design and displays general aspects of day surgery in the two study centres. All the three study groups will be provided with a copy of the informed consent form as it is standard by now. The third group's link will lead to the digital version of the informed consent brochure. Primary outcomes will consist of (1) score in a multiple choice test assessing gain of knowledge regarding hernia repair, (2) difference in the State-Trait Anxiety Inventory and (3) patient satisfaction questionnaire Individual Clinician Feedback (ICF, Picker Institute, Germany) as assessed 1-2 days after the first consultation. The study design guarantees double blinding, there will be no unblinding at any point. All patients will receive the same, quality and number of medical consultations as well as in the same surgical treatment. (Minor differences in the total extraperitoneal technique of the surgical treatment due to anatomical or pathophysiological differences are independent of the group allocation). Except for the additional videos, there will be no difference in in the information provided and the treatment prior, during or after the hernia repair. Ethics and dissemination: We plan to publish the study in a peer-reviewed journal. The proposed research project has been reviewed by the Cantonal Ethics Committee (BASEC-No 2020-01548). In accordance with national legal regulations in Switzerland stated by the Human Research Act, the proposed project was declared exempt from approval requirement. Trial registration number: NCT04494087; Pre-results.
MeSH term(s)	Anxiety ; Germany ; Hernia, Inguinal/psychology ; Hernia, Inguinal/surgery ; Herniorrhaphy ; Humans ; Multicenter Studies as Topic ; Patient Satisfaction ; Personal Satisfaction ; Randomized Controlled Trials as Topic ; Switzerland
Language	English
Publishing date	2021-01-26
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-043702
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Definition of the "Drug-Angiogenic-Activity-Index" that allows the quantification of the positive and negative angiogenic active drugs: a study based on the chorioallantoic membrane model.

Demir, Resit / Peros, Georgios / Hohenberger, Werner

Pathology oncology research : POR

2011 Volume 17, Issue 2, Page(s) 309–313

Abstract: Since the introduction of the angiogenic therapy by Folkman et al. in the 1970'ies many antiangiogenic drugs were identified. Only few of them are still now in clinical use. Also the Vascular Endothelial Growth Factor (VEGF), the cytokine with the ... ...

Abstract	Since the introduction of the angiogenic therapy by Folkman et al. in the 1970'ies many antiangiogenic drugs were identified. Only few of them are still now in clinical use. Also the Vascular Endothelial Growth Factor (VEGF), the cytokine with the highest angiogenic activity, has been identified. Its antagonist, Bevacizumab, is produced and admitted for the angiogenic therapy in first line for metastatic colorectal cancer. When we look at preclinical studies, they fail of in vivo models that define the "Drug-Angiogenic-Activity-Index" of angiogenic or antiangiogenic drugs. This work proposes a possible standardized procedure to define the "Drug Angiogenic Activity Index" by counting the vascular intersections (VIS) on the Chorioallantoic Membrane after drug application. The equation was defined as follows: {ΔVIS[Drug]-ΔVIS[Control]} / Δ VIS[Control]. For VEGF a Drug-Angiogenic-Activity-Index of 0.92 was found and for Bevacizumab a -1. This means almost that double of the naturally angiogenic activity was achieved by VEGF on the Chorioallantoic membrane. A complete blocking of naturally angiogenic activity was observed after Bevacizumabs application. Establishing the "Drug-Angiogenic-Activity-Index" in the preclinical phase will give us an impact of effectiveness for the new constructed antiangiogenic drugs like the impact of effectiveness in the cortisone family.
MeSH term(s)	Angiogenesis Inhibitors/pharmacology ; Animals ; Chick Embryo ; Chorioallantoic Membrane/drug effects ; Drug Evaluation, Preclinical/methods ; Drug Evaluation, Preclinical/standards
Chemical Substances	Angiogenesis Inhibitors
Language	English
Publishing date	2011-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1375979-6
ISSN	1532-2807 ; 1219-4956
ISSN (online)	1532-2807
ISSN	1219-4956
DOI	10.1007/s12253-010-9318-y
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Article: Organizing a COVID-19 triage unit: a Swiss perspective

Peros, Georgios / Gronki, Ferda / Molitor, Nadine / Streit, Michael / Sugimoto, Kiyoshi / Karrer, Urs / Lunger, Fabian / Adamina, Michel / Breitenstein, Stefan / Lamdark, Tenzin

Emerg Microbes Infect

Abstract: Background: With the rapid global spread of the acute respiratory syndrome coronavirus 2, urgent health-care measures have been implemented. We describe the organizational process in setting up a coronavirus disease 2019 triage unit in a Swiss tertiary ... ...

Abstract	Background: With the rapid global spread of the acute respiratory syndrome coronavirus 2, urgent health-care measures have been implemented. We describe the organizational process in setting up a coronavirus disease 2019 triage unit in a Swiss tertiary care hospital. Methods: Our triage unit was set-up outside of the main hospital building and consists of three areas: 1. Pre-triage, 2. Triage, and 3. Triage plus. The Pre-triage check-points identify any potential COVID-19-infected patients and re-direct them to the main Triage area where trained medical staff screen which patients undergo diagnostic testing. If testing is indicated, nasopharyngeal swabs are performed. If patients require further investigations, they are referred to Triage plus. At this stage, patients are then discharged home after additional testing or admitted to the hospital for management. Observations: A total of 1265 patients were screened between 10 March 2020 and 12 April 2020 at our Triage unit. Of these, 112 (8.9%) tested positive. 73 (65%) of the positively-tested patients were female and 39 (35%) were male. The mean age for all patients was 43.8 years (SD 16.3 years). Distinguishing between genders, mean age for females was 41.1 (SD 16.5) and mean age for males was 48.6 (SD 14.9), with females being significantly younger than males (p < 0.001). Conclusion: Our triage unit was set-up as part of a large-scale restructuring process. Current challenges include low sensitivity for test results as well as limited staff and resources. We hope that our experience will help other health care institutions develop similar triage systems.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #647630
Database	COVID19

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Article ; Online: Organising a COVID-19 Triage Unit

Peros, Georgios / Gronki, Ferda / Molitor, Nadine / Streit, Michael / Sugimoto, Kiyoshi / Karrer, Urs / Lunger, Fabian / Adamina, Michel / Breitenstein, Stefan / Lamdark, Tenzin

SSRN Electronic Journal ; ISSN 1556-5068

A Swiss Perspective

2020

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.2139/ssrn.3582767
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Organizing a COVID-19 triage unit

Peros, Georgios / Gronki, Ferda / Molitor, Nadine / Streit, Michael / Sugimoto, Kiyoshi / Karrer, Urs / Lunger, Fabian / Adamina, Michel / Breitenstein, Stefan / Lamdark, Tenzin

Emerging Microbes & Infections

a Swiss perspective

2020 Volume 9, Issue 1, Page(s) 1506–1513

Keywords	Immunology ; Epidemiology ; Microbiology ; Drug Discovery ; Parasitology ; Virology ; Infectious Diseases ; General Medicine ; covid19
Language	English
Publisher	Informa UK Limited
Publishing country	uk
Document type	Article ; Online
ZDB-ID	2681359-2
ISSN	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2020.1787107
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: ECCO Topical Review Optimising Reporting in Surgery, Endoscopy, and Histopathology.

Adamina, Michel / Feakins, Roger / Iacucci, Marietta / Spinelli, Antonino / Cannatelli, Rosanna / D'Hoore, André / Driessen, Ann / Katsanos, Konstantinos / Mookhoek, Aart / Myrelid, Pär / Pellino, Gianluca / Peros, Georgios / Tontini, Gian Eugenio / Tripathi, Monika / Yanai, Henit / Svrcek, Magali

Journal of Crohn's & colitis

2021 Volume 15, Issue 7, Page(s) 1089–1105

Abstract: Background and aims: Diagnosis and management of inflammatory bowel diseases [IBD] requires a lifelong multidisciplinary approach. The quality of medical reporting is crucial in this context. The present topical review addresses the need for optimised ... ...

Abstract	Background and aims: Diagnosis and management of inflammatory bowel diseases [IBD] requires a lifelong multidisciplinary approach. The quality of medical reporting is crucial in this context. The present topical review addresses the need for optimised reporting in endoscopy, surgery, and histopathology. Methods: A consensus expert panel consisting of gastroenterologists, surgeons, and pathologists, convened by the European Crohn's and Colitis Organisation, performed a systematic literature review. The following topics were covered: in endoscopy: [i] general IBD endoscopy; [ii] disease activity and surveillance; [iii] endoscopy treatment in IBD; in surgery: [iv] medical history with surgical relevance, surgical indication, and strategy; [v] operative approach; [vi] intraoperative disease description; [vii] operative steps; in pathology: [viii] macroscopic assessment and interpretation of resection specimens; [ix] IBD histology, including biopsies, surgical resections, and neoplasia; [x] IBD histology conclusion and report. Statements were developed using a Delphi methodology incorporating two consecutive rounds. Current practice positions were set when ≥ 80% of participants agreed on a recommendation. Results: Thirty practice positions established a standard terminology for optimal reporting in endoscopy, surgery, and histopathology. Assessment of disease activity, surveillance recommendations, advice to surgeons for operative indication and strategies, including margins and extent of resection, and diagnostic criteria of IBD, as well as guidance for the interpretation of dysplasia and cancer, were handled. A standardised report including a core set of items to include in each specialty report, was defined. Conclusions: Interdisciplinary high-quality care requires thorough and standardised reporting across specialties. This topical review offers an actionable framework and practice recommendations to optimise reporting in endoscopy, surgery, and histopathology.
MeSH term(s)	Biopsy ; Delphi Technique ; Documentation/standards ; Endoscopy, Gastrointestinal ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/pathology ; Inflammatory Bowel Diseases/surgery ; Practice Guidelines as Topic ; Quality Assurance, Health Care ; Terminology as Topic
Language	English
Publishing date	2021-01-11
Publishing country	England
Document type	Consensus Development Conference ; Journal Article
ZDB-ID	2390120-2
ISSN	1876-4479 ; 1873-9946
ISSN (online)	1876-4479
ISSN	1873-9946
DOI	10.1093/ecco-jcc/jjab011
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Article ; Online: Modest agreement between magnetic resonance and pathological tumor regression after neoadjuvant therapy for rectal cancer in the real world.

International journal of cancer

2022 Volume 151, Issue 1, Page(s) 120–127

Abstract: Magnetic resonance imaging (MRI) is routinely used for preoperative tumor staging and to assess response to therapy in rectal cancer patients. The aim of our study was to evaluate the accuracy of MRI based restaging after neoadjuvant chemoradiotherapy ( ... ...

Abstract	Magnetic resonance imaging (MRI) is routinely used for preoperative tumor staging and to assess response to therapy in rectal cancer patients. The aim of our study was to evaluate the accuracy of MRI based restaging after neoadjuvant chemoradiotherapy (CRT) in predicting pathologic response. This multicenter cohort study included adult patients with histologically confirmed locally advanced rectal adenocarcinoma treated with neoadjuvant CRT followed by curative intent elective surgery between January 2014 and December 2019 at four academic high-volume institutions. Magnetic resonance tumor regression grade (mrTRG) and pathologic tumor regression grade (pTRG) were reviewed and compared for all the patients. The agreement between radiologist and pathologist was assessed with the weighted k test. Risk factors for poor agreement were investigated using logistic regression. A total of 309 patients were included. Modest agreement was found between mrTRG and pTRG when regression was classified according to standard five-tier systems (k = 0.386). When only two categories were considered for each regression system, (pTRG 0-3 vs pTRG 4; mrTRG 2-5 vs mrTRG 1) an accuracy of 78% (95% confidence interval [CI] 0.73-0.83) was found between radiologic and pathologic assessment with a k value of 0.185. The logistic regression model revealed that "T3 greater than 5 mm extent" was the only variable significantly impacting on disagreement (OR 0.33, 95% CI 0.15-0.68, P = .0034). Modest agreement exists between mrTRG and pTRG. The chances of appropriate assessment of the regression grade after neoadjuvant CRT appear to be higher in case of a T3 tumor with at least 5 mm extension in the mesorectal fat at the pretreatment MRI.
MeSH term(s)	Adult ; Chemoradiotherapy/methods ; Cohort Studies ; Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy ; Neoadjuvant Therapy/methods ; Neoplasm Staging ; Rare Diseases/pathology ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/therapy ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-03-09
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.33975
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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