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  1. Book: Düngung der Reben

    Perret, P.

    (Flugschrift / Eidgenössische Forschungsanstalt für Obst-, Wein- und Gartenbau ; 46)

    1995  

    Author's details [Perret ...]
    Series title Flugschrift / Eidgenössische Forschungsanstalt für Obst-, Wein- und Gartenbau ; 46
    Mitteilungen der Eidgenössischen Forschungsanstalt für Obst, Wein und Gartenbau
    Collection Mitteilungen der Eidgenössischen Forschungsanstalt für Obst, Wein und Gartenbau
    Keywords Weinrebe ; Düngung ; Düngebedürfnis
    Subject Düngerbedarf ; Echte Weinrebe ; Kulturrebe ; Rebe ; Vitis ; Vitis vinifera ; Vitis vinifera sativa ; Weinstock ; Rebstock ; Pflanzendüngung
    Size 46 S. : graph. Darst.
    Publishing place Wädenswil
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT006824356
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  2. Book: Düngung der Reben

    Perret, P.

    (Flugschrift / Eidgenössische Forschungsanstalt für Obst-, Wein- und Gartenbau ; 46)

    1994  

    Author's details P. Perret
    Series title Flugschrift / Eidgenössische Forschungsanstalt für Obst-, Wein- und Gartenbau ; 46
    Mitteilungen der Eidgenössischen Forschungsanstalt für Obst, Wein und Gartenbau
    Collection Mitteilungen der Eidgenössischen Forschungsanstalt für Obst, Wein und Gartenbau
    Keywords Weinrebe ; Düngung
    Subject Pflanzendüngung ; Echte Weinrebe ; Kulturrebe ; Rebe ; Vitis ; Vitis vinifera ; Vitis vinifera sativa ; Weinstock ; Rebstock
    Size 47 S. : graph. Darst.
    Publishing place Wädenswil
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT006274940
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  3. Article: Herzpatient und Höhe: Welcher Herzpatient darf den Ausflug in die Höhe wagen?

    Hoigné-Perret, Philipp

    Therapeutische Umschau. Revue therapeutique

    2017  Volume 74, Issue 10, Page(s) 549–552

    Title translation Heart patient and height: Can my patient with cardiovascular disease travel to high altitude?
    MeSH term(s) Acclimatization/physiology ; Altitude ; Altitude Sickness/diagnosis ; Altitude Sickness/physiopathology ; Altitude Sickness/prevention & control ; Cardiac Output/physiology ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Exercise Test ; Humans ; Hypertension/diagnosis ; Hypertension/physiopathology ; Hypertension/prevention & control ; Myocardial Ischemia/diagnosis ; Myocardial Ischemia/physiopathology ; Myocardial Ischemia/prevention & control ; Myocardial Revascularization ; Myocardium/metabolism ; Oxygen/blood ; Risk Factors ; Travel-Related Illness ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/prevention & control
    Chemical Substances Oxygen (S88TT14065)
    Language German
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    DOI 10.1024/0040-5930/a000955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: El niño viajero: Recomendaciones.

    Perret P, Cecilia

    Revista chilena de infectología : órgano oficial de la Sociedad Chilena de Infectología

    2011  Volume 28, Issue 2, Page(s) 153–156

    Title translation The travelling child: recommendations.
    MeSH term(s) Accident Prevention ; Child ; Child Welfare ; Diarrhea/prevention & control ; Humans ; Malaria/prevention & control ; Practice Guidelines as Topic ; Travel ; Vaccination
    Language Spanish
    Publishing date 2011-04
    Publishing country Chile
    Document type Journal Article
    ISSN 0716-1018
    ISSN 0716-1018
    DOI /S0716-10182011000200007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Children's Allocation of Study Time during the Solution of Raven's Progressive Matrices.

    Perret, Patrick / Dauvier, Bruno

    Journal of Intelligence

    2018  Volume 6, Issue 1

    Abstract: The acuity of reasoning on Raven's Progressive Matrices is strongly influenced by strategic determinants. Building on metamemory studies that highlight the influence of study-time allocation on memory development, we investigated children's allocation of ...

    Abstract The acuity of reasoning on Raven's Progressive Matrices is strongly influenced by strategic determinants. Building on metamemory studies that highlight the influence of study-time allocation on memory development, we investigated children's allocation of study time while solving these matrices. A total of 170 children aged 6-12 years completed a computerized short-form version of the standard matrices featuring items selected to represent a broad range of difficulties. Beyond analyzing changes in mean latencies and performances with age, we used generalized additive mixed models to explore within-participant variability in response times as a function of both item complexity and overall individual efficiency. Results revealed that individual differences in performances were significantly associated with children's adaptive modulation of response times. Mediation analysis further indicated that response-time modulation contributed to age-related changes in performance. Taking account of study-time allocation in reasoning tasks may open up new avenues for the study of reasoning development and the assessment of intellectual functioning.
    Language English
    Publishing date 2018-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721035-2
    ISSN 2079-3200 ; 2079-3200
    ISSN (online) 2079-3200
    ISSN 2079-3200
    DOI 10.3390/jintelligence6010009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Die Vorbereitung des Bodens für eine Neubepflanzung

    Perret, P. / Koblet, Werner

    (Flugschrift / Eidgenössische Forschungsanstalt für Obst-, Wein- und Gartenbau Wädenswil ; 115)

    1984  

    Author's details P. Perret und W. Koblet
    Series title Flugschrift / Eidgenössische Forschungsanstalt für Obst-, Wein- und Gartenbau Wädenswil ; 115
    Mitteilungen der Eidgenössischen Forschungsanstalt für Obst, Wein und Gartenbau
    Collection Mitteilungen der Eidgenössischen Forschungsanstalt für Obst, Wein und Gartenbau
    Size S. 681 - 688
    Publishing place Wädenswil
    Publishing country Switzerland
    Document type Book
    Note Aus: Schweizerische Zeitschrift für Obst- und Weinbau ; 120. 1984
    HBZ-ID HT007110052
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  7. Book: Bodenpflege im Weinbau

    Perret, P. / Koblet, Werner

    (Flugschrift / Eidgenössische Forschungsanstalt für Obst-, Wein- und Gartenbau Wädenswil ; 82)

    1984  

    Author's details P. Perret und W. Koblet
    Series title Flugschrift / Eidgenössische Forschungsanstalt für Obst-, Wein- und Gartenbau Wädenswil ; 82
    Mitteilungen der Eidgenössischen Forschungsanstalt für Obst, Wein und Gartenbau
    Collection Mitteilungen der Eidgenössischen Forschungsanstalt für Obst, Wein und Gartenbau
    Size 16 S.
    Publishing place Wädenswil
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT007111408
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  8. Article: Influenza pandémica a un año de la primera ola. ¿Qué podemos decir ahora?

    Perret P, Cecilia

    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia

    2010  Volume 27, Issue 2, Page(s) 144–147

    Abstract: During year 2009 our nation experimented the first influenza pandemic wave due to the novel influenza A (H1N1) 2009 virus that emerged in the Northern hemisphere at the end of April, 2009. Estimated attack rate was about 6 to 12% affecting mainly to ... ...

    Title translation Pandemic influenza one year after the first wave: what did we learn?.
    Abstract During year 2009 our nation experimented the first influenza pandemic wave due to the novel influenza A (H1N1) 2009 virus that emerged in the Northern hemisphere at the end of April, 2009. Estimated attack rate was about 6 to 12% affecting mainly to schoolchildren who presented with a mild disease. Age groups with highest risk of hospitalization were elderly people and children under 5 years old. Elderly patients and patients with co-morbidities had the highest risk to die. We have learned that clinical diagnosis of influenza has a laboratory confirmation in about 80% of cases but its correlation is lower in kids under 5 years old, especially in infants when RSV co-circulates with influenza virus. Laboratory diagnostic methods like DFA and immuno-chromatography have about 80% of sensitivity but a significantly lower rate in elderly patients compared to PCR. The clinical impact of this new virus justifies the recommendation to vaccinate traditionally established risk groups and to prescribe antiviral treatment to patients that acquire severe influenza or have risk factors to progress to complications.
    MeSH term(s) Adolescent ; Adult ; Aged ; Antiviral Agents/therapeutic use ; Child ; Child, Preschool ; Chile/epidemiology ; Disease Outbreaks ; Fluorescent Antibody Technique ; Humans ; Infant ; Influenza A Virus, H1N1 Subtype ; Influenza Vaccines/administration & dosage ; Influenza, Human/diagnosis ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Middle Aged ; Oseltamivir/therapeutic use ; Polymerase Chain Reaction ; Risk Factors ; Sensitivity and Specificity
    Chemical Substances Antiviral Agents ; Influenza Vaccines ; Oseltamivir (20O93L6F9H)
    Language Spanish
    Publishing date 2010-04
    Publishing country Chile
    Document type English Abstract ; Journal Article
    ZDB-ID 2048815-4
    ISSN 0717-6341 ; 0716-1018
    ISSN (online) 0717-6341
    ISSN 0716-1018
    DOI /S0716-10182010000200008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: La rhinite allergique.

    PERRET, P

    Practica oto-rhino-laryngologica

    2003  Volume 15, Issue 3-4, Page(s) 243–254

    Title translation Allergic rhinitis.
    MeSH term(s) Humans ; Hyperthermia, Induced ; Rhinitis, Allergic ; Rhinitis, Allergic, Seasonal/therapy
    Language Undetermined
    Publishing date 2003-09-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 209011-9
    ISSN 0032-6305
    ISSN 0032-6305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization.

    De Leiris, Nicolas / Perret, Pascale / Lombardi, Charlotte / Gözel, Bülent / Chierici, Sabine / Millet, Philippe / Debiossat, Marlène / Bacot, Sandrine / Tournier, Benjamin B / Chames, Patrick / Lenormand, Jean-Luc / Ghezzi, Catherine / Fagret, Daniel / Moulin, Marcelle

    Journal of translational medicine

    2024  Volume 22, Issue 1, Page(s) 163

    Abstract: Background: Soluble oligomeric forms of Tau protein have emerged as crucial players in the propagation of Tau pathology in Alzheimer's disease (AD). Our objective is to introduce a single-domain antibody (sdAb) named 2C5 as a novel radiotracer for the ... ...

    Abstract Background: Soluble oligomeric forms of Tau protein have emerged as crucial players in the propagation of Tau pathology in Alzheimer's disease (AD). Our objective is to introduce a single-domain antibody (sdAb) named 2C5 as a novel radiotracer for the efficient detection and longitudinal monitoring of oligomeric Tau species in the human brain.
    Methods: The development and production of 2C5 involved llama immunization with the largest human Tau isoform oligomers of different maturation states. Subsequently, 2C5 underwent comprehensive in vitro characterization for affinity and specificity via Enzyme-Linked Immunosorbent Assay and immunohistochemistry on human brain slices. Technetium-99m was employed to radiolabel 2C5, followed by its administration to healthy mice for biodistribution analysis.
    Results: 2C5 exhibited robust binding affinity towards Tau oligomers (Kd = 6.280 nM ± 0.557) and to Tau fibers (Kd = 5.024 nM ± 0.453), with relatively weaker binding observed for native Tau protein (Kd = 1791 nM ± 8.714) and amyloid peptide (Kd > 10,000 nM). Remarkably, this SdAb facilitated immuno-histological labeling of pathological forms of Tau in neurons and neuritic plaques, yielding a high-contrast outcome in AD patients, closely mirroring the performance of reference antibodies AT8 and T22. Furthermore, 2C5 SdAb was successfully radiolabeled with 99mTc, preserving stability for up to 6 h post-radiolabeling (radiochemical purity > 93%). However, following intravenous injection into healthy mice, the predominant uptake occurred in kidneys, amounting to 115.32 ± 3.67, 97.70 ± 43.14 and 168.20 ± 34.52% of injected dose per gram (% ID/g) at 5, 10 and 45 min respectively. Conversely, brain uptake remained minimal at all measured time points, registering at 0.17 ± 0.03, 0.12 ± 0.07 and 0.02 ± 0.01% ID/g at 5, 10 and 45 min post-injection respectively.
    Conclusion: 2C5 demonstrates excellent affinity and specificity for pathological Tau oligomers, particularly in their early stages of oligomerization. However, the current limitation of insufficient blood-brain barrier penetration necessitates further modifications before considering its application in nuclear medicine imaging for humans.
    MeSH term(s) Animals ; Humans ; Mice ; Alzheimer Disease/diagnostic imaging ; Brain/pathology ; Single-Domain Antibodies/chemistry ; Single-Domain Antibodies/metabolism ; tau Proteins/chemistry ; tau Proteins/immunology ; Tissue Distribution
    Chemical Substances Single-Domain Antibodies ; tau Proteins
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-024-04987-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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