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Article ; Online: HBsAg kinetics after 7 years of therapy with tenofovir disoproxil fumarate in a cohort of naïve patients affected by chronic hepatitis B with different genotypes.

Boglione, Lucio / Lupia, Tommaso / Stroffolini, Giacomo / Dodaro, Valentina / Perri, Giovanni Di

Infectious medicine

2024 Volume 3, Issue 1, Page(s) 100087

Abstract: The role of different genotypes in nucleos(t)ide analogs (NAs) treatment is still debated. Previous studies conducted on special populations evidenced that the E genotype had the lower virological and serological response. This descriptive study aims to ... ...

Abstract	The role of different genotypes in nucleos(t)ide analogs (NAs) treatment is still debated. Previous studies conducted on special populations evidenced that the E genotype had the lower virological and serological response. This descriptive study aims to recognize the hepatitis B "s" antigen (HBsAg) decline during tenofovir disoproxil fumarate (TDF) treatment in a cohort of patient affected by chronic hepatitis B (CHB). We retrospectively included all patients with CHB treated with TDF between April 2007 and March 2012 with a duration of treatment of 7 years. Kinetics of HBsAg was determined as serological response in this cohort. We include 110 subjects; virological response was observed in all subjects with genotypes A, B, and D; in 17 patients with C genotype (94.4%) and 24 with E genotype (96%). HBeAg loss was observed in 2 patients with genotype A (50%), 3 with B (100%), 0 with C (0%), 1 with D (20%), and 1 with E genotype (25%). In multivariate analysis we observed as predictive factors of HBsAg decline the baseline level of HBsAg (OR = 1.467; 95%CI: 1.221-5.113;
Language	English
Publishing date	2024-02-01
Publishing country	China
Document type	Journal Article
ISSN	2772-431X
ISSN (online)	2772-431X
DOI	10.1016/j.imj.2024.100087
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Article ; Online: Host Single Nucleotide Polymorphisms and Biomarkers of Neuronal Damage and Inflammation in People Living with HIV.

Cusato, Jessica / Manca, Alessandra / Palermiti, Alice / Mula, Jacopo / Avataneo, Valeria / Antonucci, Miriam / Marinaro, Letizia / Bonora, Stefano / Trunfio, Mattia / Perri, Giovanni Di / D'Avolio, Antonio / Calcagno, Andrea

International journal of antimicrobial agents

2024 , Page(s) 107137

Abstract: Background: Blood brain barrier impairment is frequent in people living with HIV (PLWH), affecting the penetration of target cells and antiretrovirals into the central nervous system, through transporters (e.g. ABCB1), leading to neuroinflammation.: ... ...

Abstract	Background: Blood brain barrier impairment is frequent in people living with HIV (PLWH), affecting the penetration of target cells and antiretrovirals into the central nervous system, through transporters (e.g. ABCB1), leading to neuroinflammation. Objectives: The aim of this study was to identify variants of genes encoding transporters able to predict neuroinflammation biomarker levels. Materials and methods: Cerebrospinal fluid (CSF) and plasma samples were obtained from PLWH. CSF biomarkers were quantified by commercial assays. Genetic variants were evaluated through real-time polymerase chain reaction (PCR). Results: 107 PLWH (163 samples) were included in the study: 79% were male, median age was 48.5 years, CD4% was 25%, HIV-associated neurolocognitive disorder (HAND) was observed in 17.8% of patients. ABCB1 2677G>T genetic variant showed a different allelic distribution according to the clinical group (p=0.026). In linear regression analyses, HIV-related central nervous system disorders, ABCG2 1194+928CC genotype, log viral load, CSAR, β-1,42 levels and CSF proteins were retained in the final model as factors independently associated with CSF neopterin levels; CSF proteins and integrase inhibitors use were associated with CSF tau level in the multivariate model. Phospho-tau regression analysis reported ABCB1 2677GT/TT genotype and CSF proteins as predictors in the final model; gender and protease inhibitors, neopterin, ABCB1 2677 GT/ TT genotype resulted predictors in the multivariate regression for β-1,42. Conclusions: For the first time, pharmacogenetic and clinical features were predictors of neuro-inflammation biomarkers.
Language	English
Publishing date	2024-03-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107137
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Good times, bad times: A diary of a physician in the COVID-19 era.

Lupia, Tommaso / Stroffolini, Giacomo / Angilletta, Roberto / Bonora, Stefano / Perri, Giovanni Di

European journal of internal medicine

2020 Volume 77, Page(s) 132–133

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Diaries as Topic ; Humans ; Italy ; Pandemics ; Physicians/psychology ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Workload/psychology
Keywords	covid19
Language	English
Publishing date	2020-05-15
Publishing country	Netherlands
Document type	Letter ; Personal Narrative
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2020.04.009
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Article: Good times, bad times: A diary of a physician in the COVID-19 era

Lupia, Tommaso / Stroffolini, Giacomo / Angilletta, Roberto / Bonora, Stefano / Perri, Giovanni Di

Eur J Intern Med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #276454
Database	COVID19

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Article ; Online: Good times, bad times

Lupia, Tommaso / Stroffolini, Giacomo / Angilletta, Roberto / Bonora, Stefano / Perri, Giovanni Di

European Journal of Internal Medicine

A diary of a physician in the COVID-19 era

2020 Volume 77, Page(s) 132–133

Keywords	Internal Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1038679-8
ISSN	0953-6205
ISSN	0953-6205
DOI	10.1016/j.ejim.2020.04.009
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Article ; Online: Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease Patients.

Ribaldone, Davide Giuseppe / Adriani, Alessandro / Caviglia, Gian Paolo / Nicolò, Amedeo De / Agnesod, Danilo / Simiele, Marco / Riganò, Danila / Pellicano, Rinaldo / Canaparo, Roberto / Perri, Giovanni Di / D'Avolio, Antonio / Luzza, Francesco / Saracco, Giorgio Maria / Astegiano, Marco

Medicina (Kaunas, Lithuania)

2019 Volume 55, Issue 8

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Adolescent ; Adult ; Aged ; Azathioprine/adverse effects ; Azathioprine/therapeutic use ; Female ; Genotype ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/genetics ; Male ; Methyltransferases/adverse effects ; Methyltransferases/analysis ; Methyltransferases/blood ; Methyltransferases/genetics ; Middle Aged
Chemical Substances	Immunosuppressive Agents ; Methyltransferases (EC 2.1.1.-) ; TPMT protein, human (EC 2.1.1.67) ; thiopurine methyltransferase (EC 2.1.1.67) ; Azathioprine (MRK240IY2L)
Language	English
Publishing date	2019-08-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina55080441
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Article ; Online: Anti-Tat immunity defines CD4

Tripiciano, Antonella / Picconi, Orietta / Moretti, Sonia / Sgadari, Cecilia / Cafaro, Aurelio / Francavilla, Vittorio / Arancio, Angela / Paniccia, Giovanni / Campagna, Massimo / Pavone-Cossut, Maria Rosaria / Sighinolfi, Laura / Latini, Alessandra / Mercurio, Vito S / Pietro, Massimo Di / Castelli, Francesco / Saracino, Annalisa / Mussini, Cristina / Perri, Giovanni Di / Galli, Massimo /

Nozza, Silvia / Ensoli, Fabrizio / Monini, Paolo / Ensoli, Barbara

EBioMedicine

2021 Volume 66, Page(s) 103306

Abstract: Background: Low-level HIV viremia originating from virus reactivation in HIV reservoirs is often present in cART treated individuals and represents a persisting source of immune stimulation associated with sub-optimal recovery of CD4: Methods: ... ...

Abstract	Background: Low-level HIV viremia originating from virus reactivation in HIV reservoirs is often present in cART treated individuals and represents a persisting source of immune stimulation associated with sub-optimal recovery of CD4 Methods: Volunteers enrolled in a 3-year longitudinal observational study were stratified by residual viremia, Tat serostatus and frequency of anti-Tat cellular immune responses. The impact of anti-Tat immunity on low-level viremia, persistent immune activation and CD4 Findings: Anti-Tat immunity is significantly associated with higher nadir CD4 Interpretation: Therapeutic approaches aiming at reinforcing anti-Tat immunity should be investigated to improve immune reconstitution in people living with HIV on long-term cART. Trial registration: ISS OBS T-002 ClinicalTrials.gov identifier: NCT01024556 FUNDING: Italian Ministry of Health, special project on the Development of a vaccine against HIV based on the Tat protein and Ricerca Corrente 2019/2020.
MeSH term(s)	Antiretroviral Therapy, Highly Active ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Biomarkers ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; HIV Antibodies/immunology ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/immunology ; Host-Pathogen Interactions/immunology ; Humans ; Immunophenotyping ; Lymphocyte Activation ; Viral Load ; tat Gene Products, Human Immunodeficiency Virus/immunology
Chemical Substances	Biomarkers ; HIV Antibodies ; tat Gene Products, Human Immunodeficiency Virus
Language	English
Publishing date	2021-04-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2021.103306
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Article ; Online: Pharmacogenetic of voriconazole antifungal agent in pediatric patients.

Allegra, Sarah / Fatiguso, Giovanna / Francia, Silvia De / Pirro, Elisa / Carcieri, Chiara / Cusato, Jessica / Nicolò, Amedeo De / Avataneo, Valeria / Perri, Giovanni Di / D'Avolio, Antonio

Pharmacogenomics

2018 Volume 19, Issue 11, Page(s) 913–925

Abstract: Aim: We explored the role of SNPs within the SLCO1B3, SLCO1B1, SLC22A6, ABCB1, ABCG2, SLCO3A1, CYP2C19, ABCC2, SLC22A1, ABCB11 and NR1I2 genes on voriconazole pharmacokinetics.: Patients & methods: 233 pediatric patients were enrolled. Drug plasma C!# ...

Abstract	Aim: We explored the role of SNPs within the SLCO1B3, SLCO1B1, SLC22A6, ABCB1, ABCG2, SLCO3A1, CYP2C19, ABCC2, SLC22A1, ABCB11 and NR1I2 genes on voriconazole pharmacokinetics. Patients & methods: 233 pediatric patients were enrolled. Drug plasma C Results: SLCO1B3 rs4149117 c.334 GT/TT (p = 0.046), ABCG2 rs13120400 c.1194 + 928 CC (p = 0.029) and ABCC2 rs717620 c.-24 GA/AA (p = 0.025) genotype groups significantly influenced C Conclusion: Understanding how some gene polymorphisms affect the voriconazole pharmacokinetic is essential to optimally dose this agent.
MeSH term(s)	Adolescent ; Antifungal Agents/therapeutic use ; Child ; Female ; Genotype ; Humans ; Male ; Pharmacogenetics/methods ; Pharmacogenomic Testing/methods ; Polymorphism, Single Nucleotide/genetics ; Voriconazole/therapeutic use
Chemical Substances	Antifungal Agents ; Voriconazole (JFU09I87TR)
Language	English
Publishing date	2018-06-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2019513-8
ISSN	1744-8042 ; 1462-2416
ISSN (online)	1744-8042
ISSN	1462-2416
DOI	10.2217/pgs-2017-0173
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Article ; Online: A 30-years review on pharmacokinetics of antibiotics: is the right time for pharmacogenetics?

Baietto, Lorena / Corcione, Silvia / Pacini, Giovanni / Perri, Giovanni Di / D'Avolio, Antonio / De Rosa, Francesco Giuseppe

Current drug metabolism

2014 Volume 15, Issue 6, Page(s) 581–598

Abstract: Drug bioavailability may vary greatly amongst individuals, affecting both efficacy and toxicity: in humans, genetic variations account for a relevant proportion of such variability. In the last decade the use of pharmacogenetics in clinical practice, as ... ...

Abstract	Drug bioavailability may vary greatly amongst individuals, affecting both efficacy and toxicity: in humans, genetic variations account for a relevant proportion of such variability. In the last decade the use of pharmacogenetics in clinical practice, as a tool to individualize treatment, has shown a different degree of diffusion in various clinical fields. In the field of infectious diseases, several studies identified a great number of associations between host genetic polymorphisms and responses to antiretroviral therapy. For example, in patients treated with abacavir the screening for HLA-B*5701 before starting treatment is routine clinical practice and standard of care for all patients; efavirenz plasma levels are influenced by single nucleotide polymorphism (SNP) CYP2B6-516G>T (rs3745274). Regarding antibiotics, many studies investigated drug transporters involved in antibiotic bioavailability, especially for fluoroquinolones, cephalosporins, and antituberculars. To date, few data are available about pharmacogenetics of recently developed antibiotics such as tigecycline, daptomycin or linezolid. Considering the effect of SNPs in gene coding for proteins involved in antibiotics bioavailability, few data have been published. Increasing knowledge in the field of antibiotic pharmacogenetics could be useful to explain the high drug inter-patients variability and to individualize therapy. In this paper we reported an overview of pharmacokinetics, pharmacodynamics, and pharmacogenetics of antibiotics to underline the importance of an integrated approach in choosing the right dosage in clinical practice.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Monitoring ; Humans ; Pharmacogenetics
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2014-06-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2064815-7
ISSN	1875-5453 ; 1389-2002
ISSN (online)	1875-5453
ISSN	1389-2002
DOI	10.2174/1389200215666140605130935
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Article ; Online: Ethambutol plasma and intracellular pharmacokinetics: A pharmacogenetic study.

Fatiguso, Giovanna / Allegra, Sarah / Calcagno, Andrea / Baietto, Lorena / Motta, Ilaria / Favata, Fabio / Cusato, Jessica / Bonora, Stefano / Perri, Giovanni Di / D'Avolio, Antonio

International journal of pharmaceutics

2016 Volume 497, Issue 1-2, Page(s) 287–292

Abstract: We evaluated ethambutol plasma and intracellular pharmacokinetic according to single nucleotide polymorphisms in ABCB1, OATP1B1, PXR, VDR, CYP24A1 and CYP27B1 genes. Mycobacterium tubercolosis infected patients were enrolled. Standard weight-adjusted ... ...

Abstract	We evaluated ethambutol plasma and intracellular pharmacokinetic according to single nucleotide polymorphisms in ABCB1, OATP1B1, PXR, VDR, CYP24A1 and CYP27B1 genes. Mycobacterium tubercolosis infected patients were enrolled. Standard weight-adjusted antitubercular treatment was administered intravenously for 2 weeks and then orally. Allelic discrimination was performed by real-time PCR. Ethambutol plasma and intracellular concentrations were measured by UPLC-MS/MS methods. Twenty-four patients were included. Considering weeks 2 and 4, median plasma Ctrough were 73 ng/mL and 247 ng/mL, intracellular Ctrough were 16,863 ng/mL and 13,535 ng/mL, plasma Cmax were 5627 ng/mL and 2229 ng/mL, intracellular Cmax were 133,830 ng/mL and 78,544 ng/mL. At week 2, ABCB1 3435 CT/TT (p=0.023) and CYP24A1 8620 AG/GG (p=0.030) genotypes for plasma Ctrough, BsmI AA (p=0.036) for intracellular Ctrough and BsmI AA (p<0.001) and ApaI AA (p=0.048) for intracellular Cmax, remained in linear regression analysis as predictive factors. Concerning week 4 only ABCB1 3435 CT/TT (p=0.035) and Cdx2 AG/GG (p=0.004) genotypes for plasma Ctrough and BsmI AA (p=0.028) for plasma Cmax were retained in final regression model. We reveal, for the first time, the possible role of single nucleotide polymorphisms on ethambutol plasma and intracellular concentrations; this may further the potential use of pharmacogenetic for tailoring antitubercular treatment.
MeSH term(s)	25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; ATP Binding Cassette Transporter, Sub-Family B/genetics ; Ethambutol/blood ; Ethambutol/pharmacokinetics ; Female ; Genotype ; Humans ; Leukocytes, Mononuclear/metabolism ; Male ; Organic Anion Transporters/genetics ; Peroxisome-Targeting Signal 1 Receptor ; Polymorphism, Single Nucleotide/genetics ; Receptors, Calcitriol/genetics ; Receptors, Cytoplasmic and Nuclear/genetics ; Solute Carrier Organic Anion Transporter Family Member 1b1 ; Time Factors ; Tuberculosis/blood ; Tuberculosis/genetics ; Vitamin D3 24-Hydroxylase/genetics
Chemical Substances	ABCB1 protein, human ; ATP Binding Cassette Transporter, Sub-Family B ; Organic Anion Transporters ; Peroxisome-Targeting Signal 1 Receptor ; Receptors, Calcitriol ; Receptors, Cytoplasmic and Nuclear ; SLCO1B1 protein, human ; Solute Carrier Organic Anion Transporter Family Member 1b1 ; VDR protein, human ; Ethambutol (8G167061QZ) ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.13.13) ; Vitamin D3 24-Hydroxylase (EC 1.14.15.16)
Language	English
Publishing date	2016-01-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2015.11.044
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