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  1. Article ; Online: Kinetics of the reaction of ferrous ions with hydroxyl radicals in the temperature range 25-300 °C.

    Barr, Logan / Conrad, Jacy K / McGregor, Christine / Perron, Randy / Yakabuskie, Pamela A / Stuart, Craig R

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 5, Page(s) 4278–4283

    Abstract: The kinetics and mechanism of the reaction between OH radicals and ferrous ions in the temperature range 25-300 °C were studied using pulse radiolysis. At temperatures <150 °C the rate of reaction is essentially independent of temperature, while at ... ...

    Abstract The kinetics and mechanism of the reaction between OH radicals and ferrous ions in the temperature range 25-300 °C were studied using pulse radiolysis. At temperatures <150 °C the rate of reaction is essentially independent of temperature, while at temperatures >150 °C the activation energy is 45.8 ± 3.0 kJ mol
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp03819j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Construction of a thorium/actinium generator at the Canadian Nuclear Laboratories.

    Perron, Randy / Gendron, Denise / Causey, Patrick W

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2020  Volume 164, Page(s) 109262

    Abstract: Targeted Alpha Therapy (TAT) has demonstrated considerable promise in the treatment of a range of cancers in both preclinical and, more recently clinical research. In particular, work with the alpha-emitting ... ...

    Abstract Targeted Alpha Therapy (TAT) has demonstrated considerable promise in the treatment of a range of cancers in both preclinical and, more recently clinical research. In particular, work with the alpha-emitting radionuclide
    MeSH term(s) Actinium/chemistry ; Alpha Particles ; Canada ; Chromatography, Liquid/methods ; Radiometry/methods ; Solubility ; Thorium/chemistry
    Chemical Substances Thorium (60YU5MIG9W) ; Actinium (NIK1K0956U)
    Language English
    Publishing date 2020-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2020.109262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.279: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: 232

    Robertson, Andrew K H / McNeil, Brooke L / Yang, Hua / Gendron, Denise / Perron, Randy / Radchenko, Valery / Zeisler, Stefan / Causey, Patrick / Schaffer, Paul

    Inorganic chemistry

    2020  Volume 59, Issue 17, Page(s) 12156–12165

    Abstract: Recent clinical results have demonstrated remarkable treatment responses of late-stage cancer patients when treated with alpha-emitting radionuclides such as actinium-225 ( ...

    Abstract Recent clinical results have demonstrated remarkable treatment responses of late-stage cancer patients when treated with alpha-emitting radionuclides such as actinium-225 (
    Language English
    Publishing date 2020-07-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.0c01081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Synthesis and Evaluation of a Macrocyclic Actinium-225 Chelator, Quality Control and In Vivo Evaluation of

    Yang, Hua / Zhang, Chengcheng / Yuan, Zheliang / Rodriguez-Rodriguez, Cristina / Robertson, Andrew / Radchenko, Valery / Perron, Randy / Gendron, Denise / Causey, Patrick / Gao, Feng / Bénard, François / Schaffer, Paul

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2020  Volume 26, Issue 50, Page(s) 11435–11440

    Abstract: Targeted alpha-therapy (TAT) has great potential for treating a broad range of late-stage cancers by delivering a focused and lethal radiation dose to tumors. Actinium-225 ( ...

    Abstract Targeted alpha-therapy (TAT) has great potential for treating a broad range of late-stage cancers by delivering a focused and lethal radiation dose to tumors. Actinium-225 (
    MeSH term(s) Actinium ; Chelating Agents ; Coordination Complexes ; Crown Compounds ; Quality Control ; Tissue Distribution ; alpha-MSH/metabolism
    Chemical Substances Actinium-225 ; Chelating Agents ; Coordination Complexes ; Crown Compounds ; alpha-MSH (581-05-5) ; Actinium (NIK1K0956U)
    Language English
    Publishing date 2020-08-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202002999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Nimotuzumab Site-Specifically Labeled with

    Solomon, Viswas Raja / Barreto, Kris / Bernhard, Wendy / Alizadeh, Elahe / Causey, Patrick / Perron, Randy / Gendron, Denise / Alam, Md Kausar / Carr, Adriana / Geyer, C Ronald / Fonge, Humphrey

    Cancers

    2020  Volume 12, Issue 11

    Abstract: To develop imaging and therapeutic agents, antibodies are often conjugated randomly to a chelator/radioisotope or drug using a primary amine ( ... ...

    Abstract To develop imaging and therapeutic agents, antibodies are often conjugated randomly to a chelator/radioisotope or drug using a primary amine (NH
    Language English
    Publishing date 2020-11-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12113449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comparison of various radioactive payloads for a human monoclonal antibody to glycoprotein 41 for elimination of HIV-infected cells.

    Garg, Ravendra / Mills, Kienna / Allen, Kevin J H / Causey, Patrick / Perron, Randy W / Gendron, Denise / Sanche, Stephen / Berman, Joan W / Gorny, Miroslaw K / Dadachova, Ekaterina

    Nuclear medicine and biology

    2020  Volume 82-83, Page(s) 80–88

    Abstract: Background: cART has significantly improved the life expectancy of people living with HIV (PLWH). However, it fails to eliminate the long-lived reservoir of latent HIV-infected cells. Radioimmunotherapy (RIT) relies on antigen-specific monoclonal ... ...

    Abstract Background: cART has significantly improved the life expectancy of people living with HIV (PLWH). However, it fails to eliminate the long-lived reservoir of latent HIV-infected cells. Radioimmunotherapy (RIT) relies on antigen-specific monoclonal antibodies (mAbs) for targeted delivery of lethal doses of ionizing radiation to cells. Previously, we have demonstrated that human mAb 2556 against HIV gp41 conjugated with
    Methods: In this study we have conjugated 2556 mAb with
    Results: After three days post-treatment of infected PBMCs and monocytes,
    Conclusion: These results indicate that RIT holds promise as a novel treatment option for the eradication of HIV-infected cells that merits further study in combination with cART and reactivation drugs.
    MeSH term(s) Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Cell Line ; DNA Breaks, Double-Stranded/radiation effects ; HIV-1/physiology ; HIV-1/radiation effects ; Humans ; Isotope Labeling ; Leukocytes, Mononuclear/virology ; Membrane Glycoproteins/immunology ; Monocytes/virology
    Chemical Substances Antibodies, Monoclonal ; Membrane Glycoproteins ; glycoprotein 41
    Language English
    Publishing date 2020-02-19
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1138098-6
    ISSN 1872-9614 ; 0883-2897 ; 0969-8051
    ISSN (online) 1872-9614
    ISSN 0883-2897 ; 0969-8051
    DOI 10.1016/j.nucmedbio.2020.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1090: Show issues Location:
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  7. Article ; Online: Production and Supply of α-Particle-Emitting Radionuclides for Targeted α-Therapy.

    Radchenko, Valery / Morgenstern, Alfred / Jalilian, Amir R / Ramogida, Caterina F / Cutler, Cathy / Duchemin, Charlotte / Hoehr, Cornelia / Haddad, Ferrid / Bruchertseifer, Frank / Gausemel, Haavar / Yang, Hua / Osso, Joao Alberto / Washiyama, Kohshin / Czerwinski, Kenneth / Leufgen, Kirsten / Pruszyński, Marek / Valzdorf, Olga / Causey, Patrick / Schaffer, Paul /
    Perron, Randy / Maxim, Samsonov / Wilbur, D Scott / Stora, Thierry / Li, Yawen

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2021  Volume 62, Issue 11, Page(s) 1495–1503

    Abstract: Encouraging results from targeted α-therapy have received significant attention from academia and industry. However, the limited availability of suitable radionuclides has hampered widespread translation and application. In the present review, we discuss ...

    Abstract Encouraging results from targeted α-therapy have received significant attention from academia and industry. However, the limited availability of suitable radionuclides has hampered widespread translation and application. In the present review, we discuss the most promising candidates for clinical application and the state of the art of their production and supply. In this review, along with 2 forthcoming reviews on chelation and clinical application of α-emitting radionuclides,
    MeSH term(s) Alpha Particles/therapeutic use ; Radioimmunotherapy
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.261016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 114: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 328: Show issues

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