Article ; Online: Association of Cumulative Lifetime Exposure to Female Hormones With Cerebral Small Vessel Disease in Postmenopausal Women in the UK Biobank.
2023 Volume 101, Issue 20, Page(s) e1970–e1978
Abstract: Background and objectives: Rates of cerebrovascular disease increase after menopause, which is often attributed to the absence of hormones. It remains unknown whether the cumulative exposure to hormones across a female person's premenopausal life ... ...
| Abstract | Background and objectives: Rates of cerebrovascular disease increase after menopause, which is often attributed to the absence of hormones. It remains unknown whether the cumulative exposure to hormones across a female person's premenopausal life extends the window of cerebrovascular protection to the postmenopausal period. To investigate this, we examined the relationship between lifetime hormone exposure (LHE) and cerebral small vessel disease in more than 9,000 postmenopausal women in the UK-Biobank. Methods: The cohort consisted of women (aged 40-69 years) who attended one of 22 research centers across the United Kingdom between 2006 and 2010. Women were excluded if they were premenopausal when scanned, had missing reproductive history data, self-reported neurologic disorders, brain cancer, cerebral vascular incidents, head or neurologic injury, and nervous system infection. Endogenous LHE (LHE Results: A total of 9,163 postmenopausal women (age 64.21 ± 6.81 years) were retained for analysis. Average LHE Discussion: Women with more prolonged exposure to endogenous hormones show relatively smaller burden of cerebral small vessel disease independent of the history of oral contraceptive use or hormone replacement therapy. Our results highlight the critical role endogenous hormones play in female brain health and provide real-world evidence of the protective effects premenopausal endogenous hormone exposure plays on postmenopausal cerebrovascular health. |
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| MeSH term(s) | Pregnancy ; Humans ; Female ; Postmenopause ; Risk Factors ; Biological Specimen Banks ; Menopause ; Cerebral Small Vessel Diseases/diagnostic imaging ; Cerebral Small Vessel Diseases/epidemiology ; Hormones | |||||||||||||||
| Chemical Substances | Hormones | |||||||||||||||
| Language | English | |||||||||||||||
| Publishing date | 2023-09-27 | |||||||||||||||
| Publishing country | United States | |||||||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||||||||||||
| ZDB-ID | 207147-2 | |||||||||||||||
| ISSN | 1526-632X ; 0028-3878 | |||||||||||||||
| ISSN (online) | 1526-632X | |||||||||||||||
| ISSN | 0028-3878 | |||||||||||||||
| DOI | 10.1212/WNL.0000000000207845 | |||||||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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