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  1. Article: Post-Operative Complications after Foramen Magnum Decompression with Duraplasty Using Different Graft Materials in Adults Patients with Chiari I Malformation: A Systematic Review and Meta-Analysis.

    Perrini, Paolo / Lorenzini, Daniele / Vercelli, Alberto / Perrone, Alessandra / Di Carlo, Davide Tiziano

    Journal of clinical medicine

    2023  Volume 12, Issue 10

    Abstract: Despite extensive investigations, the choice of graft material for reconstructive duraplasty after foramen magnum decompression for Chiari type I malformation (CMI) is still a topic of discussion. The authors performed a systematic review and meta- ... ...

    Abstract Despite extensive investigations, the choice of graft material for reconstructive duraplasty after foramen magnum decompression for Chiari type I malformation (CMI) is still a topic of discussion. The authors performed a systematic review and meta-analysis of the literature examining the post-operative complications in adult patients with CMI after foramen magnum decompression and duraplasty (FMDD) using different graft materials. Our systematic review included 23 studies with a total of 1563 patients with CMI who underwent FMDD with different dural substitutes. The most common complications were pseudomeningocele (2.7%, 95% CI 1.5-3.9%,
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12103382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series.

    Guerrera, Luigi Pio / Suarato, Gabriella / Napolitano, Rossella / Perrone, Alessandra / Caputo, Vincenza / Ventriglia, Anna / Martini, Giulia / Della Corte, Carminia Maria / Orditura, Michele / Martinelli, Erika / Ciardiello, Fortunato / Montella, Marco / Franco, Renato / Troiani, Teresa / Napolitano, Stefania

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 4

    Abstract: Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) refer to heterogenous rare neoplasms constituted of at least a neuroendocrine population-either well-differentiated, or more frequently poorly differentiated-and a non-neuroendocrine population, ... ...

    Abstract Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) refer to heterogenous rare neoplasms constituted of at least a neuroendocrine population-either well-differentiated, or more frequently poorly differentiated-and a non-neuroendocrine population, both accounting for at least 30% of the whole tumor mass. Several studies recently focused on the key genetic and epigenetic changes underlying MiNENs to better understand how they develop, and explore biological similarities among the two components and their pure counterparts. However, their molecular landscape still remains poorly understood. NGS may represent a useful tool to study this orphan disease by detecting the main genetic alterations and possible therapeutic targets. NGS analysis on tissue and/or blood samples through the Foundation One (F1) platform was performed on consecutive samples collected from four patients diagnosed with MiNENs of the gastroenteric tract. Several genetic alterations were shared among samples from the same patients, thus suggesting a common origin between them, although morphology sometimes changed at histopathological evaluation. Common molecular alterations among samples from different patients that had not been previously described to our knowledge were also detected. Finally, it is of the utmost importance to clarify if the maintenance of the 30% cut-off is still essential in defining MiNENs and really manages to include all of the mixed neoplasms.
    Language English
    Publishing date 2022-04-11
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10040708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Expression of c-MET in Estrogen Receptor Positive and HER2 Negative Resected Breast Cancer Correlated with a Poor Prognosis.

    Iovino, Francesco / Diana, Anna / Carlino, Francesca / Ferraraccio, Franca / Antoniol, Giuliano / Fisone, Francesca / Perrone, Alessandra / Zito Marino, Federica / Panarese, Iacopo / Tathode, Madhura S / Caraglia, Michele / Gatta, Gianluca / Ruggiero, Roberto / Parisi, Simona / De Vita, Ferdinando / Ciardiello, Fortunato / Docimo, Ludovico / Orditura, Michele

    Journal of clinical medicine

    2022  Volume 11, Issue 23

    Abstract: Introduction: The mesenchymal-epithelial transition factor (c-MET) receptor is overexpressed in about 14−54% of invasive breast cancers, but its prognostic value in clinical practice is still unclear. Methods: In order to investigate the relationship ... ...

    Abstract Introduction: The mesenchymal-epithelial transition factor (c-MET) receptor is overexpressed in about 14−54% of invasive breast cancers, but its prognostic value in clinical practice is still unclear. Methods: In order to investigate the relationship between c-MET expression levels and prognosis, we retrospectively reviewed the clinical features and outcomes of 105 women with estrogen receptor positive HER2 negative (ER+/HER2-) resected breast cancer. We used the Kaplan Meier method to estimate Disease Free Survival (DFS) and Breast Cancer Specific Survival (BCSS) in the subgroups of patients with high (≥50%) and low (<50%) c-MET expression. Univariate and multivariate Cox proportional regression models were performed to assess the prognostic impact of clinicopathological parameters for DFS an BCSS. Results: High c-MET values significantly correlated with tumor size, high Ki67 and low (<20%) progesterone receptor expression. At a median follow up of 60 months, patients with high c-MET tumor had significantly worse (p = 0.00026) and BCSS (p = 0.0013). Univariate analysis showed a significant association between large tumor size, elevated Ki67, c-MET values and increased risk of recurrence or death. The multivariate COX regression model showed that tumor size and high c-MET expression were independent predictors of DFS (p = 0.019 and p = 0.022). Moreover, large tumor size was associated with significantly higher risk of cancer related death at multivariate analysis (p = 0.017), while a trend towards a poorer survival was registered in the high c-MET levels cohort (p = 0.084). Conclusions: In our series, high c-MET expression correlated with poor survival outcomes. Further studies are warranted to validate the clinical relevance and applicability of c-MET as a prognostic factor in ER+/HER2- early BC.
    Language English
    Publishing date 2022-11-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11236987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Real-World Activity and Safety of Trifluridine-Tipiracil Plus Bevacizumab Therapy in Patients with Refractory Metastatic Colorectal Cancer.

    Arrichiello, Gianluca / Perrone, Alessandra / Napolitano, Stefania / Martini, Giulia / De Falco, Vincenzo / Incoronato, Pasquale / Laterza, Maria Maddalena / Facchini, Gaetano / Famiglietti, Vincenzo / Nacca, Valeria / Paragliola, Fernando / Napolitano, Rossella / Suarato, Gabriella / Nicastro, Antonella / Martinelli, Erika / Ciardiello, Davide / Ciardiello, Fortunato / Troiani, Teresa

    Targeted oncology

    2022  Volume 17, Issue 6, Page(s) 635–642

    Abstract: Background: The combination of trifluridine-tipiracil and bevacizumab was compared with trifluridine-tipiracil monotherapy in a randomized, open-label, phase II trial, resulting in a statistically significant and clinically relevant improvement in ... ...

    Abstract Background: The combination of trifluridine-tipiracil and bevacizumab was compared with trifluridine-tipiracil monotherapy in a randomized, open-label, phase II trial, resulting in a statistically significant and clinically relevant improvement in progression-free survival (PFS), with tolerable toxicity in patients with refractory metastatic colorectal cancer (mCRC); however, evidence supporting the role of this combination in a real-world setting is limited.
    Objective: The aim of our work was to provide further evidence on the activity and safety of this combination in a real-world series of Western mCRC patients refractory or intolerant to previous therapies.
    Patient and methods: We conducted a retrospective, observational study of patients with mCRC refractory or intolerant to standard therapies. Patients were treated with trifluridine-tipiracil and bevacizumab. Previous therapy with fluoropyrimidines, irinotecan, oxaliplatin, bevacizumab, aflibercept, regorafenib, and cetuximab or panitumumab (only RAS wild-type) was allowed, as was previous participation in clinical trials. Clinicopathological characteristics, overall response rate (ORR), disease control rate (DCR), overall survival (OS), PFS, and safety data were retrospectively collected and analyzed.
    Results: We recorded 31 patients treated between 1 December 2017 and 30 June 2022. Median age was 69 years (range 38-82 years), 39% were male, 100% had an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0-1, tumor location was left-sided in 77% of cases, 54% had synchronous presentation, 35% were RAS mutant, 3% were BRAF mutant, and 71% underwent primary tumor resection; 64% of patients had liver metastases, 55% had lung metastases, and 23% had peritoneal carcinomatosis. The median number of previous treatment lines was 2 (range 0-5), and 84% of patients received at least one previous anti-angiogenic agent. The ORR and DCR were 3% and 71%, respectively. With a median follow-up of 8 months (range 2-39), median PFS was 6 months (95% confidence interval [CI] 3.1-8.9 months) and median OS was 14 months (95% CI 10.1-17.8 months). Adverse events of any grade were reported in 58% of patients. The most common grade 3-4 toxicities were neutropenia (19%) and anemia (6%); 35% of patients required either dose delays or dose reductions due to toxicity. Granulocyte colony-stimulating factor (G-CSF) prophylaxis was administered either on first or subsequent cycles of treatment in 35% of patients. No treatment-related deaths occurred. Sixty percent of the patients who discontinued treatment eventually received one or more lines of subsequent therapy.
    Conclusions: Our series provides further evidence on the activity and safety of the combination of trifluridine-tipiracil and bevacizumab in a real-world series of Western refractory mCRC patients.
    MeSH term(s) Humans ; Male ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Trifluridine/pharmacology ; Trifluridine/therapeutic use ; Bevacizumab/pharmacology ; Bevacizumab/therapeutic use ; Retrospective Studies ; Uracil/therapeutic use ; Colorectal Neoplasms/pathology ; Colonic Neoplasms/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances Trifluridine (RMW9V5RW38) ; tipiracil (NGO10K751P) ; Bevacizumab (2S9ZZM9Q9V) ; Uracil (56HH86ZVCT)
    Language English
    Publishing date 2022-10-14
    Publishing country France
    Document type Observational Study ; Journal Article
    ZDB-ID 2222136-0
    ISSN 1776-260X ; 1776-2596
    ISSN (online) 1776-260X
    ISSN 1776-2596
    DOI 10.1007/s11523-022-00916-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Clinical Utility of Liquid Biopsy to Detect BRAF and NRAS Mutations in Stage III/IV Melanoma Patients by Using Real-Time PCR.

    Giunta, Emilio Francesco / De Falco, Vincenzo / Vitiello, Pietro Paolo / Guerrera, Luigi Pio / Suarato, Gabriella / Napolitano, Rossella / Perrone, Alessandra / Argenziano, Giuseppe / Franco, Renato / Caraglia, Michele / Martinelli, Erika / Ciardiello, Davide / Ciardiello, Fortunato / Napolitano, Stefania / Troiani, Teresa

    Cancers

    2022  Volume 14, Issue 13

    Abstract: Background: Liquid biopsy is a potentially useful tool for melanoma patients, also for detecting BRAS/NRAS mutations, even if the tissue analysis remains the current standard.: Methods: In this work, we tested ctDNA on plasma samples from 56 BRAF- ... ...

    Abstract Background: Liquid biopsy is a potentially useful tool for melanoma patients, also for detecting BRAS/NRAS mutations, even if the tissue analysis remains the current standard.
    Methods: In this work, we tested ctDNA on plasma samples from 56 BRAF-V600/NRAS mutant stage III/IV melanoma patients using a real-time quantitative PCR (qPCR)-based platform. The study population was divided into two cohorts: the first including 26 patients who had undergone radical resection (resected cohort) and the second including 30 patients who had unresected measurable disease (advanced cohort). Moreover, for 10 patients in the advanced cohort, ctDNA assessment was repeated at specified timepoints after baseline testing. Data were analyzed and correlated to the clinicopathologic characteristics and outcomes.
    Results: In the baseline cohort, a higher tissue-plasma concordance was seen in patients with high burden of disease (sum of diameters ≥30 mm, ≥2 metastatic sites, elevated LDH levels); furthermore, monitoring of these patients through ctDNA analysis was informative for therapeutic responses. On the other hand, the low sensitivity of this technique did not allow for clinically valuable prediction of relapses in radically resected stage III/IV patients.
    Conclusions: Overall, our data suggest that qPCR-based ctDNA analysis could be informative in a subset of locally advanced and metastatic melanoma patients with specific clinical-radiological characteristics, supporting further investigations in this setting.
    Language English
    Publishing date 2022-06-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14133053
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  6. Article ; Online: Multiple Acquired Mutations Captured by Liquid Biopsy in the EGFR Addicted Metastatic Colorectal Cancer.

    Guerrera, Luigi Pio / Napolitano, Stefania / De Falco, Vincenzo / Giunta, Emilio Francesco / Vitiello, Pietro Paolo / Gravina, Antonietta Gerarda / Suarato, Gabriella / Perrone, Alessandra / Napolitano, Rossella / Martinelli, Erika / Ciardiello, Fortunato / Troiani, Teresa

    Clinical colorectal cancer

    2021  Volume 20, Issue 4, Page(s) 354–358

    MeSH term(s) Colonic Neoplasms ; ErbB Receptors/genetics ; Humans ; Liquid Biopsy ; Mutation ; Rectal Neoplasms
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2021-07-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2112638-0
    ISSN 1938-0674 ; 1533-0028
    ISSN (online) 1938-0674
    ISSN 1533-0028
    DOI 10.1016/j.clcc.2021.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5798: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  7. Article: Evaluation of patellar chondromalacia with MR: comparison between T2-weighted FSE SPIR and GE MTC.

    Macarini, Luca / Perrone, Alessandra / Murrone, Mario / Marini, Stefania / Stefanelli, Michele

    La Radiologia medica

    2004  Volume 108, Issue 3, Page(s) 159–171

    Abstract: Purpose: To compare two different MR sequences to tissue signal suppression in the study of patellar cartilage abnormalities.: Materials and methods: We examined 26 patients with magnetic resonance (MR) imaging: sequences included spectral ... ...

    Abstract Purpose: To compare two different MR sequences to tissue signal suppression in the study of patellar cartilage abnormalities.
    Materials and methods: We examined 26 patients with magnetic resonance (MR) imaging: sequences included spectral presaturation with inversion recovery (SPIR), with fat suppression and T2-weighted images, magnetization transfer contrast (MTC) sequences, T1-weighted and T2-weighted spin-echo sequences. All patients underwent conventional knee arthroscopy and in all patients a hyaline cartilage lesion was assessed in three articular zones: the patellar medial facet, the lateral facet and the patellar crista. Was assessed 78 articular facets. The lesions were classified using a standard arthroscopic grading system adapted to MR imaging: normal cartilage that corresponds to the grade 0 according to the Noyes grading system, low grade lesions that correspond to the grade I e IIa and high grade lesions that correspond to grades IIb and III. The arthroscopic results were compared with MR images. We assessed the MR diagnostic accuracy, sensitivity, specificity and MR positive predictive value and negative predictive value of the two sequences taking into consideration total lesions, and high-grade and low grade lesions separately.
    Results: Twenty-four low grade lesions (16 grade I e 8 grade IIa) and 18 high grade lesions (10 grade IIb e 8 grade III) were diagnosed by arthroscopy. Regarding low grade and high-grade lesions together, the accuracy was 77% for MTC sequences and 90% for SPIR sequences. In identifying low-grade lesions, the sensitivity was 88% for SPIR sequence and 42% for MTC sequences. Specificity for the detection of all lesions was 89% for the SPIR sequences and 94% for the MTC sequences. The SPIR sequence visualised water content abnormalities in degenerating cartilage, which are representative of low-grade lesions. The sensitivity of the sequence enabled us to obtain improved contrast for detecting cartilage surface irregularities. The MTC sequences allowed us to grade high-grade lesions susceptible to surgery and small cartilage defects in the presence of joint fluid. The MTC sequences were insufficient in the diagnosis of early stages of chondromalacia because the suppression of the signal of bonded water reduced the contrast among areas of articular cartilage with different water content. For this reason cartilage oedema and early superficial fibrillation were not identified.
    Conclusions: In our experience the SPIR sequence proved superior to the MTC sequence in the identification of low grade lesions of the patellar cartilage. The overall value of such sequences in the study of articular pathology also needs to be assessed in the others sites where the articular cartilage is thinner and surfaces more curvilinear.
    MeSH term(s) Adolescent ; Adult ; Arthroscopy ; Chondromalacia Patellae/classification ; Chondromalacia Patellae/diagnosis ; Chondromalacia Patellae/pathology ; Female ; Humans ; Knee Joint/pathology ; Magnetic Resonance Imaging/instrumentation ; Magnetic Resonance Imaging/methods ; Male ; Sensitivity and Specificity
    Language Italian
    Publishing date 2004-09
    Publishing country Italy
    Document type Comparative Study ; Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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