LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 157

Search options

  1. Article ; Online: Correspondence on 'MicroRNA expression as a diagnostic parameter in early endometrial cancer' by Blagojević et al.

    Coada, Camelia Alexandra / Ravegnini, Gloria / Perrone, Anna Myriam

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2023  

    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Letter
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-005110
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Synergizing health: combined gynecological and bariatric robotic surgery for endometrial cancer in obese women.

    Perrone, Anna Myriam / Mezzapesa, Francesco / Bernante, Paolo / Balsamo, Francesca / Garelli, Silvia / De Iaco, Pierandrea

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2024  

    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-005121
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Cisplatin? Why not?

    Perrone, Anna Myriam / Corrado, Giacomo / De Iaco, Pierandrea

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2020  Volume 30, Issue 10, Page(s) 1656

    MeSH term(s) Cisplatin/therapeutic use ; Electrochemotherapy ; Female ; Humans ; Neoplasms, Second Primary ; Vaginal Neoplasms ; Vulvar Neoplasms/drug therapy
    Chemical Substances Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2020-08-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2020-001917
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: COVID-19 global pandemic: options for management of gynecologic cancers. The experience in surgical management of ovarian cancer in the second highest affected Italian region.

    Perrone, Anna Myriam / De Palma, Alessandra / De Iaco, Pierandrea

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2020  Volume 30, Issue 6, Page(s) 902

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Female ; Humans ; Italy ; Ovarian Neoplasms ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2020-001489
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Current methodologies to detect circulating tumor cells: a focus on ovarian cancer.

    Lemma, Silvia / Perrone, Anna M / De Iaco, Pierandrea / Gasparre, Giuseppe / Kurelac, Ivana

    American journal of cancer research

    2021  Volume 11, Issue 9, Page(s) 4111–4126

    Abstract: Identification of circulating tumor cells (CTC) in liquid biopsies opens a window of opportunities for the optimization of clinical management of oncologic patients. In ovarian cancer (OC), which involves atypical routes of metastatic spread, CTC ... ...

    Abstract Identification of circulating tumor cells (CTC) in liquid biopsies opens a window of opportunities for the optimization of clinical management of oncologic patients. In ovarian cancer (OC), which involves atypical routes of metastatic spread, CTC analyses may also offer novel insights about the mechanisms behind malignant progression of the disease. However, current methodologies struggle to precisely define CTC number in the peripheral blood of OC patients, and the isolation of viable cells for further characterization is still challenging. The biggest limitation is the lack of methodological standardization for OC CTC detection, preventing comprehensive definition of their clinical potential required for the transfer to practice. Here we describe and compare methods for CTC analysis that have been implemented for OC thus far, discussing pros, cons and improvements needed. We identify biophysical separation approaches as optimal for CTC enrichment. On the other hand, the identification of specific tumor antigens or gene transcripts, despite displaying drawbacks related to tumor heterogeneity, still remains the best approach for OC CTC detection.
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Radiomics and artificial intelligence in malignant uterine body cancers: Protocol for a systematic review.

    Ravegnini, Gloria / Ferioli, Martina / Pantaleo, Maria Abbondanza / Morganti, Alessio G / De Leo, Antonio / De Iaco, Pierandrea / Rizzo, Stefania / Perrone, Anna Myriam

    PloS one

    2022  Volume 17, Issue 6, Page(s) e0267727

    Abstract: Introduction: Uterine body cancers (UBC) are represented by endometrial carcinoma (EC) and uterine sarcoma (USa). The clinical management of both is hindered by the complex classification of patients into risk classes. This problem could be simplified ... ...

    Abstract Introduction: Uterine body cancers (UBC) are represented by endometrial carcinoma (EC) and uterine sarcoma (USa). The clinical management of both is hindered by the complex classification of patients into risk classes. This problem could be simplified through the development of predictive models aimed at treatment tailoring based on tumor and patient characteristics. In this context, radiomics represents a method of extracting quantitative data from images in order to non-invasively acquire tumor biological and genetic information and to predict response to treatments and prognosis. Furthermore, artificial intelligence (AI) methods are an emerging field of translational research, with the aim of managing the amount of data provided by the various -omics, including radiomics, through the process of machine learning, in order to promote precision medicine.
    Objective: The aim of this protocol for systematic review is to provide an overview of radiomics and AI studies on UBCs.
    Methods and analysis: A systematic review will be conducted using PubMed, Scopus, and the Cochrane Library to collect papers analyzing the impact of radiomics and AI on UBCs diagnosis, prognostic classification, and clinical outcomes. The PICO strategy will be used to formulate the research questions: What is the impact of radiomics and AI on UBCs on diagnosis, prognosis, and clinical results? How could radiomics or AI improve the differential diagnosis between sarcoma and fibroids? Does Radiomics or AI have a predictive role on UBCs response to treatments? Three authors will independently screen articles at title and abstract level based on the eligibility criteria. The risk of bias and quality of the cohort studies, case series, and case reports will be based on the QUADAS 2 quality assessment tools.
    Trial registration: PROSPERO registration number: CRD42021253535.
    MeSH term(s) Artificial Intelligence ; Female ; Humans ; Machine Learning ; Precision Medicine ; Prognosis ; Sarcoma/diagnostic imaging ; Systematic Reviews as Topic ; Uterine Neoplasms/diagnosis
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0267727
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: miRNA levels are associated with body mass index in endometrial cancer and may have implications for therapy.

    Ravegnini, Gloria / Gorini, Francesca / Coada, Camelia Alexandra / De Leo, Antonio / de Biase, Dario / Di Costanzo, Stella / De Crescenzo, Eugenia / Coschina, Emma / Monesmith, Sarah / Bernante, Paolo / Garelli, Silvia / Balsamo, Francesca / Hrelia, Patrizia / De Iaco, Pierandrea / Angelini, Sabrina / Perrone, Anna Myriam

    Cancer science

    2024  Volume 115, Issue 3, Page(s) 883–893

    Abstract: Endometrial cancer (EC) is the most prevalent gynecological cancer in high-income countries. Its incidence is skyrocketing due to the increase in risk factors such as obesity, which represents a true pandemic. This study aimed to evaluate microRNA (miRNA) ...

    Abstract Endometrial cancer (EC) is the most prevalent gynecological cancer in high-income countries. Its incidence is skyrocketing due to the increase in risk factors such as obesity, which represents a true pandemic. This study aimed to evaluate microRNA (miRNA) expression in obesity-related EC to identify potential associations between this specific cancer type and obesity. miRNA levels were analyzed in 84 EC patients stratified based on body mass index (BMI; ≥30 or <30) and nine noncancer women with obesity. The data were further tested in The Cancer Genome Atlas (TCGA) cohort, including 384 EC patients, 235 with BMI ≥30 and 149 with BMI <30. Prediction of miRNA targets and analysis of their expression were also performed to identify the potential epigenetic networks involved in obesity modulation. In the EC cohort, BMI ≥30 was significantly associated with 11 deregulated miRNAs. The topmost deregulated miRNAs were first analyzed in 84 EC samples by single miRNA assay and then tested in the TCGA dataset. This independent validation provided further confirmation about the significant difference of three miRNAs (miR-199a-5p, miR-449a, miR-449b-5p) in normal-weight EC patients versus EC patients with obesity, resulting significantly higher expressed in the latter. Moreover, the three miRNAs were significantly correlated with grade, histological type, and overall survival. Analysis of their target genes revealed that these miRNAs may regulate obesity-related pathways. In conclusion, we identified specific miRNAs associated with BMI that are potentially involved in modulating obesity-related pathways and that may provide novel implications for the clinical management of obese EC patients.
    MeSH term(s) Humans ; Female ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Body Mass Index ; Gene Expression Profiling/methods ; Endometrial Neoplasms/genetics ; Obesity/complications ; Obesity/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.15977
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) with cisplatin and doxorubicin in patients with ovarian cancer: A systematic review.

    Taliento, Cristina / Restaino, Stefano / Scutiero, Gennaro / Arcieri, Martina / Bernardi, Giulia / Martinello, Ruby / Driul, Lorenza / Perrone, Anna Myriam / Fagotti, Anna / Scambia, Giovanni / Greco, Pantaleo / Vizzielli, Giuseppe

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2023  Volume 49, Issue 12, Page(s) 107250

    Abstract: Background: PIPAC consists in delivering normothermic chemotherapy solution directly into the peritoneal cavity as an aerosol under pressure. Currently PIPAC is considered as a palliative treatment for patients suffering from non-resectable peritoneal ... ...

    Abstract Background: PIPAC consists in delivering normothermic chemotherapy solution directly into the peritoneal cavity as an aerosol under pressure. Currently PIPAC is considered as a palliative treatment for patients suffering from non-resectable peritoneal carcinomatosis. We performed a SR to assess tolerance and response of this novel method among patient with OC.
    Methods: We searched electronic database PubMed, Embase, Web of Science, Clinical Trials.gov. We only included clinical studies reporting PIPAC with cisplatin and doxorubicin in patients with ovarian cancer.
    Results: This systematic review included 4 studies. In 3 studies all patients were pretreated with cytoreductive surgery, in 1 study surgery was performed in 8/34 (23 %) patients. Mean PCI at first PIPAC procedure ranged from 16.3 to 19.6. All studies reported the proportion of patients with ascites at the first PIPAC with a pooled rate of 48,3 %. Pooled rate of CTCAE Grade 3 toxicity calculated on the total number of PIPAC was 6 % and Grade 4 was 0.9 %. One study reported two cases of small bowel perforation related or potentially related to PIPAC. On study reported a cumulative survival after 400 days of 62 % and a mean actuarial survival time of all patients who underwent PIPAC of 442 days. In another study the mean time to progression was 144 days (95 % CI 122-168 days).
    Conclusion: This systematic review demonstrated that PIPAC with cisplatin and doxorubicin appear to have a good safety profile with low toxicity and encouraging trend in terms of overall survival.
    MeSH term(s) Humans ; Female ; Cisplatin ; Percutaneous Coronary Intervention ; Antineoplastic Combined Chemotherapy Protocols ; Ovarian Neoplasms/drug therapy ; Doxorubicin ; Aerosols/therapeutic use
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Doxorubicin (80168379AG) ; Aerosols
    Language English
    Publishing date 2023-11-04
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2023.107250
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1149: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 549: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Combination of Electrochemotherapy with Radiotherapy: A Comprehensive, Systematic, PRISMA-Compliant Review of Efficacy and Potential Radiosensitizing Effects in Tumor Control.

    Ferioli, Martina / Perrone, Anna M / Buwenge, Milly / Arcelli, Alessandra / Vadala', Maria / Fionda, Bruno / Malato, Maria C / De Iaco, Pierandrea / Zamagni, Claudio / Cammelli, Silvia / Tagliaferri, Luca / Morganti, Alessio G

    Current oncology (Toronto, Ont.)

    2023  Volume 30, Issue 11, Page(s) 9895–9905

    Abstract: Radiotherapy (RT) and electrochemotherapy (ECT) are established local treatments for cancer. While effective, both therapies have limitations, especially in treating bulky and poorly oxygenated tumors. ECT has emerged as a promising palliative treatment, ...

    Abstract Radiotherapy (RT) and electrochemotherapy (ECT) are established local treatments for cancer. While effective, both therapies have limitations, especially in treating bulky and poorly oxygenated tumors. ECT has emerged as a promising palliative treatment, raising interest in exploring its combination with RT to enhance tumor response. However, the potential benefits and challenges of combining these treatments remain unclear. A systematic review was conducted following PRISMA guidelines. PubMed, Scopus, and Cochrane libraries were searched. Studies were screened and selected based on predefined inclusion and exclusion criteria. Ten studies were included, comprising in vitro and in vivo experiments. Different tumor types were treated with ECT alone or in combination with RT. ECT plus RT demonstrated superior tumor response compared to that under single therapies or other combinations, regardless of the cytotoxic agent and RT dose. However, no study demonstrated a clear superadditive effect in cell survival curves, suggesting inconclusive evidence of specific ECT-induced radiosensitization. Toxicity data were limited. In conclusion, the combination of ECT and RT consistently improved tumor response compared to that with individual therapies, supporting the potential benefit of their combination. However, evidence for a specific ECT-induced radiosensitization effect is currently lacking. Additional investigations are necessary to elucidate the potential benefits of this combination therapy.
    MeSH term(s) Humans ; Electrochemotherapy ; Radiation-Sensitizing Agents/pharmacology ; Radiation-Sensitizing Agents/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/radiotherapy ; Antineoplastic Agents/therapeutic use ; Palliative Care
    Chemical Substances Radiation-Sensitizing Agents ; Antineoplastic Agents
    Language English
    Publishing date 2023-11-13
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30110719
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Pre-operative geriatric screening and assessment as predictors of postoperative complications in older adults with gynecologic cancer: A pilot cohort study on a neglected issue.

    Cioli Puviani, Filippo / Calogero, Pietro / Bianchi, Giampaolo / De Benedetti, Pierandrea / Boussedra, Safia / Dondi, Giulia / Perrone, Anna Myriam / De Iaco, Pierandrea / Galetti, Caterina

    Journal of geriatric oncology

    2023  Volume 14, Issue 4, Page(s) 101419

    MeSH term(s) Humans ; Female ; Aged ; Pilot Projects ; Early Detection of Cancer/adverse effects ; Postoperative Complications/etiology ; Cohort Studies ; Neoplasms/complications ; Geriatric Assessment
    Language English
    Publishing date 2023-01-18
    Publishing country Netherlands
    Document type Research Support, Non-U.S. Gov't ; Letter
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2022.101419
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top