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Article ; Online: Guyana housecall.

Perry, Joanne

Canadian family physician Medecin de famille canadien

2014 Volume 60, Issue 11, Page(s) 1028

MeSH term(s)	Guyana ; House Calls ; Patient Care Team ; Physicians ; Rural Health Services ; Volunteers
Language	English
Publishing date	2014-11
Publishing country	Canada
Document type	Journal Article ; Personal Narratives
ZDB-ID	2146676-2
ISSN	1715-5258 ; 0008-350X
ISSN (online)	1715-5258
ISSN	0008-350X
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Article ; Online: Clinical predictors of rectal cancer response after neo-adjuvant (Chemo)Radiotherapy in Australia and New Zealand: Analysis of the Bi-National Colorectal Cancer Audit (BCCA).

Liu, Jianliang / Lee, Justin Y T / Bedrikovetski, Sergei / Traeger, Luke / Moore, James W / Perry, Joanne L / Kroon, Hidde M / Sammour, Tarik

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2023 Volume 49, Issue 11, Page(s) 107070

Abstract: Pathological complete response (pCR) is observed in 11-26% of locally advanced rectal cancers undergoing neoadjuvant chemoradiotherapy (nCRT). This study aims to determine pCR rates and clinicopathological predictors in the Australian and New Zealand ( ... ...

Abstract	Pathological complete response (pCR) is observed in 11-26% of locally advanced rectal cancers undergoing neoadjuvant chemoradiotherapy (nCRT). This study aims to determine pCR rates and clinicopathological predictors in the Australian and New Zealand (ANZ) cohort. The Bi-National Colorectal Cancer Audit (BCCA) was interrogated for all rectal cancer patients who underwent nCRT prior to surgical resection between 2007 and 2020. Patients were divided in two groups: pCR (AJCC tumour regression grade 0) and partial/no response (pPR, regression grade 1,2 or 3). In total, 3230 patients were included. Rates of pCR and pPR were 704 (21.8%) and 2526 (78.2%), respectively. Long-course nCRT (p < 0.0001), lower clinical tumour stage (cT; p < 0.0001), and nodal stage (cN; p = 0.003) were associated with pCR on univariate analysis. On multivariable analysis, cN0 stage and long-course nCRT remained independent factors for a pCR. Awareness of these predictors provides valuable information when counseling patients regarding prognosis and treatment options.
MeSH term(s)	Humans ; Neoadjuvant Therapy ; Treatment Outcome ; New Zealand/epidemiology ; Neoplasm Staging ; Australia/epidemiology ; Rectal Neoplasms/therapy ; Rectal Neoplasms/pathology ; Chemoradiotherapy ; Retrospective Studies
Language	English
Publishing date	2023-09-09
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2023.107070
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Personalized total neoadjuvant therapy versus chemotherapy during the 'wait period' versus standard chemoradiotherapy for locally advanced rectal cancer.

Bedrikovetski, Sergei / Traeger, Luke / Fitzsimmons, Tracy / Perry, Joanne / Vather, Ryash / Moore, James W / Sammour, Tarik

ANZ journal of surgery

2022 Volume 93, Issue 5, Page(s) 1267–1273

Abstract: Background: This study aimed to compare current treatment response rates with personalized Total Neoadjuvant Therapy (pTNT), against extended chemotherapy in the 'wait period' (xCRT) and standard chemoradiotherapy (sCRT) with adjuvant chemotherapy for ... ...

Abstract	Background: This study aimed to compare current treatment response rates with personalized Total Neoadjuvant Therapy (pTNT), against extended chemotherapy in the 'wait period' (xCRT) and standard chemoradiotherapy (sCRT) with adjuvant chemotherapy for rectal cancer. Methods: This was a multicentre retrospective cohort analysis. Consecutive patients with rectal cancer treated with pTNT over a 3.9-year period were compared to a historical cohort of patients treated with xCRT or sCRT as part of the published WAIT Trial. pTNT patients received 8 cycles mFOLFOX6 or 6 cycles CAPOX in the neoadjuvant setting (no adjuvant treatment). Patients in the WAIT Trial received either 3 cycles 5-FU/LV during the 10-week wait period after chemoradiotherapy or standard chemoradiotherapy, followed by adjuvant chemotherapy. The primary endpoint was overall complete response (oCR) rate defined as the proportion of patients who achieved either complete clinical response (cCR) or pathological complete response (pCR). Results: Of 284 patients diagnosed with rectal cancer during the 3.9-year period, 107 received pTNT. Forty of these were matched with 49 patients from the WAIT Trial (25 received xCRT and 24 received sCRT). There was a significant difference in oCR between the groups (pTNT n = 21, xCRT n = 6, sCRT n = 7, P = 0.043). Of the patients that underwent surgery, pCR occurred in 13 patients with no significant difference between groups (P = 0.415). There were no significant differences in 2-year disease-free survival or overall survival. Conclusion: Compared with sCRT and xCRT, pTNT results in a significantly higher complete response rate which may facilitate organ preservation.
MeSH term(s)	Humans ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemoradiotherapy/methods ; Neoadjuvant Therapy/methods ; Neoplasm Staging ; Rectal Neoplasms/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-12-27
Publishing country	Australia
Document type	Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.18229
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Article ; Online: Personalized total neoadjuvant therapy (pTNT) for advanced rectal cancer with tailored treatment sequencing based on clinical stage at presentation.

Bedrikovetski, Sergei / Fitzsimmons, Tracy / Perry, Joanne / Vather, Ryash / Carruthers, Scott / Selva-Nayagam, Sudarsha / Thomas, Michelle L / Moore, James W / Sammour, Tarik

ANZ journal of surgery

2022 Volume 93, Issue 1-2, Page(s) 173–181

Abstract: Background: This study aimed to assess short-term outcomes of a personalized total neoadjuvant treatment (pTNT) protocol, with treatment sequencing based on clinical stage at presentation.: Methods: A multidisciplinary pTNT protocol was implemented ... ...

Abstract	Background: This study aimed to assess short-term outcomes of a personalized total neoadjuvant treatment (pTNT) protocol, with treatment sequencing based on clinical stage at presentation. Methods: A multidisciplinary pTNT protocol was implemented across two metropolitan hospitals. This consists of two-schema based on clinical stage: patients with distant failure risk were offered induction chemotherapy before chemoradiation (nCRT), and patients with locoregional failure risk received nCRT followed by consolidation chemotherapy. Patients underwent surgical resection unless a complete clinical response (cCR) was achieved, in which case non-operative management (NOM) was offered. A prospective cohort analysis of all patients with rectal cancer who underwent pTNT with curative intent between Jan 2019 and Aug 2022 was performed. Results: Of 270 patients referred with rectal cancer, 102 received pTNT with curative intent and 79 have completed their treatment thus far. Thirty-three patients (41.8%) received induction chemotherapy and 46 (58.2%) received consolidation chemotherapy per protocol. The percentage of patients with EMVI, resectable M1 disease, cT4 disease, and positive lateral lymph nodes were 54.4%, 36.7%, 27.8% and 15.2%, respectively. Overall, 32 (40.5%) patients had cCR and 4 (5.1%) pCR, and 40 (50.6%) patients had non-operative management. Grade 3 toxicity was reported in 10.1% of patients and only three patients (3.8%) experienced Grade 4 chemotherapy-related toxicity, with no treatment related mortality. Conclusion: Early results with a defined two-schema pTNT protocol are encouraging and suggest that tailoring sequencing to disease risk at presentation may represent the optimal balance between local and distant disease control, as well as treatment toxicity.
MeSH term(s)	Humans ; Neoadjuvant Therapy/methods ; Treatment Outcome ; Prospective Studies ; Rectal Neoplasms/pathology ; Chemoradiotherapy/methods ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Retrospective Studies ; Neoplasm Staging ; Neoplasm Recurrence, Local/pathology
Language	English
Publishing date	2022-09-04
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.18021
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Article ; Online: Examining positive body image, sport confidence, flow state, and subjective performance among student athletes and non-athletes.

Soulliard, Zachary A / Kauffman, Alicia A / Fitterman-Harris, Hannah F / Perry, Joanne E / Ross, Michael J

Body image

2019 Volume 28, Page(s) 93–100

Abstract: The primary purpose of the present study was to examine differences in positive body image, specifically body appreciation and functionality appreciation, between student athletes and non-athletes. A secondary purpose was to examine the relationships ... ...

Abstract	The primary purpose of the present study was to examine differences in positive body image, specifically body appreciation and functionality appreciation, between student athletes and non-athletes. A secondary purpose was to examine the relationships between positive body image and other sport-related variables. Seventy-nine National Collegiate Athletic Association (NCAA) Division I student athletes (M
MeSH term(s)	Adolescent ; Adult ; Athletes/psychology ; Athletic Performance/psychology ; Body Image/psychology ; Body Mass Index ; Female ; Humans ; Male ; Personal Satisfaction ; Physical Appearance, Body ; Self Concept ; Sex Factors ; Sports ; Students/psychology ; Universities ; Young Adult
Language	English
Publishing date	2019-01-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2211449-X
ISSN	1873-6807 ; 1740-1445
ISSN (online)	1873-6807
ISSN	1740-1445
DOI	10.1016/j.bodyim.2018.12.009
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Article: A Comprehensive Examination of Factors Impacting Collegiate Athletes' Utilization of Psychological Assessment and Intervention Services.

Donohue, Brad / Gavrilova, Elena / Danlag, Alexandra / Perry, Joanne / Kuhn, Corey / Allen, Daniel / Benning, Stephen D

Psychology in the schools

2020 Volume 58, Issue 3, Page(s) 458–474

Abstract: Although collegiate athletes underutilize mental health programming, investigators have rarely examined factors that may influence their participation in such programs. The current study examined how structured interviews and demographic factors ... ...

Abstract	Although collegiate athletes underutilize mental health programming, investigators have rarely examined factors that may influence their participation in such programs. The current study examined how structured interviews and demographic factors influence collegiate athletes to use psychological programming. Two-hundred and eighty-nine collegiate athletes were referred to the study. They were screened for mental health and randomly assigned to one of two semi-structured interviews based on experimental phase. Participants in Phase I received standard engagement (SE; N = 35) or SE+discussion of mental health (DMH; N = 44). Phase II participants received SE+DMH (N = 82) or SE+DMH + discussion of personal ambitions (DPA; N = 66). Phase III participants received SE+DMH+discussion about their culture of choice (DCC) (N = 25) or SE+DMH+discussion of sport culture (DSC) (N = 37). After receiving the respective interview participants were offered psychological assessment and intervention. Chi squared analyses revealed class standing, mental health symptom severity, referral type, and type of engagement interview influenced program commitment/utilization. Logistic regression analyses indicated SE+DMH+DPA and SE+DMH+DSC uniquely improved assessment attendance whereas referrals from the athletic department and coaches/teammates, participation in sport performance workshops, and senior status uniquely improved assessment and intervention attendance.
Language	English
Publishing date	2020-11-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2002070-3
ISSN	1520-6807 ; 0033-3085
ISSN (online)	1520-6807
ISSN	0033-3085
DOI	10.1002/pits.22458
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Article ; Online: Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia.

Gurbatri, Candice R / Radford, Georgette A / Vrbanac, Laura / Im, Jongwon / Thomas, Elaine M / Coker, Courtney / Taylor, Samuel R / Jang, YoungUk / Sivan, Ayelet / Rhee, Kyu / Saleh, Anas A / Chien, Tiffany / Zandkarimi, Fereshteh / Lia, Ioana / Lannagan, Tamsin R M / Wang, Tongtong / Wright, Josephine A / Kobayashi, Hiroki / Ng, Jia Q /

Lawrence, Matt / Sammour, Tarik / Thomas, Michelle / Lewis, Mark / Papanicolas, Lito / Perry, Joanne / Fitzsimmons, Tracy / Kaazan, Patricia / Lim, Amanda / Stavropoulos, Alexandra M / Gouskos, Dion A / Marker, Julie / Ostroff, Cheri / Rogers, Geraint / Arpaia, Nicholas / Worthley, Daniel L / Woods, Susan L / Danino, Tal

Nature communications

2024 Volume 15, Issue 1, Page(s) 646

Abstract: Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli Nissle 1917 (EcN) ...

Abstract	Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli Nissle 1917 (EcN) to a genetically-engineered murine model of CRC predisposition and orthotopic models of CRC. We next undertake an interventional, double-blind, dual-centre, prospective clinical trial, in which CRC patients take either placebo or EcN for two weeks prior to resection of neoplastic and adjacent normal colorectal tissue (ACTRN12619000210178). We detect enrichment of EcN in tumor samples over normal tissue from probiotic-treated patients (primary outcome of the trial). Next, we develop early CRC intervention strategies. To detect lesions, we engineer EcN to produce a small molecule, salicylate. Oral delivery of this strain results in increased levels of salicylate in the urine of adenoma-bearing mice, in comparison to healthy controls. To assess therapeutic potential, we engineer EcN to locally release a cytokine, GM-CSF, and blocking nanobodies against PD-L1 and CTLA-4 at the neoplastic site, and demonstrate that oral delivery of this strain reduces adenoma burden by ~50%. Together, these results support the use of EcN as an orally-deliverable platform to detect disease and treat CRC through the production of screening and therapeutic molecules.
MeSH term(s)	Animals ; Humans ; Mice ; Adenoma/diagnosis ; Adenoma/therapy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/therapy ; Escherichia coli/genetics ; Prospective Studies ; Salicylates ; Double-Blind Method
Chemical Substances	Salicylates
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Multicenter Study
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-44776-4
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Article: The Antianginal Drug Perhexiline Displays Cytotoxicity against Colorectal Cancer Cells In Vitro: A Potential for Drug Repurposing.

Cancers

2022 Volume 14, Issue 4

Abstract: Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Perhexiline, a prophylactic anti-anginal drug, has been reported to have anti-tumour effects both in vitro and in vivo. Perhexiline as used clinically is a 50:50 ... ...

Abstract	Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Perhexiline, a prophylactic anti-anginal drug, has been reported to have anti-tumour effects both in vitro and in vivo. Perhexiline as used clinically is a 50:50 racemic mixture ((R)-P) of (-) and (+) enantiomers. It is not known if the enantiomers differ in terms of their effects on cancer. In this study, we examined the cytotoxic capacity of perhexiline and its enantiomers ((-)-P and (+)-P) on CRC cell lines, grown as monolayers or spheroids, and patient-derived organoids. Treatment of CRC cell lines with (R)-P, (-)-P or (+)-P reduced cell viability, with IC
Language	English
Publishing date	2022-02-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14041043
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Article: Colorectal cancer detection and treatment with engineered probiotics.

Gurbatri, Candice R / Radford, Georgette / Vrbanac, Laura / Coker, Courtney / Im, Jong-Won / Taylor, Samuel R / Jang, YoungUk / Sivan, Ayelet / Rhee, Kyu / Saleh, Anas A / Chien, Tiffany / Zandkarimi, Fereshteh / Lia, Ioana / Lannagan, Tamsin Rm / Wang, Tongtong / Wright, Josephine A / Thomas, Elaine / Kobayashi, Hiroki / Ng, Jia Q /

Lawrence, Matt / Sammour, Tarik / Thomas, Michelle / Lewis, Mark / Papanicolas, Lito / Perry, Joanne / Fitzsimmons, Tracy / Kaazan, Patricia / Lim, Amanda / Marker, Julie / Ostroff, Cheri / Rogers, Geraint / Arpaia, Nicholas / Worthley, Daniel L / Woods, Susan L / Danino, Tal

bioRxiv : the preprint server for biology

2023

Abstract: Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral delivery of ... ...

Abstract	Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral delivery of probiotic
Language	English
Publishing date	2023-04-05
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.04.03.535370
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Article ; Online: Benefits of increased home-visitation services: exploring a case management model.

de la Rosa, Iván A / Perry, Joanne / Johnson, Victoria

Family & community health

2009 Volume 32, Issue 1, Page(s) 58–75

Abstract: This study examined outcome measures of a home-visitation program that provided services to first-born children and their parents. Home-visitation workers conducted pretest-posttest assessments for prenatal and postpartum periods for 109 families. ... ...

Abstract	This study examined outcome measures of a home-visitation program that provided services to first-born children and their parents. Home-visitation workers conducted pretest-posttest assessments for prenatal and postpartum periods for 109 families. Families were assessed using the Revised North Carolina Family Assessment Scale. Paired sample t tests were used to assess effect. Ordinary least squares regression measured effect of increased home-visitation services on family well-being. In this study, program participants displayed significantly higher posttest scores on social support, caregiver characteristics, family interaction measures, and a reduction in personal problems affecting parenting. Improved scores were significantly related to increased numbers of home-visitation services. The results are promising as participants were observed to make positive improvements in family resiliency.
MeSH term(s)	Adolescent ; Adult ; Birth Order ; Family ; Family Characteristics ; Family Relations ; Female ; Health Knowledge, Attitudes, Practice ; Hispanic Americans ; House Calls ; Humans ; Mental Health ; Mexico ; Parents ; Postnatal Care ; Poverty Areas ; Prenatal Care ; Social Support ; United States ; Young Adult
Language	English
Publishing date	2009-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	449879-3
ISSN	1550-5057 ; 0160-6379
ISSN (online)	1550-5057
ISSN	0160-6379
DOI	10.1097/01.FCH.0000342817.95390.7e
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