LIVIVO - Search results -

Search results

Result 1 - 10 of total 13

Search options

Article ; Online: Search for a Dark-Matter-Induced Cosmic Axion Background with ADMX.

Nitta, T / Braine, T / Du, N / Guzzetti, M / Hanretty, C / Leum, G / Rosenberg, L J / Rybka, G / Sinnis, J / Clarke, John / Siddiqi, I / Awida, M H / Chou, A S / Hollister, M / Knirck, S / Sonnenschein, A / Wester, W / Gleason, J R / Hipp, A T /

Sikivie, P / Sullivan, N S / Tanner, D B / Khatiwada, R / Carosi, G / Robertson, N / Duffy, L D / Boutan, C / Lentz, E / Oblath, N S / Taubman, M S / Yang, J / Daw, E J / Perry, M G / Bartram, C / Buckley, J H / Gaikwad, C / Hoffman, J / Murch, K W / Goryachev, M / Hartman, E / McAllister, B T / Quiskamp, A / Thomson, C / Tobar, M E / Dror, J A / Murayama, H / Rodd, N L

Physical review letters

2023 Volume 131, Issue 10, Page(s) 101002

Abstract: We report the first result of a direct search for a cosmic axion background (CaB)-a relativistic background of axions that is not dark matter-performed with the axion haloscope, the Axion Dark Matter eXperiment (ADMX). Conventional haloscope analyses ... ...

Abstract	We report the first result of a direct search for a cosmic axion background (CaB)-a relativistic background of axions that is not dark matter-performed with the axion haloscope, the Axion Dark Matter eXperiment (ADMX). Conventional haloscope analyses search for a signal with a narrow bandwidth, as predicted for dark matter, whereas the CaB will be broad. We introduce a novel analysis strategy, which searches for a CaB induced daily modulation in the power measured by the haloscope. Using this, we repurpose data collected to search for dark matter to set a limit on the axion photon coupling of a CaB originating from dark matter cascade decay via a mediator in the 800-995 MHz frequency range. We find that the present sensitivity is limited by fluctuations in the cavity readout as the instrument scans across dark matter masses. Nevertheless, we suggest that these challenges can be surmounted using superconducting qubits as single photon counters, and allow ADMX to operate as a telescope searching for axions emerging from the decay of dark matter. The daily modulation analysis technique we introduce can be deployed for various broadband rf signals, such as other forms of a CaB or even high-frequency gravitational waves.
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.101002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 58/153: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Dark matter axion search using a Josephson Traveling wave parametric amplifier.

Bartram, C / Braine, T / Cervantes, R / Crisosto, N / Du, N / Leum, G / Mohapatra, P / Nitta, T / Rosenberg, L J / Rybka, G / Yang, J / Clarke, John / Siddiqi, I / Agrawal, A / Dixit, A V / Awida, M H / Chou, A S / Hollister, M / Knirck, S /

Sonnenschein, A / Wester, W / Gleason, J R / Hipp, A T / Jois, S / Sikivie, P / Sullivan, N S / Tanner, D B / Lentz, E / Khatiwada, R / Carosi, G / Cisneros, C / Robertson, N / Woollett, N / Duffy, L D / Boutan, C / Jones, M / LaRoque, B H / Oblath, N S / Taubman, M S / Daw, E J / Perry, M G / Buckley, J H / Gaikwad, C / Hoffman, J / Murch, K / Goryachev, M / McAllister, B T / Quiskamp, A / Thomson, C / Tobar, M E / Bolkhovsky, V / Calusine, G / Oliver, W / Serniak, K

The Review of scientific instruments

2023 Volume 94, Issue 4

Abstract: We describe the first implementation of a Josephson Traveling Wave Parametric Amplifier (JTWPA) in an axion dark matter search. The operation of the JTWPA for a period of about two weeks achieved sensitivity to axion-like particle dark matter with axion- ... ...

Abstract	We describe the first implementation of a Josephson Traveling Wave Parametric Amplifier (JTWPA) in an axion dark matter search. The operation of the JTWPA for a period of about two weeks achieved sensitivity to axion-like particle dark matter with axion-photon couplings above 10-13 Ge V-1 over a narrow range of axion masses centered around 19.84 µeV by tuning the resonant frequency of the cavity over the frequency range of 4796.7-4799.5 MHz. The JTWPA was operated in the insert of the axion dark matter experiment as part of an independent receiver chain that was attached to a 0.56-l cavity. The ability of the JTWPA to deliver high gain over a wide (3 GHz) bandwidth has engendered interest from those aiming to perform broadband axion searches, a longstanding goal in this field.
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0122907
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 46/112: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Overnight variations in cortisol, interleukin 6, tumour necrosis factor alpha and other cytokines in people with rheumatoid arthritis.

Perry, M G / Kirwan, J R / Jessop, D S / Hunt, L P

Annals of the rheumatic diseases

2008 Volume 68, Issue 1, Page(s) 63–68

Abstract: Objective: To investigate overnight variations in absolute values and patterns of cytokines including interleukin 6 (IL6) and tumour necrosis factor alpha (TNFalpha) in rheumatoid arthritis (RA), and to relate any changes to those occurring in blood ... ...

Abstract	Objective: To investigate overnight variations in absolute values and patterns of cytokines including interleukin 6 (IL6) and tumour necrosis factor alpha (TNFalpha) in rheumatoid arthritis (RA), and to relate any changes to those occurring in blood cortisol. Methods: A total of 16 people (8 female) with active RA and who had received no recent glucocorticoids were admitted overnight. Blood samples were obtained at 13 time points between 21.00 and 10.00. Results: The geometric mean IL6 concentration rose significantly from 35 pg/ml at 22:00 to 64 pg/ml at 07:15 (repeated measures analysis of variance (ANOVA), p<0.001). The geometric mean cortisol concentration rose significantly overnight from 57 ng/ml at 01:00 to 229 ng/ml at 07:15 (repeated measures ANOVA, p<0.001). Neither TNFalpha nor the other cytokines measured changed significantly. Using cubic regression modelling IL6 began to rise before cortisol (range 0.01 to 4.83 h) in eight participants and after cortisol (range 1.11 to 5.14 h) in three participants. In a random coefficient model including data from all participants, the estimated mean IL6 value began to rise 3.05 h before the estimated mean cortisol value, with the IL6 peak occurring 0.70 h before the cortisol peak. Conclusion: The mean IL6 and cortisol concentrations showed a significant overnight variation. Neither TNFalpha nor the other cytokines measured changed significantly. In a random coefficient model IL6 began to rise approximately 3 h, and reached a peak about 40 min, before cortisol. These studies confirm that there are abnormalities in plasma cortisol and IL6 concentrations and dynamics. The data also link the overnight rise in IL6 to the circadian variation in symptoms.
MeSH term(s)	Aged ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/drug therapy ; Circadian Rhythm ; Cytokines/blood ; Drug Administration Schedule ; Female ; Humans ; Hydrocortisone/blood ; Interleukin-6/blood ; Male ; Middle Aged ; Tumor Necrosis Factor-alpha/blood
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Antirheumatic Agents ; Cytokines ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2008-03-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/ard.2007.086561
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 167: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Quantitative analysis and subsequent effects of partitioning of a mono- and dihydric C₄ alcohols into the micelles of cationic surfactants

Chavda, S / Singh, K / Perry, M.G / Marangoni, D.G / Aswal, V.K / Bahadur, P

Colloids and surfaces. 2011 Mar. 20, v. 378, no. 1-3

2011

Abstract: Surfactant–alcohol systems are not uncommon in colloidal chemistry, what is rare is a specific emphasis on the environmental sensitive behaviour of 1-butanol (C₄OH) in different surfactant solutions. Intermediate solubility of C₄OH (in between totally ... ...

Abstract	Surfactant–alcohol systems are not uncommon in colloidal chemistry, what is rare is a specific emphasis on the environmental sensitive behaviour of 1-butanol (C₄OH) in different surfactant solutions. Intermediate solubility of C₄OH (in between totally soluble short chain alcohol and partially miscible long chain alcohol) has prompted us to study its partitioning between bulk and micellar phase for monomeric and dimeric surfactants and consequences on micellar parameters. Micellar aggregation number (Nₐgg) and micelle size has been evaluated by using SANS. Partitioning of C₄OH between bulk and micellar phase was evaluated from 2D NMR NOESY and DOSY experiments. The effect of the structure of C₄ alcohol was evaluated by taking all the above studies for 1,4-butanediol (1,4-BTD), a non-partitioning alcohol by virtue of its terminal hydroxyl groups. Finally, results from SANS and NMR are supported by the routine study of micellar behaviour from conductivity and viscosity. It is revealed that C₄ alcohol plays substantial role in micellization and the two alcohols contribute differently in controlling the overall micellization and micellar parameters.
Keywords	alcohols ; cationic surfactants ; colloids ; micelles ; nuclear magnetic resonance spectroscopy ; quantitative analysis ; solubility ; viscosity
Language	English
Dates of publication	2011-0320
Size	p. 79-86.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500517-3
ISSN	0927-7757
ISSN	0927-7757
DOI	10.1016/j.colsurfa.2011.02.007
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Search for Invisible Axion Dark Matter in the 3.3-4.2 μeV Mass Range.

Bartram, C / Braine, T / Burns, E / Cervantes, R / Crisosto, N / Du, N / Korandla, H / Leum, G / Mohapatra, P / Nitta, T / Rosenberg, L J / Rybka, G / Yang, J / Clarke, John / Siddiqi, I / Agrawal, A / Dixit, A V / Awida, M H / Chou, A S /

Hollister, M / Knirck, S / Sonnenschein, A / Wester, W / Gleason, J R / Hipp, A T / Jois, S / Sikivie, P / Sullivan, N S / Tanner, D B / Lentz, E / Khatiwada, R / Carosi, G / Robertson, N / Woollett, N / Duffy, L D / Boutan, C / Jones, M / LaRoque, B H / Oblath, N S / Taubman, M S / Daw, E J / Perry, M G / Buckley, J H / Gaikwad, C / Hoffman, J / Murch, K W / Goryachev, M / McAllister, B T / Quiskamp, A / Thomson, C / Tobar, M E

Physical review letters

2022 Volume 127, Issue 26, Page(s) 261803

Abstract: We report the results from a haloscope search for axion dark matter in the 3.3-4.2 μeV mass range. This search excludes the axion-photon coupling predicted by one of the benchmark models of "invisible" axion dark matter, the Kim-Shifman-Vainshtein- ... ...

Abstract	We report the results from a haloscope search for axion dark matter in the 3.3-4.2 μeV mass range. This search excludes the axion-photon coupling predicted by one of the benchmark models of "invisible" axion dark matter, the Kim-Shifman-Vainshtein-Zakharov model. This sensitivity is achieved using a large-volume cavity, a superconducting magnet, an ultra low noise Josephson parametric amplifier, and sub-Kelvin temperatures. The validity of our detection procedure is ensured by injecting and detecting blind synthetic axion signals.
Language	English
Publishing date	2022-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.261803
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 58/153: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Sequential synovial fluid sampling suggests plasma and synovial fluid IL-6 vary independently in rheumatoid arthritis.

Perry, M G / Richards, L / Harbuz, M S / Jessop, D S / Kirwan, J R

Rheumatology (Oxford, England)

2006 Volume 45, Issue 2, Page(s) 229–230

MeSH term(s)	Adult ; Arthritis, Rheumatoid/immunology ; Circadian Rhythm ; Humans ; Interleukin-6/metabolism ; Middle Aged ; Synovial Fluid/immunology
Chemical Substances	Interleukin-6
Language	English
Publishing date	2006-02
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kei196
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 240: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 497: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Axion Dark Matter Experiment: Detailed design and operations.

Khatiwada, R / Bowring, D / Chou, A S / Sonnenschein, A / Wester, W / Mitchell, D V / Braine, T / Bartram, C / Cervantes, R / Crisosto, N / Du, N / Rosenberg, L J / Rybka, G / Yang, J / Will, D / Kimes, S / Carosi, G / Woollett, N / Durham, S /

Duffy, L D / Bradley, R / Boutan, C / Jones, M / LaRoque, B H / Oblath, N S / Taubman, M S / Tedeschi, J / Clarke, John / Dove, A / Hashim, A / Siddiqi, I / Stevenson, N / Eddins, A / O'Kelley, S R / Nawaz, S / Agrawal, A / Dixit, A V / Gleason, J R / Jois, S / Sikivie, P / Sullivan, N S / Tanner, D B / Solomon, J A / Lentz, E / Daw, E J / Perry, M G / Buckley, J H / Harrington, P M / Henriksen, E A / Murch, K W / Hilton, G C

The Review of scientific instruments

2021 Volume 92, Issue 12, Page(s) 124502

Abstract: Axion dark matter experiment ultra-low noise haloscope technology has enabled the successful completion of two science runs (1A and 1B) that looked for dark matter axions in the 2.66-3.1 μeV mass range with Dine-Fischler-Srednicki-Zhitnisky sensitivity [ ... ...

Abstract	Axion dark matter experiment ultra-low noise haloscope technology has enabled the successful completion of two science runs (1A and 1B) that looked for dark matter axions in the 2.66-3.1 μeV mass range with Dine-Fischler-Srednicki-Zhitnisky sensitivity [Du et al., Phys. Rev. Lett. 120, 151301 (2018) and Braine et al., Phys. Rev. Lett. 124, 101303 (2020)]. Therefore, it is the most sensitive axion search experiment to date in this mass range. We discuss the technological advances made in the last several years to achieve this sensitivity, which includes the implementation of components, such as the state-of-the-art quantum-noise-limited amplifiers and a dilution refrigerator. Furthermore, we demonstrate the use of a frequency tunable microstrip superconducting quantum interference device amplifier in run 1A, and a Josephson parametric amplifier in run 1B, along with novel analysis tools that characterize the system noise temperature.
Language	English
Publishing date	2021-12-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0037857
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 46/112: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: ET(B) receptor-deficient rats exhibit reduced contraction to ET-1 despite an increase in ET(A) receptors.

Perry, M G / Molero, M M / Giulumian, A D / Katakam, P V / Pollock, J S / Pollock, D M / Fuchs, L C

American journal of physiology. Heart and circulatory physiology

2001 Volume 281, Issue 6, Page(s) H2680–6

Abstract: Several disease states, including hypertension, are associated with elevations in plasma endothelin-1 (ET-1) and variable changes in vascular contraction to ET-1. The spotting lethal (sl) rat carries a deletion of the endothelin-B (ET(B)) receptor gene ... ...

Abstract	Several disease states, including hypertension, are associated with elevations in plasma endothelin-1 (ET-1) and variable changes in vascular contraction to ET-1. The spotting lethal (sl) rat carries a deletion of the endothelin-B (ET(B)) receptor gene that prevents expression of functional ET(B) receptors, resulting in elevated plasma ET-1. On a normal diet, these rats are normotensive and thus provide an opportunity to study the vascular effects of chronically elevated ET-1 in the absence of hypertension. Studies were performed in rats homozygous for the ET(B) deficiency (sl/sl; n = 8) and in transgenic rats heterozygous for the ET(B) deficiency (sl/+; n = 8). Plasma ET-1 was elevated in sl/sl rats (3.85 +/- 0.55 pg/ml) compared with sl/+ rats (0.31 +/- 0.11 pg/ml). Mean arterial blood pressure in conscious unrestrained sl/sl and sl/+ rats was 101 +/- 5 and 107 +/- 6 mmHg, respectively. Concentration-dependent contractions to ET-1 (10(-11)-10(-8) M) were reduced in mesenteric small arteries (150-250 microm) from sl/sl rats, as indicated by an approximately 10-fold increase in EC(50). A selective ET(A) antagonist, A-127722 (30 nM), abolished contraction to ET-1 in both groups, whereas a selective ET(B) antagonist had no effect. Also, ET(B) agonists (IRL-1620 and sarafatoxin 6c) produced neither contraction nor relaxation in either group, indicating that contraction to ET-1 in this vascular segment was exclusively ET(A) dependent. Despite increased plasma ET-1, protein expression of ET(A) receptors in membrane protein isolated from mesenteric small arteries was increased in sl/sl compared with sl/+ rats, as shown by Western blotting. These results indicate that, in ET(B)-deficient rats, ET(A)-induced contraction is reduced in vessels normally lacking ET(B)-mediated effects. Reduced contraction may be related to elevated plasma ET-1 and occurs in the presence of increased ET(A) receptor protein expression, suggesting an uncoupling of ET(A) receptor expression from functional activity.
MeSH term(s)	Animals ; Animals, Genetically Modified ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Blotting, Western ; Dose-Response Relationship, Drug ; Endothelin-1/blood ; Endothelin-1/pharmacology ; Heterozygote ; Homozygote ; Male ; Mesenteric Arteries/chemistry ; Mesenteric Arteries/physiology ; Rats ; Receptor, Endothelin A ; Receptor, Endothelin B ; Receptors, Endothelin/analysis ; Receptors, Endothelin/genetics ; Receptors, Endothelin/metabolism ; Vascular Resistance/drug effects ; Vascular Resistance/physiology ; Vasoconstriction/drug effects ; Vasoconstriction/physiology
Chemical Substances	Endothelin-1 ; Receptor, Endothelin A ; Receptor, Endothelin B ; Receptors, Endothelin
Language	English
Publishing date	2001-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.2001.281.6.H2680
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.89: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: A novel point mutation in the insulin gene giving rise to hyperproinsulinemia.

Warren-Perry, M G / Manley, S E / Ostrega, D / Polonsky, K / Mussett, S / Brown, P / Turner, R C

The Journal of clinical endocrinology and metabolism

1997 Volume 82, Issue 5, Page(s) 1629–1631

Abstract: A 58-yr-old obese white Caucasian male type 2 diabetic, entered into the UK Prospective Diabetes Study, was found to have raised fasting total proinsulin levels 708 pmol/L(-1) (normal range, 3-16 pmol/L(-1)) and normal specific plasma insulin level 29 ... ...

Abstract	A 58-yr-old obese white Caucasian male type 2 diabetic, entered into the UK Prospective Diabetes Study, was found to have raised fasting total proinsulin levels 708 pmol/L(-1) (normal range, 3-16 pmol/L(-1)) and normal specific plasma insulin level 29 pmol/L(-1) (normal range, 21-75 pmol/L(-1)). Immunoreactive plasma insulin, measured by RIA, was 503 pmol/L(-1). DNA was extracted, the insulin gene amplified by the PCR, and by direct sequencing, a novel point mutation, G1552C, was identified, which resulted in the substitution of proline (CCT) for arginine (CGT) at position 65. This prevented cleavage of the C-peptide A-chain dibasic cleavage site (lys-arg) by the processing protease in the pancreatic beta-cells. The plasma proinsulin and insulin levels were in accord with expression of both the wild-type and the mutant alleles. The G1552C mutation was not linked with diabetes, because it was present in a 37-yr-old nondiabetic daughter and not in a 35-yr-old daughter who had had gestational diabetes.
MeSH term(s)	Arginine ; C-Peptide/metabolism ; Chromatography, High Pressure Liquid ; DNA/analysis ; DNA/chemistry ; Female ; Genotype ; Humans ; Insulin/blood ; Insulin/genetics ; Male ; Middle Aged ; Point Mutation ; Polymerase Chain Reaction ; Proinsulin/blood ; Proline ; Sequence Analysis, DNA
Chemical Substances	C-Peptide ; Insulin ; DNA (9007-49-2) ; Proinsulin (9035-68-1) ; Arginine (94ZLA3W45F) ; Proline (9DLQ4CIU6V)
Language	English
Publishing date	1997-05
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jcem.82.5.3914
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.134: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Mitochondrial FAD-glycerophosphate dehydrogenase and G-protein-coupled inwardly rectifying K+ channel: No evidence for linkage in maturity-onset diabetes of the young or NIDDM.

Warren-Perry, M G / Stoffel, M / Saker, P J / Zhang, Y / Brown, L J / MacDonald, M J / Turner, R C

Diabetes

1996 Volume 45, Issue 5, Page(s) 639–641

Abstract: Two genes that have potentially important regulatory roles in insulin secretion are both located on chromosome 2q24.1. G-protein-coupled muscarinic potassium channel (GIRK1) is an inwardly rectifying K+ channel that helps to maintain the resting ... ...

Abstract	Two genes that have potentially important regulatory roles in insulin secretion are both located on chromosome 2q24.1. G-protein-coupled muscarinic potassium channel (GIRK1) is an inwardly rectifying K+ channel that helps to maintain the resting potential and excitability of cells. Mitochondrial FAD-linked glycerophosphate dehydrogenase (m-GDH) catalyzes a rate-limiting step of the glycerol phosphate shuttle in pancreatic islets. Reduced m-GDH activity has been demonstrated in islets isolated from diabetic subjects compared with islets from nondiabetic control subjects and from the diabetic GK rat. To study the relationship between these candidate genes and NIDDM, we have examined a simple tandem-repeat polymorphism (STRP) close to both the KCN J3 (GIRK1) locus and the m-GDH locus. In a linkage study of three maturity-onset diabetes of the young (MODY) pedigrees, not linked to MODY1, MODY2, or MODY3, a cumulative score of - 9.6 at a recombination fraction of theta = 0 excluded linkage. In a population-association study, no linkage disequilibrium for the STRP was found between 190 unselected NIDDM patients and 60 geographically and age-matched white nondiabetic subjects (chi2 = 1.51 on 3 df, P = 0.68). Thus, mutations involving the genes for GIRK1 or FAD-glycerophosphate dehydrogenase are unlikely to cause MODY, and a common mutation in either gene is unlikely to contribute to NIDDM in whites. These data do not exclude mutations in some families or other ethnic groups.
MeSH term(s)	Animals ; Base Sequence ; Chromosome Mapping ; Chromosomes, Artificial, Yeast ; Chromosomes, Human, Pair 2 ; DNA Primers ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Female ; G Protein-Coupled Inwardly-Rectifying Potassium Channels ; Genetic Linkage ; Glycerolphosphate Dehydrogenase/genetics ; Humans ; Linkage Disequilibrium ; Male ; Middle Aged ; Mitochondria/enzymology ; Molecular Sequence Data ; Pedigree ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Potassium Channels/genetics ; Potassium Channels, Inwardly Rectifying ; Rats ; Receptors, Muscarinic/genetics ; Recombination, Genetic ; Reference Values ; Repetitive Sequences, Nucleic Acid
Chemical Substances	DNA Primers ; G Protein-Coupled Inwardly-Rectifying Potassium Channels ; Potassium Channels ; Potassium Channels, Inwardly Rectifying ; Receptors, Muscarinic ; Glycerolphosphate Dehydrogenase (EC 1.1.-) ; glycerol-3-phosphate oxidase (EC 1.1.3.21)
Language	English
Publishing date	1996-05
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/diab.45.5.639
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.175: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito