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  1. Book ; Online ; Thesis: The role of aPKC polarity in migration and tumor formation

    Persa, Oana-Diana / Niessen, Carien M. / Nögel, Angelika

    2014  

    Institution Klinik und Poliklinik für Dermatologie und Venerologie
    Author's details vorgelegt von Oana-Diana Persa ; 1. Berichterstatter: Frau Universitätsprofessor Dr. rer. nat. C. Niessen, 2. Berichterstatter: Frau Universitätsprofessor Dr. rer. nat. A. A. Noegel ; aus der Klinik und Poliklinik für Dermatologie und Venerologie der Universität zu Köln
    Subject code 610
    Language English
    Size 74 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2014
    Note Zsfassung in dt. Sprache
    HBZ-ID HT018441844
    DOI 10.4126/38m-005838790
    Database Repository for Life Sciences

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  2. Book ; Thesis: The role of aPKC polarity in migration and tumor formation

    Persa, Oana-Diana / Niessen, Carien M. / Nögel, Angelika

    2014  

    Institution Klinik und Poliklinik für Dermatologie und Venerologie
    Author's details vorgelegt von Oana-Diana Persa ; 1. Berichterstatter: Frau Universitätsprofessor Dr. rer. nat. C. Niessen, 2. Berichterstatter: Frau Universitätsprofessor Dr. rer. nat. A. A. Noegel ; aus der Klinik und Poliklinik für Dermatologie und Venerologie der Universität zu Köln
    Subject code 610
    Language English
    Size 74 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2014
    Note Zsfassung in dt. Sprache
    HBZ-ID HT018455283
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 D 790 order for loan Magazin

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  3. Article ; Online: Complete excision of squamous cell carcinoma is superior to salvage radiotherapy for microscopic residual disease.

    Persa, Oana-Diana / Mauch, Cornelia

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2022  Volume 20, Issue 7, Page(s) 1020–1022

    MeSH term(s) Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/radiotherapy ; Carcinoma, Squamous Cell/surgery ; Chemoradiotherapy ; Humans ; Neoplasm Recurrence, Local/pathology ; Neoplasm, Residual ; Retrospective Studies ; Salvage Therapy
    Language English
    Publishing date 2022-05-17
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14780
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  4. Article ; Online: Komplette Plattenepithelkarzinom-Exzision ist der Strahlentherapie residualer mikroskopischer Tumorzellreste überlegen.

    Persa, Oana-Diana / Mauch, Cornelia

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2021  Volume 20, Issue 7, Page(s) 1020–1022

    Language English
    Publishing date 2021-11-10
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14780_g
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  5. Article ; Online: Was ist neu bei der Diagnostik und Therapie des malignen Melanoms?

    Persa, Oana-Diana / Mauch, Cornelia

    Deutsche medizinische Wochenschrift (1946)

    2020  Volume 145, Issue 24, Page(s) 1754–1756

    Abstract: Melanoma incidence and mortality rates are increasing. The sentinel lymph node biopsy plays an important prognostic role and is pivotal for the decision to undergo an adjuvant therapy making it an important diagnostic tool. The lack of survival benefit ... ...

    Title translation What is new in the diagnosis and therapy of malignant melanoma?
    Abstract Melanoma incidence and mortality rates are increasing. The sentinel lymph node biopsy plays an important prognostic role and is pivotal for the decision to undergo an adjuvant therapy making it an important diagnostic tool. The lack of survival benefit in patients with sentinel lymph node-positive (SLN+) melanoma upon immediate complete lymphadenectomy (CLND) suggest a parallel and not stepwise development of lymph node metastasis and distant metastasis thus questioning the role of immediate CLND. These findings also suggest adjuvant therapy may play a more important role for SLN+ melanoma patients than CLND. Recently, the PD-1 inhibitor Nivolumab and Pembrolizumab as well as the BRAF/MEK inhibitor Dabrafenib and Trametinib were approved for the adjuvant therapy of stage III malignant melanoma. Another novelty in the therapy of malignant melanoma is the approval of the first oncolytic virus, Talimogene laherparepvec, for the treatment of unresectable stage III and IV (M1a) melanoma. Significant progress has also been made in the treatment of patients with cerebral melanoma metastasis since studies indicate that both BRAF/MEK inhibitors and the immunotherapy with CTLA4 and PD-1 inhibitors are efficient in this group of patients. With this wide range of possible systemic therapies for advanced melanoma further studies regarding therapy sequence, combinations between targeted therapies and immunotherapy as well as biomarkers for treatment response are needed to help guide physicians find the optimal therapy for patients with advanced malignant melanoma.
    MeSH term(s) Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Humans ; Immunotherapy ; Lymph Node Excision ; Melanoma/diagnosis ; Melanoma/pathology ; Melanoma/therapy ; Oncolytic Virotherapy ; Sentinel Lymph Node Biopsy
    Chemical Substances Antineoplastic Agents
    Language German
    Publishing date 2020-11-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1012-2972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Whole-Body Imaging for the Primary Staging of Melanomas-A Single-Center Retrospective Study.

    Mayer, Kristine E / Gaa, Jochen / Wasserer, Sophia / Biedermann, Tilo / Persa, Oana-Diana

    Cancers

    2023  Volume 15, Issue 21

    Abstract: Background: Melanoma staging at diagnosis predominantly depends on the tumor thickness. Sentinel lymph node biopsy (SLNB) is a common tool for primary staging. However, for tumors of >4 mm with ulceration, 3D whole-body imaging and, in particular, Fluor- ...

    Abstract Background: Melanoma staging at diagnosis predominantly depends on the tumor thickness. Sentinel lymph node biopsy (SLNB) is a common tool for primary staging. However, for tumors of >4 mm with ulceration, 3D whole-body imaging and, in particular, Fluor-18-Deoxyglucose positron emission tomography combined with computed tomography (
    Methods: In this retrospective single-center study, 94 patients receiving
    Results: Besides the patients with primary tumors characterized as pT4b (63%), the patients with pT4a tumors and pT3 tumors close to 4 mm in tumor thickness also received initial whole-body imaging. In 42.6% of the patients undergoing
    Conclusion: Whole-body imaging as a primary diagnostic tool is highly valuable and influences the subsequent diagnostic and therapeutic procedures in a considerable number of patients with a relatively high tumor thickness. It can help avoid the costs and invasiveness of redundant SLNB and simultaneously hasten the staging of patients at the time of diagnosis.
    Language English
    Publishing date 2023-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15215265
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  7. Article ; Online: Epithelial polarity limits EMT.

    Persa, Oana-Diana / Niessen, Carien M

    Nature cell biology

    2019  Volume 21, Issue 3, Page(s) 299–300

    MeSH term(s) Cell Polarity ; Epithelial Cells ; Epithelial-Mesenchymal Transition ; Humans ; Neoplasms ; Snail Family Transcription Factors
    Chemical Substances SNAI1 protein, human ; Snail Family Transcription Factors
    Language English
    Publishing date 2019-02-16
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-019-0284-7
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  8. Article ; Online: [No title information]

    Persa, Oana-Diana / Fromme, Julia Elisabeth / Mauch, Cornelia

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2021  Volume 19, Issue 6, Page(s) 902–905

    Title translation Therapiesequenz von Immuntherapie und zielgerichteter Therapie beim BRAF
    Language German
    Publishing date 2021-06-15
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14329_g
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  9. Article ; Online: Sequencing of immunotherapy and targeted therapy for BRAF

    Persa, Oana-Diana / Fromme, Julia Elisabeth / Mauch, Cornelia

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2021  Volume 19, Issue 6, Page(s) 902–904

    MeSH term(s) Humans ; Immunotherapy ; Melanoma/drug therapy ; Melanoma/therapy ; Molecular Targeted Therapy ; Mutation/genetics ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins B-raf/genetics ; Retrospective Studies ; Skin Neoplasms/drug therapy ; Skin Neoplasms/therapy
    Chemical Substances Protein Kinase Inhibitors ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2021-02-22
    Publishing country Germany
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14329
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  10. Article: Was ist neu bei der Diagnostik und Therapie des malignen Melanoms?

    Persa, Oana-Diana / Mauch, Cornelia

    DMW - Deutsche Medizinische Wochenschrift

    2020  Volume 145, Issue 24, Page(s) 1754–1756

    Abstract: Diagnostik des malignen Melanoms: Die Wächterlymphknotenbiopsie spielt eine wichtige Rolle für die korrekte Stadieneinteilung beim Melanom und für die Entscheidung zur Durchführung einer adjuvanten Therapie. Eine systematische, radikale Lymphadenektomie ...

    Abstract Diagnostik des malignen Melanoms: Die Wächterlymphknotenbiopsie spielt eine wichtige Rolle für die korrekte Stadieneinteilung beim Melanom und für die Entscheidung zur Durchführung einer adjuvanten Therapie. Eine systematische, radikale Lymphadenektomie nach positivem Wächterlymphknoten verbessert das Überleben der Patienten nicht. Die Sensitivität der Bestimmung der zellfreien Tumor-DNA ist höher als beim Tumormarker S-100 und ermöglicht die frühe Erkennung eines Rezidivs beim Melanom.
    Adjuvante Therapien: Neben der adjuvanten Therapie mit Interferon wurden zwischenzeitlich die PD-1-Inhibitoren Nivolumab und Pembrolizumab sowie die BRAF/MEK-Inhibitoren Dabrafenib und Trametinib für die adjuvante Therapie im Stadium III zugelassen. Für die adjuvante Therapie im Stadium II ist weiterhin nur Interferon zugelassen, während für das vollständig resezierte Stadium IV nur Nivolumab zugelassen ist.
    Therapie der lokoregionären Metastasierung: Die intraläsionale Injektion von Talimogen laherparepvec (T-VEC) hat zu einer signifikanten Verringerung der Tumorlast im Vergleich zu intraläsionalem GM-CSF geführt und ist für das Stadium III–IV (nur M1a) zugelassen.
    Therapie bei Hirnmetastasen: Sowohl die zielgerichtete Therapie mit Dabrafenib und Trametinib als auch die Immunkombinationstherapie zwischen Ipilimumab und Nivolumab sind bei Hirnmetastasen wirksam. Die sequenzielle Systemtherapie mit zielgerichteter und Immuntherapie beim metastasierten malignen Melanom sowie die Kombination zielgerichteter Therapien mit Immuntherapien werden aktuell in klinischen Studien überprüft.
    Keywords Melanom ; Immuntherapie ; zielgerichtete Therapie ; Wächterlymphknotenbiopsie ; melanoma ; immunotherapy ; targeted therapy ; sentinel lymph node biopsy
    Language German
    Publishing date 2020-11-30
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1012-2972
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