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  1. AU="Persons, A K"
  2. AU="Carbone, Vincenzo"
  3. AU="R.G.Ormiston, " AU="R.G.Ormiston, "
  4. AU=Sinha Surabhi
  5. AU="Whitby, Thomas Michael"
  6. AU="F Hossain"
  7. AU="Xavier, Joicymara S."
  8. AU="Heidenreich, Sebastian"
  9. AU="Clifford, Muireann"
  10. AU="Armendariz, R."
  11. AU="Cho, Yoon-Kyoung"
  12. AU="Payne, Emily"
  13. AU="Desseauve, David"
  14. AU="Elrod, Virginia A"
  15. AU=Alpaydin Aylin O AU=Alpaydin Aylin O
  16. AU=Amin Kritika Premnath
  17. AU="Subramanian, Prem S"
  18. AU="S.Wang, "
  19. AU="Kotrotsiou, Evagelia"
  20. AU="Belnap, Ethan"
  21. AU="Luo, Jianming"
  22. AU=Hsu Pin-Jui
  23. AU=Debaud Charlotte
  24. AU="García-Rubia, Alfonso"
  25. AU=Belot Alexandre
  26. AU="Jorge Ospina Duque"
  27. AU="Chalot, Michel"
  28. AU="Gunsolley, J N"
  29. AU="Tuè, Giovanni"
  30. AU="de Laat, Bart"
  31. AU=Drory Omri
  32. AU="Pothlichet, Julien"
  33. AU="Douwes, Rianne M"
  34. AU="Jarzebowski, Mary"
  35. AU="Shetty, Sunil"
  36. AU="Ricardo Ryoshim Kunyioshi"
  37. AU=Santos Maria Cristina Leme Godoy Dos AU=Santos Maria Cristina Leme Godoy Dos

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  1. Artikel ; Online: A Mechanical Brain Damage Framework Used to Model Abnormal Brain Tau Protein Accumulations of National Football League Players.

    Horstemeyer, M F / Berthelson, P R / Moore, J / Persons, A K / Dobbins, A / Prabhu, R K

    Annals of biomedical engineering

    2019  Band 47, Heft 9, Seite(n) 1873–1888

    Abstract: A mechanics-based brain damage framework is used to model the abnormal accumulation of hyperphosphorylated p-tau associated with chronic traumatic encephalopathy within the brains of deceased National Football League (NFL) players studied at Boston ... ...

    Abstract A mechanics-based brain damage framework is used to model the abnormal accumulation of hyperphosphorylated p-tau associated with chronic traumatic encephalopathy within the brains of deceased National Football League (NFL) players studied at Boston University and to provide a framework for understanding the damage mechanisms. p-tau damage is formulated as the multiplicative decomposition of three independently evolving damage internal state variables (ISVs): nucleation related to number density, growth related to the average area, and coalescence related to the nearest neighbor distance. The ISVs evolve under different rates for three well known mechanical boundary conditions, which in themselves introduce three different rates making a total of nine scenarios, that we postulate are related to brain damage progression: (1) monotonic overloads, (2) cyclic fatigue which corresponds to repetitive impacts, and (3) creep which is correlated to damage accumulation over time. Different NFL player positions are described to capture the different types of damage progression. Skill position players, such as quarterbacks, are expected to exhibit a greater p-tau protein accumulation during low cycle fatigue (higher amplitude impacts with a lesser number), and linemen who exhibit a greater p-tau protein accumulation during high cycle fatigue (lower amplitude impacts with a greater number of impacts). This mechanics-based damage framework presents a foundation for developing a multiscale model for traumatic brain injury that combines mechanics with biology.
    Mesh-Begriff(e) Adult ; Aged ; Brain/metabolism ; Brain Injuries/metabolism ; Football/injuries ; Humans ; Male ; Middle Aged ; Models, Biological ; tau Proteins/metabolism
    Chemische Substanzen tau Proteins
    Sprache Englisch
    Erscheinungsdatum 2019-08-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 185984-5
    ISSN 1573-9686 ; 0191-5649 ; 0090-6964
    ISSN (online) 1573-9686
    ISSN 0191-5649 ; 0090-6964
    DOI 10.1007/s10439-019-02294-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Structure, property, and function of sheepshead (Archosargus probatocephalus) teeth.

    Deang, J F / Persons, A K / Oppedal, A L / Rhee, H / Moser, R D / Horstemeyer, M F

    Archives of oral biology

    2018  Band 89, Seite(n) 1–8

    Abstract: Objectives: This paper studies A. probatocephalus teeth and investigates the mechanical properties and chemical composition of the enameloid and dentin.: Design: Nanoindentation tests with a max load of 1000 μN and X-ray Energy Dispersive ... ...

    Abstract Objectives: This paper studies A. probatocephalus teeth and investigates the mechanical properties and chemical composition of the enameloid and dentin.
    Design: Nanoindentation tests with a max load of 1000 μN and X-ray Energy Dispersive Spectroscopy (EDS) were performed along the diameter of the polished sample. Microstructural analysis of the dentin tubules was performed from SEM images.
    Results: From nanoindentation testing, the dentin of the sheepshead teeth has a nanoindentation hardness of 0.89 ± 0.21 (mean ± S.D.) GPa and a reduced Young's modulus of 23.29 ± 5.30 GPa. The enameloid of A. probatocephalus has a hardness of 4.36 ± 0.44 GPa and a mean reduced Young's modulus of 98.14 ± 6.91 GPa. Additionally, nanoindentation tests showed that the enameloid's hardness and modulus increased closer to the surface of the tooth. X-ray Energy Dispersive Spectroscopy (EDS) data further suggests that the gradient may be a result of the wt% fluoride within the enameloid, where an increase in fluoride results in an increase in reduced Young's modulus and hardness.
    Conclusion: The microstructural characterization of the number density and area of the dentin tubules were used to address the porosity effect in the dentin to achieve the experimentally validated microhardness. The mechanical properties of the sheepshead teeth were also compared with previous nanoindentation tests from other aquatic species. The sheepshead teeth exhibit a greater reduced Young's modulus and hardness compared to shark and piranha teeth.
    Mesh-Begriff(e) Animals ; Biomechanical Phenomena ; Dental Enamel/chemistry ; Dental Enamel/diagnostic imaging ; Dental Enamel/drug effects ; Dental Stress Analysis ; Dentin/chemistry ; Dentin/diagnostic imaging ; Dentin/drug effects ; Dentin/ultrastructure ; Elastic Modulus ; Fishes/anatomy & histology ; Fluorides/pharmacology ; Hardness ; Stress, Mechanical ; Tooth/chemistry ; Tooth/diagnostic imaging ; Tooth/drug effects ; Tooth/ultrastructure
    Chemische Substanzen Fluorides (Q80VPU408O)
    Sprache Englisch
    Erscheinungsdatum 2018-02-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80227-x
    ISSN 1879-1506 ; 0003-9969
    ISSN (online) 1879-1506
    ISSN 0003-9969
    DOI 10.1016/j.archoralbio.2018.01.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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