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  1. Article ; Online: Management of Breast Abscess during Breastfeeding.

    Pileri, Paola / Sartani, Alessandra / Mazzocco, Martina Ilaria / Giani, Sofia / Rimoldi, Sara / Pietropaolo, Gaia / Pertusati, Anna / Vella, Adriana / Bazzi, Luca / Cetin, Irene

    International journal of environmental research and public health

    2022  Volume 19, Issue 9

    Abstract: 1) Background: Breast abscess (BA) is a condition leading in the majority of cases to breastfeeding interruption. Abscesses are commonly treated with antibiotics, needle aspiration or incision and drainage (I&D), but there is still no consensus on the ... ...

    Abstract (1) Background: Breast abscess (BA) is a condition leading in the majority of cases to breastfeeding interruption. Abscesses are commonly treated with antibiotics, needle aspiration or incision and drainage (I&D), but there is still no consensus on the optimal treatment. Since there are no well-defined clinical guidelines for abscess management, we conducted a retrospective, observational study with the aim of assessing ultrasound (US)-guided management of BA without surgery, regardless of the BA size. The secondary objective was the microbiologic characterization and, in particular, the
    MeSH term(s) Abscess/diagnostic imaging ; Abscess/etiology ; Abscess/therapy ; Anti-Bacterial Agents/therapeutic use ; Breast Diseases/diagnostic imaging ; Breast Diseases/etiology ; Breast Diseases/therapy ; Breast Feeding/adverse effects ; Female ; Humans ; Mastitis/drug therapy ; Mastitis/etiology ; Pregnancy ; Retrospective Studies ; Staphylococcus aureus
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-05-09
    Publishing country Switzerland
    Document type Journal Article ; Observational Study
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19095762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Low neutrophil-to-lymphocyte ratio and pan-immune-inflammation-value predict nodal pathologic complete response in 1274 breast cancer patients treated with neoadjuvant chemotherapy: a multicenter analysis.

    Gasparri, Maria Luisa / Albasini, Sara / Truffi, Marta / Favilla, Karin / Tagliaferri, Barbara / Piccotti, Francesca / Bossi, Daniela / Armatura, Giulia / Calcinotto, Arianna / Chiappa, Corrado / Combi, Francesca / Curcio, Annalisa / Della Valle, Angelica / Ferrari, Guglielmo / Folli, Secondo / Ghilli, Matteo / Listorti, Chiara / Mancini, Stefano / Marinello, Peter /
    Mele, Simone / Pertusati, Anna / Roncella, Manuela / Rossi, Lorenzo / Rovera, Francesca / Segattini, Silvia / Sgarella, Adele / Tognali, Daniela / Corsi, Fabio

    Therapeutic advances in medical oncology

    2023  Volume 15, Page(s) 17588359231193732

    Abstract: Background: Systemic inflammatory markers draw great interest as potential blood-based prognostic factors in several oncological settings.: Objectives: The aim of this study is to evaluate whether neutrophil-to-lymphocyte ratio (NLR) and pan-immune- ... ...

    Abstract Background: Systemic inflammatory markers draw great interest as potential blood-based prognostic factors in several oncological settings.
    Objectives: The aim of this study is to evaluate whether neutrophil-to-lymphocyte ratio (NLR) and pan-immune-inflammation value (PIV) predict nodal pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in node-positive (cN+) breast cancer (BC) patients.
    Design: Clinically, cN+ BC patients undergoing NAC followed by breast and axillary surgery were enrolled in a multicentric study from 11 Breast Units.
    Methods: Pretreatment blood counts were collected for the analysis and used to calculate NLR and PIV. Logistic regression analyses were performed to evaluate independent predictors of nodal pCR.
    Results: A total of 1274 cN+ BC patients were included. Nodal pCR was achieved in 586 (46%) patients. At multivariate analysis, low NLR [odds ratio (OR) = 0.71; 95% CI, 0.51-0.98;
    Conclusion: This study found that low NLR and PIV levels predict axillary pCR in patients with BC undergoing NAC.
    Registration: Eudract number NCT05798806.
    Language English
    Publishing date 2023-09-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359231193732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Development of a novel nomogram-based online tool to predict axillary status after neoadjuvant chemotherapy in cN+ breast cancer: A multicentre study on 1,950 patients.

    Corsi, Fabio / Albasini, Sara / Sorrentino, Luca / Armatura, Giulia / Carolla, Claudia / Chiappa, Corrado / Combi, Francesca / Curcio, Annalisa / Della Valle, Angelica / Ferrari, Guglielmo / Gasparri, Maria Luisa / Gentilini, Oreste / Ghilli, Matteo / Listorti, Chiara / Mancini, Stefano / Marinello, Peter / Meani, Francesco / Mele, Simone / Pertusati, Anna /
    Roncella, Manuela / Rovera, Francesca / Sgarella, Adele / Tazzioli, Giovanni / Tognali, Daniela / Folli, Secondo

    Breast (Edinburgh, Scotland)

    2021  Volume 60, Page(s) 131–137

    Abstract: Background: Type of axillary surgery in breast cancer (BC) patients who convert from cN + to ycN0 after neoadjuvant chemotherapy (NAC) is still debated. The aim of the present study was to develop and validate a preoperative predictive nomogram to ... ...

    Abstract Background: Type of axillary surgery in breast cancer (BC) patients who convert from cN + to ycN0 after neoadjuvant chemotherapy (NAC) is still debated. The aim of the present study was to develop and validate a preoperative predictive nomogram to select those patients with a low risk of residual axillary disease after NAC, in whom axillary surgery could be minimized.
    Patients and methods: 1950 clinically node-positive BC patients from 11 Breast Units, treated by NAC and subsequent surgery, were included from 2005 to 2020. Patients were divided in two groups: those who achieved nodal pCR vs. those with residual nodal disease after NAC. The cohort was divided into training and validation set with a geographic separation criterion. The outcome was to identify independent predictors of axillary pathologic complete response (pCR).
    Results: Independent predictive factors associated to nodal pCR were axillary clinical complete response (cCR) after NAC (OR 3.11, p < 0.0001), ER-/HER2+ (OR 3.26, p < 0.0001) or ER+/HER2+ (OR 2.26, p = 0.0002) or ER-/HER2- (OR 1.89, p = 0.009) BC, breast cCR (OR 2.48, p < 0.0001), Ki67 > 14% (OR 0.52, p = 0.0005), and tumor grading G2 (OR 0.35, p = 0.002) or G3 (OR 0.29, p = 0.0003). The nomogram showed a sensitivity of 71% and a specificity of 73% (AUC 0.77, 95%CI 0.75-0.80). After external validation the accuracy of the nomogram was confirmed.
    Conclusion: The accuracy makes this freely-available, nomogram-based online tool useful to predict nodal pCR after NAC, translating the concept of tailored axillary surgery also in this setting of patients.
    MeSH term(s) Axilla ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Chemotherapy, Adjuvant ; Female ; Humans ; Lymph Nodes ; Mastectomy ; Neoadjuvant Therapy ; Nomograms ; Sentinel Lymph Node Biopsy
    Language English
    Publishing date 2021-10-02
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1143210-x
    ISSN 1532-3080 ; 0960-9776
    ISSN (online) 1532-3080
    ISSN 0960-9776
    DOI 10.1016/j.breast.2021.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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