Artikel ; Online: Clinical and radiological characteristics and outcomes of patients with recurrent or relapsing tumefactive demyelination.
Multiple sclerosis and related disorders
2024 Band 82, Seite(n) 105408
Abstract: Background: Relapsing or recurrent tumefactive demyelination is rare and has not been studied beyond individual case reports.: Objective: We examined the clinical course, neuroimaging, cerebrospinal fluid (CSF), treatment and outcomes of patients ... ...
| Abstract | Background: Relapsing or recurrent tumefactive demyelination is rare and has not been studied beyond individual case reports. Objective: We examined the clinical course, neuroimaging, cerebrospinal fluid (CSF), treatment and outcomes of patients with recurrent tumefactive demyelinating lesions (TDLs). Methods: We used PubMed to identify reports of recurrent TDLs and included the details of an additional, unpublished patient. Results: We identified 18 cases (11F, 7 M). The median age at onset of the index TDL was 37 years (range 12-72) and most were solitary lesions 72 % (13/18). CSF-restricted oligoclonal bands (OCBs) were detected in 25 % (4/16). Only one of those tested (n = 13) was positive for AQP4-IgG. A moderate-to-marked treatment response (high dose corticosteroid with or without additional plasmapheresis, IVIg or disease modifying therapies) was evident in 89 % of treated patients. Median EDSS at the median follow-up of 36 months (range 6-144) was 2 (range 1-10). Most remained ambulatory (EDSS < 4 in 13/18), but 1 patient died. Conclusion: The median age of patients with relapsing TDLs is similar to that of typical MS, but differences include a lower female:male sex ratio, larger lesions, and a comparative lack of CSF-restricted OCBs. Outcomes vary among this group of patients ranging from minimal disability through to death. |
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| Mesh-Begriff(e) | Humans ; Male ; Female ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Radiography ; Neuroimaging ; Adrenal Cortex Hormones ; Recurrence ; Demyelinating Diseases/diagnostic imaging ; Demyelinating Diseases/therapy ; Multiple Sclerosis ; Magnetic Resonance Imaging ; Retrospective Studies |
| Chemische Substanzen | Adrenal Cortex Hormones |
| Sprache | Englisch |
| Erscheinungsdatum | 2024-01-05 |
| Erscheinungsland | Netherlands |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2645330-7 |
| ISSN | 2211-0356 ; 2211-0348 |
| ISSN (online) | 2211-0356 |
| ISSN | 2211-0348 |
| DOI | 10.1016/j.msard.2023.105408 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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