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  1. AU="Pesantez-Coronel, David"
  2. AU="Valente Duarte, João"

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  1. Article ; Online: Superior sagittal sinus thrombosis in a patient with acute lymphoblastic leukemia.

    Pesántez Coronel, David

    Medicina clinica

    2016  Volume 149, Issue 8, Page(s) 374

    Title translation Trombosis de seno sagital superior en una paciente con leucemia linfoblástica aguda.
    MeSH term(s) Female ; Humans ; Middle Aged ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Sagittal Sinus Thrombosis/complications ; Sagittal Sinus Thrombosis/diagnosis
    Language Spanish
    Publishing date 2016-12-27
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2016.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.279: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Data mining identifies novel RNA-binding proteins involved in colon and rectal carcinomas.

    García-Cárdenas, Jennyfer M / Armendáriz-Castillo, Isaac / García-Cárdenas, Nathali / Pesantez-Coronel, David / López-Cortés, Andrés / Indacochea, Alberto / Guerrero, Santiago

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1088057

    Abstract: Colorectal adenocarcinoma (COREAD) is the second most deadly cancer and third most frequently encountered malignancy worldwide. Despite efforts in molecular subtyping and subsequent personalized COREAD treatments, multidisciplinary evidence suggests ... ...

    Abstract Colorectal adenocarcinoma (COREAD) is the second most deadly cancer and third most frequently encountered malignancy worldwide. Despite efforts in molecular subtyping and subsequent personalized COREAD treatments, multidisciplinary evidence suggests separating COREAD into colon cancer (COAD) and rectal cancer (READ). This new perspective could improve diagnosis and treatment of both carcinomas. RNA-binding proteins (RBPs), as critical regulators of every hallmark of cancer, could fulfill the need to identify sensitive biomarkers for COAD and READ separately. To detect new RBPs involved in COAD and READ progression, here we used a multidata integration strategy to prioritize tumorigenic RBPs. We analyzed and integrated 1) RBPs genomic and transcriptomic alterations from 488 COAD and 155 READ patients, 2) ∼ 10,000 raw associations between RBPs and cancer genes, 3) ∼ 15,000 immunostainings, and 4) loss-of-function screens performed in 102 COREAD cell lines. Thus, we unraveled new putative roles of NOP56, RBM12, NAT10, FKBP1A, EMG1, and CSE1L in COAD and READ progression. Interestingly, FKBP1A and EMG1 have never been related with any of these carcinomas but presented tumorigenic features in other cancer types. Subsequent survival analyses highlighted the clinical relevance of FKBP1A, NOP56, and NAT10 mRNA expression to predict poor prognosis in COREAD and COAD patients. Further research should be performed to validate their clinical potential and to elucidate their molecular mechanisms underlying these malignancies.
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1088057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Toward Equitable Precision Oncology: Monitoring Racial and Ethnic Inclusion in Genomics and Clinical Trials.

    García-Cárdenas, Jennyfer M / Indacochea, Alberto / Pesantez-Coronel, David / Terán-Navas, Martín / Aleaga, Ana / Armendáriz-Castillo, Isaac / Peña Zúñiga, Lizbeth / Morán-Erazo, Carla / Chávez-Vélez, Erik / Pérez-Villa, Andy / López-Cortés, Andrés / Guerrero, Santiago

    JCO precision oncology

    2024  Volume 8, Page(s) e2300398

    Abstract: Purpose: Ethnic diversity in cancer research is crucial as race/ethnicity influences cancer incidence, survival, drug response, molecular pathways, and epigenetic phenomena. In 2018, we began a project to examine racial/ethnic diversity in cancer ... ...

    Abstract Purpose: Ethnic diversity in cancer research is crucial as race/ethnicity influences cancer incidence, survival, drug response, molecular pathways, and epigenetic phenomena. In 2018, we began a project to examine racial/ethnic diversity in cancer research, with a commitment to review these disparities every 4 years. This report is our second assessment, detailing the present state of racial/ethnic diversity in cancer genomics and clinical trials.
    Methods: To study racial/ethnic inclusion in cancer genomics, we extracted ethnic records from all data sets available at cBioPortal (n = 125,128 patients) and cancer-related genome-wide association studies (n = 28,011,282 patients) between 2018 and 2022. Concerning clinical trials, we selected studies related to breast cancer (n = 125,518 patients, 181 studies), lung cancer (n = 34,329 patients, 119 studies), and colorectal cancer (n = 40,808 patients, 105 studies).
    Results: In cancer genomics (N = 28,136,410), 3% of individuals lack racial/ethnic registries; tumor samples were collected predominantly from White patients (89.14%), followed by Asian (7%), African American (0.55%), and Hispanic (0.21%) patients and other populations (0.1%). In clinical trials (N = 200,655), data on race/ethnicity are missing for 60.14% of the participants; for individuals whose race/ethnicity was recorded, most were characterized as White (28.33%), followed by Asian (7.64%), African (1.79), other ethnicities (1.37), and Hispanic (0.73). Racial/ethnic representation significantly deviates from global ethnic proportions (
    Conclusion: Our second update on racial/ethnic representation in cancer research highlights the persistent overrepresentation of White populations in cancer genomics and a notable absence of racial/ethnic information across clinical trials. To ensure more equitable and effective precision oncology, future efforts should address the reasons behind the insufficient representation of ethnically diverse populations in cancer research.
    MeSH term(s) Humans ; Genomics ; Precision Medicine ; Clinical Trials as Topic/statistics & numerical data ; Neoplasms/genetics ; Neoplasms/ethnology ; Neoplasms/therapy ; Ethnicity/genetics ; Ethnicity/statistics & numerical data ; Medical Oncology ; Racial Groups/genetics ; Racial Groups/statistics & numerical data
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.23.00398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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