Article ; Online: Determinants of platelet activation in hypertensives with microalbuminuria.
Free radical biology & medicine
2009 Volume 46, Issue 7, Page(s) 922–927
Abstract: Microalbuminuria is a predictor of adverse outcome in hypertension.We evaluated in vivo platelet activation, by urinary 11-dehydrothromboxane (TX)B2 and plasma P-selectin, in hypertensives with or without microalbuminuria, and its possible association ... ...
| Abstract | Microalbuminuria is a predictor of adverse outcome in hypertension.We evaluated in vivo platelet activation, by urinary 11-dehydrothromboxane (TX)B2 and plasma P-selectin, in hypertensives with or without microalbuminuria, and its possible association with oxidative stress, by urinary 8-iso-prostaglandin (PG)F2alpha and endothelial dysfunction. Sixty essential hypertensive patients, with (n=30) or without (n=30) microalbuminuria, and 30 controls were studied. Endothelial function was assessed by nitric oxide products, intercellular adhesion molecule (ICAM)-1, and asymmetric dimethylarginine (ADMA) levels. Urinary 11-dehydro-TXB2 excretion was higher in microalbuminuric (median 805 pg/mg creatinine) compared to nonmicroalbuminuric patients or controls (414 and 291 pg/mg, respectively; P<0.0001). Plasma P-selectinwas significantly higher in patients with microalbuminuria (median 136 ng/ml) as compared to those without microalbuminuria or controls (85 and 65 ng/ml; P<0.0001). Urinary 8-iso-PGF2alpha excretion was also enhanced in microalbuminuric (median 279 pg/mg creatinine) compared to nonmicroalbuminuric patients or controls (157 and 146 pg/mg, respectively; P<0.0001). A significant impairment in endothelial function was found in microalbuminuric patients, with decreased nitric oxide and increased ICAM-1 and ADMA levels. Multivariate regression analysis showed that urinary 8-iso-PGF2alpha excretion (beta=0.49; P<0.0001) and microalbuminuria (beta=0.36; P<0.001) were independently related to 11-dehydro-TXB2 in hypertensives. Vitamin E supplementation (900 mg daily for 1 month) in 10 hypertensives with microalbuminuria was associated with normalization in median 11-dehydro-TXB2 and 8-iso-PGF2alpha. We conclude that lipid peroxidation is a major determinant of persistent platelet activation in hypertensive patients with microalbuminuria. |
|---|---|
| MeSH term(s) | Aged ; Albuminuria ; Arginine/analogs & derivatives ; Arginine/metabolism ; Biomarkers/blood ; Biomarkers/urine ; Disease Progression ; Endothelium/drug effects ; Endothelium/metabolism ; Endothelium/pathology ; Female ; Humans ; Hypertension/blood ; Hypertension/physiopathology ; Hypertension/urine ; Intercellular Adhesion Molecule-1/metabolism ; Lipid Peroxidation/drug effects ; Lipid Peroxidation/physiology ; Male ; Middle Aged ; Nitric Oxide/metabolism ; Oxidative Stress/physiology ; P-Selectin/blood ; Platelet Activation/physiology ; Prostaglandins A/urine ; Thromboxane B2/analogs & derivatives ; Thromboxane B2/urine ; Vitamin E/administration & dosage |
| Chemical Substances | 8-isoprostaglandin A2 ; Biomarkers ; P-Selectin ; Prostaglandins A ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Vitamin E (1406-18-4) ; Nitric Oxide (31C4KY9ESH) ; Thromboxane B2 (54397-85-2) ; N,N-dimethylarginine (63CV1GEK3Y) ; 11-dehydro-thromboxane B2 (67910-12-7) ; Arginine (94ZLA3W45F) |
| Language | English |
| Publishing date | 2009-04-07 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 807032-5 |
| ISSN | 1873-4596 ; 0891-5849 |
| ISSN (online) | 1873-4596 |
| ISSN | 0891-5849 |
| DOI | 10.1016/j.freeradbiomed.2009.01.005 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 2109: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.