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  1. Article ; Online: Elderly patients with brain metastases: new support for the balancing act in treatment decision making.

    Baumert, Brigitta G / Pesce, Gianfranco Angelo

    Neuro-oncology

    2021  Volume 23, Issue 4, Page(s) 533–534

    MeSH term(s) Aged ; Brain Neoplasms/therapy ; Decision Making ; Humans
    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noab028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Magnetic resonance imaging-guided stereotactic body radiotherapy for prostate cancer: more than a simple "MIRAGE"?

    Bosetti, Davide Giovanni / Angrisani, Antonio / Castronovo, Francesco Mosè / Pesce, Gianfranco Angelo / Zilli, Thomas

    Translational cancer research

    2023  Volume 12, Issue 10, Page(s) 2454–2457

    Language English
    Publishing date 2023-10-07
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-23-611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical Relevance and Interplay between miRNAs in Influencing Glioblastoma Multiforme Prognosis.

    Epistolio, Samantha / Dazio, Giulia / Zaed, Ismail / Sahnane, Nora / Cipriani, Debora / Polinelli, Francesco / Barizzi, Jessica / Spina, Paolo / Stefanini, Federico Mattia / Cerati, Michele / Balbi, Sergio / Mazzucchelli, Luca / Sessa, Fausto / Pesce, Gianfranco Angelo / Reinert, Michael / Cardia, Andrea / Marchi, Francesco / Frattini, Milo

    Cells

    2024  Volume 13, Issue 3

    Abstract: Glioblastoma multiforme (GBM) is usually treated with surgery followed by adjuvant partial radiotherapy combined with temozolomide (TMZ) chemotherapy. Recent studies demonstrated a better survival and good response to TMZ in methylguanine-DNA ... ...

    Abstract Glioblastoma multiforme (GBM) is usually treated with surgery followed by adjuvant partial radiotherapy combined with temozolomide (TMZ) chemotherapy. Recent studies demonstrated a better survival and good response to TMZ in methylguanine-DNA methyltransferase (
    MeSH term(s) Humans ; Glioblastoma/metabolism ; MicroRNAs/metabolism ; Dacarbazine/therapeutic use ; Clinical Relevance ; Temozolomide/pharmacology ; Temozolomide/therapeutic use
    Chemical Substances MicroRNAs ; Dacarbazine (7GR28W0FJI) ; Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13030276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Identification of MGMT Downregulation Induced by miRNA in Glioblastoma and Possible Effect on Temozolomide Sensitivity.

    Cardia, Andrea / Epistolio, Samantha / Zaed, Ismail / Sahnane, Nora / Cerutti, Roberta / Cipriani, Debora / Barizzi, Jessica / Spina, Paolo / Stefanini, Federico Mattia / Cerati, Michele / Balbi, Sergio / Mazzucchelli, Luca / Sessa, Fausto / Pesce, Gianfranco Angelo / Reinert, Michael / Frattini, Milo / Marchi, Francesco

    Journal of clinical medicine

    2023  Volume 12, Issue 5

    Abstract: Glioblastoma multiforme (GBM) remains one of the tumors with the worst prognosis. In recent years, a better overall survival (OS) has been described in cases subjected to Gross Total Resection (GTR) that were presenting hypermethylation of Methylguanine- ... ...

    Abstract Glioblastoma multiforme (GBM) remains one of the tumors with the worst prognosis. In recent years, a better overall survival (OS) has been described in cases subjected to Gross Total Resection (GTR) that were presenting hypermethylation of Methylguanine-DNA methyltransferase (MGMT) promoter. Recently, also the expression of specific miRNAs involved in MGMT silencing has been related to survival. In this study, we evaluate MGMT expression by immunohistochemistry (IHC), MGMT promoter methylation and miRNA expression in 112 GBMs and correlate the data to patients' clinical outcomes. Statistical analyses demonstrate a significant association between positive MGMT IHC and the expression of miR-181c, miR-195, miR-648 and miR-767.3p between unmethylated cases and the low expression of miR-181d and miR-648 and between methylated cases and the low expression of miR-196b. Addressing the concerns of clinical associations, a better OS has been described in presence of negative MGMT IHC, in methylated patients and in the cases with miR-21, miR-196b overexpression or miR-767.3 downregulation. In addition, a better progression-free survival (PFS) is associated with MGMT methylation and GTR but not with MGMT IHC and miRNA expression. In conclusion, our data reinforce the clinical relevance of miRNA expression as an additional marker to predict efficacy of chemoradiation in GBM.
    Language English
    Publishing date 2023-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12052061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: #Stayathome: Smart working for radiation oncologists during the corona pandemic.

    Deantonio, Letizia / Bosetti, Davide / Cima, Simona / Martucci, Francesco / Borgonovo, Giulia / Di Bella, Gianluca / Pesce, Gianfranco Angelo / Valli, Mariacarla / Richetti, Antonella

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2020  Volume 196, Issue 12, Page(s) 1094–1095

    MeSH term(s) COVID-19/epidemiology ; Humans ; Neoplasms/radiotherapy ; Pandemics ; Physical Distancing ; Radiation Oncologists ; Radiation Oncology ; Switzerland/epidemiology ; Telemedicine ; Teleworking
    Keywords covid19
    Language English
    Publishing date 2020-09-18
    Publishing country Germany
    Document type Letter
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-020-01683-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.40: Show issues Location:
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  6. Article ; Online: Cone-beam computed tomography-based radiomics in prostate cancer: a mono-institutional study.

    Bosetti, Davide Giovanni / Ruinelli, Lorenzo / Piliero, Maria Antonietta / van der Gaag, Linda Christina / Pesce, Gianfranco Angelo / Valli, Mariacarla / Bosetti, Marco / Presilla, Stefano / Richetti, Antonella / Deantonio, Letizia

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2020  Volume 196, Issue 10, Page(s) 943–951

    Abstract: Purpose: The purpose of the reported study was to investigate the value of cone-beam computed tomography (CBCT)-based radiomics for risk stratification and prediction of biochemical relapse in prostate cancer.: Methods: The study population consisted ...

    Abstract Purpose: The purpose of the reported study was to investigate the value of cone-beam computed tomography (CBCT)-based radiomics for risk stratification and prediction of biochemical relapse in prostate cancer.
    Methods: The study population consisted of 31 prostate cancer patients. Radiomics features were extracted from weekly CBCT scans performed for verifying treatment position. From the data, logistic-regression models were learned for establishing tumor stage, Gleason score, level of prostate-specific antigen, and risk stratification, and for predicting biochemical recurrence. Performance of the learned models was assessed using the area under the receiver operating characteristic curve (AUC-ROC) or the area under the precision-recall curve (AUC-PRC).
    Results: Results suggest that the histogram-based Energy and Kurtosis features and the shape-based feature representing the standard deviation of the maximum diameter of the prostate gland during treatment are predictive of biochemical relapse and indicative of patients at high risk.
    Conclusion: Our results suggest the usefulness of CBCT-based radiomics for treatment definition in prostate cancer.
    MeSH term(s) Adenocarcinoma/blood ; Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/pathology ; Adenocarcinoma/radiotherapy ; Aged ; Aged, 80 and over ; Area Under Curve ; Computational Biology ; Cone-Beam Computed Tomography/methods ; Humans ; Image Processing, Computer-Assisted/methods ; Logistic Models ; Machine Learning ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; ROC Curve ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2020-09-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-020-01677-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.40: Show issues Location:
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  7. Article: The Impact of Surgery in IDH 1 Wild Type Glioblastoma in Relation With the MGMT Deregulation.

    Marchi, Francesco / Sahnane, Nora / Cerutti, Roberta / Cipriani, Debora / Barizzi, Jessica / Stefanini, Federico Mattia / Epistolio, Samantha / Cerati, Michele / Balbi, Sergio / Mazzucchelli, Luca / Sessa, Fausto / Pesce, Gianfranco Angelo / Reinert, Michael / Frattini, Milo

    Frontiers in oncology

    2020  Volume 9, Page(s) 1569

    Abstract: Object: ...

    Abstract Object:
    Language English
    Publishing date 2020-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2019.01569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: #Stayathome: Smart working for radiation oncologists during the corona pandemic

    Deantonio, Letizia / Bosetti, Davide / Cima, Simona / Martucci, Francesco / Borgonovo, Giulia / Di Bella, Gianluca / Pesce, Gianfranco Angelo / Valli, Mariacarla / Richetti, Antonella

    Strahlenther. Onkol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #777699
    Database COVID19

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