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  1. AU="Pesce R."
  2. AU="Gambitta, P"
  3. AU="Imran, Aqeel"
  4. AU="Sharma, Yashoda"
  5. AU="Kosai, Jordyn"
  6. AU="Aroca Ferri, María"
  7. AU="Laba, Stephanie"
  8. AU="Kim, Ye-Sel"

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  1. Artikel ; Online: Personalized embryo transfer guided by endometrial receptivity analysis: a systematic review with meta-analysis.

    Glujovsky, D / Lattes, K / Miguens, M / Pesce, R / Ciapponi, A

    Human reproduction (Oxford, England)

    2023  Band 38, Heft 7, Seite(n) 1305–1317

    Abstract: Study question: Does a personalized embryo transfer (pET) guided by tests for endometrial receptivity (TER) increase the effectiveness of ART procedures?: Summary answer: The use of TER-guided pET is not supported by current published evidence in ... ...

    Abstract Study question: Does a personalized embryo transfer (pET) guided by tests for endometrial receptivity (TER) increase the effectiveness of ART procedures?
    Summary answer: The use of TER-guided pET is not supported by current published evidence in women without repeated implantation failure (RIF), while in women with RIF more research is needed to assess a potential benefit.
    What is known already: Implantation rates are still far from ideal, especially in some patients that have RIF with good-quality embryos. As a potential solution, a wide range of diverse TER use different sets of genes to identify displacements of the window of implantation to adjust the individual length of progesterone exposure in a pET.
    Study design, size, duration: A systematic review with meta-analysis was performed. Search terms included endometrial receptivity analysis, ERA, personalized embryo transfer. CENTRAL, PubMed, Embase, reference lists, clinical trials registers, and conference proceedings (search date October 2022) were searched, with no language restrictions.
    Participants/materials, setting, methods: Randomized controlled trials (RCTs) and cohort studies comparing a pET guided by TER vs standard embryo transfer (sET) in different subgroups that undergo ART were identified. We also investigated pET in non-receptive-TER vs sET in receptive-TER, and pET in a specific population vs sET in a general population. Risk of bias (RoB) was assessed with the Cochrane tool and ROBINS-I. Only those with low/moderate RoB underwent meta-analysis. The GRADE approach was used to evaluate the certainty of evidence (CoE).
    Main results and the role of chance: We screened 2136 studies and included 35 (85% used ERA and 15% used other TER). Two studies were RCTs comparing endometrial receptivity analysis (ERA)-guided pET vs sET in women with no history of RIF. In women without RIF, no important differences (moderate-CoE) were found in live birth rates and clinical pregnancy rates (CPR). We also performed a meta-analysis of four cohort studies that were adjusted for confounding. In agreement with the RCTs, no benefits were found in women without RIF. However, in women with RIF, low CoE suggests that pET might improve the CPR (OR 2.50, 95% CI 1.42-4.40).
    Limitations, reasons for caution: We found few studies with low RoB. Only two RCTs in women without RIF were published, and none in women with RIF. Furthermore, the heterogeneity observed in populations, interventions, co-interventions, outcomes, comparisons, and procedures limited the pooling of many of the included studies.
    Wider implications of the findings: In the population of women without RIF, in agreement with previously published reviews, pET did not prove to be more effective than sET and, therefore, it precludes the routine use of this strategy in this population until more evidence is available. However, more research is advisable in women with RIF as low-certainty evidence from observational studies adjusted for confounders suggests that the CPR might be higher with pET guided by TER in this population. Although this review presents the best available evidence, it is still insufficient to change current policies.
    Study funding/competing interest(s): No specific funding was obtained for this study. There are no conflicts of interest to declare.
    Registration number: PROSPERO CRD42022299827.
    Mesh-Begriff(e) Pregnancy ; Female ; Humans ; Pregnancy Rate ; Embryo Transfer/methods ; Embryo Implantation/genetics ; Endometrium/diagnostic imaging ; Progesterone ; Live Birth/epidemiology
    Chemische Substanzen Progesterone (4G7DS2Q64Y)
    Sprache Englisch
    Erscheinungsdatum 2023-06-01
    Erscheinungsland England
    Dokumenttyp Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/dead098
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  2. Artikel ; Online: Progestogens for prevention of luteinising hormone (LH) surge in women undergoing controlled ovarian hyperstimulation as part of an assisted reproductive technology (ART) cycle.

    Glujovsky, Demián / Pesce, Romina / Miguens, Mariana / Sueldo, Carlos / Ciapponi, Agustín

    The Cochrane database of systematic reviews

    2023  Band 11, Seite(n) CD013827

    Abstract: Background: Currently, gonadotrophin releasing hormone (GnRH) analogues are used to prevent premature ovulation in ART cycles. However, their costs remain high, the route of administration is invasive and has some adverse effects. Oral progestogens ... ...

    Abstract Background: Currently, gonadotrophin releasing hormone (GnRH) analogues are used to prevent premature ovulation in ART cycles. However, their costs remain high, the route of administration is invasive and has some adverse effects. Oral progestogens could be cheaper and effective to prevent a premature LH surge.
    Objectives: To evaluate the effectiveness and safety of using progestogens to avoid spontaneous ovulation in women undergoing controlled ovarian hyperstimulation (COH).
    Search methods: We searched the Cochrane Gynaecology and Fertility Group trials register, CENTRAL, MEDLINE, Embase and PsycINFO in Dec 2021. We contacted study authors and experts to identify additional studies.
    Selection criteria: We included randomised controlled trials (RCTs) that included progestogens for ovulation inhibition in women undergoing controlled ovarian hyperstimulation (COH).
    Data collection and analysis: We used standard methodological procedures recommended by Cochrane, including the risk of bias (RoB) assessment. The primary review outcomes were live birth rate (LBR) and oocyte pick-up cancellation rate (OPCR). Secondary outcomes were clinical pregnancy rate (CPR), cumulative pregnancy, miscarriage rate (MR), multiple pregnancies, LH surge, total and MII oocytes, days of stimulation, dose of gonadotropins, and moderate/severe ovarian hyperstimulation syndrome (OHSS) rate. The primary analyses were restricted to studies at overall low and some concerns RoB, and sensitivity analysis included all studies. We used the GRADE approach to assess the certainty of evidence.
    Main results: We included 14 RCTs (2643 subfertile women undergoing ART, 47 women used oocyte freezing for fertility preservation and 534 oocyte donors). Progestogens versus GnRH antagonists We are very uncertain of the effect of medroxyprogesterone acetate (MPA) 10 mg compared with cetrorelix on the LBR in poor responders (odds ratio (OR) 1.25, 95% confidence interval (CI) 0.73 to 2.13, one RCT, N = 340, very-low-certainty evidence), suggesting that if the chance of live birth following GnRH antagonists is assumed to be 18%, the chance following MPA would be 14% to 32%. There may be little or no difference in OPCR between progestogens and GnRH antagonists, but due to wide Cs (CIs), we are uncertain (OR 0.92, 95%CI 0.42 to 2.01, 3 RCTs, N = 648, I² = 0%, low-certainty evidence), changing the chance of OPCR from 4% with progestogens to 2% to 8%. Given the imprecision found, no conclusions can be retrieved on CPR and MR. Low-quality evidence suggested that using micronised progesterone in normo-responders may increase by 2 to 6 the MII oocytes in comparison to GnRH antagonists. There may be little or no differences in gonadotropin doses. Progestogens versus GnRH agonists Results were uncertain for all outcomes comparing progestogens with GnRH agonists. One progestogen versus another progestogen The analyses comparing one progestogen versus another progestogen for LBR did not meet our criteria for primary analyses. The OPCR was probably lower in the MPA 10 mg in comparison to MPA 4 mg (OR 2.27, 95%CI 0.90 to 5.74, one RCT, N = 300, moderate-certainty evidence), and MPA 4 mg may be lower than micronised progesterone 100 mg, but due to wide CI, we are uncertain of the effect (OR 0.81, 95%CI 0.43 to 1.53, one RCT, N = 300, low-certainty evidence), changing the chance of OPCR from 5% with MPA 4 mg to 5% to22%, and from 17% with micronised progesterone 100 mg to 8% to 24%. When comparing dydrogesterone 20 mg to MPA, the OPCR is probably lower in the dydrogesterone group in comparison to MPA 10 mg (OR 1.49, 95%CI 0.80 to 2.80, one RCT, N = 520, moderate-certainty evidence), and it may be lower in dydrogesterone group in comparison to MPA 4 mg but due to wide confidence interval, we are uncertain of the effect (OR 1.19, 95%CI 0.61 to 2.34, one RCT, N = 300, low-certainty evidence), changing the chance of OPCR from 7% with dydrogesterone 20 to 6-17%, and in MPA 4 mg from 12% to 8% to 24%. When comparing dydrogesterone 20 mg to micronised progesterone 100 mg, the OPCR is probably lower in the dydrogesterone group (OR 1.54, 95%CI 0.94 to 2.52, two RCTs, N=550, I² = 0%, moderate-certainty evidence), changing OPCR from 11% with dydrogesterone to 10% to 24%. We are very uncertain of the effect in normo-responders of micronised progesterone 100 mg compared with micronised progesterone 200 mg on the OPCR (OR 0.35, 95%CI 0.09 to 1.37, one RCT, N = 150, very-low-certainty evidence). There is probably little or no difference in CPR and MR between MPA 10 mg and dydrogesterone 20 mg. There may be little or no differences in MII oocytes and gonadotropins doses. No cases of moderate/severe OHSS were reported in most of the groups in any of the comparisons.
    Authors' conclusions: Little or no differences in LBR may exist when comparing MPA 4 mg with GnRH agonists in normo-responders. OPCR may be slightly increased in the MPA 4 mg group, but MPA 4 mg reduces the doses of gonadotropins in comparison to GnRH agonists. Little or no differences in OPCR may exist between progestogens and GnRH antagonists in normo-responders and donors. However, micronised progesterone could improve by 2 to 6 MII oocytes. When comparing one progestogen to another, dydrogesterone suggested slightly lower OPCR than MPA and micronised progesterone, and MPA suggested slightly lower OPCR than the micronised progesterone 100 mg. Finally, MPA 10 mg suggests a lower OPCR than MPA 4 mg. There is uncertainty regarding the rest of the outcomes due to imprecision and no solid conclusions can be drawn.
    Mesh-Begriff(e) Female ; Humans ; Pregnancy ; Abortion, Spontaneous ; Dydrogesterone ; Gonadotropin-Releasing Hormone ; Gonadotropins ; Live Birth ; Luteinizing Hormone ; Ovarian Hyperstimulation Syndrome/prevention & control ; Ovulation Induction/methods ; Pregnancy Rate ; Progesterone ; Progestins/therapeutic use ; Reproductive Techniques, Assisted
    Chemische Substanzen Dydrogesterone (90I02KLE8K) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Gonadotropins ; Luteinizing Hormone (9002-67-9) ; Progesterone (4G7DS2Q64Y) ; Progestins
    Sprache Englisch
    Erscheinungsdatum 2023-11-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.CD013827.pub2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Violência familiar e comportamento agressivo e transgressor na infância: uma revisão da literatura.

    Pesce, Renata

    Ciencia & saude coletiva

    2009  Band 14, Heft 2, Seite(n) 507–518

    Abstract: This article presents a review of the world literature about two important subjects: family violence and problems of aggressive behavior and oppositional defiant disorder in childhood. We opted for publications that had used the CBCL- Child Behavior ... ...

    Titelübersetzung Family violence and aggressive and oppositional behavior in childhood: a literature review.
    Abstract This article presents a review of the world literature about two important subjects: family violence and problems of aggressive behavior and oppositional defiant disorder in childhood. We opted for publications that had used the CBCL- Child Behavior Checklist for investigating behavior problems in children. This instrument is internationally recognized for its reliability and validity, considered an efficient tool for identifying behavior problems in children. Our findings showed that marital violence predominated in the studies as kind of familiar violence able to cause problems of aggressiveness and transgression in children. Another point discussed was the lack of consensus on the terms used in the articles to refer to such behavior problems. The review showed the need for in-depth studies into this subject, mainly in the sense of thinking about prevention and health promotion in childhood and adolescence. Aggressive behavior in children tends to remain and increase over time, a fact that points to the need for strategies for preventing these problems in the school, familiar and health environments.
    Mesh-Begriff(e) Adolescent ; Adolescent Behavior/psychology ; Aggression ; Child ; Child Behavior/psychology ; Child Behavior Disorders/psychology ; Child, Preschool ; Domestic Violence ; Female ; Humans ; Male
    Sprache Portugiesisch
    Erscheinungsdatum 2009-02-04
    Erscheinungsland Brazil
    Dokumenttyp English Abstract ; Journal Article ; Review
    ZDB-ID 2078799-6
    ISSN 1678-4561 ; 1413-8123
    ISSN (online) 1678-4561
    ISSN 1413-8123
    DOI 10.1590/s1413-81232009000200019
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Electrochemical Characterization of Magnetite (Fe

    Accogli, Alessandra / Bertoli, Luca / Panzeri, Gabriele / Gibertini, Eugenio / Pesce, Ruggiero / Bussetti, Gianlorenzo / Magagnin, Luca

    ACS omega

    2021  Band 6, Heft 41, Seite(n) 26880–26887

    Abstract: The electrochemical behavior of magnetite ( ... ...

    Abstract The electrochemical behavior of magnetite (Fe
    Sprache Englisch
    Erscheinungsdatum 2021-10-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c03142
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  5. Artikel ; Online: Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes.

    Glujovsky, Demián / Pesce, Romina / Sueldo, Carlos / Quinteiro Retamar, Andrea Marta / Hart, Roger J / Ciapponi, Agustín

    The Cochrane database of systematic reviews

    2020  Band 10, Seite(n) CD006359

    Abstract: Background: A frozen embryo transfer (FET) cycle is when one or more embryos (frozen during a previous treatment cycle) are thawed and transferred to the uterus. Some women undergo fresh embryo transfer (ET) cycles with embryos derived from donated ... ...

    Abstract Background: A frozen embryo transfer (FET) cycle is when one or more embryos (frozen during a previous treatment cycle) are thawed and transferred to the uterus. Some women undergo fresh embryo transfer (ET) cycles with embryos derived from donated oocytes. In both situations, the endometrium is primed with oestrogen and progestogen in different doses and routes of administration.
    Objectives: To evaluate the most effective endometrial preparation for women undergoing transfer with frozen embryos or embryos from donor oocytes with regard to the subsequent live birth rate (LBR).
    Search methods: The Cochrane Gynaecology and Fertility Group trials register, CENTRAL, MEDLINE, Embase, PsycINFO, LILACS, trials registers and abstracts of reproductive societies' meetings were searched in June 2020 together with reference checking and contact with study authors and experts in the field to identify additional studies.
    Selection criteria: Randomised controlled trials (RCTs) evaluating endometrial preparation in women undergoing fresh donor cycles and frozen embryo transfers.
    Data collection and analysis: We used standard methodological procedures recommended by Cochrane. We analysed all available interventions versus placebo, no treatment, or between each other. The primary review outcome was live birth rate. Secondary outcomes were clinical and multiple pregnancy, miscarriage, cycle cancellation, endometrial thickness and adverse effects.
    Main results: Thirty-one RCTs (5426 women) were included. Evidence was moderate to very low-quality: the main limitations were serious risk of bias due to poor reporting of methods, and serious imprecision. Stimulated versus programmed cycle We are uncertain whether a letrozole-stimulated cycle compared to a programmed cycle, for endometrial preparation, improves LBR (odds ratio (OR) 1.26, 95% confidence interval (CI) 0.49 to 3.26; 100 participants; one study; very low-quality evidence). Stimulating with follicle stimulating hormone (FSH), letrozole or clomiphene citrate may improve clinical pregnancy rate (CPR) (OR 1.63, 95% CI 1.12 to 2.38; 656 participants; five studies; I
    Authors' conclusions: There is insufficient evidence on the use of any particular intervention for endometrial preparation in women undergoing fresh donor cycles and frozen embryo transfers. In frozen embryo transfers, low-quality evidence showed that clinical pregnancy rates may be improved in a stimulated cycle compared to a programmed one, and we are uncertain of the effect when comparing a programmed cycle to a natural cycle. Cycle cancellation rates are probably reduced in a natural cycle. Although administering a GnRH agonist, compared to without, may improve live birth rates, clinical pregnancy rates will probably be improved in a GnRH antagonist cycle over an agonist cycle. In fresh synchronised oocyte donor cycles, the clinical pregnancy rate is probably improved and cycle cancellation rates are probably reduced when starting progestogen the day of or day after donor oocyte retrieval. Adequately powered studies are needed to evaluate each treatment more accurately.
    Mesh-Begriff(e) Abortion, Spontaneous/epidemiology ; Bias ; Clomiphene/administration & dosage ; Cryopreservation ; Drug Administration Schedule ; Embryo Implantation/physiology ; Embryo Transfer/methods ; Embryo, Mammalian ; Endometrium/drug effects ; Endometrium/physiology ; Female ; Follicle Stimulating Hormone/administration & dosage ; Gonadotropin-Releasing Hormone/agonists ; Humans ; Letrozole/administration & dosage ; Live Birth/epidemiology ; Oocyte Donation ; Pregnancy ; Pregnancy Rate ; Progesterone/administration & dosage ; Progestins/administration & dosage ; Randomized Controlled Trials as Topic
    Chemische Substanzen Progestins ; Clomiphene (1HRS458QU2) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Progesterone (4G7DS2Q64Y) ; Letrozole (7LKK855W8I) ; Follicle Stimulating Hormone (9002-68-0)
    Sprache Englisch
    Erscheinungsdatum 2020-10-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Meta-Analysis ; Systematic Review
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.CD006359.pub3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Reversing Inoperability in Eisenmenger Syndrome: The "Drug-and-Banding" Approach.

    Pradegan, Nicola / Pesce, Rita / Castaldi, Biagio / Zanotto, Lorenza / Stellin, Giovanni / Vida, Vladimiro L

    World journal for pediatric & congenital heart surgery

    2020  Band 11, Heft 5, Seite(n) 646–648

    Abstract: Eisenmenger syndrome (ES) has been considered a cause of inoperability in patients with congenital heart disease (CHD). Even if long-standing vasodilators are efficient to reduce pulmonary vascular resistance (PVR), the best approach to grant stable ... ...

    Abstract Eisenmenger syndrome (ES) has been considered a cause of inoperability in patients with congenital heart disease (CHD). Even if long-standing vasodilators are efficient to reduce pulmonary vascular resistance (PVR), the best approach to grant stable repair of these patients is still unknown. We describe the case of a 28-year-old man with a diagnosis of untreated large ventricular septal defect and established ES. After few years of vasodilator therapy, the patient underwent pulmonary banding with significant reduction of his PVR. His CHD was then repaired, with clinical and functional improvement at 2-year follow-up.
    Mesh-Begriff(e) Adult ; Cardiac Catheterization ; Eisenmenger Complex/diagnosis ; Eisenmenger Complex/physiopathology ; Eisenmenger Complex/therapy ; Humans ; Imaging, Three-Dimensional ; Ligation ; Male ; Pulmonary Artery/surgery ; Tomography, X-Ray Computed ; Vascular Resistance ; Vasodilator Agents/therapeutic use
    Chemische Substanzen Vasodilator Agents
    Sprache Englisch
    Erscheinungsdatum 2020-09-07
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2550261-X
    ISSN 2150-136X ; 2150-1351
    ISSN (online) 2150-136X
    ISSN 2150-1351
    DOI 10.1177/2150135120926977
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: How effective are the non-conventional ovarian stimulation protocols in ART? A systematic review and meta-analysis.

    Glujovsky, Demian / Pesce, Romina / Miguens, Mariana / Sueldo, Carlos E / Lattes, Karinna / Ciapponi, Agustín

    Journal of assisted reproduction and genetics

    2020  Band 37, Heft 12, Seite(n) 2913–2928

    Abstract: Purpose: To compare the effectiveness of starting the ovarian stimulation on the early follicular phase ("Conventional") with the newer range of non-conventional approaches starting in the luteal phase ("Luteal"), random-start, and studies implementing ... ...

    Abstract Purpose: To compare the effectiveness of starting the ovarian stimulation on the early follicular phase ("Conventional") with the newer range of non-conventional approaches starting in the luteal phase ("Luteal"), random-start, and studies implementing them in DuoStim ("Conventional"+"Luteal").
    Methods: Systematic review. We searched CENTRAL, PubMed, and Embase, on March 2020. We included randomized and non-randomized controlled trials that compared "Luteal," random-start ovarian stimulation or DuoStim with "Conventional"; we analyzed them by subgroups: oocyte freezing and patients undergoing ART treatments, both, in the general infertile population and among poor responders.
    Results: The following results come from a sensitivity analysis that included only the low/moderate risk of bias studies. When comparing "Luteal" to "Conventional," clinically relevant differences in MII oocytes were ruled out in all subgroups. We found that "Luteal" probably increases the COH length both, in the general infertile population (OR 2.00 days, 95% CI 0.81 to 3.19, moderate-quality evidence) and in oocyte freezing cycles (MD 0.85 days, 95% CI 0.53 to 1.18, moderate-quality evidence). When analyzing DuoStim among poor responders, we found that it appears to generate a higher number of MII oocytes in comparison with a single "Conventional" (MD 3.35, 95%CI 2.54-4.15, moderate-quality evidence).
    Conclusion: Overall, this systematic review of the available data demonstrates that in poor responders, general infertile population and oocyte freezing for cancer stimulation in the late follicular and luteal phases can be utilized in non-conventional approaches such as random-start and DuoStim cycles, offering similar outcomes to the conventional cycles but potentially with increased flexibility, within a reduced time frame. However, more well-designed trials are required to establish certainty.
    Mesh-Begriff(e) Female ; Fertilization in Vitro/methods ; Follicular Phase/physiology ; Humans ; Infertility, Female/therapy ; Luteal Phase/physiology ; Ovulation Induction/methods ; Treatment Outcome
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-11-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1112577-9
    ISSN 1573-7330 ; 1058-0468
    ISSN (online) 1573-7330
    ISSN 1058-0468
    DOI 10.1007/s10815-020-01966-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Transapical TAVI: Survival, Hemodynamics, Devices and Machine Learning. Lessons Learned After 10-Year Experience.

    D'Onofrio, Augusto / Tessari, Chiara / Tarantini, Giuseppe / Cibin, Giorgia / Lorenzoni, Giulia / Pesce, Rita / Fraccaro, Chiara / Napodano, Massimo / Gregori, Dario / Gerosa, Gino

    Current problems in cardiology

    2023  Band 48, Heft 8, Seite(n) 101734

    Abstract: Aim of this single-center, retrospective study was to assess early and long-term clinical and hemodynamic results of transapical aortic valve implantation (TA-TAVI), and to identify predictors of survival at follow-up. All patients undergoing TA-TAVI for ...

    Abstract Aim of this single-center, retrospective study was to assess early and long-term clinical and hemodynamic results of transapical aortic valve implantation (TA-TAVI), and to identify predictors of survival at follow-up. All patients undergoing TA-TAVI for severe aortic valve stenosis at our institution were reviewed. A hybrid approach based on machine-learning techniques was employed to identify survival predictors, using a bagging-decision-tree algorithm and a Random-Forest algorithm, respectively. Two-hundred-thirty-four consecutive patients underwent TA-TAVI (March 2009-May 2019). All cause 30-day mortality was 5.1%. Device success was 95.7%. Median follow-up time was 35.2 months. Kaplan-Meier overall survival rates at 2, 5, and 8 years were 75%, 44%, and 15%, respectively. Structural-valve-deterioration occurred in 25 patients (11.3%) overall. The strongest predictors of survival at follow-up were age, body-mass-index, and ejection fraction. TA-TAVI provided valid early and long-term outcomes. These data support its choice as an optimal alternative access whenever the transfemoral route is not feasible.
    Mesh-Begriff(e) Humans ; Retrospective Studies ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Transcatheter Aortic Valve Replacement ; Hemodynamics
    Sprache Englisch
    Erscheinungsdatum 2023-04-10
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2023.101734
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Ash wednesday.

    Pesce, R R

    The Western journal of medicine

    2008  Band 170, Heft 4, Seite(n) 237–238

    Sprache Englisch
    Erscheinungsdatum 2008-08-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 189235-6
    ISSN 1476-2978 ; 0093-0415 ; 0008-1264
    ISSN (online) 1476-2978
    ISSN 0093-0415 ; 0008-1264
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Fulminant myocarditis parvovirus B19 related in a young woman.

    Pesce, Rita / Taffarello, PierPaolo / Rizzo, Stefania / Basso, Cristina / Cacciavillani, Luisa / Del Monte, Alvise / Babuin, Luciano / Gerosa, Gino / Bottio, Tomaso

    Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs

    2021  Band 24, Heft 4, Seite(n) 498–502

    Abstract: We present the case of a 18-year-old female with fulminant lymphocytic myocarditis caused by Parvovirus B19 (PVB19), successfully treated using temporary LVAD. In the literature there is no consensus on the surgical strategy. While some surgeons prefer ... ...

    Abstract We present the case of a 18-year-old female with fulminant lymphocytic myocarditis caused by Parvovirus B19 (PVB19), successfully treated using temporary LVAD. In the literature there is no consensus on the surgical strategy. While some surgeons prefer to use a single device supporting only the LV, others prefer to start immediately with a biventricular supporting. At pre-procedural ultrasound evaluation, her anatomical features were not suitable for a percutaneous device such as the Impella. Thus, a temporary paracorporeal continuous flow LVAD was inserted. The heart recovery allowed LVAD removal 9 days after the implant.
    Mesh-Begriff(e) Adolescent ; Female ; Humans ; Myocarditis/diagnosis ; Myocarditis/therapy ; Parvovirus B19, Human
    Sprache Englisch
    Erscheinungsdatum 2021-01-24
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1463555-0
    ISSN 1619-0904 ; 1434-7229
    ISSN (online) 1619-0904
    ISSN 1434-7229
    DOI 10.1007/s10047-021-01247-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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