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  1. AU="Petagine, Lucy"
  2. AU="Jessa R. Alexander"
  3. AU=Rauner Martina
  4. AU="Richlen, Mindy L"
  5. AU="Merghani, Nada M"
  6. AU=Splitt M P
  7. AU="Zlatanović, Gordana"

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  1. Artikel ; Online: Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments.

    Petagine, Lucy / Zariwala, Mohammed Gulrez / Patel, Vinood B

    World journal of gastroenterology

    2023  Band 29, Heft 32, Seite(n) 4831–4850

    Abstract: Non-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level. Although the disease spectrum of ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level. Although the disease spectrum of NAFLD is widely recognised, the precise triggers for disease progression are still to be fully elucidated. Furthermore, the propagation to cirrhosis is poorly understood. Whilst some progress in terms of treatment options have been explored, an incomplete understanding of the hepatic cellular and molecular alterations limits their clinical utility. We have therefore reviewed some of the key pathways responsible for the pathogenesis of NAFLD such as innate and adaptative immunity, lipotoxicity and fibrogenesis, and highlighted current trials and treatment options for NAFLD patients.
    Mesh-Begriff(e) Humans ; Non-alcoholic Fatty Liver Disease/therapy ; Adaptive Immunity ; Disease Progression ; Global Burden of Disease ; Hepatocytes
    Sprache Englisch
    Erscheinungsdatum 2023-08-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i32.4831
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  2. Artikel: Alcoholic liver disease: Current insights into cellular mechanisms.

    Petagine, Lucy / Zariwala, Mohammed Gulrez / Patel, Vinood B

    World journal of biological chemistry

    2021  Band 12, Heft 5, Seite(n) 87–103

    Abstract: Alcoholic liver disease (ALD) due to chronic alcohol consumption is a significant global disease burden and a leading cause of mortality. Alcohol abuse induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level. Although ...

    Abstract Alcoholic liver disease (ALD) due to chronic alcohol consumption is a significant global disease burden and a leading cause of mortality. Alcohol abuse induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level. Although the disease spectrum of ALD is widely recognized, the precise triggers for disease progression are still to be fully elucidated. Oxidative stress, mitochondrial dysfunction, gut dysbiosis and altered immune system response plays an important role in disease pathogenesis, triggering the activation of inflammatory pathways and apoptosis. Despite many recent clinical studies treatment options for ALD are limited, especially at the alcoholic hepatitis stage. We have therefore reviewed some of the key pathways involved in the pathogenesis of ALD and highlighted current trials for treating patients.
    Sprache Englisch
    Erscheinungsdatum 2021-06-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2564793-3
    ISSN 1949-8454
    ISSN 1949-8454
    DOI 10.4331/wjbc.v12.i5.87
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Bio-Hacking Better Health-Leveraging Metabolic Biochemistry to Maximise Healthspan.

    Cooper, Isabella D / Kyriakidou, Yvoni / Petagine, Lucy / Edwards, Kurtis / Elliott, Bradley T

    Antioxidants (Basel, Switzerland)

    2023  Band 12, Heft 9

    Abstract: In the pursuit of longevity and healthspan, we are challenged with first overcoming chronic diseases of ageing: cardiovascular disease, hypertension, cancer, dementias, type 2 diabetes mellitus. These are hyperinsulinaemia diseases presented in different ...

    Abstract In the pursuit of longevity and healthspan, we are challenged with first overcoming chronic diseases of ageing: cardiovascular disease, hypertension, cancer, dementias, type 2 diabetes mellitus. These are hyperinsulinaemia diseases presented in different tissue types. Hyperinsulinaemia reduces endogenous antioxidants, via increased consumption and reduced synthesis. Hyperinsulinaemia enforces glucose fuelling, consuming 4 NAD
    Sprache Englisch
    Erscheinungsdatum 2023-09-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12091749
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females.

    Cooper, Isabella D / Kyriakidou, Yvoni / Edwards, Kurtis / Petagine, Lucy / Seyfried, Thomas N / Duraj, Tomas / Soto-Mota, Adrian / Scarborough, Andrew / Jacome, Sandra L / Brookler, Kenneth / Borgognoni, Valentina / Novaes, Vanusa / Al-Faour, Rima / Elliott, Bradley T

    International journal of molecular sciences

    2023  Band 24, Heft 21

    Abstract: Most studies on ketosis have focused on short-term effects, male athletes, or weight loss. Hereby, we studied the effects of short-term ketosis suppression in healthy women on long-standing ketosis. Ten lean (BMI 20.5 ± 1.4), metabolically healthy, pre- ... ...

    Abstract Most studies on ketosis have focused on short-term effects, male athletes, or weight loss. Hereby, we studied the effects of short-term ketosis suppression in healthy women on long-standing ketosis. Ten lean (BMI 20.5 ± 1.4), metabolically healthy, pre-menopausal women (age 32.3 ± 8.9) maintaining nutritional ketosis (NK) for > 1 year (3.9 years ± 2.3) underwent three 21-day phases: nutritional ketosis (NK; P1), suppressed ketosis (SuK; P2), and returned to NK (P3). Adherence to each phase was confirmed with daily capillary D-beta-hydroxybutyrate (BHB) tests (P1 = 1.9 ± 0.7; P2 = 0.1 ± 0.1; and P3 = 1.9 ± 0.6 pmol/L). Ageing biomarkers and anthropometrics were evaluated at the end of each phase. Ketosis suppression significantly increased: insulin, 1.78-fold from 33.60 (± 8.63) to 59.80 (± 14.69) pmol/L (
    Mesh-Begriff(e) Animals ; Cattle ; Humans ; Male ; Female ; Young Adult ; Adult ; Cattle Diseases/metabolism ; Ketosis ; Diet, Ketogenic ; Insulin/pharmacology ; Hyperinsulinism ; 3-Hydroxybutyric Acid/metabolism
    Chemische Substanzen Insulin ; 3-Hydroxybutyric Acid (TZP1275679)
    Sprache Englisch
    Erscheinungsdatum 2023-10-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115621
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model.

    Cooper, Isabella D / Sanchez-Pizarro, Claudio / Norwitz, Nicholas G / Feldman, David / Kyriakidou, Yvoni / Edwards, Kurtis / Petagine, Lucy / Elliot, Bradley T / Soto-Mota, Adrian

    Frontiers in endocrinology

    2023  Band 14, Seite(n) 1326768

    Abstract: Introduction: There is a large heterogeneity in LDL-cholesterol change among individuals adopting ketogenic diets. Interestingly, lean metabolically healthy individuals seem to be particularly susceptible, with an inverse association between body mass ... ...

    Abstract Introduction: There is a large heterogeneity in LDL-cholesterol change among individuals adopting ketogenic diets. Interestingly, lean metabolically healthy individuals seem to be particularly susceptible, with an inverse association between body mass index and LDL-cholesterol change. The lipid energy model proposes that, in lean healthy individuals, carbohydrate restriction upregulates systemic lipid trafficking to meet energy demands. To test if anthropometric and energy metabolism markers predict LDL-cholesterol change during carbohydrate restriction.
    Methods: Ten lean, healthy, premenopausal women who habitually consumed a ketogenic diet for ≥6 months were engaged in a three-phase crossover study consisting of continued nutritional ketosis, suppression of ketosis with carbohydrate reintroduction, and return to nutritional ketosis. Each phase lasted 21 days. The predictive performance of all available relevant variables was evaluated with the linear mixed-effects models.
    Results: All body composition metrics, free T
    Discussion: Among lean, healthy women undergoing carbohydrate restriction, body composition and energy metabolism markers are major drivers of LDL-cholesterol change, not saturated fat, consistent with the lipid energy model.
    Mesh-Begriff(e) Humans ; Female ; Diet, Ketogenic ; Cross-Over Studies ; Thyroid Gland ; Body Composition ; Cholesterol, LDL ; Ketosis ; Carbohydrates
    Chemische Substanzen Cholesterol, LDL ; Carbohydrates
    Sprache Englisch
    Erscheinungsdatum 2023-12-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1326768
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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