Article ; Online: Toxic optic neuropathy
Indian Journal of Ophthalmology, Vol 62, Iss 10, Pp 1036-
An unusual cause
2014 Volume 1039
Abstract: A 60-year-old woman with a history of chronic alcoholism and tobacco use presented with the complaint of a painless decrease in vision in both eyes. She lost vision first in the left eye then in the right eye. She admitted consuming at least one 16 ounce ...
| Abstract | A 60-year-old woman with a history of chronic alcoholism and tobacco use presented with the complaint of a painless decrease in vision in both eyes. She lost vision first in the left eye then in the right eye. She admitted consuming at least one 16 ounce bottle of over the counter mouthwash daily and denied consumption of any other alcohols, methanol, or antifreeze. She stated that her vision had been continuing to deteriorate in both eyes. Her best-corrected visual acuity was 4/200 in each eye. Color vision was nil in each eye. Her pupils were sluggish bilaterally, and her optic discs were flat and hyperemic with peripapillary hemorrhages. Her visual fields revealed central scotomas bilaterally. The magnetic resonance imaging of the brain and lumbar puncture were within normal limits. Antinuclear antibody, human leukocyte antigen-B27 genotyping, and B12 were normal; serum thiamine was low. While continuing to ingest mouthwash, her vision decreased to count fingers at 2 feet, and maculopapillary bundle pallor developed. She was started on folate and thiamine supplementation. Once she discontinued mouthwash, her vision improved to 20/400 bilaterally, and her central scotomas improved. This case demonstrates an alcohol-induced toxic optic neuropathy from mouthwash ingestion with some visual recovery after discontinuation of the offending agent. |
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| Keywords | Atypical optic neuritis ; autoimmunity ; multiple sclerosis ; neuromyelitis optica ; neuroretinitis ; optic neuritis ; optic neuropathy ; Acetylcholine ; autoimmune ; neuro-muscular junction ; ocular myasthenia gravis ; Cortical visual impairment ; hypoxia ; hypoglycemia ; optic atrophy ; prematurity ; periventricular leukomalacia ; Idiopathic intracranial hypertension ; pseudotumor cerebri ; treatment ; Chemosis ; strabismus ; thyroid eye disease ; Childhood optic atrophy ; clinical profile ; etiology ; India ; Abducens palsy ; computed tomography ; cranial nerve palsy ; magnetic resonance imaging ; mononeuropathy ; neuroimaging ; sixth nerve palsy ; Fellowship ; neuro-ophthalmology ; ophthalmology ; sub-specialty ; lumbo-peritoneal shunt ; optic nerve sheath fenestration ; ventriculo-peritoneal shunt ; Megadose ; methylprednisolone ; steroids ; traumatic optic neuropathy ; Alcohol ; mouthwash ; toxic optic neuropathy ; Ophthalmology ; RE1-994 ; Medicine ; R |
| Language | English |
| Publishing date | 2014-01-01T00:00:00Z |
| Publisher | Medknow Publications |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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