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  1. AU="Peter M. Visscher"
  2. AU=Martn-Begu Nieves
  3. AU="Kiang, David"
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  1. Article ; Online: The effect of the scale of grant scoring on ranking accuracy [version 2; peer review

    Peter M. Visscher / Loic Yengo

    F1000Research, Vol

    2 approved]

    2023  Volume 11

    Abstract: In this study we quantify the accuracy of scoring the quality of research grants using a finite set of distinct categories (1, 2, …., k), when the unobserved grant score is a continuous random variable comprising a true quality score and measurement ... ...

    Abstract In this study we quantify the accuracy of scoring the quality of research grants using a finite set of distinct categories (1, 2, …., k), when the unobserved grant score is a continuous random variable comprising a true quality score and measurement error, both normally distributed. We vary the number of categories, the number of assessors that score the same grant and a signal-to-noise ratio parameter. We show that the loss of information of scoring a small number of categories (k > 5) compared to scoring on a continuous scale is very small, so that increasing the number of scoring categories is unlikely to lead to an improvement in the outcomes of scoring systems. In addition, we model the effect of grant assessors scoring too close to the mean and show that this results in only a very small reduction in the accuracy of scoring.
    Keywords grant scoring ; multiple threshold model ; grant quality ; grant ranking ; eng ; Medicine ; R ; Science ; Q
    Subject code 006
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Challenges in understanding common disease

    Peter M. Visscher

    Genome Medicine, Vol 9, Iss 1, Pp 1-

    2017  Volume 4

    Abstract: Abstract Peter M. Visscher discusses advances in our understanding of complex disease, the challenges in applying this knowledge to functional follow-up, and the potential implications for therapeutic interventions. ...

    Abstract Abstract Peter M. Visscher discusses advances in our understanding of complex disease, the challenges in applying this knowledge to functional follow-up, and the potential implications for therapeutic interventions.
    Keywords Medicine ; R ; Genetics ; QH426-470
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Extreme inbreeding in a European ancestry sample from the contemporary UK population

    Loic Yengo / Naomi R. Wray / Peter M. Visscher

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 11

    Abstract: Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding ... ...

    Abstract Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding and its consequence for health and other complex traits.
    Keywords Science ; Q
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Extreme inbreeding in a European ancestry sample from the contemporary UK population

    Loic Yengo / Naomi R. Wray / Peter M. Visscher

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 11

    Abstract: Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding ... ...

    Abstract Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding and its consequence for health and other complex traits.
    Keywords Science ; Q
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

    Ying Wang / Jing Guo / Guiyan Ni / Jian Yang / Peter M. Visscher / Loic Yengo

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 9

    Abstract: Polygenic scores (PGS) are often based on GWAS data from individuals of European ancestry, thus limiting their use in populations of non-European ancestry. Here, the authors predict the relative accuracy of PGS across ancestries and suggest that causal ... ...

    Abstract Polygenic scores (PGS) are often based on GWAS data from individuals of European ancestry, thus limiting their use in populations of non-European ancestry. Here, the authors predict the relative accuracy of PGS across ancestries and suggest that causal variants are mostly shared across continents.
    Keywords Science ; Q
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

    Ying Wang / Jing Guo / Guiyan Ni / Jian Yang / Peter M. Visscher / Loic Yengo

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 9

    Abstract: Polygenic scores (PGS) are often based on GWAS data from individuals of European ancestry, thus limiting their use in populations of non-European ancestry. Here, the authors predict the relative accuracy of PGS across ancestries and suggest that causal ... ...

    Abstract Polygenic scores (PGS) are often based on GWAS data from individuals of European ancestry, thus limiting their use in populations of non-European ancestry. Here, the authors predict the relative accuracy of PGS across ancestries and suggest that causal variants are mostly shared across continents.
    Keywords Science ; Q
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose

    Zhen Qiao / Julia Sidorenko / Joana A. Revez / Angli Xue / Xueling Lu / Katri Pärna / Harold Snieder / Lifelines Cohort Study / Peter M. Visscher / Naomi R. Wray / Loic Yengo

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 11

    Abstract: Most genetic studies of glucose levels have been done on fasting samples, which can be difficult to obtain. Here, the authors identify 156 genetic loci controlling the physiological variation of glucose levels in healthy non-fasting individuals, ... ...

    Abstract Most genetic studies of glucose levels have been done on fasting samples, which can be difficult to obtain. Here, the authors identify 156 genetic loci controlling the physiological variation of glucose levels in healthy non-fasting individuals, demonstrating that the results non-fasting samples can be used to predict fasting glucose levels.
    Keywords Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  8. Article ; Online: Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes

    Angli Xue / Longda Jiang / Zhihong Zhu / Naomi R. Wray / Peter M. Visscher / Jian Zeng / Jian Yang

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: Conflicting reports have found disease to sometimes be positively and sometimes negatively correlated with alcohol consumption. Here, the authors show that misreporting and reduction of alcohol consumption is associated with disease, leading to ... ...

    Abstract Conflicting reports have found disease to sometimes be positively and sometimes negatively correlated with alcohol consumption. Here, the authors show that misreporting and reduction of alcohol consumption is associated with disease, leading to misleading associations between alcohol and disease.
    Keywords Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression

    Yeda Wu / Graham K. Murray / Enda M. Byrne / Julia Sidorenko / Peter M. Visscher / Naomi R. Wray

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 17

    Abstract: Genetic factors contribute to peptic ulcer disease (PUD). Here, the authors perform a genome-wide association analysis on PUD in the UK Biobank, highlighting shared architecture with other gastrointestinal disorders and possible causal links with ... ...

    Abstract Genetic factors contribute to peptic ulcer disease (PUD). Here, the authors perform a genome-wide association analysis on PUD in the UK Biobank, highlighting shared architecture with other gastrointestinal disorders and possible causal links with depression.
    Keywords Science ; Q
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Quantifying genetic heterogeneity between continental populations for human height and body mass index

    Jing Guo / Andrew Bakshi / Ying Wang / Longda Jiang / Loic Yengo / Michael E. Goddard / Peter M. Visscher / Jian Yang

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 9

    Abstract: Abstract Genome-wide association studies (GWAS) in samples of European ancestry have identified thousands of genetic variants associated with complex traits in humans. However, it remains largely unclear whether these associations can be used in non- ... ...

    Abstract Abstract Genome-wide association studies (GWAS) in samples of European ancestry have identified thousands of genetic variants associated with complex traits in humans. However, it remains largely unclear whether these associations can be used in non-European populations. Here, we seek to quantify the proportion of genetic variation for a complex trait shared between continental populations. We estimated the between-population correlation of genetic effects at all SNPs ( $$r_{g}$$ r g ) or genome-wide significant SNPs ( $$r_{{g\left( {GWS} \right)}}$$ r g GWS ) for height and body mass index (BMI) in samples of European (EUR; $$n = 49,839$$ n = 49 , 839 ) and African (AFR; $$n = 17,426$$ n = 17 , 426 ) ancestry. The $$\hat{r}_{g}$$ r ^ g between EUR and AFR was 0.75 ( $${\text{s}}.{\text{e}}. = 0.035$$ s . e . = 0.035 ) for height and 0.68 ( $${\text{s}}.{\text{e}}. = 0.062$$ s . e . = 0.062 ) for BMI, and the corresponding $$\hat{r}_{{g\left( {GWS} \right)}}$$ r ^ g GWS was 0.82 ( $${\text{s}}.{\text{e}}. = 0.030$$ s . e . = 0.030 ) for height and 0.87 ( $${\text{s}}.{\text{e}}. = 0.064$$ s . e . = 0.064 ) for BMI, suggesting that a large proportion of GWAS findings discovered in Europeans are likely applicable to non-Europeans for height and BMI. There was no evidence that $$\hat{r}_{g}$$ r ^ g differs in SNP groups with different levels of between-population difference in allele frequency or linkage disequilibrium, which, however, can be due to the lack of power.
    Keywords Medicine ; R ; Science ; Q
    Subject code 333
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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