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  1. Article ; Online: Cervical spine kinematics measured during rugby union scrums

    Adrien Cerrito / Peter Milburn / Roger Adams / Kerrie Evans

    Cogent Medicine, Vol 5, Iss

    Reliability of optoelectronic and electromagnetic tracking systems

    2018  Volume 1

    Abstract: Measuring cervical spine kinematics in rugby scrummaging is important from an injury prevention perspective. However, choosing an appropriate measurement system is challenging. Since reliability of a measurement system is critical for meaningful ... ...

    Abstract Measuring cervical spine kinematics in rugby scrummaging is important from an injury prevention perspective. However, choosing an appropriate measurement system is challenging. Since reliability of a measurement system is critical for meaningful interpretation of results, this study evaluated test–retest reliability of an electromagnetic tracking and optoelectronic motion capture system for measurement of cervical spine kinematics during scrummaging. Reliability of joint kinematics at discrete time points was evaluated using intraclass correlation coefficients (ICC), standard error of measurement (SEM), and minimal detectable change (MDC). Reliability of kinematic curves was assessed using coefficient of multiple correlations (CMC) and standard deviations (curve SD). In both systems, seven ICC values were considered to be excellent (>0.75), while two were fair to good (0.44–0.66). Minimal detectable change values for flexion/extension were found to be higher than for other movement directions, and CMC values were only moderate. Overall, reliability was comparable in both systems.
    Keywords motion capture ; neck ; scrummaging ; reliability ; Medicine ; R
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

    Henry J. Sutton / Racheal Aye / Azza H. Idris / Rachel Vistein / Eunice Nduati / Oscar Kai / Jedida Mwacharo / Xi Li / Xin Gao / T. Daniel Andrews / Marios Koutsakos / Thi H.O. Nguyen / Maxim Nekrasov / Peter Milburn / Auda Eltahla / Andrea A. Berry / Natasha KC / Sumana Chakravarty / B. Kim Lee Sim /
    Adam K. Wheatley / Stephen J. Kent / Stephen L. Hoffman / Kirsten E. Lyke / Philip Bejon / Fabio Luciani / Katherine Kedzierska / Robert A. Seder / Francis M. Ndungu / Ian A. Cockburn

    Cell Reports, Vol 34, Iss 6, Pp 108684- (2021)

    2021  

    Abstract: Summary: The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals. This reveals two B cell ... ...

    Abstract Summary: The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals. This reveals two B cell lineages: a classical lineage of activated and resting memory B cells and an alternative lineage, which includes previously described atypical B cells. Although atypical B cells have previously been associated with disease states, the alternative lineage is common in healthy controls, as well as malaria-exposed individuals. We further track Plasmodium-specific B cells after malaria vaccination in naive volunteers. We find that alternative lineage cells are primed after the initial immunization and respond to booster doses. However, alternative lineage cells develop an atypical phenotype with repeated boosts. The data highlight that atypical cells are part of a wider alternative lineage of B cells that are a normal component of healthy immune responses.
    Keywords B cell memory ; atypical B cells ; alternative B cell lineage ; malaria ; sporozoite ; vaccination ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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