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Article: Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation.

Kappéter, Ágnes / Sipos, Dávid / Varga, Adorján / Vigvári, Szabolcs / Halda-Kiss, Bernadett / Péterfi, Zoltán

2023 Volume 11, Issue 8

Abstract: Migraine is a painful neurological condition characterized by severe pain on one or both sides of the head. It may be linked to changes in the gut microbiota, which are influenced by antibiotic use and other factors. Dysbiosis, which develops and ... ...

Abstract	Migraine is a painful neurological condition characterized by severe pain on one or both sides of the head. It may be linked to changes in the gut microbiota, which are influenced by antibiotic use and other factors. Dysbiosis, which develops and persists as a result of earlier antibiotic therapy, changes the composition of the intestinal flora, and can lead to the development of various diseases such as metabolic disorders, obesity, hematological malignancies, neurological or behavioral disorders, and migraine. Metabolites produced by the gut microbiome have been shown to influence the gut-brain axis. The use of probiotics as a dietary supplement may reduce the number and severity of migraine episodes. Dietary strategies can affect the course of migraines and are a valuable tool for improving migraine management. With fecal microbiota transplantation, gut microbial restoration is more effective and more durable. Changes after fecal microbiota transplantation were studied in detail, and many data help us to interpret the successful interventions. The microbiological alteration of the gut microflora can lead to normalization of the inflammatory mediators, the serotonin pathway, and influence the frequency and intensity of migraine pain.
Language	English
Publishing date	2023-08-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11082083
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Role of the Intestinal Microbiome in Multiple Sclerosis-Lessons to Be Learned from Hippocrates.

El-Sayed, Mohamed Mahmoud / Mohak, Sidhesh / Gala, Dhir / Fabian, Reka / Peterfi, Zoltan / Fabian, Zsolt

Biology

2023 Volume 12, Issue 12

Abstract: Based on recent advances in research of chronic inflammatory conditions, there is a growing body of evidence that suggests a close correlation between the microbiota of the gastrointestinal tract and the physiologic activity of the immune system. This ... ...

Abstract	Based on recent advances in research of chronic inflammatory conditions, there is a growing body of evidence that suggests a close correlation between the microbiota of the gastrointestinal tract and the physiologic activity of the immune system. This raises the idea that disturbances of the GI ecosystem contribute to the unfolding of chronic diseases including neurodegenerative pathologies. Here, we overview our current understanding on the putative interaction between the gut microbiota and the immune system from the aspect of multiple sclerosis, one of the autoimmune conditions accompanied by severe chronic neuroinflammation that affects millions of people worldwide.
Language	English
Publishing date	2023-11-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12121463
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Article ; Online: Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with

Varga, Adorján / Makszin, Lilla / Bufa, Anita / Sipos, Dávid / Kása, Péter / Pál, Szilárd / Rosenstiel, Philip / Sommer, Felix / Kocsis, Béla / Péterfi, Zoltán

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1041384

Abstract: Background and aims: Faecal microbiota transfer (FMT) has managed to earn its place in the : Methods: We compared the efficacy of our capsules to other treatment options of CDI at the Department of Infectology at the University of Pécs (Hungary). For ...

Abstract	Background and aims: Faecal microbiota transfer (FMT) has managed to earn its place in the Methods: We compared the efficacy of our capsules to other treatment options of CDI at the Department of Infectology at the University of Pécs (Hungary). For our study, stool was collected from a single donor. We treated 10 patients with relapsing CDI, 5 of them received supernatant, 5 received sediment. Donor samples were stored on 4 different temperatures and tested to determine the survival rates of bacteria. As pilot projects, we also assessed the changes of bacterial taxa, protein- and lipid compositions. Moreover, we selected 4 patients to compare their samples prior and after FMT by using microbiome (16S amplicon sequencing), protein, and lipid analyses. Results: 4 out of the 5 patients who received supernatant became symptomless within 2 days after FMT. In the sediment group 3 out of 5 patients were cured from CDI. Comparing the supernatant to the sediment, we found significantly lower number of colony-forming units in the supernatant. We found that -80°C is the most suitable temperature to store the samples. The stool lipid profiles of recipients showed a more diverse composition after FMT, and changes in the stool protein profiles were observed as well. In the microbiome analysis, we observed an increase in the alpha diversity after FMT. Conclusions: Our study of 10 patients showed good efficacy of lyophilised faecal supernatant using capsules. The single donor approach proved to be effective in our investigation. A significantly lower CFU number was sufficient for the effect, the separation can be achieved by widely available instruments. For storage temperature, -20°C was sufficient in our clinical practice.
MeSH term(s)	Humans ; Fecal Microbiota Transplantation ; Bacterial Load ; Capsules ; Clostridioides difficile ; Feces/microbiology ; Clostridium Infections/therapy ; Clostridium Infections/microbiology ; Bacteria ; Lipids ; Treatment Outcome ; Recurrence
Chemical Substances	Capsules ; Lipids
Language	English
Publishing date	2023-01-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1041384
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Article ; Online: GLP-1 Receptor Signaling Has Different Effects on the Perikarya and Axons of the Hypophysiotropic Thyrotropin-Releasing Hormone Synthesizing Neurons in Male Mice.

Ruska, Yvette / Peterfi, Zoltan / Szilvásy-Szabó, Anett / Kővári, Dóra / Hrabovszky, Erik / Dorogházi, Beáta / Gereben, Balázs / Tóth, Blanka / Matziari, Magdalini / Wittmann, Gábor / Fekete, Csaba

Thyroid : official journal of the American Thyroid Association

2024 Volume 34, Issue 2, Page(s) 252–260

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Mice ; Male ; Animals ; Thyrotropin-Releasing Hormone/metabolism ; Glucagon-Like Peptide-1 Receptor ; Neurons/metabolism ; Axons/metabolism ; Paraventricular Hypothalamic Nucleus ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptide 1/pharmacology
Chemical Substances	Thyrotropin-Releasing Hormone (5Y5F15120W) ; Glucagon-Like Peptide-1 Receptor ; Glucagon-Like Peptide 1 (89750-14-1)
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1086044-7
ISSN	1557-9077 ; 1050-7256
ISSN (online)	1557-9077
ISSN	1050-7256
DOI	10.1089/thy.2023.0284
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Article: Adverse Reactions after Booster SARS-CoV-2 Vaccination Have Less Impact on Antibody Response than after Basic Vaccination Scheme.

Kanizsai, Andrea / Zavori, Laszlo / Molnar, Tihamer / Tőkés-Füzesi, Margit / Szalai, Zoltan / Berecz, Janos / Varnai, Reka / Peterfi, Zoltan / Schwarcz, Attila / Csecsei, Peter

Vaccines

2023 Volume 11, Issue 1

Abstract: Background: It is known that adverse reactions following SARS-CoV-2 vaccinations show a positive correlation with the subsequent antibody titer. However, it is not clear how the adverse reactions following the booster vaccination are related to the ... ...

Abstract	Background: It is known that adverse reactions following SARS-CoV-2 vaccinations show a positive correlation with the subsequent antibody titer. However, it is not clear how the adverse reactions following the booster vaccination are related to the antibody levels that can be measured after a 3rd dose. The primary goal of this study was to investigate whether the adverse reactions following the booster vaccination show a correlation with subsequent antibody levels. Methods: Adverse reactions occurring within 7 days after the 3rd vaccination were recorded and the anti-SARS-CoV-2 spike protein immunoglobulin (Ig) level in the venous blood was measured on post-vaccination 14th, 60th and 120th days. Results: A total of 218 volunteers were included in the study. Main findings: (i) The adverse reactions that appeared after the booster dose did not show a positive correlation with the subsequent antibody level, except a correlation in the case of fever; (ii) there were more symptomatic patients in the group receiving heterologous booster vaccine, (iii) fever after the 2nd dose was independently associated with a reduction in the likelihood of COVID-19 positivity after the booster dose. Conclusion: No adverse reactions, but fever showed a correlation with the antibody level after the booster SARS-CoV-2 vaccine.
Language	English
Publishing date	2023-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11010182
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Article ; Online: Epeút- és epehólyag-gyulladás: diagnosztikus kritériumok és terápia.

Czakó, László / Gyökeres, Tibor / Hritz, István / Madácsy, László / Illés, Dóra / Szepes, Zoltán / Dubravcsik, Zsolt / Péterfi, Zoltán / Nagy, András / Szücs, Ákos / Vincze, Áron

Orvosi hetilap

2023 Volume 164, Issue 20, Page(s) 770–787

Abstract: In developed countries, diseases of the gallbladder and the biliary tract count as some of the most frequent gastrointestinal disorders. The inflammation of the gallbladder/biliary tree is a potentially severe, even lethal condition that requires rapid ... ...

Title translation	Cholangitis and cholecystitis: diagnostic criteria and management.
Abstract	In developed countries, diseases of the gallbladder and the biliary tract count as some of the most frequent gastrointestinal disorders. The inflammation of the gallbladder/biliary tree is a potentially severe, even lethal condition that requires rapid diagnosis and early multidisciplinary approach to be treated. Although the frequency of these diseases is high, the treatment is not unified in Hungary yet. The aim of the evidence-based recommendation is to clarify the diagnostic criteria and severity grading of these diseases and to highlight the indications and rules of proper application of the numerous available therapeutic interventions. The recent guideline is based on the consensus of the Board members of the Endoscopic Section of the Hungarian Gastroenterology Society in contribution with renown experts of surgery, infectology as well as interventional radiology and it counts as a clear and easy applicable guide during the all-day healthcare practice. Our guidelines are based on Tokyo guidelines established on the basis of the consensus reached in the International Consensus Meeting held in Tokyo which were revised in 2013 (TG13) and in 2018 (TG18). Orv Hetil. 2023; 164(20): 770-787.
MeSH term(s)	Humans ; Cholecystitis, Acute/diagnosis ; Cholecystitis, Acute/therapy ; Acute Disease ; Cholecystitis ; Cholangitis/diagnosis ; Cholangitis/therapy ; Tokyo
Language	Hungarian
Publishing date	2023-05-21
Publishing country	Hungary
Document type	English Abstract ; Journal Article
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2023.32770
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Article ; Online: How to Apply FMT More Effectively, Conveniently and Flexible - A Comparison of FMT Methods.

Varga, Adorján / Kocsis, Béla / Sipos, Dávid / Kása, Péter / Vigvári, Szabolcs / Pál, Szilárd / Dembrovszky, Fanni / Farkas, Kornélia / Péterfi, Zoltán

Frontiers in cellular and infection microbiology

2021 Volume 11, Page(s) 657320

Abstract: Purpose: Metronidazol and vancomycin were long the two best options against : Methods: Instead of using nasoenteric tubes or colonoscopy, we place frozen or lyophilised stool in non-coated, size "00", hard gelatine capsules or enterosolvent, size "0" ...

Abstract	Purpose: Metronidazol and vancomycin were long the two best options against Methods: Instead of using nasoenteric tubes or colonoscopy, we place frozen or lyophilised stool in non-coated, size "00", hard gelatine capsules or enterosolvent, size "0" capsules. Results: We found that non-coated, size "00", hard gelatine capsules are appropriate for conducting FMT. Capsules containing lyophilised supernatant with a low number of bacteria have been proven to be non-inferior to other FMT modalities. The primary cure rate in the supernatant group was 93.75%, and 66.67% in the sediment group. The overall cure rate was 82.14%. Depending on the protocol, 4-7 capsules are sufficient per patient. Capsules can be stored for up to one year at -20°C. Conclusions: FMT is a feasible alternative to antibiotic treatments in CDI. Our method makes the process flexible and less inconvenient to patients. Long storage time allows a consistent supply of capsules, while small volume and formulation make the procedure tolerable.
MeSH term(s)	Clostridioides difficile ; Clostridium Infections ; Fecal Microbiota Transplantation ; Humans ; Microbiota ; Recurrence ; Treatment Outcome
Language	English
Publishing date	2021-06-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.657320
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Article: Inflammatory Biomarkers Are Inaccurate Indicators of Bacterial Infection on Admission in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease-A Systematic Review and Diagnostic Accuracy Network Meta-Analysis.

Pázmány, Piroska / Soós, Alexandra / Hegyi, Péter / Dohos, Dóra / Kiss, Szabolcs / Szakács, Zsolt / Párniczky, Andrea / Garami, András / Péterfi, Zoltán / Molnár, Zsolt

Frontiers in medicine

2021 Volume 8, Page(s) 639794

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2021-11-18
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.639794
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Article: Repeated SARS-CoV-2 Positivity: Analysis of 123 Cases

Váncsa, Szilárd / Dembrovszky, Fanni / Farkas, Nelli / Szakó, Lajos / Teutsch, Brigitta / Bunduc, Stefania / Nagy, Rita / Párniczky, Andrea / Erőss, Bálint / Péterfi, Zoltán / Hegyi, Péter

Viruses. 2021 Mar. 19, v. 13, no. 3

2021

Abstract: Repeated positivity and reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is a significant concern. Our study aimed to evaluate the clinical significance of repeatedly positive testing after coronavirus disease 2019 (COVID-19) ...

Abstract	Repeated positivity and reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is a significant concern. Our study aimed to evaluate the clinical significance of repeatedly positive testing after coronavirus disease 2019 (COVID-19) recovery. We performed a systematic literature search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. With available individual patient data reporting on repeatedly SARS-CoV-2 positive (RSP) patients, case reports, and case series were included in this analysis. We performed a descriptive analysis of baseline characteristics of repeatedly positive cases. We assessed the cases according to the length of their polymerase chain reaction (PCR) negative interval between the two episodes. Risk factors for the severity of second episodes were evaluated. Overall, we included 123 patients with repeated positivity from 56 publications, with a mean repeated positivity length of 47.8 ± 29.9 days. Younger patients were predominant in the delayed (>90 days) recurrent positive group. Furthermore, comparing patients with RSP intervals of below 60 and above 60 days, we found that a more severe disease course can be expected if the repeated positivity interval is shorter. Severe and critical disease courses might predict future repeatedly positive severe and critical COVID-19 episodes. In conclusion, our results show that the second episode of SARS-CoV-2 positivity is more severe if it happens within 60 days after the first positive PCR. On the other hand, the second episode’s severity correlates with the first.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; disease course ; disease severity ; guidelines ; meta-analysis ; patients ; polymerase chain reaction
Language	English
Dates of publication	2021-0319
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13030512
Database	NAL-Catalogue (AGRICOLA)

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Article: Hepatitis C Screening and Treatment Program in Hungarian Prisons in the Era of Direct Acting Antiviral Agents

Werling, Klára / Hunyady, Béla / Makara, Mihály / Nemesi, Krisztina / Horváth, Gábor / Schneider, Ferenc / Enyedi, Judit / Müller, Zsófia / Lesch, Miklós / Péterfi, Zoltán / Tóth, Tamás / Gács, Judit / Fehér, Zsuzsanna / Ujhelyi, Eszter / Molnár, Emese / Nemes Nagy, Anna

Viruses. 2022 Feb. 02, v. 14, no. 2

2022

Abstract: A hepatitis C virus (HCV) screening and treatment program was conducted in Hungarian prisons on a voluntary basis. After HCV-RNA testing and genotyping for anti-HCV positives, treatments with direct-acting antiviral agents were commenced by hepatologists ...

Abstract	A hepatitis C virus (HCV) screening and treatment program was conducted in Hungarian prisons on a voluntary basis. After HCV-RNA testing and genotyping for anti-HCV positives, treatments with direct-acting antiviral agents were commenced by hepatologists who visited the institutions monthly. Patients were supervised by the prisons’ medical staff. Data were retrospectively collected from the Hungarian Hepatitis Treatment Registry, from the Health Registry of Prisons, and from participating hepatologists. Eighty-four percent of Hungarian prisons participated, meaning a total of 5779 individuals (28% of the inmate population) underwent screening. HCV-RNA positivity was confirmed in 317/5779 cases (5.49%); 261/317 (82.3%) started treatment. Ninety-nine percent of them admitted previous intravenous drug use. So far, 220 patients received full treatment and 41 patients are still on treatment. Based on the available end of treatment (EOT) + 24 weeks timepoint data, per protocol sustained virologic response rate was 96.8%. In conclusion, the Hungarian prison screening and treatment program, with the active participation of hepatologists and the prisons’ medical staff, is a well-functioning model. Through the Hungarian experience, we emphasize that the “test-and-treat” principle is feasible and effective at micro-eliminating HCV in prisons, where infection rate, as well as history of intravenous drug usage, are high.
Keywords	Hepatitis C virus ; correctional institutions ; drugs ; genotyping ; hepatitis C ; intravenous injection ; models
Language	English
Dates of publication	2022-0202
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v14020308
Database	NAL-Catalogue (AGRICOLA)

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