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  1. Article ; Online: Mile high on heroin: Lessons on the opioid epidemic from the Mile High City.

    Peters, Jamie

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2022  Volume 44, Issue 6, Page(s) e2100297

    Abstract: This commentary discusses the novelty of the preclinical opioid choice model published in Heinsbroek et al., Nat Commun, 2021, and the potential influence of altitude on the reported findings. The studies were performed in the Mile High City of Denver, ... ...

    Abstract This commentary discusses the novelty of the preclinical opioid choice model published in Heinsbroek et al., Nat Commun, 2021, and the potential influence of altitude on the reported findings. The studies were performed in the Mile High City of Denver, Colorado, where a unique subpopulation of heroin-choosing rats were noted.
    MeSH term(s) Analgesics, Opioid/adverse effects ; Animals ; Heroin/adverse effects ; Opioid Epidemic ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/epidemiology ; Rats
    Chemical Substances Analgesics, Opioid ; Heroin (70D95007SX)
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202100297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mile high on heroin: Lessons on the opioid epidemic from the Mile High City

    Peters, Jamie

    BioEssays. 2022 June, v. 44, no. 6

    2022  

    Abstract: This commentary discusses the novelty of the preclinical opioid choice model published in Heinsbroek et al., Nat Commun, 2021, and the potential influence of altitude on the reported findings. The studies were performed in the Mile High City of Denver, ... ...

    Abstract This commentary discusses the novelty of the preclinical opioid choice model published in Heinsbroek et al., Nat Commun, 2021, and the potential influence of altitude on the reported findings. The studies were performed in the Mile High City of Denver, Colorado, where a unique subpopulation of heroin‐choosing rats were noted.
    Keywords altitude ; heroin ; models ; Colorado
    Language English
    Dates of publication 2022-06
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202100297
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Neural circuits controlling choice behavior in opioid addiction.

    Chang, Victoria N / Peters, Jamie

    Neuropharmacology

    2022  Volume 226, Page(s) 109407

    Abstract: As the opioid epidemic presents an ever-expanding public health threat, there is a growing need to identify effective new treatments for opioid use disorder (OUD). OUD is characterized by a behavioral misallocation in choice behavior between opioids and ... ...

    Abstract As the opioid epidemic presents an ever-expanding public health threat, there is a growing need to identify effective new treatments for opioid use disorder (OUD). OUD is characterized by a behavioral misallocation in choice behavior between opioids and other rewards, as opioid use leads to negative consequences, such as job loss, family neglect, and potential overdose. Preclinical models of addiction that incorporate choice behavior, as opposed to self-administration of a single drug reward, are needed to understand the neural circuits governing opioid choice. These choice models recapitulate scenarios that humans suffering from OUD encounter in their daily lives. Indeed, patients with substance use disorders (SUDs) exhibit a propensity to choose drug under certain conditions. While most preclinical addiction models have focused on relapse as the outcome measure, our data suggest that choice is an independent metric of addiction severity, perhaps relating to loss of cognitive control over choice, as opposed to excessive motivational drive to seek drugs during relapse. In this review, we examine both preclinical and clinical literature on choice behavior for drugs, with a focus on opioids, and the neural circuits that mediate drug choice versus relapse. We argue that preclinical models of opioid choice are needed to identify promising new avenues for OUD therapy that are translationally relevant. Both forward and reverse translation will be necessary to identify novel treatment interventions. This article is part of the Special Issue on "Opioid-induced changes in addiction and pain circuits".
    MeSH term(s) Humans ; Analgesics, Opioid/therapeutic use ; Opioid-Related Disorders/drug therapy ; Drug Overdose ; Behavior, Addictive/psychology ; Choice Behavior
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2022-12-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2022.109407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: The role of alcohol in modifying behavior.

    Peters, Jamie / Trabace, Luigia / Di Giovanni, Giuseppe

    Frontiers in behavioral neuroscience

    2023  Volume 17, Page(s) 1175405

    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2023.1175405
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  5. Article ; Online: Engineering Safer Psychedelics for Treating Addiction.

    Peters, Jamie / Olson, David E

    Neuroscience insights

    2021  Volume 16, Page(s) 26331055211033847

    Abstract: Addiction is best described as a disorder of maladaptive neuroplasticity involving the simultaneous strengthening of reward circuitry that drives compulsive drug seeking and weakening of circuits involved in executive control over harmful behaviors. ... ...

    Abstract Addiction is best described as a disorder of maladaptive neuroplasticity involving the simultaneous strengthening of reward circuitry that drives compulsive drug seeking and weakening of circuits involved in executive control over harmful behaviors. Psychedelics have shown great promise for treating addiction, with many people attributing their therapeutic effects to insights gained while under the influence of the drug. However, psychedelics are also potent psychoplastogens-molecules capable of rapidly re-wiring the adult brain. The advent of non-hallucinogenic psychoplastogens with anti-addictive properties raises the intriguing possibility that hallucinations might not be necessary for all therapeutic effects of psychedelic-based medicines, so long as the underlying pathological neural circuitry can be remedied. One of these non-hallucinogenic psychoplastogens, tabernanthalog (TBG), appears to have long-lasting therapeutic effects in preclinical models relevant to alcohol and opioid addiction. Here, we discuss the implications of these results for the development of addiction treatments, as well as the next steps for advancing TBG and related non-hallucinogenic psychoplastogens as addiction therapeutics.
    Language English
    Publishing date 2021-07-20
    Publishing country United States
    Document type Journal Article
    ISSN 2633-1055
    ISSN (online) 2633-1055
    DOI 10.1177/26331055211033847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction.

    Heinsbroek, Jasper A / De Vries, Taco J / Peters, Jamie

    Cold Spring Harbor perspectives in medicine

    2021  Volume 11, Issue 3

    Abstract: Glutamate is the main excitatory neurotransmitter in the brain and is of critical importance for the synaptic and circuit mechanisms that underlie opioid addiction. Opioid memories formed over the course of repeated drug use and withdrawal can become ... ...

    Abstract Glutamate is the main excitatory neurotransmitter in the brain and is of critical importance for the synaptic and circuit mechanisms that underlie opioid addiction. Opioid memories formed over the course of repeated drug use and withdrawal can become powerful stimuli that trigger craving and relapse, and glutamatergic neurotransmission is essential for the formation and maintenance of these memories. In this review, we discuss the mechanisms by which glutamate, dopamine, and opioid signaling interact to mediate the primary rewarding effects of opioids, and cover the glutamatergic systems and circuits that mediate the expression, extinction, and reinstatement of opioid seeking over the course of opioid addiction.
    MeSH term(s) Animals ; Brain/drug effects ; Dopamine/metabolism ; Glutamic Acid/metabolism ; Humans ; Memory/drug effects ; Morphine/adverse effects ; Opioid-Related Disorders/metabolism ; Opioid-Related Disorders/pathology ; Opioid-Related Disorders/physiopathology ; Reward ; Signal Transduction/drug effects ; Synaptic Transmission/drug effects
    Chemical Substances Glutamic Acid (3KX376GY7L) ; Morphine (76I7G6D29C) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a039602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Tabernanthalog Reduces Motivation for Heroin and Alcohol in a Polydrug Use Model.

    Heinsbroek, Jasper A / Giannotti, Giuseppe / Bonilla, Joel / Olson, David E / Peters, Jamie

    Psychedelic medicine (New Rochelle, N.Y.)

    2023  Volume 1, Issue 2, Page(s) 111–119

    Abstract: Background: The potential use of psychedelic drugs as therapeutics for neuropsychiatric disorders has been limited by their hallucinogenic properties. To overcome this limitation, we developed and characterized tabernanthalog (TBG), a novel analogue of ... ...

    Abstract Background: The potential use of psychedelic drugs as therapeutics for neuropsychiatric disorders has been limited by their hallucinogenic properties. To overcome this limitation, we developed and characterized tabernanthalog (TBG), a novel analogue of the indole alkaloids ibogaine and 5-methoxy-
    Methodology: Here we employed a polydrug model of heroin and alcohol couse to screen the therapeutic efficacy of TBG on metrics of both opioid and alcohol seeking. We first exposed rats to alcohol (or control sucrose-fade solution) in the home-cage (HC), using a two-bottle binge protocol, over a period of 1 month. Rats were then split into two groups that underwent self-administration training for either intravenous heroin or oral alcohol, so that we could assess the impact of HC alcohol exposure on the self-administration of each substance separately. Thereafter, rats began self-administering both heroin and alcohol in the same sessions. Finally, we tested the effects of TBG on break points for heroin and alcohol in a progressive ratio test, where the number of lever presses required to obtain a single reward increased exponentially.
    Results and conclusion: TBG effectively reduced motivation for heroin and alcohol in this test, indicating its efficacy is preserved in animals with a history of heroin and alcohol polydrug use.
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ISSN 2831-4433
    ISSN (online) 2831-4433
    DOI 10.1089/psymed.2023.0009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Corrigendum: Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction.

    Heinsbroek, Jasper A / De Vries, Taco J / Peters, Jamie

    Cold Spring Harbor perspectives in medicine

    2020  Volume 10, Issue 6

    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a040410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking.

    Giannotti, Giuseppe / Mottarlini, Francesca / Heinsbroek, Jasper A / Mandel, Mitchel R / James, Morgan H / Peters, Jamie

    Translational psychiatry

    2022  Volume 12, Issue 1, Page(s) 432

    Abstract: As opioid-related fatalities continue to rise, the need for novel opioid use disorder (OUD) treatments could not be more urgent. Two separate hypothalamic neuropeptide systems have shown promise in preclinical OUD models. The oxytocin system, originating ...

    Abstract As opioid-related fatalities continue to rise, the need for novel opioid use disorder (OUD) treatments could not be more urgent. Two separate hypothalamic neuropeptide systems have shown promise in preclinical OUD models. The oxytocin system, originating in the paraventricular nucleus (PVN), may protect against OUD severity. By contrast, the orexin system, originating in the lateral hypothalamus (LH), may exacerbate OUD severity. Thus, activating the oxytocin system or inhibiting the orexin system are potential therapeutic strategies. The specific role of these systems with regard to specific OUD outcomes, however, is not fully understood. Here, we probed the therapeutic efficacy of pharmacological interventions targeting the orexin or oxytocin system on two distinct metrics of OUD severity in rats-heroin choice (versus choice for natural reward, i.e., food) and cued reward seeking. Using a preclinical model that generates approximately equal choice between heroin and food reward, we examined the impact of exogenously administered oxytocin, an oxytocin receptor antagonist (L-368,899), and a dual orexin receptor antagonist (DORA-12) on opioid choice. Whereas these agents did not alter heroin choice when rewards (heroin and food) were available, oxytocin and DORA-12 each significantly reduced heroin seeking in the presence of competing reward cues when no rewards were available. In addition, the number of LH orexin neurons and PVN oxytocin neurons correlated with specific behavioral economic variables indicative of heroin versus food motivation. These data identify a novel bidirectional role of the oxytocin and orexin systems in the ability of opioid-related cues to bias reward seeking.
    MeSH term(s) Analgesics, Opioid ; Animals ; Cues ; Heroin ; Intracellular Signaling Peptides and Proteins ; Neuropeptides ; Orexin Receptor Antagonists/pharmacology ; Orexins ; Oxytocin/pharmacology ; Rats ; Receptors, Oxytocin
    Chemical Substances Analgesics, Opioid ; Intracellular Signaling Peptides and Proteins ; Neuropeptides ; Orexin Receptor Antagonists ; Orexins ; Receptors, Oxytocin ; Oxytocin (50-56-6) ; Heroin (70D95007SX)
    Language English
    Publishing date 2022-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-022-02161-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Detrimental Effects of a Retrieval-Extinction Procedure on Nicotine Seeking, but Not Cocaine Seeking.

    Struik, Roeland F / De Vries, Taco J / Peters, Jamie

    Frontiers in behavioral neuroscience

    2019  Volume 13, Page(s) 243

    Abstract: Retrieval-extinction memory reactivation procedures have been used to prevent the return of learned fear and drug seeking in preclinical models. These procedures first reactivate the original memory with a brief cue exposure (i.e., retrieval) session, ... ...

    Abstract Retrieval-extinction memory reactivation procedures have been used to prevent the return of learned fear and drug seeking in preclinical models. These procedures first reactivate the original memory with a brief cue exposure (i.e., retrieval) session, and then disrupt memory reconsolidation by conducting extinction training within the reconsolidation window. The original memory is thought to be updated with the new information conveyed by extinction learning, resulting in a persistent therapeutic effect beyond that observed with extinction training alone (i.e., no retrieval). Here, we attempted to replicate the therapeutic effects on cocaine seeking reported by Xue et al. (2012), and extend these findings to nicotine seeking. Rats self-administered either cocaine or nicotine with contingent cues for weeks, and were then divided into two groups. The retrieval group underwent a 10-min retrieval session wherein drug cues were available, but drug was not. Ten minutes later, they were allowed to continue cue extinction training for an additional 60 min. The no retrieval group underwent a contiguous 70-min cue extinction session. These procedures continued for weeks, followed by a test for spontaneous recovery of drug seeking. No group differences were observed on any measure of cocaine seeking, although both groups exhibited extinction and spontaneous recovery. By contrast, for nicotine seeking, the retrieval group exhibited resistance to extinction, an effect that persisted on the spontaneous recovery test. These findings underscore the importance of drug type in the outcome of retrieval-extinction procedures and moreover indicate that retrieval-extinction procedures can be detrimental to nicotine seeking.
    Language English
    Publishing date 2019-10-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2019.00243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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