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  1. Article ; Online: Utilizing Human Genetics to Develop Chemoprevention for Cancer-Too Good an Opportunity to be Missed.

    Peters, Ulrike / Tomlinson, Ian

    Cancer prevention research (Philadelphia, Pa.)

    2024  Volume 17, Issue 1, Page(s) 7–12

    Abstract: Large-scale genetic studies are reliably identifying many risk factors for disease in the general population. Several of these genetic risk factors encode potential drug targets, and genetics has already helped to introduce targeted agents for some ... ...

    Abstract Large-scale genetic studies are reliably identifying many risk factors for disease in the general population. Several of these genetic risk factors encode potential drug targets, and genetics has already helped to introduce targeted agents for some diseases, an example being lipid-lowering drugs to reduce the incidence of cardiovascular disease. Multiple drugs have been developed to treat cancers based on somatic mutations and genomics, but in stark contrast, there seems to be a reluctance to use germline genetic data to develop drugs to prevent malignancy, despite the large numbers of people who could benefit, the potential for lowering cancer rates, and the widespread current use of non-pharmaceutical measures to reduce cancer risk factors such as tobacco, alcohol, and infectious diseases. We argue that concerted efforts for cancer prevention based on genetics, including genes influenced by common polymorphisms that modulate cancer risk, are urgently needed. There are enormous, yet underutilized, opportunities to develop novel targeted agents for chemoprevention of cancer based on human germline genetics. Such efforts are likely to require the support of a dedicated funding program by national and international agencies. See related commentary by Winham and Sherman, p. 13.
    MeSH term(s) Humans ; Neoplasms/genetics ; Neoplasms/prevention & control ; Chemoprevention ; Risk Factors ; Drug Delivery Systems ; Human Genetics
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2434717-6
    ISSN 1940-6215 ; 1940-6207
    ISSN (online) 1940-6215
    ISSN 1940-6207
    DOI 10.1158/1940-6207.CAPR-22-0523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Leveraging GWAS: Path to Prevention? - Letter.

    Peters, Ulrike / Tomlinson, Ian

    Cancer prevention research (Philadelphia, Pa.)

    2024  Volume 17, Issue 2, Page(s) 85

    MeSH term(s) Humans ; Genome-Wide Association Study ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2434717-6
    ISSN 1940-6215 ; 1940-6207
    ISSN (online) 1940-6215
    ISSN 1940-6207
    DOI 10.1158/1940-6207.CAPR-23-0512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Erfolgreiche Umweltkommunikation im Internet

    Peters, Ulrike

    Studie: Internetanwendungen im Natur- und Umweltschutz

    (Initiativen zum Umweltschutz ; 63)

    2005  

    Institution Deutsche Bundesstiftung Umwelt
    Author's details [DBU, Deutsche Bundesstiftung Umwelt]. Hrsg. von Ulrike Peters
    Series title Initiativen zum Umweltschutz ; 63
    Collection
    Keywords Website ; Umweltschutz ; Kommunikation ; Naturschutz
    Subject Web Site ; Web-Standort ; Web-Ort ; Webauftritt ; Internetauftritt ; Netzstelle ; Site ; Web-Präsenz ; Webseite ; Web-Seite ; WWW-Seite ; World Wide Web ; Websites ; Kommunikationsprozess ; Informationsprozess ; Ökologie ; Umweltvorsorge
    Language German
    Size XII, 222 S. : Ill., graph. Darst.
    Publisher Schmidt
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    HBZ-ID HT014487798
    ISBN 978-3-503-09012-9 ; 3-503-09012-6
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  4. Article ; Online: Unveiling challenges in Mendelian randomization for gene-environment interaction.

    Gorfine, Malka / Qu, Conghui / Peters, Ulrike / Hsu, Li

    Genetic epidemiology

    2024  

    Abstract: Gene-environment (GxE) interactions play a crucial role in understanding the complex etiology of various traits, but assessing them using observational data can be challenging due to unmeasured confounders for lifestyle and environmental risk factors. ... ...

    Abstract Gene-environment (GxE) interactions play a crucial role in understanding the complex etiology of various traits, but assessing them using observational data can be challenging due to unmeasured confounders for lifestyle and environmental risk factors. Mendelian randomization (MR) has emerged as a valuable method for assessing causal relationships based on observational data. This approach utilizes genetic variants as instrumental variables (IVs) with the aim of providing a valid statistical test and estimation of causal effects in the presence of unmeasured confounders. MR has gained substantial popularity in recent years largely due to the success of genome-wide association studies. Many methods have been developed for MR; however, limited work has been done on evaluating GxE interaction. In this paper, we focus on two primary IV approaches: the two-stage predictor substitution and the two-stage residual inclusion, and extend them to accommodate GxE interaction under both the linear and logistic regression models for continuous and binary outcomes, respectively. Comprehensive simulation study and analytical derivations reveal that resolving the linear regression model is relatively straightforward. In contrast, the logistic regression model presents a considerably more intricate challenge, which demands additional effort.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605785-8
    ISSN 1098-2272 ; 0741-0395
    ISSN (online) 1098-2272
    ISSN 0741-0395
    DOI 10.1002/gepi.22552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Esophageal cancer mutational signatures around the world.

    Giannakis, Marios / Peters, Ulrike

    Nature genetics

    2021  Volume 53, Issue 11, Page(s) 1522–1523

    MeSH term(s) Esophageal Neoplasms/genetics ; Humans ; Mutation
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-021-00958-0
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    Zs.MG 46: Show issues

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  6. Book ; Thesis: Epidemiologische Studien zur Zöliakie

    Peters, Ulrike

    Inzidenz in Norddeutschland 1985 bis 1994 sowie eine Fall-Kontroll-Studie zum Einfluß der Säuglingsernährung auf die Entstehung der Zöliakie und zum Auftreten assoziierter Erkrankungen

    (Schriftenreihe des Instituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Universität Kiel ; 15)

    1998  

    Author's details von Ulrike Peters
    Series title Schriftenreihe des Instituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Universität Kiel ; 15
    Schriftenreihe des Instituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Universität zu Kiel
    Collection Schriftenreihe des Instituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Universität zu Kiel
    Keywords Norddeutschland ; Zöliakie ; Epidemiologie ; Geschichte 1985-1994 ; Säuglingsernährung
    Subject Coeliakie ; Heubner-Herter-Krankheit ; Herter-Infantilismus ; Intestinaler Infantilismus ; Säugling ; Krankheitsverbreitung
    Size XI, 202 S. : graph. Darst., Kt.
    Publisher Inst. für Humanernährung und Lebensmittelkunde
    Publishing place Kiel
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 1998
    Note Zsfassung in engl. Sprache
    HBZ-ID HT010078634
    ISBN 3-926085-14-2 ; 978-3-926085-14-6
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  7. Article: Comparing ancestry calibration approaches for a trans-ancestry colorectal cancer polygenic risk score.

    Rosenthal, Elisabeth A / Hsu, Li / Thomas, Minta / Peters, Ulrike / Kachulis, Christopher / Patterson, Karynne / Jarvik, Gail P

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Background: Colorectal cancer (CRC) is a complex disease with monogenic, polygenic and environmental risk factors. Polygenic risk scores (PRS) are being developed to identify high polygenic risk individuals. Due to differences in genetic background, PRS ...

    Abstract Background: Colorectal cancer (CRC) is a complex disease with monogenic, polygenic and environmental risk factors. Polygenic risk scores (PRS) are being developed to identify high polygenic risk individuals. Due to differences in genetic background, PRS distributions vary by ancestry, necessitating calibration.
    Methods: We compared four calibration methods using the All of Us Research Program Whole Genome Sequence data for a CRC PRS previously developed in participants of European and East Asian ancestry. The methods contrasted results from linear models with A) the entire data set or an ancestrally diverse training set AND B) covariates including principal components of ancestry or admixture. Calibration with the training set adjusted the variance in addition to the mean.
    Results: All methods performed similarly within ancestry with OR (95% C.I.) per s.d. change in PRS: African 1.5 (1.02, 2.08), Admixed American 2.2 (1.27, 3.85), European 1.6 (1.43, 1.89), and Middle Eastern 1.1 (0.71, 1.63). Using admixture and an ancestrally diverse training set provided distributions closest to standard Normal with accurate upper tail frequencies.
    Conclusion: Although the PRS is predictive of CRC risk for most ancestries, its performance varies by ancestry.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.23.23296753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Elucidating the Risk of Colorectal Cancer for Variants in Hereditary Colorectal Cancer Genes.

    Mahmood, Khalid / Thomas, Minta / Qu, Conghui / Hsu, Li / Buchanan, Daniel D / Peters, Ulrike

    Gastroenterology

    2023  Volume 165, Issue 4, Page(s) 1070–1076.e3

    MeSH term(s) Humans ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.06.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Moving from one to many: insights from the growing list of pleiotropic cancer risk genes.

    Bien, Stephanie A / Peters, Ulrike

    British journal of cancer

    2019  Volume 120, Issue 12, Page(s) 1087–1089

    Abstract: Pleiotropy, a phenomenon in which a single gene affects multiple phenotypes, is becoming very common among different cancer types and cancer-related phenotypes, such as those in hormonal, cardiometabolic and inflammatory/immune conditions. The discovery ... ...

    Abstract Pleiotropy, a phenomenon in which a single gene affects multiple phenotypes, is becoming very common among different cancer types and cancer-related phenotypes, such as those in hormonal, cardiometabolic and inflammatory/immune conditions. The discovery of pleiotropic associations can improve our understanding of cancer and help to target investigation of genes with greater clinical relevance.
    MeSH term(s) Genetic Pleiotropy ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Neoplasms/genetics ; Penetrance ; Phenotype
    Language English
    Publishing date 2019-05-21
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-019-0475-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Weltreligionen

    Peters, Ulrike

    (Theiss WissenKompakt)

    2014  

    Author's details Ulrike Peters
    Series title Theiss WissenKompakt
    Keywords Weltreligion
    Language German
    Size 191 S., zahlr. Ill., graph. Darst., Kt.
    Publisher Theiss
    Publishing place Darmstadt
    Document type Book
    Note Literaturverz. S. 182 - 184
    ISBN 9783806226393 ; 3806226393
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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