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  1. Article ; Online: Assessing the pulmonary vascular responsiveness to oxygen with proton MRI.

    Kizhakke Puliyakote, Abhilash S / Tedjasaputra, Vincent / Petersen, Gregory M / Sá, Rui Carlos / Hopkins, Susan R

    Journal of applied physiology (Bethesda, Md. : 1985)

    2024  Volume 136, Issue 4, Page(s) 853–863

    Abstract: Ventilation-perfusion matching occurs passively and is also actively regulated through hypoxic pulmonary vasoconstriction (HPV). The extent of HPV activity in humans, particularly normal subjects, is uncertain. Current evaluation of HPV assesses changes ... ...

    Abstract Ventilation-perfusion matching occurs passively and is also actively regulated through hypoxic pulmonary vasoconstriction (HPV). The extent of HPV activity in humans, particularly normal subjects, is uncertain. Current evaluation of HPV assesses changes in ventilation-perfusion relationships/pulmonary vascular resistance with hypoxia and is invasive, or unsuitable for patients because of safety concerns. We used a noninvasive imaging-based approach to quantify the pulmonary vascular response to oxygen as a metric of HPV by measuring perfusion changes between breathing 21% and 30%O
    MeSH term(s) Humans ; Young Adult ; Adult ; Middle Aged ; Oxygen ; Protons ; Pulmonary Circulation/physiology ; Hyperoxia ; Papillomavirus Infections ; Lung/physiology ; Hypoxia ; Vasoconstriction/physiology ; Magnetic Resonance Imaging/methods
    Chemical Substances Oxygen (S88TT14065) ; Protons
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00747.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.249: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Ventilatory heterogeneity in the normal human lung is unchanged by controlled breathing.

    Prisk, G Kim / Petersen, Gregory M / Geier, Eric T / Sá, Rui C

    Journal of applied physiology (Bethesda, Md. : 1985)

    2020  Volume 129, Issue 5, Page(s) 1152–1160

    Abstract: Measurement of ventilation heterogeneity with the multiple-breath nitrogen washout (MBW) is usually performed using controlled breathing with a fixed tidal volume and breathing frequency. However, it is unclear whether controlled breathing alters the ... ...

    Abstract Measurement of ventilation heterogeneity with the multiple-breath nitrogen washout (MBW) is usually performed using controlled breathing with a fixed tidal volume and breathing frequency. However, it is unclear whether controlled breathing alters the underlying ventilatory heterogeneity. We hypothesized that the width of the specific ventilation distribution (a measure of heterogeneity) would be greater in tests performed during free breathing compared with those performed using controlled breathing. Eight normal subjects (age range = 23-50 yr, 5 female/3 male) twice underwent MRI-based specific ventilation imaging consisting of five repeated cycles with the inspired gas switching between 21% and 100% O
    MeSH term(s) Adult ; Female ; Humans ; Lung/diagnostic imaging ; Lung/physiology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Respiration ; Respiratory Function Tests ; Tidal Volume ; Young Adult
    Language English
    Publishing date 2020-08-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00278.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.249: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Solvation potentials for flexible chain molecules in solution: on the validity of a pairwise decomposition.

    Taylor, Mark P / Petersen, Gregory M

    The Journal of chemical physics

    2007  Volume 127, Issue 18, Page(s) 184901

    Abstract: The effects of a solvent on the conformation of a flexible n-site solute molecule can be described formally in terms of an n-body solvation potential. Given the practical difficulty in computing such multibody potentials, it is common to carry out a ... ...

    Abstract The effects of a solvent on the conformation of a flexible n-site solute molecule can be described formally in terms of an n-body solvation potential. Given the practical difficulty in computing such multibody potentials, it is common to carry out a pairwise decomposition in which the n-body potential is approximated by a sum of two-body potentials. Here we investigate the validity of this two-site approximation for short interaction-site chain-in-solvent systems. Using exact expressions for the conformation of an isolated chain, we construct a mapping between the full chain-in-solvent system and its solvation potential representation. We present results for both hard-sphere and square-well systems with n=5 that show that the two-site approximation is sufficient to completely capture the effects of an explicit solvent on chain conformation for a wide range of conditions (which include varying the solvent diameter in the hard-sphere system and varying the chain-solvent coupling in the square-well system). In all cases, a set of two-site potentials (one for each distinct site-site pair) is required. We also show that these two-site solvation potentials can be used to accurately compute a multisite intramolecular correlation function.
    Language English
    Publishing date 2007-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/1.2787006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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