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Article ; Online: Births in the Nordics 2021 to 2022-Pandemic fluctuation or fundamental shift?

Petersen, Jesper Padkær / Cueto, Heidi / Norman, Mikael

Acta paediatrica (Oslo, Norway : 1992)

2024 Volume 113, Issue 6, Page(s) 1143–1144

MeSH term(s)	Humans ; COVID-19/epidemiology ; Infant, Newborn ; Female ; Birth Rate/trends ; Pandemics ; Pregnancy
Language	English
Publishing date	2024-03-13
Publishing country	Norway
Document type	Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.17209
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Article ; Online: [Treatment and follow-up of preterm infants in Denmark].

Hansen, Bo Mølholm / Petersen, Jesper Padkær

Ugeskrift for laeger

2020 Volume 182, Issue 14A

Abstract: This review summarises the treatment of preterm infants in Denmark, which is dependent on the collaboration between several medical specialities. The problems of the preterm infants are related to the degree of prematurity, and the treatment should ... ...

Abstract	This review summarises the treatment of preterm infants in Denmark, which is dependent on the collaboration between several medical specialities. The problems of the preterm infants are related to the degree of prematurity, and the treatment should counter these issues, reduce complications related to prematurity and ensure growth and development. Developmental problems are the most common sequelae. There seems to be a dose-effect association between the whole spectrum of gestational age and developmental problems with the highest risk among the extremely preterm children. However, even in this group, most of the children will develop normally.
MeSH term(s)	Child ; Denmark/epidemiology ; Follow-Up Studies ; Gestational Age ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/therapy
Language	Danish
Publishing date	2020-04-14
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
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Article ; Online: Evaluation of the diagnostic process in neonates with conjugated hyperbilirubinaemia.

Pedersen, Ida Borreby / Vestergaard, Esben Thyssen / Petersen, Jesper Padkær / Pryds, Ole

Danish medical journal

2022 Volume 69, Issue 3

Abstract: Introduction: The Danish Health Authority (DHA) recommends diagnostic evaluation of infants who develop prolonged jaundice and a serum conjugated bilirubin (CB) concentration ≥ 17 μmol/l. This study aimed to assess the efficacy of the programme in ... ...

Abstract	Introduction: The Danish Health Authority (DHA) recommends diagnostic evaluation of infants who develop prolonged jaundice and a serum conjugated bilirubin (CB) concentration ≥ 17 μmol/l. This study aimed to assess the efficacy of the programme in identifying infants with biliary atresia (BA) or other liver disease. Infants born in the Central Denmark Region from 2016 to 2021 were investigated. Methods: A total of 693 infants were identified in the Central Biochemical Database (Labka). From a review of all medical records, CB measurements, results from diagnostic procedures and the final diagnosis were documented. Results: Four infants were identified with BA. They had a mean CB concentration of 105 μmol/l. A total of 33 infants were diagnosed with other cholestatic diseases; this group had a mean CB concentration of 58.9 μmol/l. The remaining 656 infants with a mean CB of 20.5 μmol/l recovered spontaneously without any sign of cholestatic disease. Approximately 75% of all HIDA scintigraphies (100/134) were conducted in 647 infants with a maximum CB concentration less-than 30 μmol/l. They all had bile drainage to the intestines. Among these infants, twelve were diagnosed as heterozygote for alfa-1-antitrypsin deficiency. Conclusion: The CB threshold limit recommended by the DHA detected all patients with BA, but its use leads to over-investigation and over-diagnosing. Funding: not relevant. Trial registration: not relevant.
MeSH term(s)	Biliary Atresia/diagnosis ; Bilirubin ; Humans ; Hyperbilirubinemia ; Infant ; Infant, Newborn ; Retrospective Studies
Chemical Substances	Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2022-02-18
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	2648771-8
ISSN	2245-1919 ; 2245-1919
ISSN (online)	2245-1919
ISSN	2245-1919
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Article ; Online: Risk of complications in late term pregnancies adjusted for induction of labor.

Andersson, Charlotte Brix / Petersen, Jesper Padkaer / Johnsen, Søren Paaske / Kesmodel, Ulrik Schiøler

Acta obstetricia et gynecologica Scandinavica

2022 Volume 101, Issue 7, Page(s) 840

MeSH term(s)	Female ; Humans ; Labor, Induced/adverse effects ; Labor, Obstetric ; Pregnancy
Language	English
Publishing date	2022-04-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80019-3
ISSN	1600-0412 ; 0001-6349
ISSN (online)	1600-0412
ISSN	0001-6349
DOI	10.1111/aogs.14357
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Article: Neonatal Phototherapy and Clinical Characteristics: The Danish National Patient Registry 2000-2016.

Sun, Yuelian / Petersen, Jesper Padkær / Wu, Chunsen / Dreier, Julie Werenberg / Maimburg, Rikke Damkjær / Henriksen, Tine Brink / Christensen, Jakob

Clinical epidemiology

2023 Volume 15, Page(s) 123–136

Abstract: Purpose: Phototherapy is the standard treatment for neonatal hyperbilirubinemia. It is important to collect data on phototherapy to support research related to the efficacy and safety of phototherapy. We explored the registration of phototherapy in the ... ...

Abstract	Purpose: Phototherapy is the standard treatment for neonatal hyperbilirubinemia. It is important to collect data on phototherapy to support research related to the efficacy and safety of phototherapy. We explored the registration of phototherapy in the Danish National Patient Registry (DNPR) and the clinical characteristics of neonates treated with phototherapy. Methods: We identified children born alive in Denmark from 1 January 2000 through 30 November 2016 from the DNPR (N=1,044,502). We calculated the proportion of children registered that received phototherapy during the neonatal period and examined temporal trends, both nationwide and at the level of individual hospitals. In a sub-cohort of children born at Aarhus University Hospital (AUH) in 2002-2016 (N=71,781), we analyzed the proportions of children registered that received phototherapy, according to sex, gestational age, birth weight, and neonatal characteristics, like Apgar score, birth asphyxia, and infections. Results: We identified 11,295 (1.1%) registered that received phototherapy. The proportions of children registered that received phototherapy differed among hospitals (range: 0 to 4.1%). Nationwide registration was low during the study period, but it increased to 1.8% in 2016. For the AUH sub-cohort the proportion of children registered with phototherapy averaged 4.4% (N=3182, range:3.9-5.1%). The proportion of children registered with phototherapy was inversely correlated with gestational age and birth weight, and positively correlated with neonatal characteristics, including low Apgar score, birth asphyxia, and infections. Conclusion: Phototherapy was under-reported in the DNPR and the proportions of children registered that received phototherapy differed among hospitals. The non-compulsory policy for reporting treatment and care in hospitals to the DNPR might explain the variation. The most consistent reporting was observed among children born in an university hospital, where 4.4% of children registered that received phototherapy, and phototherapy was inversely associated with gestational age, birth weight, and positively associated with clinical characteristics like birth asphyxia, and infections.
Language	English
Publishing date	2023-01-25
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494772-6
ISSN	1179-1349
ISSN	1179-1349
DOI	10.2147/CLEP.S373289
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Article ; Online: Risk of complications in the late vs early days of the 42nd week of pregnancy: A nationwide cohort study.

Andersson, Charlotte Brix / Petersen, Jesper Padkaer / Johnsen, Søren Paaske / Jensen, Martin / Kesmodel, Ulrik Schiøler

Acta obstetricia et gynecologica Scandinavica

2021 Volume 101, Issue 2, Page(s) 200–211

Abstract: Introduction: Uncertainty remains about the most appropriate timing of induction of labor in late-term pregnancies. To address this issue, this study aimed to compare the risk of neonatal morbidity and pregnancy- and birth-related complications between ... ...

Abstract	Introduction: Uncertainty remains about the most appropriate timing of induction of labor in late-term pregnancies. To address this issue, this study aimed to compare the risk of neonatal morbidity and pregnancy- and birth-related complications between gestational age (GA) 41 Material and methods: This nationwide registry-based cohort study included singleton births without major congenital malformations, with registered GA, and with intended vaginal delivery at GA 41 Results: A higher incidence of neonatal morbidity and birth complications was observed in births at GA 41 Conclusions: Births at GA 41
MeSH term(s)	Cohort Studies ; Denmark/epidemiology ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Logistic Models ; Male ; Pregnancy ; Pregnancy Complications/epidemiology ; Pregnancy Complications/etiology ; Pregnancy Outcome ; Pregnancy Trimester, Third ; Pregnancy, Prolonged ; Registries ; Risk Factors
Language	English
Publishing date	2021-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	80019-3
ISSN	1600-0412 ; 0001-6349
ISSN (online)	1600-0412
ISSN	0001-6349
DOI	10.1111/aogs.14299
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Article ; Online: The Danish neonatal clinical database is valuable for epidemiologic research in respiratory disease in preterm infants.

Andersson, Sofia / Petersen, Jesper Padkær / Henriksen, Tine Brink / Ebbesen, Finn

BMC pediatrics

2014 Volume 14, Page(s) 47

Abstract: Background: We examined the quality of the information on the use of surfactant and the use of and duration of nasal continuous positive airway pressure (nCPAP), oxygen supplementation, and mechanical ventilation in the Danish Neonatal Clinical Database ...

Abstract	Background: We examined the quality of the information on the use of surfactant and the use of and duration of nasal continuous positive airway pressure (nCPAP), oxygen supplementation, and mechanical ventilation in the Danish Neonatal Clinical Database (NeoBase). Methods: We included all neonates born with a gestational age < 32 weeks admitted to a Neonatal Intensive Care Unit (NICU) at two university hospitals in 2005. On discharge, the clinicians complete a structured form with information related to the delivery and course of stay in the NICU. These forms were entered into the NeoBase. The nurses' daily bedside documentation was used as reference standard. Concordance was used as a measure of agreement between the NeoBase and the reference standard. For the dichotomous variables the concordance was defined as the sensitivity of the information registered in the NeoBase. For the continuous variables, it was based on the discrepancy in days between the NeoBase and the reference standard. The percentage of concordance was described as high (> 90), moderate (70-90) or low (< 70). Results: Overall, 153 infants participated in the study. Concordance was high for all dichotomous variables. The NeoBase slightly underestimated the duration of nCPAP and mechanical ventilation. The duration of oxygen therapy was neither over- nor underestimated in the NeoBase. Concordance was low for all continuous variables if we assumed that the registered information was identical. It was 100% for duration of mechanical ventilation and moderate for nCPAP and oxygen supplementation if we allowed for a discrepancy of 1 day. Conclusion: The NeoBase is a valuable tool for clinical and epidemiologic research and quality assurance regarding neonatal respiratory disease.
MeSH term(s)	Continuous Positive Airway Pressure ; Databases, Factual ; Denmark ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/epidemiology ; Infant, Premature, Diseases/therapy ; Intensive Care Units, Neonatal ; Male ; Oxygen Inhalation Therapy ; Respiration, Artificial ; Respiratory Tract Diseases/epidemiology ; Respiratory Tract Diseases/therapy ; Surface-Active Agents/therapeutic use
Chemical Substances	Surface-Active Agents
Language	English
Publishing date	2014-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/1471-2431-14-47
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Article ; Online: Surfactant Need by Gestation for Very Preterm Babies Initiated on Early Nasal CPAP: A Danish Observational Multicentre Study of 6,628 Infants Born 2000-2013.

Wiingreen, Rikke / Greisen, Gorm / Ebbesen, Finn / Petersen, Jesper Padkær / Zachariassen, Gitte / Henriksen, Tine Brink / Mølholm Hansen, Bo

Neonatology

2017 Volume 111, Issue 4, Page(s) 331–336

Abstract: Background: In recent years, early nasal continuous positive airway pressure (nCPAP) as respiratory support for preterm infants is being advocated as an alternative to prophylactic surfactant and treatment with mechanical ventilation. A number of ... ...

Abstract	Background: In recent years, early nasal continuous positive airway pressure (nCPAP) as respiratory support for preterm infants is being advocated as an alternative to prophylactic surfactant and treatment with mechanical ventilation. A number of infants treated with early nCPAP do not need treatment with surfactant, but few studies provide data on this. Since the 1990s, the first approach to respiratory support to preterm infants in Denmark has been early nCPAP combined with surfactant administration by the INSURE method by which the infant is intubated and surfactant administration is followed by rapid extubation to nCPAP if possible. Objectives: To investigate how often surfactant was administered in preterm infants with a gestational age below 34 weeks treated with early nCPAP as a first approach to respiratory support. Methods: An observational multicentre study including all inborn infants with a gestational age below 34 weeks admitted to 1 of the 4 level 3 neonatal intensive care units in Denmark in the period from 2000 to 2013. Results: A total of 6,628 infants were included in this study. We found that surfactant was administered in 1,056 of 1,799 (59%; 95% CI: 57-61%), in 821 of 2,864 (29%; 95% CI: 27-31%), and in 132 of 1,796 (7%; 95% CI: 6-8%) of the infants with a gestational age from 24 to 27, 28 to 31, and 32 to 33 weeks and 6 days, respectively. Conclusions: A large proportion of preterm infants treated with early nCPAP as the first approach to respiratory support was never treated with surfactant.
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2266911-5
ISSN	1661-7819 ; 1661-7800
ISSN (online)	1661-7819
ISSN	1661-7800
DOI	10.1159/000451021
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Article ; Online: UGT1A1*28 Genotypes and Respiratory Disease in Very Preterm Infants: A Cohort Study.

Petersen, Jesper Padkær / Ebbesen, Finn / Hollegaard, Mads Vilhelm / Andersson, Sofia / Hougaard, David Michael / Thorlacius-Ussing, Ole / Henriksen, Tine Brink

Neonatology

2016 Volume 109, Issue 2, Page(s) 124–129

Abstract: Background: Respiratory disease in the very preterm infant is frequent and often severe. Bilirubin is both a potent neurotoxin and antioxidant, and may have a clinical impact on preterm respiratory disease. The Gilbert genotype, the UGT1A1*28 allele, is ...

Abstract	Background: Respiratory disease in the very preterm infant is frequent and often severe. Bilirubin is both a potent neurotoxin and antioxidant, and may have a clinical impact on preterm respiratory disease. The Gilbert genotype, the UGT1A128 allele, is the major known genetic cause of variation in bilirubin. Objectives:* To study the association between respiratory disease in the very preterm infant and the UGT1A128 allele. Methods:* This is a cohort study of 1,354 very preterm infants (gestational age <32 weeks) born in Jutland, Denmark in 1997-2011. Genotypes were obtained from the Danish Neonatal Screening Biobank, and clinical information was obtained from the databases of two tertiary neonatal intensive care units. Outcomes were the need for surfactant therapy, any need for and duration of supplementary oxygen and bronchopulmonary dysplasia (BPD). Results: Per UGT1A128 allele, odds were increased for any need of supplementary oxygen (odds ratio 1.26; 1.05-1.50) and for BPD (odds ratio 1.71; 1.23-2.39), the need of supplementary oxygen increased by 6.38 days (1.87-10.89), and chance per day of no longer needing supplementary oxygen was reduced (hazard rate 0.84; 0.76-0.93). No effect was observed for need of surfactant treatment (odds ratio 1.08; 0.91-1.28). Hardy-Weinberg equilibrium was unlikely for the cohort (p < 0.012). This could be explained by death prior to genotype sampling. In tests of robustness this failed to explain the primary results. Conclusions:* Compared to the common genotype, UGT1A1*28 genotypes were associated with an increased need of oxygen supplementation and risk of BPD in very preterm newborns.
MeSH term(s)	Bronchopulmonary Dysplasia/enzymology ; Bronchopulmonary Dysplasia/genetics ; Bronchopulmonary Dysplasia/therapy ; Cohort Studies ; Continuous Positive Airway Pressure ; Denmark ; Genetic Predisposition to Disease ; Genotype ; Glucuronosyltransferase/genetics ; Humans ; Infant, Extremely Premature ; Infant, Newborn ; Infant, Premature, Diseases/enzymology ; Infant, Premature, Diseases/genetics ; Pulmonary Surfactants/therapeutic use ; Respiration Disorders/enzymology ; Respiration Disorders/genetics ; Severity of Illness Index
Chemical Substances	Pulmonary Surfactants ; UGT1A1 enzyme (EC 2.4.1.-) ; Glucuronosyltransferase (EC 2.4.1.17)
Language	English
Publishing date	2016
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2266911-5
ISSN	1661-7819 ; 1661-7800
ISSN (online)	1661-7819
ISSN	1661-7800
DOI	10.1159/000442042
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Article ; Online: Sudden vs Pressure Wean From Nasal Continuous Positive Airway Pressure in Infants Born Before 32 Weeks of Gestation: A Randomized Clinical Trial.

Jensen, Christina Friis / Sellmer, Anna / Ebbesen, Finn / Cipliene, Rasa / Johansen, Anders / Hansen, Rikke Monrad / Nielsen, Jens Peter / Nikitina, Olga Hogreffe / Petersen, Jesper Padkær / Henriksen, Tine Brink

JAMA pediatrics

2018 Volume 172, Issue 9, Page(s) 824–831

Abstract: Importance: Nasal continuous positive airway pressure (nCPAP) is a well-established treatment of respiratory distress syndrome in preterm infants. Suboptimal weaning from nCPAP may be associated with lung injury, pulmonary morbidity, and infant weight ... ...

Abstract	Importance: Nasal continuous positive airway pressure (nCPAP) is a well-established treatment of respiratory distress syndrome in preterm infants. Suboptimal weaning from nCPAP may be associated with lung injury, pulmonary morbidity, and infant weight gain. To our knowledge, the best weaning strategy from nCPAP is unknown. Objective: To compare the effect of sudden wean and pressure wean from nCPAP in very preterm infants. Design, setting, and participants: A randomized, clinical, open-label, multicenter trial was conducted at 6 neonatal intensive care units in Denmark from September 2012 to December 2016 and included infants born before 32 weeks of gestation. Interventions: Sudden wean with discontinuation of nCPAP without a prior reduction in pressure. Pressure wean with gradual pressure reduction prior to the discontinuation of nCPAP. Main outcome and measures: The primary outcome was weight gain velocity from randomization to postmenstrual age 40 weeks. Secondary outcomes included other measures of growth, nCPAP and the duration of oxygen supplementation, postmenstrual age at successful wean and at discharge, successful wean at the first attempt, the number of attempts to wean, and the length of the hospital stay. Prespecified subgroup analyses by gestational age were performed. Results: Of the 372 randomized infants, 185 (49.7%) were randomized to sudden wean and 187 infants (50.3%) to pressure wean. A total of 177 infants in both groups completed the trial (median gestational age for sudden and pressure wean, 30 weeks [interquartile range, 29-31]; male: sudden wean, 89 [50%]; pressure wean, 96 [54%]). There was no difference in mean [SD] weight gain velocity from randomization to 40 weeks postmenstrual age between the 2 groups (22 [6] g/kg/day). No difference was found in any of the secondary outcomes. More infants born before 28 weeks of gestation were successfully weaned from nCPAP during the first attempt in the pressure wean group compared with the sudden wean group (risk difference, 31%; 95% CI, 13%-50%), but there was no difference in the duration of nCPAP and oxygen supplementation. Conclusions and relevance: Overall, we found no difference in weight gain velocity or any of the secondary outcomes between very preterm infants who were randomized to sudden wean or pressure wean from nCPAP. However, among infants born before 28 weeks' gestation, infants from the pressure wean group were more often successfully weaned during the first attempt without a longer total duration of nCPAP treatment. Trial registration: ClinicalTrials.gov Identifier: NCT01721629.
MeSH term(s)	Continuous Positive Airway Pressure/methods ; Denmark ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Intensive Care Units, Neonatal ; Length of Stay/statistics & numerical data ; Male ; Respiratory Distress Syndrome, Newborn/therapy ; Treatment Outcome ; Ventilator Weaning/methods
Language	English
Publishing date	2018-07-20
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2701223-2
ISSN	2168-6211 ; 2168-6203
ISSN (online)	2168-6211
ISSN	2168-6203
DOI	10.1001/jamapediatrics.2018.2074
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