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  1. Article ; Online: Taking Mastery Learning One Step Further.

    Petersen, Rebecca Y

    Academic medicine : journal of the Association of American Medical Colleges

    2016  Volume 91, Issue 6, Page(s) 751

    MeSH term(s) Curriculum ; Humans ; Learning
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000001192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 112: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Effects of Discontinuation of Weekly Surveillance Testing on Methicillin-Resistant Staphylococcus aureus in the NICU.

    Petersen, Rebecca Y / Hillman, Noah H / Sadiq, Farouk H / Brownsworth, Christopher A / Williams, Howard L / Josephsen, Justin B

    American journal of perinatology

    2023  

    Abstract: Objective:  Methicillin-resistant : Study design:  This is a retrospective cohort study of infants admitted to two affiliated NICUs. The ADI cohort infants received weekly nasal MRSA cultures and were placed in contact isolation if MRSA colonized for ...

    Abstract Objective:  Methicillin-resistant
    Study design:  This is a retrospective cohort study of infants admitted to two affiliated NICUs. The ADI cohort infants received weekly nasal MRSA cultures and were placed in contact isolation if MRSA colonized for the duration of their hospitalization. The No Surveillance cohort infants were only placed in isolation if there was active MRSA infection or if MRSA colonization was identified incidentally. The rates of infection were determined between the cohorts.
    Results:  There were 8,406 neonates representing 193,684 NICU days in the comparison period. In the ADI cohort, MRSA colonization occurred in 3.4% of infants and infection occurred in 29 infants (0.4%). There were no differences between cohorts in the percent of infants with a MRSA infection at any site (0.5 vs. 0.5%,
    Conclusion:  The rates of MRSA infection did not change when weekly ADI was discontinued and was associated with a decrease in cost and resource utilization.
    Key points: · Placing MRSA-colonized infants in contact isolation is a common practice.. · Data are limited with respect to efficacy in the NICU.. · This study provides evidence that active detection and contact isolation for MRSA colonization may not be beneficial..
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0043-1763481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Effects of Discontinuation of Weekly Surveillance Testing on Methicillin-Resistant Staphylococcus aureus in the NICU

    Petersen, Rebecca Y. / Hillman, Noah H. / Sadiq, Farouk H. / Brownsworth, Christopher A. / Williams, Howard L. / Josephsen, Justin B.

    American Journal of Perinatology

    2023  

    Abstract: Objective: Methicillin-resistant Staphylococcus aureus (MRSA) infection is a major cause of serious morbidity and mortality in the neonatal intensive care unit (NICU). There is no clear consensus on infection control measures. Some approaches to MRSA ... ...

    Abstract Objective: Methicillin-resistant Staphylococcus aureus (MRSA) infection is a major cause of serious morbidity and mortality in the neonatal intensive care unit (NICU). There is no clear consensus on infection control measures. Some approaches to MRSA colonization management may be burdensome with unclear benefits. The objective of this study was to determine if stopping weekly MRSA surveillance with active detection and contact isolation (ADI) was associated with a change in infection rate.
    Study Design: This is a retrospective cohort study of infants admitted to two affiliated NICUs. The ADI cohort infants received weekly nasal MRSA cultures and were placed in contact isolation if MRSA colonized for the duration of their hospitalization. The No Surveillance cohort infants were only placed in isolation if there was active MRSA infection or if MRSA colonization was identified incidentally. The rates of infection were determined between the cohorts.
    Results: There were 8,406 neonates representing 193,684 NICU days in the comparison period. In the ADI cohort, MRSA colonization occurred in 3.4% of infants and infection occurred in 29 infants (0.4%). There were no differences between cohorts in the percent of infants with a MRSA infection at any site (0.5 vs. 0.5%, p  = 0.89), rate of MRSA infections per 1,000 patient-days (0.197 vs. 0.201, p  = 0.92), rate of bloodstream infections (0.12 vs. 0.26%, p  = 0.18), or in the overall mortality rate (3.7 vs. 3.0% p  = 0.13). ADI represented an annual cost of $590,000.
    Conclusion: The rates of MRSA infection did not change when weekly ADI was discontinued and was associated with a decrease in cost and resource utilization.
    Key Points: Placing MRSA-colonized infants in contact isolation is a common practice. Data are limited with respect to efficacy in the NICU. This study provides evidence that active detection and contact isolation for MRSA colonization may not be beneficial.
    Keywords methicillin-resistant ; surveillance ; contact isolation
    Language English
    Publishing date 2023-02-27
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0043-1763481
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Distending Pressure Did Not Activate Acute Phase or Inflammatory Responses in the Airways and Lungs of Fetal, Preterm Lambs.

    Petersen, Rebecca Y / Royse, Emily / Kemp, Matthew W / Miura, Yuichiro / Noe, Andres / Jobe, Alan H / Hillman, Noah H

    PloS one

    2016  Volume 11, Issue 7, Page(s) e0159754

    Abstract: Background: Mechanical ventilation at birth causes airway injury and lung inflammation in preterm sheep. Continuous positive airway pressure (CPAP) is being increasingly used clinically to transition preterm infants at birth.: Objective: To test if ... ...

    Abstract Background: Mechanical ventilation at birth causes airway injury and lung inflammation in preterm sheep. Continuous positive airway pressure (CPAP) is being increasingly used clinically to transition preterm infants at birth.
    Objective: To test if distending pressures will activate acute phase reactants and inflammatory changes in the airways of fetal, preterm lambs.
    Methods: The head and chest of fetal lambs at 128±1 day GA were surgically exteriorized. With placental circulation intact, fetal lambs were then randomized to one of five 15 minute interventions: PEEP of 0, 4, 8, 12, or 16 cmH2O. Recruitment volumes were recorded. Fetal lambs remained on placental support for 30 min after the intervention. The twins of each 0 cmH2O animal served as controls. Fetal lung fluid (FLF), bronchoalveolar lavage fluid (BAL), right mainstem bronchi and peripheral lung tissue were evaluated for inflammation.
    Results: Recruitment volume increased from 0.4±0.04 mL/kg at 4 cmH2O to 2.4±0.3 mL/kg at 16 cmH2O. The lambs were surfactant deficient, and all pressures were below the opening inflection pressure on pressure-volume curve. mRNA expression of early response genes and pro-inflammatory cytokines did not increase in airway tissue or lung tissue at any pressure compared to controls. FLF and BAL also did not have increases in early response proteins. No histologic changes or Egr-1 activation was present at the pressures used.
    Conclusion: Distending pressures as high as 16 cmH2O did not recruit lung volume at birth and did not increase markers of injury in the lung or airways in non-breathing preterm fetal sheep.
    MeSH term(s) Acute-Phase Reaction/etiology ; Animals ; Asphyxia Neonatorum/therapy ; Biomarkers/metabolism ; Cytokines/genetics ; Cytokines/metabolism ; Female ; Lung/immunology ; Lung/pathology ; Positive-Pressure Respiration/adverse effects ; Positive-Pressure Respiration/methods ; Sheep
    Chemical Substances Biomarkers ; Cytokines
    Language English
    Publishing date 2016-07-27
    Publishing country United States
    Document type Comparative Study ; Evaluation Study ; Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0159754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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