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  1. AU="Petese, Alessandro"
  2. AU="Villa, Eduardo"
  3. AU="Vinjamuri, Sobhan"
  4. AU="Schulze-Makuch, Dirk"
  5. AU=Lam Jamie C M
  6. AU="See Ting Leong"
  7. AU="Sangeeta Mangubhai"

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  1. Artikel ; Online: Are Lysosomes Potential Therapeutic Targets for Parkinson's Disease?

    Petese, Alessandro / Cesaroni, Valentina / Cerri, Silvia / Blandini, Fabio

    CNS & neurological disorders drug targets

    2021  Band 21, Heft 8, Seite(n) 642–655

    Abstract: Parkinson´s Disease (PD) is the second most common neurodegenerative disorder, affecting ~2-3% of the population over 65 years old. In addition to progressive degeneration of nigrostriatal neurons, the histopathological feature of PD is the accumulation ... ...

    Abstract Parkinson´s Disease (PD) is the second most common neurodegenerative disorder, affecting ~2-3% of the population over 65 years old. In addition to progressive degeneration of nigrostriatal neurons, the histopathological feature of PD is the accumulation of misfolded α-synuclein protein in abnormal cytoplasmatic inclusions, known as Lewy Bodies (LBs). Recently, Genome-Wide Association Studies (GWAS) have indicated a clear association of variants within several lysosomal genes with risk for PD. Newly evolving data have been shedding light on the relationship between lysosomal dysfunction and alpha-synuclein aggregation. Defects in lysosomal enzymes could lead to the insufficient clearance of neurotoxic protein materials, possibly leading to selective degeneration of dopaminergic neurons. Specific modulation of lysosomal pathways and their components could be considered a novel opportunity for therapeutic intervention for PD. The purpose of this review is to illustrate lysosomal biology and describe the role of lysosomal dysfunction in PD pathogenesis. Finally, the most promising novel therapeutic approaches designed to modulate lysosomal activity, as a potential disease-modifying treatment for PD will be highlighted.
    Mesh-Begriff(e) Aged ; Dopaminergic Neurons/metabolism ; Genome-Wide Association Study ; Humans ; Lysosomes/metabolism ; Parkinson Disease/metabolism ; alpha-Synuclein/metabolism
    Chemische Substanzen alpha-Synuclein
    Sprache Englisch
    Erscheinungsdatum 2021-08-09
    Erscheinungsland United Arab Emirates
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2228394-8
    ISSN 1996-3181 ; 1871-5273
    ISSN (online) 1996-3181
    ISSN 1871-5273
    DOI 10.2174/1871527320666210809123630
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5892: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Artikel ; Online: Lineage Analysis of

    Petese, Alessandro / Fries, Franca L / Broske, Bianca / Stumm, Ralf / Blaess, Sandra

    eNeuro

    2022  Band 9, Heft 4

    Abstract: Midbrain dopaminergic (mDA) neurons are generated from a ventral midbrain progenitor zone over a time span of several days [embryonic day 10.0 (E10.0) to E14.5 in mouse]. Within this neurogenic period, a progressively changing fate potential of mDA ... ...

    Abstract Midbrain dopaminergic (mDA) neurons are generated from a ventral midbrain progenitor zone over a time span of several days [embryonic day 10.0 (E10.0) to E14.5 in mouse]. Within this neurogenic period, a progressively changing fate potential of mDA progenitors could contribute to the generation of diverse mDA neuronal subpopulations. To test this idea, we combined inducible genetic fate mapping and intersectional labeling approaches to trace the lineage of cells expressing the chemokine receptor CXCR4. The
    Mesh-Begriff(e) Animals ; Dopamine ; Dopaminergic Neurons ; Mesencephalon/physiology ; Mice ; Stem Cells ; Substantia Nigra
    Chemische Substanzen Dopamine (VTD58H1Z2X)
    Sprache Englisch
    Erscheinungsdatum 2022-08-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0052-22.2022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: The natural Disc1-deletion present in several inbred mouse strains does not affect sleep.

    Dittrich, Lars / Petese, Alessandro / Jackson, Walker S

    Scientific reports

    2017  Band 7, Heft 1, Seite(n) 5665

    Abstract: The gene Disrupted in Schizophrenia-1 (DISC1) is linked to a range of psychiatric disorders. Two recent transgenic studies suggest DISC1 is also involved in homeostatic sleep regulation. Several strains of inbred mice commonly used for genome ... ...

    Abstract The gene Disrupted in Schizophrenia-1 (DISC1) is linked to a range of psychiatric disorders. Two recent transgenic studies suggest DISC1 is also involved in homeostatic sleep regulation. Several strains of inbred mice commonly used for genome manipulation experiments, including several Swiss and likely all 129 substrains, carry a natural deletion mutation of Disc1. This constitutes a potential confound for studying sleep in genetically modified mice. Since disturbed sleep can also influence psychiatric and neurodegenerative disease models, this putative confound might affect a wide range of studies in several fields. Therefore, we asked to what extent the natural Disc1 deletion affects sleep. To this end, we first compared sleep and electroencephalogram (EEG) phenotypes of 129S4 mice carrying the Disc1 deletion and C57BL/6N mice carrying the full-length version. We then bred Disc1 from C57BL/6N into the 129S4 background, resulting in S4-Disc1 mice. The differences between 129S4 and C57BL/6N were not detected in the 129S4 to S4-Disc1 comparison. We conclude that the mutation has no effect on the measured sleep and EEG characteristics. Thus, it is unlikely the widespread Disc1 deletion has led to spurious results in previous sleep studies or that it alters sleep in mouse models of psychiatric or neurodegenerative diseases.
    Mesh-Begriff(e) Animals ; Breeding ; Electroencephalography ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Nerve Tissue Proteins/genetics ; Sequence Deletion ; Sleep/genetics ; Sleep/physiology
    Chemische Substanzen Disc1 protein, mouse ; Nerve Tissue Proteins
    Sprache Englisch
    Erscheinungsdatum 2017-07-18
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-06015-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson's Disease.

    Giuliano, Claudio / Francavilla, Miriam / Ongari, Gerardo / Petese, Alessandro / Ghezzi, Cristina / Rossini, Nora / Blandini, Fabio / Cerri, Silvia

    International journal of molecular sciences

    2021  Band 22, Heft 16

    Abstract: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the Substantia Nigra pars compacta, leading to classical PD motor symptoms. Current therapies are purely symptomatic and do not modify disease ... ...

    Abstract Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the Substantia Nigra pars compacta, leading to classical PD motor symptoms. Current therapies are purely symptomatic and do not modify disease progression. Cannabidiol (CBD), one of the main phytocannabinoids identified in Cannabis Sativa, which exhibits a large spectrum of therapeutic properties, including anti-inflammatory and antioxidant effects, suggesting its potential as disease-modifying agent for PD. The aim of this study was to evaluate the effects of chronic treatment with CBD (10 mg/kg, i.p.) on PD-associated neurodegenerative and neuroinflammatory processes, and motor deficits in the 6-hydroxydopamine model. Moreover, we investigated the potential mechanisms by which CBD exerted its effects in this model. CBD-treated animals showed a reduction of nigrostriatal degeneration accompanied by a damping of the neuroinflammatory response and an improvement of motor performance. In particular, CBD exhibits a preferential action on astrocytes and activates the astrocytic transient receptor potential vanilloid 1 (TRPV1), thus, enhancing the endogenous neuroprotective response of ciliary neurotrophic factor (CNTF). These results overall support the potential therapeutic utility of CBD in PD, as both neuroprotective and symptomatic agent.
    Sprache Englisch
    Erscheinungsdatum 2021-08-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22168920
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.

    Peviani, Marco / Salvaneschi, Eleonora / Bontempi, Leonardo / Petese, Alessandro / Manzo, Antonio / Rossi, Daniela / Salmona, Mario / Collina, Simona / Bigini, Paolo / Curti, Daniela

    Neurobiology of disease

    2013  Band 62, Seite(n) 218–232

    Abstract: The identification of novel molecular targets crucially involved in motor neuron degeneration/survival is a necessary step for the development of hopefully more effective therapeutic strategies for amyotrophic lateral sclerosis (ALS) patients. In this ... ...

    Abstract The identification of novel molecular targets crucially involved in motor neuron degeneration/survival is a necessary step for the development of hopefully more effective therapeutic strategies for amyotrophic lateral sclerosis (ALS) patients. In this view, S1R, an endoplasmic reticulum (ER)-resident receptor with chaperone-like activity, has recently attracted great interest. S1R is involved in several processes leading to acute and chronic neurodegeneration, including ALS pathology. Treatment with the S1R agonist PRE-084 improves locomotor function and motor neuron survival in presymptomatic and early symptomatic mutant SOD1-G93A ALS mice. Here, we tested the efficacy of PRE-084 in a model of spontaneous motor neuron degeneration, the wobbler mouse (wr) as a proof of concept that S1R may be regarded as a key therapeutic target also for ALS cases not linked to SOD1 mutation. Increased staining for S1R was detectable in morphologically spared cervical spinal cord motor neurons of wr mice both at early (6th week) and late (12th week) phases of clinical progression. S1R signal was also detectable in hypertrophic astrocytes and reactive microglia of wr mice. Chronic treatment with PRE-084 (three times a week, for 8weeks), starting at symptom onset, significantly increased the levels of BDNF in the gray matter, improved motor neuron survival and ameliorated paw abnormality and grip strength performance. In addition, the treatment significantly reduced the number of reactive astrocytes whereas, that of CD11b+ microglial cells was increased. A deeper evaluation of microglial markers revealed significant increased number of cells positive for the pan-macrophage marker CD68 and of CD206+ cells, involved in tissue restoration, in the white matter of PRE-084-treated mice. The mRNA levels of TNF-α and IL-1β were not affected by PRE-084 treatment. Thus, our results support pharmacological manipulation of S1R as a promising strategy to cure ALS and point to increased availability of growth factors and modulation of astrocytosis and of macrophage/microglia as part of the mechanisms involved in S1R-mediated neuroprotection.
    Mesh-Begriff(e) Age Factors ; Amyotrophic Lateral Sclerosis/drug therapy ; Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Disease Models, Animal ; Female ; Locomotion/drug effects ; Male ; Mice ; Mice, Transgenic ; Morpholines/therapeutic use ; Motor Neuron Disease/drug therapy ; Motor Neuron Disease/genetics ; Motor Neurons/metabolism ; Motor Neurons/pathology ; Mutation ; Neuroglia/metabolism ; Neuroprotective Agents/therapeutic use ; Receptors, sigma/agonists ; Receptors, sigma/metabolism ; Spinal Cord/metabolism ; Spinal Cord/pathology ; Superoxide Dismutase/genetics ; Superoxide Dismutase-1 ; Sigma-1 Receptor
    Chemische Substanzen Brain-Derived Neurotrophic Factor ; Morpholines ; Neuroprotective Agents ; Receptors, sigma ; 2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate (138847-85-5) ; Sod1 protein, mouse (EC 1.15.1.1) ; Superoxide Dismutase (EC 1.15.1.1) ; Superoxide Dismutase-1 (EC 1.15.1.1)
    Sprache Englisch
    Erscheinungsdatum 2013-10-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2013.10.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4444: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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