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Article: Red Flags, Prognostic Impact, and Management of Patients With Cardiac Amyloidosis and Aortic Valve Stenosis: A Systematic Review and Meta-Analysis.

Myasoedova, Veronika A / Conte, Maddalena / Valerio, Vincenza / Moschetta, Donato / Massaiu, Ilaria / Petraglia, Laura / Leosco, Dario / Poggio, Paolo / Parisi, Valentina

Frontiers in medicine

2022 Volume 9, Page(s) 858281

Abstract: Background: Cardiac amyloidosis (CA) has been recently recognized as a condition frequently associated with aortic stenosis (AS). The aim of this study was to evaluate: the main characteristics of patients with AS with and without CA, the impact of CA ... ...

Abstract	Background: Cardiac amyloidosis (CA) has been recently recognized as a condition frequently associated with aortic stenosis (AS). The aim of this study was to evaluate: the main characteristics of patients with AS with and without CA, the impact of CA on patients with AS mortality, and the effect of different treatment strategies on outcomes of patients with AS with concomitant CA. Materials and methods: A detailed search related to CA in patients with AS and outcomes was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Seventeen studies enrolling 1,988 subjects (1,658 AS alone and 330 AS with CA) were included in the qualitative and quantitative analysis of main patients with AS characteristics with and without CA, difference in mortality, and treatment strategy. Results: The prevalence of CA resulted in a mean of 15.4% and it was even higher in patients with AS over 80 years old (18.2%). Patients with the dual diagnosis were more often males, had lower body mass index (BMI), were more prone to have low flow, low gradient with reduced left ventricular ejection fraction AS phenotype, had higher E/A and E/e', and greater interventricular septum hypertrophy. Lower Sokolow-Lyon index, higher QRS duration, higher prevalence of right bundle branch block, higher levels of Conclusion: Results from our meta-analysis suggest that several specific clinical, electrocardiographic, and echocardiographic features can be considered "red flags" of CA in patients with AS. CA negatively affects the outcome of patients with AS. Patients with concomitant CA and AS benefit from SAVR or TAVI.
Language	English
Publishing date	2022-03-09
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.858281
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Aortic rupture in patient on oral therapy with levofloxacin.

Campana, Pasquale / Leosco, Dario / Petraglia, Laura / Radice, Leonardo / Parisi, Valentina

Aging clinical and experimental research

2019 Volume 32, Issue 4, Page(s) 755–757

Language	English
Publishing date	2019-07-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-019-01267-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The elderly at risk: aldosterone as modulator of the immune response to SARS-CoV-2 infection.

Campana, Pasquale / Palaia, Maria Emiliana / Conte, Maddalena / Cante, Teresa / Petraglia, Laura / Femminella, Grazia Daniela / Parisi, Valentina / Leosco, Dario

GeroScience

2021 Volume 44, Issue 2, Page(s) 567–572

Abstract: The elderly population is the most susceptible to SARS-CoV-2 infection and develops the worst clinical phenotype with severe pneumonia and cardiac complications. Older COVID-19 patients are also at higher risk of sudden death, mainly attributable to ... ...

Abstract	The elderly population is the most susceptible to SARS-CoV-2 infection and develops the worst clinical phenotype with severe pneumonia and cardiac complications. Older COVID-19 patients are also at higher risk of sudden death, mainly attributable to electrolyte disorders and to an uncontrolled inflammatory response. After the identification of ACE 2 as the receptor of SARS-CoV-2 in human cells, several research studies have focused on the role of the activation of Renin Angiotensin System in COVID-19 clinical course. In the present opinion paper, we discuss the role of hyperaldosteronism in the increasing risk of cardiac complications in COVID-19 older patients. In particular, we focus on the immunoregulatory activity of aldosterone, as the last mediator of the Renin Angiotensin System cascade, in activating the innate and adaptive immune response related to SARS-CoV-2 infection in the elderly. Aldosterone may stimulate dendritic cells and the recruitment of monocytes/macrophages in the endothelium of coronary vessels, favoring the production of pro-inflammatory mediators and T-cells response. Higher basal levels of aldosterone together with SARS-CoV-2-induced production may explain the unfavorable course of COVID-19 in the elderly.
MeSH term(s)	Adaptive Immunity ; Aged ; Aldosterone ; COVID-19 ; Humans ; Renin-Angiotensin System/physiology ; SARS-CoV-2
Chemical Substances	Aldosterone (4964P6T9RB)
Language	English
Publishing date	2021-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2886586-8
ISSN	2509-2723 ; 2509-2715
ISSN (online)	2509-2723
ISSN	2509-2715
DOI	10.1007/s11357-021-00481-4
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Article: Epicardial Adipose Tissue and Postoperative Atrial Fibrillation.

Petraglia, Laura / Conte, Maddalena / Comentale, Giuseppe / Cabaro, Serena / Campana, Pasquale / Russo, Carmela / Amaranto, Ilaria / Bruzzese, Dario / Formisano, Pietro / Pilato, Emanuele / Ferrara, Nicola / Leosco, Dario / Parisi, Valentina

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 810334

Abstract: Background: Atrial fibrillation (AF) often occurs after cardiac surgery and is associated with increased risk of stroke and mortality. Prior studies support the important role of inflammation in the pathogenesis of postoperative atrial fibrillation ( ... ...

Abstract	Background: Atrial fibrillation (AF) often occurs after cardiac surgery and is associated with increased risk of stroke and mortality. Prior studies support the important role of inflammation in the pathogenesis of postoperative atrial fibrillation (POAF). It is known that an increased volume and a pro-inflammatory phenotype of epicardial adipose tissue (EAT) are both associated with AF onset in non surgical context. In the present study, we aim to evaluate whether also POAF occurrence may be triggered by an increased production of inflammatory mediators from EAT. Methods: The study population was composed of 105 patients, with no history of paroxysmal or permanent AF, undergoing elective cardiac surgery. After clinical evaluation, all patients performed an echocardiographic study including the measurement of EAT thickness. Serum samples and EAT biopsies were collected before surgery. Levels of 10 inflammatory cytokines were measured in serum and EAT conditioned media. After surgery, cardiac rhythm was monitored for 7 days. Results: Forty-four patients (41.3%) developed POAF. As regard to cardiovascular therapy, only statin use was significantly lower in POAF patients (65.1% vs. 84.7%; Conclusion: Higher EAT levels of IL-6 and MCP-1 are significantly associated with the occurrence of POAF. Statin therapy seems to play a role in preventing POAF. These results might pave the way for a targeted use of these drugs in the perioperative period.
Language	English
Publishing date	2022-02-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.810334
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Article: Epicardial Adipose Tissue and Cardiac Arrhythmias: Focus on Atrial Fibrillation.

Conte, Maddalena / Petraglia, Laura / Cabaro, Serena / Valerio, Vincenza / Poggio, Paolo / Pilato, Emanuele / Attena, Emilio / Russo, Vincenzo / Ferro, Adele / Formisano, Pietro / Leosco, Dario / Parisi, Valentina

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 932262

Abstract: Atrial Fibrillation (AF) is the most frequent cardiac arrhythmia and its prevalence increases with age. AF is strongly associated with an increased risk of stroke, heart failure and cardiovascular mortality. Among the risk factors associated with AF ... ...

Abstract	Atrial Fibrillation (AF) is the most frequent cardiac arrhythmia and its prevalence increases with age. AF is strongly associated with an increased risk of stroke, heart failure and cardiovascular mortality. Among the risk factors associated with AF onset and severity, obesity and inflammation play a prominent role. Numerous recent evidence suggested a role of epicardial adipose tissue (EAT), the visceral fat depot of the heart, in the development of AF. Several potential arrhythmogenic mechanisms have been attributed to EAT, including myocardial inflammation, fibrosis, oxidative stress, and fat infiltration. EAT is a local source of inflammatory mediators which potentially contribute to atrial collagen deposition and fibrosis, the anatomical substrate for AF. Moreover, the close proximity between EAT and myocardium allows the EAT to penetrate and generate atrial myocardium fat infiltrates that can alter atrial electrophysiological properties. These observations support the hypothesis of a strong implication of EAT in structural and electrical atrial remodeling, which underlies AF onset and burden. The measure of EAT, through different imaging methods, such as echocardiography, computed tomography and cardiac magnetic resonance, has been proposed as a useful prognostic tool to predict the presence, severity and recurrence of AF. Furthermore, EAT is increasingly emerging as a promising potential therapeutic target. This review aims to summarize the recent evidence exploring the potential role of EAT in the pathogenesis of AF, the main mechanisms by which EAT can promote structural and electrical atrial remodeling and the potential therapeutic strategies targeting the cardiac visceral fat.
Language	English
Publishing date	2022-06-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.932262
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Article: Inflammation and Cardiovascular Diseases in the Elderly: The Role of Epicardial Adipose Tissue.

Conte, Maddalena / Petraglia, Laura / Poggio, Paolo / Valerio, Vincenza / Cabaro, Serena / Campana, Pasquale / Comentale, Giuseppe / Attena, Emilio / Russo, Vincenzo / Pilato, Emanuele / Formisano, Pietro / Leosco, Dario / Parisi, Valentina

Frontiers in medicine

2022 Volume 9, Page(s) 844266

Abstract: Human aging is a complex phenomenon characterized by a wide spectrum of biological changes which impact on behavioral and social aspects. Age-related changes are accompanied by a decline in biological function and increased vulnerability leading to ... ...

Abstract	Human aging is a complex phenomenon characterized by a wide spectrum of biological changes which impact on behavioral and social aspects. Age-related changes are accompanied by a decline in biological function and increased vulnerability leading to frailty, thereby advanced age is identified among the major risk factors of the main chronic human diseases. Aging is characterized by a state of chronic low-grade inflammation, also referred as inflammaging. It recognizes a multifactorial pathogenesis with a prominent role of the innate immune system activation, resulting in tissue degeneration and contributing to adverse outcomes. It is widely recognized that inflammation plays a central role in the development and progression of numerous chronic and cardiovascular diseases. In particular, low-grade inflammation, through an increased risk of atherosclerosis and insulin resistance, promote cardiovascular diseases in the elderly. Low-grade inflammation is also promoted by visceral adiposity, whose accumulation is paralleled by an increased inflammatory status. Aging is associated to increase in epicardial adipose tissue (EAT), the visceral fat depot of the heart. Structural and functional changes in EAT have been shown to be associated with several heart diseases, including coronary artery disease, aortic stenosis, atrial fibrillation, and heart failure. EAT increase is associated with a greater production and secretion of pro-inflammatory mediators and neuro-hormones, so that thickened EAT can pathologically influence, in a paracrine and vasocrine manner, the structure and function of the heart and is associated to a worse cardiovascular outcome. In this review, we will discuss the evidence underlying the interplay between inflammaging, EAT accumulation and cardiovascular diseases. We will examine and discuss the importance of EAT quantification, its characteristics and changes with age and its clinical implication.
Language	English
Publishing date	2022-02-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.844266
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Article: Epicardial Adipose Tissue-Derived IL-1β Triggers Postoperative Atrial Fibrillation.

Cabaro, Serena / Conte, Maddalena / Moschetta, Donato / Petraglia, Laura / Valerio, Vincenza / Romano, Serena / Di Tolla, Michele Francesco / Campana, Pasquale / Comentale, Giuseppe / Pilato, Emanuele / D'Esposito, Vittoria / Di Mauro, Annabella / Cantile, Monica / Poggio, Paolo / Parisi, Valentina / Leosco, Dario / Formisano, Pietro

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 893729

Abstract: Background and aims: ...

Abstract	Background and aims:
Language	English
Publishing date	2022-05-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.893729
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Article ; Online: Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance.

Conte, Maddalena / Poggio, Paolo / Monti, Maria / Petraglia, Laura / Cabaro, Serena / Bruzzese, Dario / Comentale, Giuseppe / Caruso, Aurelio / Grimaldi, Mariagabriella / Zampella, Emilia / Gencarelli, Annarita / Cervasio, Maria Rosaria / Cozzolino, Flora / Monaco, Vittoria / Myasoedova, Veronika / Valerio, Vincenza / Ferro, Adele / Insabato, Luigi / Bellino, Michele /

Galasso, Gennaro / Graziani, Francesca / Pucci, Pietro / Formisano, Pietro / Pilato, Emanuele / Cuocolo, Alberto / Perrone Filardi, Pasquale / Leosco, Dario / Parisi, Valentina

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition ... ...

Abstract	Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid deposition was found in 21 AS valves (37%), 4 sclerotic AVs (10%), and none of the controls. Patients with and without isolated AV amyloid deposition had similar clinical and echocardiographic characteristics and survival rates. Isolated AV amyloid deposition was associated with higher degrees of AV fibrosis (
MeSH term(s)	Humans ; Catheters ; Aortic Valve Stenosis ; Amyloidosis ; Calcification, Physiologic ; Calcinosis ; Interleukin-1beta
Chemical Substances	Interleukin-1beta
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021171
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Article: Epicardial Adipose Tissue and IL-13 Response to Myocardial Injury Drives Left Ventricular Remodeling After ST Elevation Myocardial Infarction.

Parisi, Valentina / Cabaro, Serena / D'Esposito, Vittoria / Petraglia, Laura / Conte, Maddalena / Campana, Pasquale / Gerundo, Gerardo / Abitabile, Marianna / Tuccillo, Andrea / Accadia, Maria / Comentale, Giuseppe / Pilato, Emanuele / Sansone, Mario / Leosco, Dario / Formisano, Pietro

Frontiers in physiology

2020 Volume 11, Page(s) 575181

Abstract: Introduction: Left ventricular (LV) remodeling after ST-segment elevation myocardial infarction (STEMI) is explained only in part by the infarct size, and the inter-patient variability may be ascribed to different inflammatory response to myocardial ... ...

Abstract	Introduction: Left ventricular (LV) remodeling after ST-segment elevation myocardial infarction (STEMI) is explained only in part by the infarct size, and the inter-patient variability may be ascribed to different inflammatory response to myocardial injury. Epicardial adipose tissue (EAT) is a source of inflammatory mediators which directly modulates the myocardium. EAT increase is associated to several cardiovascular diseases; however, its response to myocardial injury is currently unknown. Among inflammatory mediators, IL-13 seems to play protective role in LV regeneration, but its variations after STEMI have not been described yet. Purpose: In the present study we analyzed the association between infarct-related changes of EAT and IL-13 in post-STEMI LV remodeling. Methods: We enrolled 100 patients with STEMI undergoing primary angioplasty. At the enrolment (T0) and after 3 months (T1), we measured EAT thickness by echocardiography and circulating levels of IL-13 by ELISA. Results: At T1, the 60% of patients displayed increased EAT thickness (ΔEAT > 0). ΔEAT was directly associated to LV end-diastolic volume ( Conclusion: The variability of STEMI-induced "inflammatory response" may be associated to the post-infarct LV remodeling. ΔEAT thickness and ΔIL-13 levels could be novel prognostic markers in STEMI patients.
Language	English
Publishing date	2020-10-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2020.575181
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Article ; Online: The role of inflammation and metabolic risk factors in the pathogenesis of calcific aortic valve stenosis.

Conte, Maddalena / Petraglia, Laura / Campana, Pasquale / Gerundo, Gerardo / Caruso, Aurelio / Grimaldi, Maria Gabriella / Russo, Vincenzo / Attena, Emilio / Leosco, Dario / Parisi, Valentina

Aging clinical and experimental research

2020 Volume 33, Issue 7, Page(s) 1765–1770

Abstract: Given the epidemiologic increase of aged population in the world, aortic stenosis (AS) represents now the most common valvular heart disease in industrialized countries. It is a very challenging disease, representing an important cause of morbidity, ... ...

Abstract	Given the epidemiologic increase of aged population in the world, aortic stenosis (AS) represents now the most common valvular heart disease in industrialized countries. It is a very challenging disease, representing an important cause of morbidity, hospitalization and death in the elderly population. It is widely recognized that AS is the result of a very complex active process, driven by inflammation and involving multifactorial pathological mechanisms promoting valvular calcification and valvular bone deposition. Several evidence suggest that epicardial adipose tissue (EAT), the visceral fat depot of the heart, represents a direct source of cytokines and could mediate the deleterious effects of systemic inflammation on the myocardium. Importantly, obesity and metabolic disorders are associated with chronic systemic inflammation leading to a significant increase of EAT amount and to a pro-inflammatory phenotypic shift of this fat depot. It has been hypothesized that the EAT inflammatory state can influence the structure and function of the heart, thus contributing to the pathogenesis of several cardiac diseases, including calcific AS. The current review will discuss the recently discovered mechanisms involved in the pathogenesis of AS, with particular attention to the role of inflammation, metabolic risk factors and pro-fibrotic and pro-osteogenic signal pathways promoting the onset and progression of the disease. Moreover, it will be explored the potential role of EAT in the AS pathophysiology.
MeSH term(s)	Aged ; Aortic Valve ; Aortic Valve Stenosis ; Calcinosis ; Humans ; Inflammation ; Risk Factors
Language	English
Publishing date	2020-09-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-020-01681-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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