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Article ; Online: Response to: Neprilysin inhibitor-angiotensin II receptor blocker combination (sacubitril/valsartan).

Petramala, Luigi / Letizia, Claudio

European heart journal. Cardiovascular pharmacotherapy

2020 Volume 6, Issue 4, Page(s) 252

MeSH term(s)	Aminobutyrates ; Angiotensin Receptor Antagonists ; Anticoagulants ; Atrial Fibrillation ; Cardiology ; Drug Combinations ; Humans ; Neprilysin ; Stroke ; Tetrazoles ; Valsartan
Chemical Substances	Aminobutyrates ; Angiotensin Receptor Antagonists ; Anticoagulants ; Drug Combinations ; Tetrazoles ; Valsartan (80M03YXJ7I) ; Neprilysin (EC 3.4.24.11) ; sacubitril and valsartan sodium hydrate drug combination (WB8FT61183)
Language	English
Publishing date	2020-04-14
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2808613-2
ISSN	2055-6845 ; 2055-6837
ISSN (online)	2055-6845
ISSN	2055-6837
DOI	10.1093/ehjcvp/pvaa035
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Article ; Online: A speckle-tracking echocardiographic study on right ventricular function in primary aldosteronism.

Petramala, Luigi / Letizia, Claudio

Journal of hypertension

2020 Volume 38, Issue 11, Page(s) 2152–2153

MeSH term(s)	Echocardiography ; Humans ; Hyperaldosteronism/diagnostic imaging ; Ventricular Function, Right
Language	English
Publishing date	2020-10-07
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000002537
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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Relevance of obesity-related organ damage and metabolic syndrome classification in cardiovascular and renal risk stratification in patients with essential hypertension.

Petramala, Luigi / Gigante, Antonietta / Sarlo, Francesca / Servello, Adriana / Circosta, Francesco / Marino, Luca / Ciccarelli, Antonello / Cavallaro, Giuseppe / Letizia, Claudio

Frontiers in cardiovascular medicine

2024 Volume 11, Page(s) 1369090

Abstract: Introduction: Hypertension is a relevant cardiovascular comorbidity. Adipose tissue represents a metabolically active tissue involved in the regulation of blood pressure and metabolic alterations. In recent decades, several classifications for the ... ...

Abstract	Introduction: Hypertension is a relevant cardiovascular comorbidity. Adipose tissue represents a metabolically active tissue involved in the regulation of blood pressure and metabolic alterations. In recent decades, several classifications for the metabolic syndrome (MS) have been proposed. Recently, a new syndrome called the "Cardiovascular-kidney-metabolic" (CKM) syndrome was identified, to determine patients at high cardiovascular and metabolic risk. The aim of the study was to compare different classifications in a large population of hypertensive patients. Materials and methods: Between September 2022 and August 2023, we consecutively enrolled 772 hypertensive patients (407 men; 365 women; mean age 52.2 ± 15.1 years), evaluating anthropometric, biochemical, and instrumental parameters (transthoracic echocardiogram, carotid echo-Doppler, 24-h ambulatory blood pressure monitoring, fundus oculi). Results: Using different classifications we found MS prevalence: Adult Treatment Panel III (ATP-III) 28.8%, International Diabetes Federation (IDF) 31.5%, CKM 40.7%. CKM Classes 3 and 4 showed higher body mass index and waist circumference compared with other groups. Compared with ATP-III and IDF, CKM Class 4 showed higher 24-h systolic blood pressure, lower percentage of controlled hypertension, increased interventricular septum and posterior wall, reduced ejection fraction, and greater prevalence of hypertensive arterial retinal damage. Discussion: Visceral obesity and MS are frequent conditions with healthy impact, becoming an important trigger for the development of cardiovascular and metabolic complications. The different MS classifications allow the early identification of patients at high risk of cardiometabolic complications. The new CKM syndrome proves useful to identify individuals at high risk for CKM morbidity and mortality.
Language	English
Publishing date	2024-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2024.1369090
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Article ; Online: Clinical impact of transient lymphopenia.

Petramala, Luigi / Milito, Cinzia / Sarlo, Francesca / Servello, Adriana / Circosta, Francesco / Marino, Luca / Sardella, Germano / Trapani, Piero / D'aguanno, Giulio / Cimo', Antonino / Galardo, Gioacchino / Letizia, Claudio

Clinical and experimental medicine

2024 Volume 24, Issue 1, Page(s) 77

Abstract: Transient or persistent immunosuppression is a known risk factor for morbidity and mortality in critically ill patients. Aim of the present study is to evaluate the lymphopenia in patients admitted to the Emergency Unit of AOU Policlinico Umberto I, to ... ...

Abstract	Transient or persistent immunosuppression is a known risk factor for morbidity and mortality in critically ill patients. Aim of the present study is to evaluate the lymphopenia in patients admitted to the Emergency Unit of AOU Policlinico Umberto I, to investigate its prevalence at admission and the persistence during hospitalization until discharge. Possible correlations were evaluated between lymphopenia, diagnosis of admission, comorbidities and chronic treatments. In this study, 240 patients (142 men; 98 female; mean age 75.1 ± 15.1) were enrolled. Patients were divided into two groups according to the lymphocytes count at hospital admission, namely "Group A" with lymphopenia and "Group B" with values in the normal range. Moreover, the patients in group A were distinguished in relation to the regression or persistence of the lymphopenia assessed at the time of hospital discharge (Group A1: persistence; Group A2: normalization). Prevalence of lymphopenia at admission was 57%; Group A showed higher mean age and percentage of patients over 65 years of age; and none differences were observed regarding gender. Prevalence of lymphopenia at admission was 57%; Group A showed higher mean age and percentage of patients over 65 years of age; no differences were observed regarding gender. All subsets of the lymphocytes (CD4
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Aged ; Aged, 80 and over ; Lymphopenia/epidemiology ; Patient Discharge ; Emergency Service, Hospital ; Risk Factors
Language	English
Publishing date	2024-04-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-024-01340-0
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Article ; Online: Prognostic Role of sST2 in Acute Heart Failure and COVID-19 Infection-A Narrative Review on Pathophysiology and Clinical Prospective.

Marino, Luca / Concistrè, Antonio / Suppa, Marianna / Galardo, Gioacchino / Rosa, Antonello / Bertazzoni, Giuliano / Pugliese, Francesco / Letizia, Claudio / Petramala, Luigi

International journal of molecular sciences

2022 Volume 23, Issue 15

Abstract: The importance of cardiovascular biomarkers in clinical practice increased dramatically in the last years, and the interest extends from the diagnosis purpose to prognostic applications and response to specific treatment. Acute heart failure, ischemic ... ...

Abstract	The importance of cardiovascular biomarkers in clinical practice increased dramatically in the last years, and the interest extends from the diagnosis purpose to prognostic applications and response to specific treatment. Acute heart failure, ischemic heart failure, and COVID-19 infection represent different clinical settings that are challenging in terms of the proper prognostic establishment. The aim of the present review is to establish the useful role of sST2, the soluble form of the interleukin-1 receptor superfamily (ST2), physiologically involved in the signaling of interleukin-33 (IL-33)-ST2 axis, in the clinical setting of acute heart failure (HF), ischemic heart disease, and SARS-CoV-2 acute infection. Molecular mechanisms associated with the IL33/ST2 signaling pathways are discussed in view of the clinical usefulness of biomarkers to early diagnosis, evaluation therapy to response, and prediction of adverse outcomes in cardiovascular diseases.
MeSH term(s)	Biomarkers ; COVID-19 ; Heart Failure ; Humans ; Interleukin-1 Receptor-Like 1 Protein ; Prognosis ; Prospective Studies ; SARS-CoV-2
Chemical Substances	Biomarkers ; Interleukin-1 Receptor-Like 1 Protein
Language	English
Publishing date	2022-07-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23158230
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Article ; Online: Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism.

Petramala, Luigi / Concistrè, Antonio / Sarlo, Francesca / Baroni, Silvia / Suppa, Marianna / Servello, Adriana / Circosta, Francesco / Galardo, Gioacchino / Gandini, Orietta / Marino, Luca / Cavallaro, Giuseppe / Iannucci, Gino / Letizia, Claudio

International journal of molecular sciences

2023 Volume 24, Issue 5

Abstract: Pulmonary embolism (PE) is a potentially life-threatening disorder. Beyond its usefulness in the prognostic stratification of heart failure, sST2 can represent a biomarker with high utility in several acute conditions. Our study was aimed to investigate ... ...

Abstract	Pulmonary embolism (PE) is a potentially life-threatening disorder. Beyond its usefulness in the prognostic stratification of heart failure, sST2 can represent a biomarker with high utility in several acute conditions. Our study was aimed to investigate whether sST2 can be used as a clinical marker of severity and prognostic outcome in acute PE. We enrolled 72 patients with documented PE and 38 healthy subjects; we measured the plasma concentrations of sST2 to evaluate the prognostic and severity performance of different levels of sST2 according to its association with the pulmonary embolism severity index (PESI) score and several parameters of respiratory function. PE patients had significantly higher levels of sST2 compared with healthy subjects (87.74 ± 17.1 vs. 17.1 ± 0.4 ng/mL,
MeSH term(s)	Humans ; Pulmonary Embolism ; Biomarkers ; Lactates
Chemical Substances	Biomarkers ; Lactates
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24054591
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Article ; Online: Pulmonary embolism post-Covid-19 infection: physiopathological mechanisms and vascular damage biomarkers.

Petramala, Luigi / Sarlo, Francesca / Servello, Adriana / Baroni, Silvia / Suppa, Marianna / Circosta, Francesco / Galardo, Gioacchino / Gandini, Orietta / Marino, Luca / Cavallaro, Giuseppe / Iannucci, Gino / Concistrè, Antonio / Letizia, Claudio

Clinical and experimental medicine

2023 Volume 23, Issue 8, Page(s) 4871–4880

Abstract: Covid-19 infection is characterized by several acute complications, as well long-term sequelae, mostly sustained by endothelial dysfunction; several studies show that complications as pulmonary embolism (PE) are described both in the acute phase and ... ...

Abstract	Covid-19 infection is characterized by several acute complications, as well long-term sequelae, mostly sustained by endothelial dysfunction; several studies show that complications as pulmonary embolism (PE) are described both in the acute phase and after negativization. Aim of research was to evaluate anthropometric, bio-humoral, instrumental parameters in a group of patients affected by PE after recent Covid-19 infection compared to PE patients without previous Covid-19 infection. We enrolled 72 consecutive patients (35M, 37F) with acute PE, distinguished in relation to previous acute Covid-19 infection: 54 pts without previous acute Covid-19 infection and 18 pts with previous Covid-19 infection within negativity at least 2 months before PE diagnosis; 44 healthy subjects (21M, 23F) were recruited as control group. Patients who had previously developed Covid-19 needed hospitalization in high percentage (84%); this group showed significantly higher prevalence of diabetes mellitus than Covid-19-free PE patients, reduced serum levels of C-reactive protein, sST2 and PESI score. In post-Covid-19 PE group, we observed higher mean IMPROVE risk score, whereas in Covid-19-free group lower P/F ratio, higher radiological severity, and worse PESI score and severity index. Covid-19 infection affects not just the lung parenchyma but also other organs; endothelial damage plays pivotal role in long-term alterations; in high thrombotic risk group (recent hospitalization due to acute Covid-19 infection), we have described thrombotic complications characterized by persistent prothrombotic state after recovery, highlighted by well-known markers as PCR and D-Dimer as well as novel vascular marker (sST2).
MeSH term(s)	Humans ; COVID-19/complications ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnosis ; Biomarkers ; Lung ; Risk Factors
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-08-03
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-023-01150-w
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Jg. 1995 - 2021: Lesesall (2.OG)
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Article: Application of enhanced recovery after surgery (ERAS) protocols in adrenal surgery: A retrospective, preliminary analysis.

Lelli, Giulio / Micalizzi, Alessandra / Iossa, Angelo / Fassari, Alessia / Concistre, Antonio / Circosta, Francesco / Petramala, Luigi / De Angelis, Francesco / Letizia, Claudio / Cavallaro, Giuseppe

Journal of minimal access surgery

2023 Volume 20, Issue 2, Page(s) 163–168

Abstract: Background: The present study was conducted to evaluate the impact of enhanced recovery after surgery (ERAS) pathway in patients undergoing laparoscopic adrenalectomy (LA) for primary and secondary adrenal disease, in reducing the length of primary ... ...

Abstract	Background: The present study was conducted to evaluate the impact of enhanced recovery after surgery (ERAS) pathway in patients undergoing laparoscopic adrenalectomy (LA) for primary and secondary adrenal disease, in reducing the length of primary hospital stay and return to daily activities. Materials and methods: This retrospective study was carried out on 61 patients who underwent LA. A total of 32 patients formed the ERAS group. A total of 29 patients received conventional perioperative care and were assigned as the control group. Groups were compared in terms of patient's characteristics (sex, age, pre-operative diagnosis, side of tumour, tumour size and co-morbidities), post-operative compliance (anaesthesia time, operative time, post-operative stay, post-operative numeric rating scale (NRS) score, analgesic assumption and days to return to daily activities) and post-operative complications. Results: No significant differences in anaesthesia time ( P = 0.4) and operative time ( P = 0.6) were reported. NRS score 24 h postoperatively was significantly lower in the ERAS group ( P < 0.05). The analgesic assumption in post-operative period in the ERAS group was lower ( P < 0.05). ERAS protocol led to a significantly shorter length of post-operative stay ( P < 0.05) and to return to daily activities ( P < 0.05). No differences in peri-operative complications were reported. Discussion: ERAS protocols seem safe and feasible, potentially improving perioperative outcomes of patients undergoing LA, mainly improving pain control, hospital stay and return to daily activities. Further studies are needed to investigate overall compliance with ERAS protocols and their impact on clinical outcomes.
Language	English
Publishing date	2023-05-10
Publishing country	India
Document type	Journal Article
ZDB-ID	2186884-0
ISSN	1998-3921 ; 0972-9941
ISSN (online)	1998-3921
ISSN	0972-9941
DOI	10.4103/jmas.jmas_319_22
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Article ; Online: Evaluation of Intra-Renal Stiffness in Patients with Primary Aldosteronism.

Petramala, Luigi / Concistrè, Antonio / Circosta, Francesco / Gigante, Antonietta / Sarlo, Francesca / Schina, Mauro / Soldini, Maurizio / Iannucci, Gino / Cianci, Rosario / Letizia, Claudio

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

2021 Volume 29, Issue 1, Page(s) 49–56

Abstract: Intorduction: Aldosterone is known to play important role in developing cardiovascular, metabolic, renal damage in hypertensive patients.: Aim: Aim of study was to evaluate parameters obtained by eco-color Doppler study, as non-invasive and easly ... ...

Abstract	Intorduction: Aldosterone is known to play important role in developing cardiovascular, metabolic, renal damage in hypertensive patients. Aim: Aim of study was to evaluate parameters obtained by eco-color Doppler study, as non-invasive and easly performed method in asyntomatic patients with Essential Hypertension (EH) and Primary Aldosteronism (PA), without overt organ damage. Methods: From April 2019 to March 2020 we consecutively enrolled 73 hypertensive subjects (48 males, 25 women), distinguished in two groups: 30 EH patients (mean age 49.5 ± 18.7 years) and 43 PA patients (mean age 53.1 ± 11.6 years)] [23 with aldosterone-secreting adrenal adenoma (APA), 20 with idiopathic aldosteronism (IHA)]. Results: PA group showed higher renal filtration rate and 24-h urinary excretion of albumin respect to EH; moreover, in PA we found higher Pulsatility Index, altered percentage of Renale Resistance Index, Atrophy Index, and reducted parietal thickness than EH. The correlation study showed that plasma aldosterone were positively correlated with pulsatility index in PA group (right r = 0.35; p < 0.05; left r = 0.36; p < 0.05). Conclusion: parameters obtained through the intra-renal eco-color Doppler examination, easly performed and non-invasive, can be useful in the early-stage identification of subclinical microvascular alterations, especially in PA, condition characterized by increased risk of cardio-vascular remodelling and metabolic alterations.
MeSH term(s)	Adult ; Aged ; Aldosterone ; Essential Hypertension/diagnostic imaging ; Female ; Humans ; Hyperaldosteronism/diagnostic imaging ; Hypertension/diagnosis ; Male ; Middle Aged ; Risk Assessment
Chemical Substances	Aldosterone (4964P6T9RB)
Language	English
Publishing date	2021-11-10
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	1236337-6
ISSN	1179-1985 ; 1120-9879
ISSN (online)	1179-1985
ISSN	1120-9879
DOI	10.1007/s40292-021-00485-3
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Zs.A 4289: Show issues

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Article ; Online: Natural Activators of Autophagy Reduce Oxidative Stress and Muscle Injury Biomarkers in Endurance Athletes: A Pilot Study.

D'Amico, Alessandra / Fossati, Chiara / Pigozzi, Fabio / Borrione, Paolo / Peruzzi, Mariangela / Bartimoccia, Simona / Saba, Filippo / Pingitore, Annachiara / Biondi-Zoccai, Giuseppe / Petramala, Luigi / De Grandis, Fabrizio / Vecchio, Daniele / D'Ambrosio, Luca / Schiavon, Sonia / Sciarra, Luigi / Nocella, Cristina / Cavarretta, Elena

Nutrients

2023 Volume 15, Issue 2

Abstract: Background: Oxidative stress and impaired autophagy are directly and indirectly implicated in exercise-mediated muscle injury. Trehalose, spermidine, nicotinamide, and polyphenols possess pro-autophagic and antioxidant properties, and could therefore ... ...

Abstract	Background: Oxidative stress and impaired autophagy are directly and indirectly implicated in exercise-mediated muscle injury. Trehalose, spermidine, nicotinamide, and polyphenols possess pro-autophagic and antioxidant properties, and could therefore reduce exercise-induced damage to skeletal muscle. The aim of this study was to investigate whether a mixture of these compounds was able to improve muscle injury biomarkers in endurance athletes through the modulation of oxidative stress and autophagic machinery. Methods and results: sNOX2-dp; H Conclusion: Supplementation with this mixture positively affected redox state and autophagy and improved muscle injury biomarkers in athletes, allowing for better muscle recovery. Moreover, it is speculated that this mixture could also benefit patients suffering from muscle injuries, such as cancer or cardiovascular patients, or elderly subjects.
MeSH term(s)	Humans ; Aged ; Pilot Projects ; Hydrogen Peroxide ; Oxidative Stress ; Antioxidants/pharmacology ; Athletes ; Muscle, Skeletal ; Biomarkers ; Autophagy
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Antioxidants ; Biomarkers
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15020459
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