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  1. Article ; Online: Hyperthermia and Serotonin: The Quest for a "Better Cyproheptadine".

    Petroianu, Georg A

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: Fine temperature control is essential in homeothermic animals. Both hyper- and hypothermia can have deleterious effects. Multiple, efficient and partly redundant mechanisms of adjusting the body temperature to the value set by the internal thermostat ... ...

    Abstract Fine temperature control is essential in homeothermic animals. Both hyper- and hypothermia can have deleterious effects. Multiple, efficient and partly redundant mechanisms of adjusting the body temperature to the value set by the internal thermostat exist. The neural circuitry of temperature control and the neurotransmitters involved are reviewed. The GABAergic inhibitory output from the brain thermostat in the preoptic area POA to subaltern neural circuitry of temperature control (Nucleus Raphe Dorsalis and Nucleus Raphe Pallidus) is a function of the balance between the (opposite) effects mediated by the transient receptor potential receptor TRPM2 and EP3 prostaglandin receptors. Activation of TRPM2-expressing neurons in POA favors hypothermia, while inhibition has the opposite effect. Conversely, EP3 receptors induce elevation in body temperature. Activation of EP3-expressing neurons in POA results in hyperthermia, while inhibition has the opposite effect. Agonists at TRPM2 and/or antagonists at EP3 could be beneficial in hyperthermia control. Activity of the neural circuitry of temperature control is modulated by a variety of 5-HT receptors. Based on the theoretical model presented the "ideal" antidote against serotonin syndrome hyperthermia appears to be an antagonist at the 5-HT receptor subtypes 2, 4 and 6 and an agonist at the receptor subtypes 1, 3 and 7. Very broadly speaking, such a profile translates in a sympatholytic effect. While a compound with such an ideal profile is presently not available, better matches than the conventional antidote cyproheptadine (used off-label in severe serotonin syndrome cases) appear to be possible and need to be identified.
    MeSH term(s) Animals ; Antidotes ; Cyproheptadine/pharmacology ; Hyperthermia ; Hyperthermia, Induced ; Hypothermia ; Serotonin/pharmacology ; Serotonin Syndrome ; TRPM Cation Channels
    Chemical Substances Antidotes ; TRPM Cation Channels ; Cyproheptadine (2YHB6175DO) ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2022-03-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: On saline infusion, clonus, molecules and forgotten scientists: Who was Dr Julius Sander (1840-1909)?

    Petroianu, Georg A

    Journal of medical biography

    2021  Volume 32, Issue 1, Page(s) 36–41

    Abstract: Zitterbewegungen des Fusses bei ... ...

    Abstract Zitterbewegungen des Fusses bei Dorsalflexion
    MeSH term(s) Humans ; Physiology/history ; History, 19th Century ; Saline Solution
    Chemical Substances Saline Solution
    Language English
    Publishing date 2021-12-16
    Publishing country England
    Document type Biography ; Journal Article
    ZDB-ID 1159267-9
    ISSN 1758-1087 ; 0967-7720
    ISSN (online) 1758-1087
    ISSN 0967-7720
    DOI 10.1177/09677720211065357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Singultus, paper-bag ventilation, and hypercapnia.

    Petroianu, Georg A

    Journal of the history of the neurosciences

    2020  Volume 29, Issue 3, Page(s) 286–298

    Abstract: Sir Louis Francis Knuthsen (1869-1957), the physician who painstakingly listed almost all treatments known for obstinate hiccough, ascribes the holding of breath method to Philip Henry Pye-Smith, FRS (1840-1914), consultant at Guy's Hospital in London. ... ...

    Abstract Sir Louis Francis Knuthsen (1869-1957), the physician who painstakingly listed almost all treatments known for obstinate hiccough, ascribes the holding of breath method to Philip Henry Pye-Smith, FRS (1840-1914), consultant at Guy's Hospital in London. In fact, the strategy is much older and was mentioned by greats such as Francis Bacon (1561-1626), Aristoteles (384-322 BC), and Eryximachus (late-fifth century bce). Hypoventilation to reduce central nervous system excitability was used in antiquity as evidenced by Cyriacus' treatment of Artemia, the daughter of Emperor Diocletian (≈ 244-311). She was suffering from (among others) seizures that Cyriacus was apparently controlling by tightening a scarf around her neck, as depicted by Mathias Grünewald (1460-1528) on a wing of the so-called Heller Altar now on display at the Historical Museum, Frankfurt, Germany. In modern times, around 1920, inducing hypercapnia by CO
    MeSH term(s) Europe ; Hiccup/history ; Hiccup/physiopathology ; Hiccup/therapy ; History, 19th Century ; History, 20th Century ; Humans ; Hypercapnia ; Hypoventilation/therapy ; Physicians
    Language English
    Publishing date 2020-01-08
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 1233549-6
    ISSN 1744-5213 ; 0964-704X
    ISSN (online) 1744-5213
    ISSN 0964-704X
    DOI 10.1080/0964704X.2019.1708161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Abolishing the venous-arterial CO

    Petroianu, Georg A

    The clinical respiratory journal

    2019  Volume 13, Issue 6, Page(s) 408–409

    MeSH term(s) Blood Gas Analysis ; Carbon Dioxide ; Hiccup ; Humans ; Hypercapnia
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2019-05-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2442214-9
    ISSN 1752-699X ; 1752-6981
    ISSN (online) 1752-699X
    ISSN 1752-6981
    DOI 10.1111/crj.13021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Neuropathic pain: Mechanisms and therapeutic strategies.

    Petroianu, Georg A / Aloum, Lujain / Adem, Abdu

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1072629

    Abstract: The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The number of pharmacodynamically distinct and clinically available ... ...

    Abstract The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The number of pharmacodynamically distinct and clinically available medications is low and the successes achieved modest. Pain Medicine practitioners are confronted with the ethical dichotomy imposed by Hippocrates: On one hand the mandate of
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1072629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Endogenous ionone. Commentary on "Study on the developmental toxicity of β-ionone in the rat".

    Petroianu, Georg A

    Regulatory toxicology and pharmacology : RTP

    2018  Volume 101, Page(s) 194–195

    MeSH term(s) Animals ; Norisoprenoids ; Rats
    Chemical Substances Norisoprenoids ; beta-ionone (A7NRR1HLH6)
    Language English
    Publishing date 2018-12-06
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2018.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1711: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Chitosan-based nanoparticles in Alzheimer's disease: messenger or message?

    Manek, Eniko / Petroianu, Georg A

    Neural regeneration research

    2021  Volume 16, Issue 11, Page(s) 2204–2205

    Language English
    Publishing date 2021-04-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.310685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives.

    Khalid, Mariyam / Petroianu, Georg / Adem, Abdu

    Biomolecules

    2022  Volume 12, Issue 4

    Abstract: Persistent hyperglycemic state in type 2 diabetes mellitus leads to the initiation and progression of non-enzymatic glycation reaction with proteins and lipids and nucleic acids. Glycation reaction leads to the generation of a heterogeneous group of ... ...

    Abstract Persistent hyperglycemic state in type 2 diabetes mellitus leads to the initiation and progression of non-enzymatic glycation reaction with proteins and lipids and nucleic acids. Glycation reaction leads to the generation of a heterogeneous group of chemical moieties known as advanced glycated end products (AGEs), which play a central role in the pathophysiology of diabetic complications. The engagement of AGEs with its chief cellular receptor, RAGE, activates a myriad of signaling pathways such as MAPK/ERK, TGF-β, JNK, and NF-κB, leading to enhanced oxidative stress and inflammation. The downstream consequences of the AGEs/RAGE axis involve compromised insulin signaling, perturbation of metabolic homeostasis, RAGE-induced pancreatic beta cell toxicity, and epigenetic modifications. The AGEs/RAGE signaling instigated modulation of gene transcription is profoundly associated with the progression of type 2 diabetes mellitus and pathogenesis of diabetic complications. In this review, we will summarize the exogenous and endogenous sources of AGEs, their role in metabolic dysfunction, and current understandings of AGEs/RAGE signaling cascade. The focus of this review is to recapitulate the role of the AGEs/RAGE axis in the pathogenesis of type 2 diabetes mellitus and its associated complications. Furthermore, we present an overview of future perspectives to offer new therapeutic interventions to intervene with the AGEs/RAGE signaling pathway and to slow down the progression of diabetes-related complications.
    MeSH term(s) Diabetes Complications ; Diabetes Mellitus, Type 2 ; Glycation End Products, Advanced/metabolism ; Humans ; NF-kappa B/metabolism ; Oxidative Stress ; Receptor for Advanced Glycation End Products/metabolism
    Chemical Substances Glycation End Products, Advanced ; NF-kappa B ; Receptor for Advanced Glycation End Products
    Language English
    Publishing date 2022-04-04
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12040542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Anästhesie in Frage und Antwort

    Petroianu, Georg / Osswald, Peter M.

    2000  

    Author's details G. Petroianu ; P. M. Osswald
    Keywords Anesthesiology / examination questions ; Anästhesie
    Language German
    Size XII, 442 S. : Ill.
    Edition 3., völlig überarb. und erw. Aufl.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT012814362
    ISBN 3-540-66276-6 ; 978-3-540-66276-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 A 3991 order for loan Magazin

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  10. Article: The Role of Serotonin in Singultus: A Review.

    Petroianu, Georg A / Lorke, Dietrich E

    Frontiers in neuroscience

    2020  Volume 14, Page(s) 629

    Abstract: The use of dopamine receptor blockers for chronic singultus treatment is based-at least partially-on circular thinking: chlorpromazine is FDA-approved for hiccups, chlorpromazine is a neuroleptic, neuroleptics are dopamine receptor blockers, and ... ...

    Abstract The use of dopamine receptor blockers for chronic singultus treatment is based-at least partially-on circular thinking: chlorpromazine is FDA-approved for hiccups, chlorpromazine is a neuroleptic, neuroleptics are dopamine receptor blockers, and therefore hiccup is due to dopaminergic dysfunction. Chlorpromazine interacts with high affinity with a multitude of receptors and ion channels. This promiscuity is the basis for many of the therapeutic effects and adverse drug reactions of this drug. While an involvement of dopamine is certain, it is by no means clear that dopaminergic dysfunction is the hallmark of singultus. The common denominator of most remedies for transient hiccup is their ability to activate the vagus nerve. Both afferent and efferent vagal activity and the central integration of the Xth cranial nerve function are modulated, inter alia, via serotonergic mechanisms; beneficial (therapeutic) effects for hiccup are to be expected from serotonin (5-HT) receptor subtype ligands that enhance vagal activity. Taken together, it appears that the ability to increase vagus output is mainly associated with 5-HT
    Language English
    Publishing date 2020-07-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2020.00629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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