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  1. Book ; Online ; E-Book: Non-canonical autophagy

    Petroni, Giulia / Galluzzi, Lorenzo

    mechanisms and pathophysiological implications

    2021  

    Abstract: Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between 'canonical' and 'non-canonical' forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional ... ...

    Author's details editors, Giulia Petroni, Lorenzo Galluzzi
    Abstract Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between 'canonical' and 'non-canonical' forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of 'non-canonical' autophagy. The book discusses all forms of 'non-canonical' autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying 'non-canonical' autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies
    Keywords Autophagic vacuoles
    Subject code 571.655
    Language English
    Size 1 online resource (184 pages)
    Publisher Academic Press
    Publishing place London
    Document type Book ; Online ; E-Book
    Note Includes index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-820911-9 ; 0-12-820538-5 ; 978-0-12-820911-0 ; 978-0-12-820538-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Cellular Senescence and Aging

    Petroni, Giulia / Kepp, Oliver / Galluzzi, Lorenzo

    2024  

    Subject code 571.6
    Language English
    Size 1 online resource (252 pages)
    Edition 1st ed.
    Publisher Elsevier Science & Technology
    Publishing place San Diego
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-18896-3 ; 0-443-18897-1 ; 978-0-443-18896-1 ; 978-0-443-18897-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Targeting potassium channels and autophagy to defeat chemoresistance.

    Petroni, Giulia

    Molecular & cellular oncology

    2020  Volume 7, Issue 3, Page(s) 1745038

    Abstract: Both autophagy and hERG1 potassium channels have been shown to promote tumor progression and resistance to treatment. Our findings indicate that the antibiotic clarithromycin can target hERG1 and modulate autophagy to promote the death of chemoresistant ... ...

    Abstract Both autophagy and hERG1 potassium channels have been shown to promote tumor progression and resistance to treatment. Our findings indicate that the antibiotic clarithromycin can target hERG1 and modulate autophagy to promote the death of chemoresistant colorectal cancer cells. Thus, clarithromycin stands out as promising combinatorial partner to improve the efficacy of chemotherapy in patients with colorectal cancer.
    Language English
    Publishing date 2020-03-30
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2020.1745038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cellular senescence and aging at the crossroad between immunity and cancer.

    Kepp, Oliver / Galluzzi, Lorenzo / Petroni, Giulia

    Methods in cell biology

    2024  Volume 181, Page(s) xvii–xxiv

    MeSH term(s) Humans ; Aging/genetics ; Cellular Senescence ; Neoplasms/genetics
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Editorial
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/S0091-679X(24)00009-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exploiting Tertiary Lymphoid Structures to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy.

    Petroni, Giulia / Pillozzi, Serena / Antonuzzo, Lorenzo

    Cancer research

    2024  Volume 84, Issue 8, Page(s) 1199–1209

    Abstract: Tumor-associated tertiary lymphoid structures (TLS) have been associated with favorable clinical outcomes and response to immune checkpoint inhibitors in many cancer types, including non-small cell lung cancer. Although the detailed cellular and ... ...

    Abstract Tumor-associated tertiary lymphoid structures (TLS) have been associated with favorable clinical outcomes and response to immune checkpoint inhibitors in many cancer types, including non-small cell lung cancer. Although the detailed cellular and molecular mechanisms underlying these clinical associations have not been fully elucidated, growing preclinical and clinical studies are helping to elucidate the mechanisms at the basis of TLS formation, composition, and regulation of immune responses. However, a major challenge remains how to exploit TLS to enhance naïve and treatment-mediated antitumor immune responses. Here, we discuss the current understanding of tumor-associated TLS, preclinical models that can be used to study them, and potential therapeutic interventions to boost TLS formation, with a particular focus on lung cancer research.
    MeSH term(s) Humans ; Tertiary Lymphoid Structures ; Carcinoma, Non-Small-Cell Lung/therapy ; Lung Neoplasms/therapy ; Immunotherapy
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-23-3325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Unconventional strategy could be the future: From target to KRAS broad range treatment.

    Fancelli, Sara / Petroni, Giulia / Pillozzi, Serena / Antonuzzo, Lorenzo

    Heliyon

    2024  Volume 10, Issue 9, Page(s) e29739

    Abstract: The RAS gene family comprises genes that regulate cell growth and differentiation. KRAS, a member of this family, is often mutated in different cancers, resulting in uncontrolled cell growth and tumor development. Recent clinical trial results on KRAS ... ...

    Abstract The RAS gene family comprises genes that regulate cell growth and differentiation. KRAS, a member of this family, is often mutated in different cancers, resulting in uncontrolled cell growth and tumor development. Recent clinical trial results on KRAS inhibition in NSCLC have defined the presence of a significant proportion of patients resistant to direct G12C inhibition. The presence of co-mutations and the occurrence of secondary resistance phenomena observed in preclinical and clinical settings partly justify these poor results. In addition, all other non-G12C mutations currently remain without specific strategies. Evidence of interactions between KRAS signaling and the TME suggests potential
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of treatment schedule on the efficacy of cytostatic and immunostimulatory agents.

    Petroni, Giulia / Galluzzi, Lorenzo

    Oncoimmunology

    2021  Volume 10, Issue 1, Page(s) 1889101

    Abstract: Radiation therapy (RT) and cyclin-dependent kinase 4/6 (CDK4/6) inhibitors mediate poorly overlapping cytostatic and immunostimulatory effects, suggesting that combinatorial regimens may enable supra-additive tumor control. Our preclinical findings ... ...

    Abstract Radiation therapy (RT) and cyclin-dependent kinase 4/6 (CDK4/6) inhibitors mediate poorly overlapping cytostatic and immunostimulatory effects, suggesting that combinatorial regimens may enable supra-additive tumor control. Our preclinical findings demonstrate that administration schedule stands out as a major determinant of efficacy when RT and CDK4/6 inhibitors are combined for breast cancer therapy.
    MeSH term(s) Breast Neoplasms/drug therapy ; Cyclin-Dependent Kinase 4 ; Cyclin-Dependent Kinase 6 ; Cytostatic Agents ; Female ; Humans
    Chemical Substances Cytostatic Agents ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; Cyclin-Dependent Kinase 6 (EC 2.7.11.22)
    Language English
    Publishing date 2021-02-19
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2021.1889101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cancer Immunotherapy with CDK7 Inhibitors.

    Petroni, Giulia / Galluzzi, Lorenzo

    Trends in cancer

    2020  Volume 6, Issue 5, Page(s) 361–363

    Abstract: Recent findings demonstrate that pharmacological cyclin-dependent kinase 7 (CDK7) inhibitors can evoke anticancer immunity upon genomic destabilization of neoplastic cells. Besides adding CDK7 to the expanding list of cell cycle proteins that impinge on ... ...

    Abstract Recent findings demonstrate that pharmacological cyclin-dependent kinase 7 (CDK7) inhibitors can evoke anticancer immunity upon genomic destabilization of neoplastic cells. Besides adding CDK7 to the expanding list of cell cycle proteins that impinge on immune regulation, these results support the value of aggravating genomic instability in cancer cells to enable immunological disease control.
    MeSH term(s) Genomic Instability ; Humans ; Immunotherapy ; Neoplasms
    Language English
    Publishing date 2020-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2020.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Senescence Inflames the Pancreatic Tumor Microenvironment.

    Petroni, Giulia / Galluzzi, Lorenzo

    Cell reports. Medicine

    2020  Volume 1, Issue 2, Page(s) 100020

    Abstract: Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue ... ...

    Abstract Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of
    MeSH term(s) CD8-Positive T-Lymphocytes ; Carcinoma, Pancreatic Ductal ; Humans ; Immunotherapy ; Pancreatic Neoplasms/drug therapy ; Tumor Microenvironment
    Language English
    Publishing date 2020-05-19
    Publishing country United States
    Document type News ; Comment
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2020.100020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Immunogenic Therapies Drive CAR T Cells towards Superior Efficacy.

    Petroni, Giulia / Kroemer, Guido / Galluzzi, Lorenzo

    Trends in cancer

    2021  Volume 7, Issue 3, Page(s) 179–181

    Abstract: Autologous T cells engineered to express a chimeric antigen receptor (CAR) remain poorly effective against solid tumors, partly because solid neoplasms can establish an immunosuppressive microenvironment. Recent findings by Srivastava et al. suggest that ...

    Abstract Autologous T cells engineered to express a chimeric antigen receptor (CAR) remain poorly effective against solid tumors, partly because solid neoplasms can establish an immunosuppressive microenvironment. Recent findings by Srivastava et al. suggest that immunogenic chemotherapeutics such as oxaliplatin can be harnessed to maximize the capacity of CAR T cells to infiltrate and control solid tumors.
    MeSH term(s) Humans ; Neoplasms ; Receptors, Chimeric Antigen ; T-Lymphocytes ; Tumor Microenvironment
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2021.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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