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Article ; Online: Pyrimidopteridine-catalyzed Photo-mediated Hydroacetoxylation.

Petrosyan, Andranik / Zach, Luisa / Taeufer, Tobias / Mayer, T S / Rabeah, Jabor / Pospech, Jola

Chemistry (Weinheim an der Bergstrasse, Germany)

2022 Volume 28, Issue 57, Page(s) e202201761

Abstract: Herein we report a photo-mediated formal addition of carboxylic acids to activated alkenes catalyzed by a pyrimidopteridine photoredox catalyst. The decarboxylation of aliphatic carboxylic acids upon single-electron oxidation is countered in the presence ...

Abstract	Herein we report a photo-mediated formal addition of carboxylic acids to activated alkenes catalyzed by a pyrimidopteridine photoredox catalyst. The decarboxylation of aliphatic carboxylic acids upon single-electron oxidation is countered in the presence of electron-rich alkenes and a hydroacetoxylation is observed. Mechanistic proposals have been made based on CV measurements, competitive Stern-Volmer quenching and EPR experiments. Evidence that tetra-N-substituted pyrimidopteridines function as dual photoredox and hydrogen atom transfer catalyst was supported by spectroscopic means.
MeSH term(s)	Alkenes/chemistry ; Carboxylic Acids/chemistry ; Catalysis ; Hydrogen/chemistry ; Oxidation-Reduction
Chemical Substances	Alkenes ; Carboxylic Acids ; Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2022-08-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202201761
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Article ; Online: Regional anaesthesia via parasternal catheters inserted preoperatively and postoperative delirium after cardiac surgery: A prospective unrandomised clinical trial.

Elhadjene, Nory / Grand, Nathalie / Azarnoush, Kasra / Petrosyan, Andranik / Raissouni, Khalil / Campisi, Salvatore / Sandri, Fabrizio / Palao, Jean Charles / Awad, Sahar / Magand, Clément / Molliex, Serge / Ollier, Edouard / Morel, Jérôme / Lanoiselee, Julien

European journal of anaesthesiology

2024 Volume 41, Issue 6, Page(s) 447–450

Abstract: Visual abstract: http://links.lww.com/EJA/A927. ...

Abstract	Visual abstract: http://links.lww.com/EJA/A927.
MeSH term(s)	Humans ; Prospective Studies ; Cardiac Surgical Procedures/adverse effects ; Male ; Aged ; Female ; Anesthesia, Conduction/methods ; Emergence Delirium/prevention & control ; Emergence Delirium/etiology ; Emergence Delirium/diagnosis ; Emergence Delirium/epidemiology ; Middle Aged ; Preoperative Care/methods ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Delirium/etiology ; Delirium/prevention & control ; Delirium/diagnosis
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Letter ; Clinical Trial ; Journal Article
ZDB-ID	605770-6
ISSN	1365-2346 ; 0265-0215
ISSN (online)	1365-2346
ISSN	0265-0215
DOI	10.1097/EJA.0000000000001973
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Article ; Online: Factors Influencing Unfractionated Heparin Pharmacokinetics and Pharmacodynamics During a Cardiopulmonary Bypass.

Gibert, Audrick / Lanoiselée, Julien / Gouin-Thibault, Isabelle / Pontis, Adeline / Azarnoush, Kasra / Petrosyan, Andranik / Grand, Nathalie / Molliex, Serge / Morel, Jérome / Gergelé, Laurent / Hodin, Sophie / Bin, Valérie / Chaux, Robin / Delavenne, Xavier / Ollier, Edouard

Clinical pharmacokinetics

2024 Volume 63, Issue 2, Page(s) 211–225

Abstract: Background: Unfractionated heparin (UFH) is commonly used during cardiac surgery with a cardiopulmonary bypass to prevent blood clotting. However, empirical administration of UFH leads to variable responses. Pharmacokinetic and pharmacodynamic modeling ... ...

Abstract	Background: Unfractionated heparin (UFH) is commonly used during cardiac surgery with a cardiopulmonary bypass to prevent blood clotting. However, empirical administration of UFH leads to variable responses. Pharmacokinetic and pharmacodynamic modeling can be used to optimize UFH dosing and perform real-time individualization. In previous studies, many factors that could influence UFH pharmacokinetics/pharmacodynamics had not been taken into account such as hemodilution or the type of UFH. Few covariates were identified probably owing to a lack of statistical power. This study aims to address these limitations through a meta-analysis of individual data from two studies. Methods: An individual patient data meta-analysis was conducted using data from two single-center prospective observational studies, where different UFH types were used for anticoagulation. A pharmacodynamic/pharmacodynamic model of UFH was developed using a non-linear mixed-effects approach. Time-varying covariates such as hemodilution and fluid infusions during a cardiopulmonary bypass were considered. Results: Activities of UFH's anti-activated factor/anti-thrombin were best described by a two-compartment model. Unfractionated heparin clearance was influenced by body weight and the specific UFH type. Volume of distribution was influenced by body weight and pre-operative fibrinogen levels. Pharmacodynamic data followed a log-linear model, accounting for the effect of hemodilution and the pre-operative fibrinogen level. Equations were derived from the model to personalize UFH dosing based on the targeted activated clotting time level and patient covariates. Conclusions: The population model effectively characterized UFH's pharmacokinetics/pharmacodynamics in cardiopulmonary bypass patients. This meta-analysis incorporated new covariates related to UFH's pharmacokinetics/pharmacodynamics, enabling personalized dosing regimens. The proposed model holds potential for individualization using a Bayesian estimation.
MeSH term(s)	Humans ; Heparin/pharmacokinetics ; Cardiopulmonary Bypass ; Bayes Theorem ; Body Weight ; Fibrinogen ; Anticoagulants/pharmacokinetics ; Observational Studies as Topic
Chemical Substances	Heparin (9005-49-6) ; Fibrinogen (9001-32-5) ; Anticoagulants
Language	English
Publishing date	2024-01-02
Publishing country	Switzerland
Document type	Meta-Analysis ; Journal Article
ZDB-ID	197627-8
ISSN	1179-1926 ; 0312-5963
ISSN (online)	1179-1926
ISSN	0312-5963
DOI	10.1007/s40262-023-01334-3
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Article ; Online: Mechanistic Insight into the Mode of Action of Acid β-Glucosidase Enhancer Ambroxol.

Pantoom, Supansa / Hules, Larissa / Schöll, Christopher / Petrosyan, Andranik / Monticelli, Maria / Pospech, Jola / Cubellis, Maria Vittoria / Hermann, Andreas / Lukas, Jan

International journal of molecular sciences

2022 Volume 23, Issue 7

Abstract: Ambroxol (ABX) is a mucolytic agent used for the treatment of respiratory diseases. Bioactivity has been demonstrated as an enhancement effect on lysosomal acid β-glucosidase (β-Glu) activity in Gaucher disease (GD). The positive effects observed have ... ...

Abstract	Ambroxol (ABX) is a mucolytic agent used for the treatment of respiratory diseases. Bioactivity has been demonstrated as an enhancement effect on lysosomal acid β-glucosidase (β-Glu) activity in Gaucher disease (GD). The positive effects observed have been attributed to a mechanism of action similar to pharmacological chaperones (PCs), but an exact mechanistic description is still pending. The current study uses cell culture and in vitro assays to study the effects of ABX on β-Glu activity, processing, and stability upon ligand binding. Structural analogues bromohexine, 4-hydroxybromohexine, and norbromohexine were screened for chaperone efficacy, and in silico docking was performed. The sugar mimetic isofagomine (IFG) strongly inhibits β-Glu, while ABX exerts its inhibitory effect in the micromolar range. In GD patient fibroblasts, IFG and ABX increase mutant β-Glu activity to identical levels. However, the characteristics of the banding patterns of Endoglycosidase-H (Endo-H)-digested enzyme and a substantially lower half-life of ABX-treated β-Glu suggest different intracellular processing. In line with this observation, IFG efficiently stabilizes recombinant β-Glu against thermal denaturation in vitro, whereas ABX exerts no significant effect. Additional β-Glu enzyme activity testing using Bromohexine (BHX) and two related structures unexpectedly revealed that ABX alone can refunctionalize β-Glu in cellula. Taken together, our data indicate that ABX has little in vitro ability to act as PC, so the mode of action requires further clarification.
MeSH term(s)	Ambroxol/pharmacology ; Ambroxol/therapeutic use ; Gaucher Disease/drug therapy ; Glucosylceramidase/metabolism ; Humans ; Molecular Chaperones/metabolism ; beta-Glucosidase/chemistry
Chemical Substances	Molecular Chaperones ; Ambroxol (200168S0CL) ; beta-Glucosidase (EC 3.2.1.21) ; Glucosylceramidase (EC 3.2.1.45)
Language	English
Publishing date	2022-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23073536
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Article ; Online: Extensive Surgical Treatment of Primary Pulmonary Synovial Sarcoma After Recurrent Pneumothorax.

Petrosyan, Andranik / Bergeron, Patrice

The Annals of thoracic surgery

2015 Volume 100, Issue 5, Page(s) 1893–1895

Abstract: A 26-year-old woman with a history of right-sided recurrent pneumothorax and resection of pulmonary bullae, pleural abrasion, and talc pleurodesis underwent right-sided extensive pleural pneumonectomy for a monophasic primary pleural-pulmonary synovial ... ...

Abstract	A 26-year-old woman with a history of right-sided recurrent pneumothorax and resection of pulmonary bullae, pleural abrasion, and talc pleurodesis underwent right-sided extensive pleural pneumonectomy for a monophasic primary pleural-pulmonary synovial sarcoma (PPSS). The pathologic diagnosis was predominantly fusiform PPSS with R0 resection. Sixteen months after the operation, she is alive, without signs of new lesions. The extensive tumor resection can achieve a good result for controlling local disease.
MeSH term(s)	Adult ; Combined Modality Therapy ; Female ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Neoplasm Invasiveness ; Pneumonectomy/methods ; Pneumothorax/therapy ; Recurrence ; Sarcoma, Synovial/pathology ; Sarcoma, Synovial/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2015-11
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2014.12.092
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Zs.A 252: Show issues

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Article ; Online: Technical points for aortic valve replacement through right anterior minithoracotomy.

Bouchot, Olivier / Petrosyan, Andranik / Morgant, Marie Catherine / Malapert, Ghislain

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2018 Volume 53, Issue suppl_2, Page(s) ii24–ii26

Abstract: After 8 years of practice and over 400 operated patients, we present a technique of minimally invasive aortic valve replacement that can be used by all surgeons on many patients. The access to the aorta is via the 2nd or 3rd right anterior intercostal ... ...

Abstract	After 8 years of practice and over 400 operated patients, we present a technique of minimally invasive aortic valve replacement that can be used by all surgeons on many patients. The access to the aorta is via the 2nd or 3rd right anterior intercostal space. Cardiopulmonary bypass is provided using the femoral artery and vein. The aorta is clamped directly. One shot of Custodiol (EUSA Pharma, Limonest, France) is the most commonly used cardioplegia. Aortic valve replacement is performed in the regular way. To reduce the aortic cross-clamping time, sutureless or rapid-deployment valves, as well as the Cor-Knot (LSI Solutions, Inc., Victor, NY, USA) automatic knotting system, are excellent options. Right anterior minithoracotomy for aortic valve replacement is safe and reproducible.
MeSH term(s)	Aortic Valve/surgery ; Heart Valve Prosthesis Implantation/methods ; Humans ; Minimally Invasive Surgical Procedures/methods ; Sutureless Surgical Procedures/methods ; Thoracotomy/methods ; Treatment Outcome
Language	English
Publishing date	2018-04-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezy105
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Zs.A 2303: Show issues

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Article ; Online: Comparison of automated fastener device Cor-Knot versus manually-tied knot in minimally-invasive isolated aortic valve replacement surgery.

Morgant, Marie-Catherine / Malapert, Ghislain / Petrosyan, Andranik / Pujos, Charline / Jazayeri, Saed / Bouchot, Olivier

The Journal of cardiovascular surgery

2019 Volume 61, Issue 1, Page(s) 123–128

Abstract: Background: The aim of our prospective study was to evaluate the efficacy and the safety of the Cor-Knot device in isolated aortic valve replacement by right anterior minithoracotomy.: Methods: A single-center, prospective study was conducted between ...

Abstract	Background: The aim of our prospective study was to evaluate the efficacy and the safety of the Cor-Knot device in isolated aortic valve replacement by right anterior minithoracotomy. Methods: A single-center, prospective study was conducted between September 2009 and June 2018. Four hundred and forty patients were operated on for aortic valve replacement by right anterior minithoracotomy. Of these patients, 221 underwent isolated AVR surgery with stented prosthesis. Sutures were secured using the Cor-Knot titanium fastener in 63 patients (28.5%) and knots were hand-tied in 158 (71.5%). Statistical analyses were done using a propensity score with 1:1 matching for the automatically tied (AT) and manually tied (MT) patients. Results: The aortic cross-clamping and cardiopulmonary bypass times were significantly decreased in the AT group (74±13.8 minutes vs. 90.4±23.7 minutes, P<0.0001, and 100.8±20.6 minutes vs. 117.6±33.1 minutes, P<0.0001), compared with the MT group. Clinical outcomes were similar in the two groups, whether in the analysis of non-matched or matched groups. There was no difference in 30 day-mortality (1.2% vs. 0%, P=0.37), and the stroke and transient ischemic attack rates were comparable (2.5% vs. 1.6%; P=0.67). There was no significant increase in pacemaker implantation in the AT group (1.3% vs. 0%, P=0.36), and the rate of aortic regurgitation ≥ 2 was lower (3.9% vs. 0%; P=0.11) but not statistically significant. Conclusions: The automated Cor-Knot fastener is an easy-to-use, time-saving device which does not increase perioperative morbidity and mortality in patients undergoing aortic valve replacement by right anterior minithoracotomy.
MeSH term(s)	Aged ; Aged, 80 and over ; Automation ; Equipment Design ; Female ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/instrumentation ; Humans ; Male ; Middle Aged ; Operative Time ; Postoperative Complications/etiology ; Prospective Studies ; Risk Factors ; Stents ; Suture Techniques/adverse effects ; Suture Techniques/instrumentation ; Thoracotomy/adverse effects ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2019-10-04
Publishing country	Italy
Document type	Comparative Study ; Journal Article ; Observational Study
ZDB-ID	80143-4
ISSN	1827-191X ; 0021-9509
ISSN (online)	1827-191X
ISSN	0021-9509
DOI	10.23736/S0021-9509.19.10792-6
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Article ; Online: Concomitant Cardiac Surgery and Radiofrequency Ablation of Atrial Fibrillation: A Retrospective Single Center Study.

Raissouni, Khalil / Petrosyan, Andranik / Malapert, Ghislain / Jazayeri, Saed / Morgant, Marie-Catherine / Bouchot, Olivier

Journal of cardiothoracic and vascular anesthesia

2019 Volume 34, Issue 2, Page(s) 401–408

Abstract: Objectives: Concomitant cardiac surgery and radiofrequency atrial fibrillation (AF) ablation is an established procedure recommended in guidelines. However, the results have not been as good as expected. The authors therefore searched for predictive ... ...

Abstract	Objectives: Concomitant cardiac surgery and radiofrequency atrial fibrillation (AF) ablation is an established procedure recommended in guidelines. However, the results have not been as good as expected. The authors therefore searched for predictive factors of success of the ablation procedure. Design: The authors carried out a retrospective cohort study. Setting: All the included patients had cardiac surgery in the Dijon University Hospital. Participants: One hundred sixty-three patients with AF underwent a concomitant radiofrequency ablation between January 2009 and December 2016. Interventions: A radiofrequency device was used to isolate the pulmonary veins creating a "Box lesion." Measurements and main results: The primary endpoint of the study was freedom from AF at 12 months with follow-up assessed by an electrocardiogram or a 24-hour recording electrocardiogram Holter. The patient's mean age was 71 ± 9 years with a sex ratio of 1.4. Sixty-six percent of patients had paroxysmal AF and 34% nonparoxysmal AF, which includes persistent and long-standing persistent AF. Sixty-one percent of patients had an AF history for more than 1 year. The mean left atrial diameter was 47 ± 10 mm. No major ablation complications related to the procedure occurred. Overall freedom from AF rate after 1-year follow-up was 60% (n = 98). Six patients (4%) received an additional catheter-based ablation, and 10 patients (6%) had an electrical cardioversion during the follow-up period. The authors identified preoperative paroxysmal AF (odds ratio [OR] 2.54 [1.27-5.14] p = 0.008) and recent history of AF, less than 1 year, (OR 1.99 [1-4.06] p = 0.05) as statistically significant predictors for sinus rhythm maintenance at the 12-month follow-up. At the 12-month follow-up, 64% of patients who had concomitant epicardial treatment were in sinus rhythm and 57% of patients were in sinus rhythm after endocardial treatment. There were no significant differences in rhythm outcome between epicardial and endocardial radiofrequency approach, or between surgical procedures (mitral valve replacement versus coronary artery bypass grafting). The authors could not identify in a univariate analysis a significant left atrium size cutoff upon which ablation was less likely to be successful at 12 months follow-up. Conclusions: Concomitant cardiac surgery and radiofrequency AF ablation provided freedom from AF for 60% of patients after 1-year follow-up. The authors have shown that paroxysmal AF and recent AF are predictive factors of success. Nevertheless, thorough postoperative care is necessary to improve long-term results, including the use of additional catheter ablation or cardioversion.
MeSH term(s)	Aged ; Aged, 80 and over ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Cardiac Surgical Procedures/adverse effects ; Catheter Ablation ; Humans ; Middle Aged ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2019-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2019.09.021
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Zs.A 2203: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Pyrimidopteridine N-Oxide Organic Photoredox Catalysts: Characterization, Application and Non-Covalent Interaction in Solid State.

Hauptmann, Richy / Petrosyan, Andranik / Fennel, Franziska / Argüello Cordero, Miguel A / Surkus, Annette-E / Pospech, Jola

Chemistry (Weinheim an der Bergstrasse, Germany)

2019 Volume 25, Issue 17, Page(s) 4325–4329

Abstract: Herein we report the photo- and electrochemical characterization of pyrimidopteridine N-oxide-based heterocycles. The potential of their application as organic photoredox catalysts is showcased in the photomediated contra-thermodynamic E→Z isomerization ... ...

Abstract	Herein we report the photo- and electrochemical characterization of pyrimidopteridine N-oxide-based heterocycles. The potential of their application as organic photoredox catalysts is showcased in the photomediated contra-thermodynamic E→Z isomerization of cinnamic acid derivatives and oxidative cyclization of 2-phenyl benzoic acid to benzocoumarin using molecular oxygen as a mild oxidant. Furthermore, unprecedented intermolecular non-covalent n-π-hole interactions in solid state are discussed based on crystallographic and theoretical data.
Language	English
Publishing date	2019-03-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-x
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.201900118
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Article ; Online: Cardiac stereotactic radiation therapy for refractory ventricular arrhythmias in patients with left ventricular assist devices.

Benali, Karim / Lloyd, Michael S / Petrosyan, Andranik / Rigal, Louis / Quivrin, Magali / Bessieres, Igor / Vlachos, Konstantinos / Hammache, Nefissa / Bellec, Julien / Simon, Antoine / Laurent, Gabriel / Higgins, Kristin / Garnier, Fabien / de Crevoisier, Renaud / Martins, Raphaël / Da Costa, Antoine / Guenancia, Charles

Journal of cardiovascular electrophysiology

2023 Volume 35, Issue 1, Page(s) 206–213

Abstract: Left ventricular assist device (LVAD) implantation is an established treatment for patients with advanced heart failure refractory to medical therapy. However, the incidence of ventricular arrhythmias (VAs) is high in this population, both in the acute ... ...

Abstract	Left ventricular assist device (LVAD) implantation is an established treatment for patients with advanced heart failure refractory to medical therapy. However, the incidence of ventricular arrhythmias (VAs) is high in this population, both in the acute and delayed phases after implantation. About one-third of patients implanted with an LVAD will experience sustained VAs, predisposing these patients to worse outcomes and complicating patient management. The combination of pre-existing myocardial substrate and complex electrical remodeling after LVAD implantation account for the high incidence of VAs observed in this population. LVAD patients presenting VAs refractory to antiarrhythmic therapy and catheter ablation procedures are not rare. In such patients, treatment options are extremely limited. Stereotactic body radiation therapy (SBRT) is a technique that delivers precise and high doses of radiation to highly defined targets, reducing exposure to adjacent normal tissue. Cardiac SBRT has recently emerged as a promising alternative with a growing number of case series reporting the effectiveness of the technique in reducing the VA burden in patients with arrhythmias refractory to conventional therapies. The safety profile of cardiac SBRT also appears favorable, even though the current clinical experience remains limited. The use of cardiac SBRT for the treatment of refractory VAs in patients implanted with an LVAD are even more scarce. This review summarizes the clinical experience of cardiac SBRT in LVAD patients and describes technical considerations related to the implementation of the SBRT procedure in the presence of an LVAD.
MeSH term(s)	Humans ; Radiosurgery/adverse effects ; Heart-Assist Devices/adverse effects ; Retrospective Studies ; Arrhythmias, Cardiac/surgery ; Heart Failure/therapy ; Treatment Outcome ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/radiotherapy ; Tachycardia, Ventricular/surgery
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.16139
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