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Article ; Online: Resemblances and differences between osteoradionecrosis of the jaw and medication-related osteonecrosis of the jaw.

Golu, Mihai Vlad / Paşcanu, Ionela / Petrovan, Cecilia / Mocan, Simona / Cosarcă, Adina / Temistocle, Despina Bereczki / Ormenişan, Alina

Medicine and pharmacy reports

2024 Volume 97, Issue 1, Page(s) 76–83

Abstract: Aim: The aim of this retrospective study was to identify the clinical, radiological, and histological characteristics of patients diagnosed with osteonecrosis of the jaw (ONJ) and treated at the Oral and Maxillo-Facial Surgery Clinic of the Emergency ... ...

Abstract	Aim: The aim of this retrospective study was to identify the clinical, radiological, and histological characteristics of patients diagnosed with osteonecrosis of the jaw (ONJ) and treated at the Oral and Maxillo-Facial Surgery Clinic of the Emergency Clinical County Hospital of Targu Mures between 2017 and 2022. The study aimed to analyze correlations between patient characteristics, particularly their history of bone modifying agent use or local radiotherapy during cancer treatment, in order to identify specific patient profiles that could aid in evaluating treatment response and guide individualized treatment strategies. Methods: Fifty-two patients diagnosed with ONJ were included in the study. The patients were divided into two groups based on their medical history: the bone modifying agent use group and the radiotherapy group. Clinical, radiological, and histological data were collected and analyzed. Statistical analysis, including p-values, was performed to compare patient characteristics between the two groups. Results: Patients in the radiotherapy group were significantly older than those in the bone modifying agent use group (66 years vs. 56.9 years, p=0.001). There was a higher proportion of males in the radiotherapy group compared to the bone modifying agent use group (90% vs. 22%, p<0.001). Jaw involvement was more prevalent in the radiotherapy group compared to the bone modifying agent use group (95% vs. 66%, p=0.018). Histological analysis showed a similar frequency of Actinomyces species in both groups (50% vs. 34%, p=0.264). Conclusions: The findings of this study suggest the existence of two distinct patient profiles based on their treatment history (bone modifying agent use vs. radiotherapy) in ONJ. Patients in the radiotherapy group were older, predominantly male, and exhibited a higher prevalence of jaw involvement. Histological analysis revealed no significant differences in Actinomyces species frequency between the two groups. These distinct patient profiles may indicate different responses to treatment, emphasizing the need for individualized treatment strategies tailored to specific patient characteristics. Further research is warranted to validate these findings and develop personalized approaches for managing ONJ.
Language	English
Publishing date	2024-01-29
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2974425-8
ISSN	2668-0572 ; 2602-0807
ISSN (online)	2668-0572
ISSN	2602-0807
DOI	10.15386/mpr-2610
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recurrent submandibular fistula after Sunitinib treatment in a patient with renal cell carcinoma: a case report.

Golu, Mihai Vlad / Paşcanu, Ionela / Petrovan, Cecilia / Cosarca, Adina / Bereczki, Despina Temistocle / Ormenisan, Alina

Medicine and pharmacy reports

2023 Volume 96, Issue 3, Page(s) 323–327

Abstract: Sunitinib is commonly used in the treatment of patients with renal cell carcinoma and is associated with serious side-effects. We present the first report of a recurrent submandibular fistula in a patient treated with sunitinib. A 68-year-old man was ... ...

Abstract	Sunitinib is commonly used in the treatment of patients with renal cell carcinoma and is associated with serious side-effects. We present the first report of a recurrent submandibular fistula in a patient treated with sunitinib. A 68-year-old man was referred to our clinic for a cutaneous fistula situated on the right side of his lower jaw. The patient had been diagnosed with bone metastases from a renal carcinoma 2 years ago and had received a single 4 mg dose of zoledronic acid and subsequent treatment with sunitinib 37.5 mg once daily for the past 4 weeks. The patient was treated surgically by a perilesional incision and primary closure with sutures, advised on meticulous oral hygiene and was kept on an antimicrobial agent in the form of clindamycin. After reinitiating his oncological treatment with sunitinib the cutaneous fistula re-appeared and bone abnormalities were also detected on his X-ray. After 18 months a contralateral cutaneous fistula was observed along with a spontaneous avulsion of the patient's left molar. Repeat surgical treatment and sequestrectomy was performed with the subsequent histopathological examination revealing a suspicion of osteonecrosis of the jaw and an associated Actinomyces infection.
Language	English
Publishing date	2023-07-27
Publishing country	Romania
Document type	Case Reports
ZDB-ID	2974425-8
ISSN	2668-0572 ; 2602-0807
ISSN (online)	2668-0572
ISSN	2602-0807
DOI	10.15386/mpr-2502
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Original Research. Candida in Oral and Maxillofacial Pathology

Petrovan Cecilia / Bereczki-Temistocle Despina Luciana / Man Adrian

Journal of Interdisciplinary Medicine, Vol 2, Iss s1, Pp 36-

Clinical Findings and Risk Factors

2017 Volume 42

Abstract: Background: Candida, and especially Candida albicans, colonizes the oral mucosa and becomes invasive when the immune system weakens. Therefore, frequently, oral and maxillofacial pathology can be associated with Candida. Objective: The qualitative and ... ...

Abstract	Background: Candida, and especially Candida albicans, colonizes the oral mucosa and becomes invasive when the immune system weakens. Therefore, frequently, oral and maxillofacial pathology can be associated with Candida. Objective: The qualitative and quantitative assessment of Candida colonization of the oral cavity in patients with oro-maxillo-facial conditions; to establish an association between the different contributing factors and colonization. Material and methods: Samples were collected from 70 patients hospitalized in the Clinic of Oral and Maxillo-Facial Surgery, by rinsing the mouth with sterile saline; historical data were also collected. The samples were analyzed at the Microbiology Laboratory of the University of Medicine and Pharmacy of Tîrgu Mureș, using Sabouraud agar medium. For each isolate, the antifungigram for Fluconazole and Voriconazole was performed following the CLSI standards. Results: From the 70 samples 45.7% were positive for 11 different yeast species. Regarding predisposing factors, most importantly, smoking was significantly associated with Candida colonization (OR = 2.34; 95% CI = 1.42-3.84; p <0.05). Other factors, such as radiotherapy, oral hygiene or antibiotics, are related, but not statistically significant in our study. Candida albicans was the predominant species (38.8%). The testing of Candida albicans and non-albicans to Fluconazole showed an increased resistance (52.4%) in both cases, while the resistance to Voriconazole was 50% and 12.5%, respectively. Conclusions: Colonization of the oral cavity with Candida is present in about half of the patients with OMF conditions, and this is probably not only due to classical predisposing factors, but also due to chronic oral pathology and to several risk factors like smoking or radiotherapy.
Keywords	candida ; colonization ; factors ; oral ; Medicine ; R
Subject code	610
Language	English
Publishing date	2017-03-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Selecting the Best Surgical Treatment Methods in Oro-Antral Communications.

Bereczki-Temistocle, Despina Luciana / Gurzu, Simona / Jung, Ioan / Cosarca, Adina / Beresescu, Gabriela / Golu, Vlad / Petrovan, Cecilia / Ormenisan, Alina

International journal of environmental research and public health

2022 Volume 19, Issue 21

Abstract: Introduction: an oro-antral communication is defined as a permanent pathological connection between the maxillary sinus and the septic oral cavity. Several flaps can be used for the closure (buccal flap, palatal flap, combination techniques) but ... ...

Abstract	Introduction: an oro-antral communication is defined as a permanent pathological connection between the maxillary sinus and the septic oral cavity. Several flaps can be used for the closure (buccal flap, palatal flap, combination techniques) but relapses occur often in case of a large defects and underlying general conditions. Bichat fad pad flap is a multipotent pedicled fatty tissue that is easily accessible from the oral cavity that can be used for the closure of medium-sized defects, even in immunocompromised patients due to its stem cell capacity. Materials and methods: the medical information of the patients diagnosed with oro-antral communications who were admitted and treated in the Oral and Maxillo-Facial Clinic Targu Mures, between 2013 and 2020 were analyzed. A database containing general information, reported causes, associated diseases, surgical methods used during admission, and relapses, was created. The information was statistically processed. The written consent and ethical approval were obtained. Results: the study shows that from a total of 140 cases, 72 were treated using buccal advancement flap, 49 using Bichat fat pad flap, and 19 using palatal flaps. The dimensions of the communications ranged between 0.3 cm and 1.5 cm. Several statistically significant results could be found when comparing the surgical methods. Of the 72 patients treated with buccal advancement flaps, 25 presented relapses as opposed to the patients treated with Bichat fat pad flaps who showed no complications, Conclusions: the most frequently used surgical treatment is the buccal flap, which also has the highest relapse rate. Both primary treatment with Bichat fat-pad flap and re-treatment of relapses using this flap have had 100% success rates, even in patients with general associated conditions, in contrast with patients treated by using the buccal flap. The dimensions of the oro-antral communication and general conditions are crucial factors for the success of the surgical treatment.
MeSH term(s)	Humans ; Oroantral Fistula/etiology ; Oroantral Fistula/surgery ; Surgical Flaps ; Adipose Tissue ; Maxillary Sinus ; Recurrence
Language	English
Publishing date	2022-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192114543
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Article ; Online: Oral Epithelioid Hemangioendothelioma — Unusual Location of a Rare Entity

Iacob Alina / Comișel Sebastian / Tilinca Mariana / Mezei Tibor / Petrovan Cecilia

Journal of Interdisciplinary Medicine, Vol 2, Iss 4, Pp 349-

2017 Volume 353

Abstract: Introduction: Epithelioid hemangioendothelioma is a rare, locally aggressive vascular tumor, originating from soft tissue, bone, skin, and organs such as the liver or lung, exceptionally located in the oral cavity. Most of the cases of oral epithelioid ... ...

Abstract	Introduction: Epithelioid hemangioendothelioma is a rare, locally aggressive vascular tumor, originating from soft tissue, bone, skin, and organs such as the liver or lung, exceptionally located in the oral cavity. Most of the cases of oral epithelioid hemangioendothelioma are asymptomatic, and diagnosis is hampered by the fact that the histological features are somewhat between hemangioma and angiosarcoma, with epithelioid cells, intracytoplasmic vacuoles, low mitotic activity, and (rarely) necrosis. Immunohistochemical analysis is required to rule out carcinoma or other epithelioid vascular neoplasms.
Keywords	epithelioid hemangioendothelioma ; rare oral lesions ; vascular tumor ; Medicine ; R
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Erratum

Iacob Alina / Comișel Sebastian / Tilinca Mariana / Mezei Tibor / Mocan Simona / Petrovan Cecilia

Journal of Interdisciplinary Medicine, Vol 3, Iss 2, Pp 116-

2018 Volume 116

Keywords	Medicine ; R
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: Knowledge and Attitude of Dentists Regarding Patients Undergoing Bisphosphonate Treatment

Albu-Stan Ioana-Aurița / Petrovan Cecilia / Cerghizan Diana / Eremie Lia Yero / Crăciun Adriana Elena / Copotoiu Constantin

Journal of Interdisciplinary Medicine, Vol 3, Iss 3, Pp 169-

a Comparative Questionnaire

2018 Volume 172

Abstract: Background: Osteonecrosis of the jaw is an uncommon but serious complication related to oral and intravenous bisphosphonate (BP) therapy. Its pathogenesis is not well understood, and there are no universal protocols accepted to treat it. ...

Abstract	Background: Osteonecrosis of the jaw is an uncommon but serious complication related to oral and intravenous bisphosphonate (BP) therapy. Its pathogenesis is not well understood, and there are no universal protocols accepted to treat it.
Keywords	osteonecrosis ; jaw ; bisphosphonates ; surgery ; quality of life ; Medicine ; R
Language	English
Publishing date	2018-09-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intraosseous venous malformation of the zygomatico-orbital complex. Case report and literature review with focus on confusions in vascular lesion terms.

Fábián, Zoltán / Szabó, György / Petrovan, Cecilia / Horváth, Karin Ursula / Babicsák, Botond / Hüttl, Kálmán / Németh, Zsolt / Bogdán, Sándor

Oral and maxillofacial surgery

2018 Volume 22, Issue 2, Page(s) 241–247

Abstract: Intraosseous vascular malformations (VascM) of the facial skeleton are rare entities, raising difficulties even today in their treatment. We present a case for zygomatic intraosseous venous malformation of traumatic etiology with growth dynamics ... ...

Abstract	Intraosseous vascular malformations (VascM) of the facial skeleton are rare entities, raising difficulties even today in their treatment. We present a case for zygomatic intraosseous venous malformation of traumatic etiology with growth dynamics presentation and a multidisciplinary treatment approach, with intravascular embolization surgical ablation and primary reconstructruction using a titanium patient-specific implant (PSI), and a review of the literature for intraosseous vascular lesions of the facial skeleton focusing on the diagnostic syntagms used by the involved medical personnel, to shed light on the confusions over these terms.
MeSH term(s)	Adolescent ; Dental Implants ; Embolization, Therapeutic/methods ; Humans ; Imaging, Three-Dimensional ; Male ; Skull/surgery ; Titanium ; Tomography, X-Ray Computed ; Vascular Malformations/diagnostic imaging ; Vascular Malformations/surgery
Chemical Substances	Dental Implants ; Titanium (D1JT611TNE)
Language	English
Publishing date	2018-04-13
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2406731-3
ISSN	1865-1569 ; 1865-1550
ISSN (online)	1865-1569
ISSN	1865-1550
DOI	10.1007/s10006-018-0691-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4767: Show issues

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Article: Ultrasonography-histopathology correlation in major salivary glands lesions.

Petrovan, Cecilia / Nekula, Diana Maria / Mocan, Simona Liliana / Voidăzan, Toader Septimiu / Coşarcă, Adina

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2015 Volume 56, Issue 2, Page(s) 491–497

Abstract: Major salivary glands display a various and complex pathology, showing different evolution and prognosis, depending on the histopathological form. The choice of an appropriate treatment plan for the best outcome, therefore the proper surgical approach, ... ...

Abstract	Major salivary glands display a various and complex pathology, showing different evolution and prognosis, depending on the histopathological form. The choice of an appropriate treatment plan for the best outcome, therefore the proper surgical approach, would imply preoperative knowledge of the histopathological diagnosis. However, any core-biopsy performed prior to surgery presents the risk of a false result and increases the difficulty of latter surgery. Therefore, some complementary examinations are used, among these, ultrasonography. The retrospective study (April 2010-March 2013) conducted in the Clinic of Oral and Maxillofacial Surgery, Emergency County Hospital, Tirgu Mures, Romania, aims to evaluate the relevance of the ultrasonography by itself in leading towards a proper preoperative assessment and diagnosis, and thus, in choosing the proper treatment plan. The study included 33 lesions of the major salivary glands, undergoing first ultrasonography, then curative surgery. Different characteristics (shape, dimension, consistency, vascularization, homogeneity, delimitation) were assessed on ultrasonography as well as on histopathology; finally, the correlation between those two examinations was evaluated, by comparing diagnoses. The results of our study are similar to others, showing that ultrasonography can diagnose preoperatively the majority lesions of major salivary glands. The conclusions of the study sustain the importance of ultrasonography as a routine examination in major salivary glands lesions.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; ROC Curve ; Salivary Gland Neoplasms/diagnostic imaging ; Salivary Gland Neoplasms/pathology ; Salivary Glands/diagnostic imaging ; Salivary Glands/pathology ; Ultrasonography ; Young Adult
Language	English
Publishing date	2015
Publishing country	Romania
Document type	Journal Article
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Adenocarcinom cu celule acinare cu localizare la nivelul buzei. Prezentare de caz.

Mocan, Simona / Stolnicu, Simona / Rădulescu, Doiniţa / Petrovan, Cecilia

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi

2005 Volume 109, Issue 1, Page(s) 164–169

Abstract: The variable histological appearance of acinic cell carcinoma coupled with its uncommon occurrence account for considerable diagnostic difficulties. We present the case of a 68 years old women, with a salivary cyst localised in the upper lip. The tumour ... ...

Title translation	Acinic cell adenocarcinoma of the lip.
Abstract	The variable histological appearance of acinic cell carcinoma coupled with its uncommon occurrence account for considerable diagnostic difficulties. We present the case of a 68 years old women, with a salivary cyst localised in the upper lip. The tumour mass was excised, fixed in formaline, embedded in paraffin and the sections were stained with Haematoxylin-Eosin, PAS-Haematoxylin, PAS-Alcian blue and Perls. The tumour was nodular, well circumscribed, with a cystic appearance on the cut surface. Microscopically, the tumour had a papillary-cystic growth, with one large cystic space lined by epithelium of variable thickness and branching projections of epithelium occupying a large portion of the cyst's lumen. Different cellular features were recognised in the tumour, with the presence of both serous and mucous acinar differentiation. Also, vacuolated cells were present in a large number. Acinic cell adenocarcinoma is a malignant epithelial neoplasm in which the neoplastic cells demonstrate not only serous acinar differentiation. The clinical and histopathological findings are discussed in the light of the literature.
MeSH term(s)	Aged ; Carcinoma, Acinar Cell/diagnosis ; Carcinoma, Acinar Cell/pathology ; Carcinoma, Acinar Cell/surgery ; Female ; Humans ; Lip Neoplasms/diagnosis ; Lip Neoplasms/pathology ; Lip Neoplasms/surgery ; Salivary Gland Neoplasms/diagnosis ; Salivary Gland Neoplasms/pathology ; Salivary Gland Neoplasms/surgery ; Salivary Glands, Minor/pathology ; Treatment Outcome
Language	Romanian
Publishing date	2005-01
Publishing country	Romania
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	123880-2
ISSN	0048-7848 ; 0300-8738
ISSN	0048-7848 ; 0300-8738
Database	MEDical Literature Analysis and Retrieval System OnLINE

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