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Article ; Online: Ablation of accessory pathways in different anatomic locations using focal pulsed field ablation.

Brešković, Toni / Lisica, Lucija / Jurišić, Zrinka / Petrović, Davor / Sikirić, Ivan / Metličić, Vitomir / Anić, Ante

2024

Abstract: Background: Ablation of accessory pathways (APs) is the cornerstone for treatment of patients with Wolff-Parkinson-White syndrome and manifestation of atrioventricular reentrant tachycardia. Pulsed field ablation (PFA) is a new type of nonthermal energy ...

Abstract	Background: Ablation of accessory pathways (APs) is the cornerstone for treatment of patients with Wolff-Parkinson-White syndrome and manifestation of atrioventricular reentrant tachycardia. Pulsed field ablation (PFA) is a new type of nonthermal energy source delivered to the underlying tissue via the ablation catheter and used for ablation of arrhythmic substrates. Objective: The purpose of this study was to determine the efficiency and long-term outcome of ablation of APs of different localizations using a focal pulsed electrical field. Methods: Electrophysiological study was performed in patients with indication for AP ablation. An ablation catheter was used to map the position of AP insertion. Pulsed electric field was delivered through a standard ablation catheter. In left-sided APs, the first ablation attempt was within the coronary sinus (CS). Patient follow-up was scheduled 1-3 months after the ablation. Additional check-up was performed after 6 and 12 months. Results: Fourteen 14 patients (3 pediatric) were treated. Termination of AP conduction was achieved in all procedures. The cohort consisted of 3 right free wall, 3 posteroseptal, and 8 left-sided APs. Ablation through CS was successfully used in 7 of 8 patients with left-sided APs. No complications were reported. Median follow-up was 5.5 months. Conduction recurrence through AP was documented in 1 patient. Conclusion: Focal PFA for AP shows promising results in terms of efficacy and safety. A high rate of successful termination of left-sided APs by ablation within CS may represent a new standard approach. The safety and efficacy profile of PFA seems to be transferable to the pediatric population.
Language	English
Publishing date	2024-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2024.03.030
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Article ; Online: Incidence and Clinical Phenotype of Multisystem Inflammatory Syndrome in Children After Two SARS-CoV-2 Pandemic Waves: A Croatian Prospective Nationwide Study.

Stemberger Marić, Lorna / Trkulja, Vladimir / Petrović, Davor / Lah Tomulić, Kristina / Bartulović, Ines / Tešović, Goran

The Pediatric infectious disease journal

2023 Volume 42, Issue 7, Page(s) e229–e231

Abstract: This prospective nationwide study in Croatia (March 1, 2020-December 31, 2021) embraced 121 children with multisystem inflammatory syndrome. Incidence rates, disease course and outcomes were similar to those reported from other European countries. The ... ...

Abstract	This prospective nationwide study in Croatia (March 1, 2020-December 31, 2021) embraced 121 children with multisystem inflammatory syndrome. Incidence rates, disease course and outcomes were similar to those reported from other European countries. The severe acute respiratory syndrome coronavirus 2 virus Alpha strain appeared associated with a higher propensity to result in multisystem inflammatory syndrome in children than the Delta strain but did not appear related to disease severity.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/complications ; Incidence ; Croatia/epidemiology ; Pandemics ; Prospective Studies ; Systemic Inflammatory Response Syndrome/epidemiology ; Systemic Inflammatory Response Syndrome/complications
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000003924
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Zs.A 1852: Show issues

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Article: Three Cases of Joubert Syndrome in a Consanguineous Syrian Family and a Interesting Case of Multinational Collaboration.

Petrović, Davor / Čulić, Vida / Swinderek-Alsayed, Zofia

Journal of pediatric genetics

2021 Volume 12, Issue 2, Page(s) 167–170

Abstract: Joubert syndrome (JS) is a rare congenital, autosomal recessive disorder characterized by a distinctive brain malformation, developmental delay, ocular motor apraxia, breathing abnormalities, and high clinical and genetic heterogeneity. We are reporting ... ...

Abstract	Joubert syndrome (JS) is a rare congenital, autosomal recessive disorder characterized by a distinctive brain malformation, developmental delay, ocular motor apraxia, breathing abnormalities, and high clinical and genetic heterogeneity. We are reporting three siblings with JS from consanguineous parents in Syria. Two of them had the same homozygous c.2172delA (p.Trp725Glyfs*)
Language	English
Publishing date	2021-01-06
Publishing country	Germany
Document type	Journal Article
ISSN	2146-4596
ISSN	2146-4596
DOI	10.1055/s-0040-1721826
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Article: Knowledge and Practice of Pediatricians Regarding Hypovitaminosis D-A Survey across 33 European Countries.

Petrović, Davor / Runjić, Edita / Buljan, Ivan / Jeličić Kadić, Antonia / Markić, Joško

Children (Basel, Switzerland)

2022 Volume 9, Issue 12

Abstract: Hypovitaminosis D has been recognized as a worldwide pandemic, but there are disagreements regarding its diagnosis and treatment. This study aimed to evaluate the knowledge and practice of European pediatricians concerning vitamin D (VD) and ... ...

Abstract	Hypovitaminosis D has been recognized as a worldwide pandemic, but there are disagreements regarding its diagnosis and treatment. This study aimed to evaluate the knowledge and practice of European pediatricians concerning vitamin D (VD) and hypovitaminosis D and their adherence to relevant guidelines. A cross-sectional study was conducted through an anonymous survey via SurveyMonkey on 304 European pediatricians. Most of the participants were general pediatricians, followed by endocrinologists and neonatologists. ESPGHAN's and the national guidelines were the most frequently used. VD testing was mostly performed in patients with skeletal, chronic kidney, and autoimmune diseases. Participants predominantly answered the questions regarding the definition of hypovitaminosis D and VD supplementation correctly, especially in children younger than 12 months. They showed the least knowledge regarding the cut off-point for the initiation of the therapy and therapeutic doses used to treat confirmed hypovitaminosis D. Participants' conflicting answers could be related to the differences between the guidelines. We consider that experts in this field should create uniform guidelines, and that those guidelines should also be promoted by national or local pediatric associations.
Language	English
Publishing date	2022-11-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9121831
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Article: The Impact of Vitamin D Levels on Clinical Manifestations of Multisystem Inflammatory Syndrome in Children: A Cross-Sectional Study.

Petrovic, Davor / Benzon, Benjamin / Srsen, Sasa / Polic, Branka / Vukovic Novogradec, Antonija / Milic, Petra / Markic, Josko

Life (Basel, Switzerland)

2023 Volume 13, Issue 3

Abstract: Background: Hyperinflammatory response that resembles Kawasaki disease may develop in children after COVID-19 disease, and it is called multisystem inflammatory syndrome in children. The cause of MIS-C is dysregulated innate immune response and a ... ...

Abstract	Background: Hyperinflammatory response that resembles Kawasaki disease may develop in children after COVID-19 disease, and it is called multisystem inflammatory syndrome in children. The cause of MIS-C is dysregulated innate immune response and a subsequent cytokine storm that results in endothelial damage. It has been determined that low levels of serum 25(OH)D increase the risk of developing immune-related diseases and disorders. Methods: To determine the incidence of hypovitaminosis D, and a possible correlation between 25(OH)D levels and the clinical severity of MIS-C, 21 patients hospitalized in the University Hospital of Split due to MIS-C were evaluated. Results: Hypovitaminosis D was detected in 95% of MIS-C patients. We found a significant relationship between the severity of MIS-C and 25(OH)D levels, as patients with more severe MIS-C had lower 25(OH)D. MIS-C patients with lower vitamin D levels had worse systolic and diastolic function of the left ventricle according to echocardiograms. There was no relationship between 25(OH)D levels and the tested laboratory inflammatory and cardiac markers. Conclusion: Hypovitaminosis D is very common in children with MIS-C and influences the severity of the disease. VD could be a new potential biomarker in MIS-C, and VD replacement therapy should be considered early on in the treatment of MIS-C.
Language	English
Publishing date	2023-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13030674
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Article ; Online: A suicide attempt by ingestion of oleander leaves and treatment with digoxin-specific Fab antibody fragments.

Kovačević, Tanja / Polić, Branka / Ardalić, Tatjana Ćatipović / Petrović, Davor / Stričević, Luka / Rogulj, Maja / Markić, Joško

Arhiv za higijenu rada i toksikologiju

2023 Volume 74, Issue 4, Page(s) 292–295

Abstract: Natural cardiac glycosides have positive inotropic heart effects but at high, toxic doses they can cause life-threatening cardiac arrhythmias. Here we present the first Croatian case of a 16-year-old girl who attempted suicide by eating dried oleander ... ...

Abstract	Natural cardiac glycosides have positive inotropic heart effects but at high, toxic doses they can cause life-threatening cardiac arrhythmias. Here we present the first Croatian case of a 16-year-old girl who attempted suicide by eating dried oleander leaves, which contain natural cardiac glycosides, and her treatment with a specific antidote. The girl presented with an oedema of the uvula indicating local toxicity, severe bradycardia, first-degree atrioventricular block, drowsiness, and vomiting. Having taken her medical history, we started treatment with atropine, intravenous infusion of dextrose-saline solution and gastroprotection, but it was not successful. Then we introduced digoxin-specific Fab antibody fragments and within two hours, the patient's sinus rhythm returned to normal. Cases of self-poisoning with this oleander are common in South-East Asia, because it is often used as a medicinal herb, and digoxin-specific Fab fragments have already been reported as effective antidote against oleander poisoning there. Our case has taught us that it is important to have this drug in the hospital pharmacy both for digitalis and oleander poisoning.
MeSH term(s)	Humans ; Female ; Adolescent ; Suicide, Attempted ; Nerium ; Antidotes/therapeutic use ; Digoxin/therapeutic use ; Cardiac Glycosides/therapeutic use ; Plant Poisoning/drug therapy ; Plant Poisoning/etiology ; Immunoglobulin Fab Fragments/therapeutic use ; Eating
Chemical Substances	Antidotes ; Digoxin (73K4184T59) ; Cardiac Glycosides ; Immunoglobulin Fab Fragments
Language	English
Publishing date	2023-12-29
Publishing country	Croatia
Document type	Case Reports
ZDB-ID	127289-5
ISSN	1848-6312 ; 0004-1254
ISSN (online)	1848-6312
ISSN	0004-1254
DOI	10.2478/aiht-2023-74-3752
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Article: Three Cases of Joubert Syndrome in a Consanguineous Syrian Family and a Interesting Case of Multinational Collaboration

Petrović, Davor / Čulić, Vida / Swinderek-Alsayed, Zofia

Journal of Pediatric Genetics

2021 Volume 12, Issue 02, Page(s) 167–170

Abstract	Joubert syndrome (JS) is a rare congenital, autosomal recessive disorder characterized by a distinctive brain malformation, developmental delay, ocular motor apraxia, breathing abnormalities, and high clinical and genetic heterogeneity. We are reporting three siblings with JS from consanguineous parents in Syria. Two of them had the same homozygous c.2172delA (p.Trp725Glyfs*) AHI1 mutation and the third was diagnosed prenatally with magnetic resonance imaging. This pathogenic variant is very rare and described in only a few cases in the literature. Multinational collaboration could be of benefit for the patients from undeveloped, low-income countries that have a low-quality health care system, especially for the diagnosis of rare diseases.
Keywords	Joubert syndrome ; consanguineous family ; mutation
Language	English
Publishing date	2021-01-06
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2146-460X ; 2146-4596
ISSN (online)	2146-460X
ISSN	2146-4596
DOI	10.1055/s-0040-1721826
Database	Thieme publisher's database

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Article: Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease.

Petrovic, Davor / Benzon, Benjamin / Batinic, Marijan / Culic, Srđana / Roganovic, Jelena / Markic, Josko

Journal of clinical medicine

2019 Volume 8, Issue 11

Abstract: Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by isolated thrombocytopenia defined as platelet count in peripheral blood <100 × ... ...

Abstract	Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by isolated thrombocytopenia defined as platelet count in peripheral blood <100 × 10
Language	English
Publishing date	2019-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm8111861
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Article ; Online: Serum vitamin D levels in children with newly diagnosed and chronic immune thrombocytopenia.

Čulić, Srđana / Markić, Joško / Petrović, Davor / Konjevoda, Paško / Pavelić, Jasminka

Seminars in hematology

2016 Volume 53 Suppl 1, Page(s) S67–9

Abstract: The primary objective of the study was to assess the vitamin D (VD) status of patients suffering from ITP. Children from the case cohort (total 21) were recruited from chronic ITP patients (followed as outpatients) and newly diagnosed ITP (prospective ... ...

Abstract	The primary objective of the study was to assess the vitamin D (VD) status of patients suffering from ITP. Children from the case cohort (total 21) were recruited from chronic ITP patients (followed as outpatients) and newly diagnosed ITP (prospective study) patients. VD deficiency (values <75 nmol/L) was detected in 11 patients with newly diagnosed ITP, and seven patients with chronic ITP. Only three patients with newly diagnosed, and none with chronic ITP had normal VD values. Newly diagnosed ITP patients had statistically significantly higher values (P <.044) of VD than the patients with chronic type of ITP. Platelets values did not follow VD level. VD deficiency is very common in children with either newly diagnosed or chronic ITP form. Therefore there is a utility supplementing VD in these patients. To investigate the role of VD as an immune modulating drug for patients with ITP, a prospective randomized placebo-controlled trial needs to be performed.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Chronic Disease ; Cohort Studies ; Female ; Humans ; Male ; Purpura, Thrombocytopenic, Idiopathic/blood ; Purpura, Thrombocytopenic, Idiopathic/immunology ; Vitamin D/blood
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2016-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	206923-4
ISSN	1532-8686 ; 0037-1963
ISSN (online)	1532-8686
ISSN	0037-1963
DOI	10.1053/j.seminhematol.2016.04.020
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Article: Behavioral pattern of overweight and obese school children.

Juresa, Vesna / Musil, Vera / Majer, Marjeta / Ivanković, Davor / Petrović, Davor

Collegium antropologicum

2012 Volume 36 Suppl 1, Page(s) 139–146

Abstract: The aim of this study was to determine socio economic, health status, nutritional and behavioral differences in obese, overweight and normal weight children attending first grade elementary school. In overweight group there is 13.8% of boys and 12.6% of ... ...

Abstract	The aim of this study was to determine socio economic, health status, nutritional and behavioral differences in obese, overweight and normal weight children attending first grade elementary school. In overweight group there is 13.8% of boys and 12.6% of girls, in obese group 8.3% of boys and 6.9% of girls. In factor analysis 12 factors was excluded with cumulative loading of 60% variability. Discriminant analysis was performed with 12 factors as predictive variables and discriminant variables were three BMI groups: normal weight, overweight and obese. Function 1 discriminate well normal weight group from overweight and obese group. Overweight and obese groups is described with lower number of children in the family and lower order of birth, higher education of parents, they eat less vegetables and fruits, spend more time playing computer games, have less physical activity, drink more alcohol with their meals, exactly opposite to normal weight group.
MeSH term(s)	Child ; Child Behavior ; Discriminant Analysis ; Factor Analysis, Statistical ; Female ; Humans ; Male ; Obesity/physiopathology ; Overweight/physiopathology
Language	English
Publishing date	2012-01
Publishing country	Croatia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	233430-6
ISSN	0350-6134 ; 0353-3735
ISSN	0350-6134 ; 0353-3735
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