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  1. Article ; Online: Complete versus culprit-only revascularization in non-ST-segment elevation myocardial infarction and multivessel coronary artery disease

    Jaraković Milana / Petrović Milovan / Ivanišević Dragan / Mihajlović Bojan / Kovačević Mila / Popov Iva

    Srpski Arhiv za Celokupno Lekarstvo, Vol 151, Iss 3-4, Pp 172-

    2023  Volume 178

    Abstract: Introduction/Objective. The optimal percutaneous coronary intervention (PCI) in patients with non-STelevated myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) is still not clear. The aim of our study was to examine ... ...

    Abstract Introduction/Objective. The optimal percutaneous coronary intervention (PCI) in patients with non-STelevated myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) is still not clear. The aim of our study was to examine intrahospital and long-term major adverse cardiovascular and cerebrovascular events (MACCE) in this group of patients. Methods. This retrospective study included 225 patients with NSTEMI and multivessel CAD treated with PCI at the Institute of Cardiovascular Diseases of Vojvodina. Three groups were formed: complete one-stage PCI; complete multi-stage PCI, and culprit-only PCI. We analyzed intrahospital and one-year follow-up MACCE and mortality after three years in all three groups. Results. Complete one-stage PCI was performed in 112 (49.8%), complete multi-stage PCI in 70 (31.3%), and culprit-only PCI in 43 (19.1%) patients. Patients with multi-stage complete PCI had the lowest mortality in comparison with one-stage and culprit-only PCI, both intrahospital (0% vs. 0.9% and 20.9%, respectively, p < 0.0005) and after one year (0% vs. 2.7% and 30.2%, respectively, p < 0.0005) and three years (4.3% vs. 5.4% and 32.6%, respectively, p < 0.0005). There was no significant difference in other MACCE between the groups, both intrahospital and after one year. Conclusion. In our study, multi-stage PCI significantly reduces intrahospital, one-year and three-year follow-up mortality in patients with NSTEMI and multivessel CAD.
    Keywords non-st elevated myocardial infarction ; multivessel coronary artery disease ; percutaneous coronary intervention ; major adverse cardiovascular and cerebrovascular events ; mortality ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Serbian Medical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Intravascular imaging and drug-coated balloons for unprotected left main percutaneous coronary interventions: Questions with a predictable or unpredictable answer? Author's reply.

    Kovacevic, Mila / Burzotta, Francesco / Srdanovic, Ilija / Petrovic, Milovan / Trani, Carlo

    Kardiologia polska

    2022  Volume 80, Issue 6, Page(s) 721–722

    MeSH term(s) Angioplasty, Balloon, Coronary/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/surgery ; Drug-Eluting Stents ; Humans ; Percutaneous Coronary Intervention/methods ; Treatment Outcome
    Language English
    Publishing date 2022-05-31
    Publishing country Poland
    Document type Journal Article ; Comment
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2022.0139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Percutaneous coronary intervention to treat unprotected left main: Common (un-answered) challenges.

    Kovacevic, Mila / Burzotta, Francesco / Srdanovic, Ilija / Petrovic, Milovan / Trani, Carlo

    Kardiologia polska

    2022  Volume 80, Issue 4, Page(s) 417–428

    Abstract: Percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation is a widely adopted strategy to obtain myocardial revascularization in patients with unprotected left main (LM) disease. Although thoroughly investigated across ... ...

    Abstract Percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation is a widely adopted strategy to obtain myocardial revascularization in patients with unprotected left main (LM) disease. Although thoroughly investigated across scientific literature, LM PCI offers patient-specific technical options and poses many operative challenges that cannot be fully addressed by the pub-lished studies. Therefore, we have summarized and discussed in this review possible options related to PCI in LM patients. First, functional and imaging assessment for LM is still evolving and requires increased dedication to identify patients requiring revascularization and to enhance the results in the case of PCI performance. Second, specific coronary atherosclerosis patterns of LM involvement (like an isolated ostial disease of one of its bifurcation branches, extensive disease jeopardizing both branches, etc.) pose specific challenges for DES implantation so that careful selection of technical options (stepwise provisional single stent, upfront 2-stent strategy, when and how apply "kissing ballooning") is required. Third, despite improvement of techniques, PCI-related ischemia might not be tolerated by some patients with LM disease so mechanical circulatory support devices may come into play.
    MeSH term(s) Coronary Angiography ; Coronary Artery Disease/surgery ; Drug-Eluting Stents ; Humans ; Myocardial Revascularization ; Percutaneous Coronary Intervention/methods ; Treatment Outcome
    Language English
    Publishing date 2022-05-11
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2022.0078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of COVID-19 on cardiac surgery outcomes.

    Mandić, Danica / Milovančev, Aleksandra / Redžek, Aleksandar / Petrović, Milovan / Ilić, Aleksandra / Čanković, Milenko / Pekarić, Melisa Mironicki / Dudaš, Vanja / Šarošković, Bojana

    Cardiovascular journal of Africa

    2024  Volume 34, Page(s) 1–6

    Abstract: Aim: This study aimed to assess the impact of COVID-19 infection on cardiac surgery outcomes in patients who contracted COVID-19 peri-operatively or had recently recovered from COVID-19.: Methods: The study prospectively enrolled 95 patients ... ...

    Abstract Aim: This study aimed to assess the impact of COVID-19 infection on cardiac surgery outcomes in patients who contracted COVID-19 peri-operatively or had recently recovered from COVID-19.
    Methods: The study prospectively enrolled 95 patients scheduled for cardiac surgery who had recently recovered from COVID-19. This formed the post-COVID-19 group. The other group consisted of 25 patients who contracted COVID-19 peri-operatively. Patients were followed for all-cause mortality as the primary endpoint and postoperative course complications as the secondary endpoint. Data were compared to a historical cohort of 280 non-COVID-19 patients.
    Results: The peri-operative COVID-19 group exhibited a significantly higher prevalence of primary outcome all-cause mortality (28%), compared with 4.3% in the controls (
    Conclusion: Patients who contracted COVID-19 peri-operatively had an increased rate of mortality and postoperative complications, while cardiac surgery in the recently recovered COVID-19 group was associated with a higher incidence of pulmonary embolism and atrial fibrillation.
    Language English
    Publishing date 2024-02-12
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 2383233-2
    ISSN 1680-0745 ; 1996-3467 ; 1015-9657 ; 1995-1892
    ISSN (online) 1680-0745 ; 1996-3467
    ISSN 1015-9657 ; 1995-1892
    DOI 10.5830/CVJA-2023-065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: “TAP” technique on bifurcation lesion of Y graft in a patient with NSTEMI complicated with cardiogenic shock

    Čanković Milenko / Petrović Milovan / Ivanović Vladimir / Srdanović Ilija / Kovačević Mila

    Srpski Arhiv za Celokupno Lekarstvo, Vol 149, Iss 9-10, Pp 612-

    2021  Volume 615

    Abstract: Introduction. Bifurcation lesions on venous Y grafts are rare. We present a case of a woman who developed non-ST segment elevation myocardial infarction complicated by cardiogenic shock due to a bifurcation lesion on the venous Y graft for left anterior ... ...

    Abstract Introduction. Bifurcation lesions on venous Y grafts are rare. We present a case of a woman who developed non-ST segment elevation myocardial infarction complicated by cardiogenic shock due to a bifurcation lesion on the venous Y graft for left anterior descending artery (LAD) and ramus circumflex artery (RCX). Case outline. A 72-year-old woman was admitted to the coronary care unit as an emergency in September 2017 due to acute heart failure followed by the development of cardiogenic shock. Urgent coronarography revealed severe atherosclerotic disease of native coronary arteries with significant bifurcation lesion on venous Y graft for LAD and RCX (medina classification of 1,1,1) with thrombolysis in myocardial infarction (TIMI) grade 2 flow. According to the general condition of patient, a life-saving ad hoc percutaneous coronary intervention (PCI) was performed. Two stents were implanted in the Y graft with T and protrusion (TAP) technique achieving optimal result followed with patient stabilization. On one-year follow-up, the patient was without symptoms of angina, and computed tomography coronarography revealed patent both stents in the Y graft. To the best of our knowledge, this is the first described TAP technique used on the Y graft. Conclusion. The PCI on a vein graft is not uncommon either in elective cases or in cases with acute coronary syndrome due to the poorer persistence and more frequent progression of atherosclerotic disease in the venous grafts. The use of bifurcation techniques for the treatment of lesions on a vein graft and especially on the Y graft is rare, but it can be used the same way it is used in native vessels.
    Keywords pci ; y graft ; tap technique ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Serbian Medical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Spontaneous coronary artery dissection as a cause of acute myocardial infarction with ST elevation

    Ivanović Vladimir / Dabović Dragana / Petrović Milovan / Ivanov Igor / Bjelobrk Marija

    Srpski Arhiv za Celokupno Lekarstvo, Vol 149, Iss 5-6, Pp 348-

    2021  Volume 352

    Abstract: Introduction. Spontaneous coronary artery dissection (SCAD) is defined as a dissection that has not occurred with atherosclerosis, trauma, or has not developed iatrogenically. Case outline. A 53-year-old man was admitted to the hospital due to chest pain ...

    Abstract Introduction. Spontaneous coronary artery dissection (SCAD) is defined as a dissection that has not occurred with atherosclerosis, trauma, or has not developed iatrogenically. Case outline. A 53-year-old man was admitted to the hospital due to chest pain and ischemic electrocardiographical changes. Coronarography was performed and 85% of the stenosis of the first diagonal branch (D1) was registered. During percutaneous coronary intervention (PCI), one drug-eluting was directly implanted into the D1. About three hours after the intervention, the patient developed an acute myocardial infarction with ST elevation (STEMI) and recoronarography was performed. The previously implanted stent in D1 was patent without thrombi. The subocclusive stenosis of the left anterior descending artery (LAD) was registered and PCI was performed. After implantation of the stents into the LAD, propagation of dissection towards left circumflex artery (LCx) was creating significant stenosis. Following the registration of the stenosis, PCI was performed on this branch. In order to determine the cause of acute STEMI, intravascular imaging was performed, seven days after last PCI. Optical coherence tomography showed an excellent stent apposition and expansion. In the area under the stents, in the proximal segment of LAD and LCx, showed duplication in the blood vessel wall. This duplication represents an unresorbed intramural hematoma as a consequence of SCAD. Conclusion. When performing coronarography on younger patients, on women in the peripartum and on patients with connective tissue, SCAD disorders should be kept in mind. The use of intravascular imaging could reduce the number of unrecognized SCAD.
    Keywords spontaneous coronary artery dissection ; acute myocardial infarction with st elevation ; optical coherence tomography ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Serbian Medical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Primary percutaneous coronary intervention in a patient with anomalous origin of the left coronary artery from the opposite sinus of Valsalva and left main coronary artery occlusion

    Čanković Milenko / Čanji Tibor / Debeljački Dragan / Komazec Nikola / Petrović Milovan / Velicki Lazar

    Vojnosanitetski Pregled, Vol 79, Iss 9, Pp 932-

    2022  Volume 937

    Abstract: Introduction. Congenital coronary anomalies are detected in about 5% of all performed coronarographies. Coronary artery (CA) anomalies (CAA), considered to be of great risk, are the ones where the CA arises from the opposite sinus (anomalous origination ... ...

    Abstract Introduction. Congenital coronary anomalies are detected in about 5% of all performed coronarographies. Coronary artery (CA) anomalies (CAA), considered to be of great risk, are the ones where the CA arises from the opposite sinus (anomalous origination of CA from opposite sinus, ACA-OS) of Valsalva. These anomalies are detected in about 1% of cases. This report shows a unique case of a patient with anterior wall ST-elevation myocardial infarction (STEMI) caused by left main CA (LMCA) occlusion, which arose from the right coronary cusp and had an interarterial course, successfully treated with primary percutaneous coronary intervention (PCI). Case report. A 46-year-old male patient was admitted to the hospital due to STEMI of the anterior region. On admission, the patient was hypertensive (150/100 mmHg) in sinus rhythm (heart rate 70/min), Killip I. After the initial examination and admitting dual antiplatelet therapy, the patient underwent urgent coronarography. Coronarography was performed using the transradial approach. The right CA had no significant stenosis and was easily cannulated, whereas the left CA could not be cannulated at the usual position. Attempts to cannulate the left CA with multiple catheters of various curves were unsuccessful. The conclusion was that there was a CA anomaly, and the cannulation of the anomalous left CA, which arose from the opposite (right) coronary cusp (anomalous aortic origin of the left CA, AAOLCA), was successfully performed with a Multipurpose catheter. Moreover, the LMCA was occluded in the distal segment. Two drug-eluting stents (DES) were implanted, but the patient developed the no-reflow phenomenon and cardiogenic shock. After the patient was stabilized, computed tomography (CT) coronarography was performed, and AAOLCA with an interarterial course was registered. During the follow-up period, single photon emission computed tomography (SPECT) was per-formed, and in the staged procedure, a stent was implanted into the proximal circumflex artery using the T and ...
    Keywords computed tomography angiography ; coronary angiography ; coronary occlusion ; coronary vessel anomalies ; percutaneous coronary intervention ; sinus of valsalva ; st elevation myocardial infarction ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Military Health Department, Ministry of Defance, Serbia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Disrupting arrhythmia in a professional male wrestler athlete after rapid weight loss and high-intensity training-Case report.

    Milovančev, Aleksandra / Miljković, Tatjana / Ilić, Aleksandra / Stojšić Milosavljević, Anastazija / Petrović, Milovan / Roklicer, Roberto / Lakičević, Nemanja / Trivić, Tatjana / Drid, Patrik

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1091603

    Abstract: Introduction: Physiological heart adaptations may lead to increased susceptibility to arrhythmia in athletes. Furthermore, vigorous training and method like rapid weight loss (RWL) in combat sports could pose additional risks. This case represents how ... ...

    Abstract Introduction: Physiological heart adaptations may lead to increased susceptibility to arrhythmia in athletes. Furthermore, vigorous training and method like rapid weight loss (RWL) in combat sports could pose additional risks. This case represents how routine cardiovascular screening during high-risk methods like RWL and high-intensity training (HIT) reveal abrupt ventricular arrhythmias in a young athlete.
    Case report: We report a case of a 20-year-old male wrestler athlete who developed disrupting arrhythmia during RWL and HIT. The study included: a medical exam, 12 lead electrocardiograms (ECG), transthoracic echocardiogram (ECHO), and 24 h of continuous ECG monitoring in baseline, phase one (P1), (in which the athlete had to simulate RWL through vigorous training and dietary intervention and HIT) and phase two (P2), (with the same HIT protocol performed without the RWL procedure). Baseline laboratory analyses were without abnormalities, ECG showed sinus rhythm with one premature atrial contraction (PAC) and ECHO showed signs of concentric remodeling with preserved systolic, diastolic function, and global longitudinal strain. After P1 RWL simulation, he lost 5.15% of body weight in 3 days, which resulted in lower blood glucose levels, higher urea, creatinine, creatine kinase (CK), CK-MB levels, and slightly increased levels of NT pro-BNP, ECG revealed sinus rhythm with one ventricular premature beat (VPB), 24-h continuous electrocardiogram (ECG) revealed frequent ventricular premature beats (PVB) 2,150/ 24 h, with two couplets, and 8 PAC. After an advised 4-week period of de-training continuous 24 h, ECG monitoring was improved with only occasional PVB. The 24 h continuous ECG monitoring was repeated after HIT and revealed even more frequent PVB, 5% of all beats for 24 h, 4,205 in total, and almost all VPB were in bigeminy and trigeminy. The athlete was advised against RWL and extremely vigorous exercise and for regular, frequent checkups with occasional ECG monitoring during and after exercise.
    Conclusion: The short and long-term implication of abrupt ventricular arrhythmias provoked by intensive training and methods like RWL is unknown. We postulate that cardiovascular screening is necessitated, especially during high-risk methods like RWL and HIT, in helping us prevent adverse outcomes and come to individual-based clinical making decisions for each athlete.
    Language English
    Publishing date 2023-01-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1091603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Management and outcomes of spontaneous coronary artery dissection: a systematic review of the literature.

    Petrović, Milovan / Miljković, Tatjana / Ilić, Aleksandra / Kovačević, Mila / Čanković, Milenko / Dabović, Dragana / Stojšić Milosavljević, Anastazija / Čemerlić Maksimović, Snežana / Jaraković, Milana / Andrić, Dragica / Golubović, Miodrag / Bjelobrk, Marija / Bjelić, Snežana / Tadić, Snežana / Slankamenac, Jelena / Apostolović, Svetlana / Djurović, Vladimir / Milovančev, Aleksandra

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1276521

    Abstract: Background: Contemporary management of spontaneous coronary artery dissection (SCAD) is still controversial. This systematic review of the literature aims to explore outcomes in the patients treated with conservative management vs. invasive strategy.: ...

    Abstract Background: Contemporary management of spontaneous coronary artery dissection (SCAD) is still controversial. This systematic review of the literature aims to explore outcomes in the patients treated with conservative management vs. invasive strategy.
    Methods: The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed when we extensively searched three electronic databases: PubMed, ScienceDirect, and Web of Science, for studies that compared conservative vs. invasive revascularization treatment outcomes for patients with SCAD from 2003 to 2023. The outcomes of interest were all-cause death and major adverse cardiovascular events (MACE), including acute coronary syndrome (ACS), heart failure (HF), need for additional revascularization, target vessel revascularization (TVR), SCAD recurrence, and stroke.
    Results: The systematic review included 13 observational studies evaluating 1,801 patients with SCAD. The overall mean age was 49.12 +/- 3.41, and 88% were females. The overall prevalence of arterial hypertension was 33.2%, hyperlipidemia, 26.9%, smoking, 17.8%, and diabetes, 3.9%. Approximately 48.5% of the patients were diagnosed with non-ST elevated myocardial infarction (NSTEMI), 36.8% with ST elevated myocardial infarction (STEMI), 3.41% with unstable angina, 0.56% with stable angina, and 0.11% were diagnosed with various types of arrhythmias. The left anterior descending artery (LAD) was the most common culprit lesion in 51% of the patients. There were initially 65.2% of conservatively treated patients vs. 33.4% that underwent percutaneous coronary intervention (PCI) or 1.28% that underwent coronary artery bypass graft (CABG). SCAD-PCI revascularization was associated with a variable range of PCI failure. The most common complications were hematoma extension and iatrogenic dissection. SCAD-PCI revascularization frequently required three or more stents and had residual areas of dissection. The overall reported in-hospital and follow-up mortality rates were 1.2% and 1.3%, respectively. The follow-up range across studies was 7.3-75.6 months. The authors reported variable prevalence of MACE, recurrent SCAD up to 31%, ACS up to 27.4%, TVR up to 30%, repeat revascularization up to 14.7%, UA up to 13.3%, HF up to 17.4%, and stroke up to 3%.
    Conclusion: Our results highlight that conservative treatment should be the preferred method of treatment in patients with SCAD. PCI revascularization is associated with a high prevalence of periprocedural complications. SCAD poses a considerable risk of MACE, mainly associated with TVR, ACS, and recurrent SCAD.
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1276521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Early massive gastrointestinal bleeding as a complication of left ventricular assist device implantation

    Redžek Aleksandar / Preveden Andrej / Golubović Miodrag / Gocić-Perić Nataša / Popov Tanja / Petrović Milovan / Nikolić Ivan / Jakovljević Đorđe G. / Velicki Lazar

    Vojnosanitetski Pregled, Vol 78, Iss 6, Pp 666-

    2021  Volume 670

    Abstract: Introduction. Implantation of left ventricular assist device (LVAD) improves survival and quality of life in patients with end-stage heart failure. We reported a case of a severe gastrointestinal bleeding as a life threatening complication in early ... ...

    Abstract Introduction. Implantation of left ventricular assist device (LVAD) improves survival and quality of life in patients with end-stage heart failure. We reported a case of a severe gastrointestinal bleeding as a life threatening complication in early recovering postoperative period of continuous blood flow LVAD implantation. Case report. The patient had a history of heart failure due to ischemic cardiomyopathy with low systolic function, as an indication for LVAD implantation. The operation and the postoperative course were uneventful. On the 17th postoperative day, the patient developed severe anemia, which was followed by melena with blood clots. Endoscopic examinations revealed diffuse colonic bleeding. Oral anticoagulation therapy was discontinued, and fresh frozen plasma, K vitamin substitution, and human prothrombin complex were administered. The LVAD speed was reduced and subcutaneous administration of somatostatin analog octreotide was initiated. These measures successfully stopped the bleeding and the patient was stabilized. Due to a multidisciplinary team approach, the bleeding was successfully managed and the patient re-covered. Conclusion. Acute gastrointestinal bleeding represents a serious, life-threatening condition that can develop after LVAD implantation, but with timely and appropriate measurements, it can be successfully treated.
    Keywords gastrointestinal hemorrhage ; heart assist devices ; heart failure ; postoperative period ; treatment outcome ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Military Health Department, Ministry of Defance, Serbia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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