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  1. AU="Petsch, Thomas"
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  1. Article: Potentially inappropriate medication in patients with chronic kidney disease and elderly patients.

    Lüthke, Nikolas / Scheuch, Matthias / Engeßer, Jonas / von Rheinbaben, Sabrina / Hoffmann, Richardt / Aymanns, Simone / Fiene, Beate / Endlich, Nicole / Endlich, Karlhans / Lendeckel, Uwe / Rettig, Rainer / Petsch, Thomas / Dabers, Thomas / Stracke, Sylvia

    Clinical nephrology

    2022  Volume 98, Issue 1, Page(s) 42–48

    Abstract: Background: Most patients with chronic kidney disease (CKD) are old, comorbid, and subjected to polypharmacy. This study describes prevalence and predictors of potentially inappropriate medication (PIM) in CKD patients.: Materials and methods: ... ...

    Abstract Background: Most patients with chronic kidney disease (CKD) are old, comorbid, and subjected to polypharmacy. This study describes prevalence and predictors of potentially inappropriate medication (PIM) in CKD patients.
    Materials and methods: Medication plans of CKD patients of the "Greifswald Approach to Individualized Medicine" cross-sectional study (GANI_MED) were checked for PIM based on kidney function (PIM-K) and PIM for elderly patients (PIM-E). PIM-K were defined by prescription instructions of product labeling. PIM-E were defined by BEERS, -PRISCUS, and FORTA criteria. Predictors for PIM were identified through multiple stepwise regression.
    Results: 375 patients were included (age: 67.9 ± 13.5 years; estimated glomerular filtration rate (eGFR): 23.3 ± 18.6 mL/min/1.73m
    Conclusion: Polypharmacy, PIM-K, and PIM-E affect many CKD patients and can lead to adverse events. Deprescribing and targeted prescribing may improve the outcome of CKD patients and elderly patients.
    MeSH term(s) Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Humans ; Inappropriate Prescribing ; Middle Aged ; Potentially Inappropriate Medication List ; Renal Insufficiency, Chronic/etiology ; Risk Factors
    Language English
    Publishing date 2022-05-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CN110808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 873: Show issues Location:
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  2. Article: Sonografie in der Nephrologie

    Dabers, Thomas / Petsch, Thomas / Maybauer, Werner / Stracke, Sylvia

    Dialyse aktuell

    2017  Volume 21, Issue 09, Page(s) 442–448

    Abstract: Die Sonografie ist das wichtigste bildgebende Verfahren in der nephrologischen Primärdiagnostik. Sie ist jederzeit verfügbar, die Patienten müssen kaum auf die Untersuchung vorbereitet werden und im Gegensatz zu vielen anderen ... ...

    Abstract Die Sonografie ist das wichtigste bildgebende Verfahren in der nephrologischen Primärdiagnostik. Sie ist jederzeit verfügbar, die Patienten müssen kaum auf die Untersuchung vorbereitet werden und im Gegensatz zu vielen anderen Untersuchungsmethoden hat die Sonografie keine schädlichen Nebenwirkungen für den Patienten und die untersuchten Organe. Die Sonografie der Nieren zeigt Organgröße und Beschaffenheit der Nierenrinde (= Nierenparenchym) und gibt Aufschluss über akute und chronische Krankheiten. Es können bestimmte Erkrankungen ausgeschlossen werden (z. B. Harnstau) und Hinweise auf andere Erkrankungen gesehen werden (z. B. Raumforderungen, Zysten, narbige Einziehungen, Verschmälerungen oder Schwellungen des Nierenparenchyms). Die Sonografie der Armgefäße vor Shuntanlage, die Beurteilung des ausgereiften Shunts (Flussvolumen, Stenosen) und auch die ultraschallgestützte Beurteilung der Füllung der Vena cava bei Dialysepatienten sind weitere wichtige Anwendungen des Verfahrens. Die Sonografie wird zudem für Interventionen eingesetzt. Sie wird leitliniengerecht bei Punktionen der Nieren oder der Anlage von zentralvenösen Kathetern verwendet. So hilft die Sonografie bei der Abklärung akuter und chronischer Krankheitsverläufe, der Therapiesteuerung (Bestimmung des Volumenhaushaltes) und ist unverzichtbar zur Risikoreduktion bei Interventionen.
    Language German
    Publishing date 2017-11-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2146225-2
    ISSN 1860-3300 ; 1434-0704
    ISSN (online) 1860-3300
    ISSN 1434-0704
    DOI 10.1055/s-0043-116625
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  3. Conference proceedings: Potentiell inadäquate Medikationen in Patienten mit chronischer Nierenerkrankung und älteren Patienten

    Lüthke, Nikolas / Scheuch, Matthias / Engeßer, Jonas / von Rheinbaben, Sabrina / Hoffmann, Richardt / Aymanns, Simone / Fiene, Beate / Endlich, Nicole / Endlich, Karlhans / Lendeckel, Uwe / Rettig, Rainer / Petsch, Thomas / Dabers, Thomas / Stracke, Sylvia

    2022  , Page(s) V–14–06

    Event/congress 56. Kongress für Allgemeinmedizin und Familienmedizin; Greifswald; Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin; 2022
    Keywords Medizin, Gesundheit
    Publishing date 2022-09-15
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22degam082
    Database German Medical Science

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  4. Article ; Online: Short-term functional adaptation of aquaporin-1 surface expression in the proximal tubule, a component of glomerulotubular balance.

    Pohl, Marcus / Shan, Qixian / Petsch, Thomas / Styp-Rekowska, Beata / Matthey, Patricia / Bleich, Markus / Bachmann, Sebastian / Theilig, Franziska

    Journal of the American Society of Nephrology : JASN

    2014  Volume 26, Issue 6, Page(s) 1269–1278

    Abstract: Transepithelial water flow across the renal proximal tubule is mediated predominantly by aquaporin-1 (AQP1). Along this nephron segment, luminal delivery and transepithelial reabsorption are directly coupled, a phenomenon called glomerulotubular balance. ...

    Abstract Transepithelial water flow across the renal proximal tubule is mediated predominantly by aquaporin-1 (AQP1). Along this nephron segment, luminal delivery and transepithelial reabsorption are directly coupled, a phenomenon called glomerulotubular balance. We hypothesized that the surface expression of AQP1 is regulated by fluid shear stress, contributing to this effect. Consistent with this finding, we found that the abundance of AQP1 in brush border apical and basolateral membranes was augmented >2-fold by increasing luminal perfusion rates in isolated, microperfused proximal tubules for 15 minutes. Mouse kidneys with diminished endocytosis caused by a conditional deletion of megalin or the chloride channel ClC-5 had constitutively enhanced AQP1 abundance in the proximal tubule brush border membrane. In AQP1-transfected, cultured proximal tubule cells, fluid shear stress or the addition of cyclic nucleotides enhanced AQP1 surface expression and concomitantly diminished its ubiquitination. These effects were also associated with an elevated osmotic water permeability. In sum, we have shown that luminal surface expression of AQP1 in the proximal tubule brush border membrane is regulated in response to flow. Cellular trafficking, endocytosis, an intact endosomal compartment, and controlled protein stability are the likely prerequisites for AQP1 activation by enhanced tubular fluid shear stress, serving to maintain glomerulotubular balance.
    MeSH term(s) Adaptation, Physiological ; Animals ; Aquaporin 1/genetics ; Aquaporin 1/metabolism ; Cell Membrane Permeability/physiology ; Cells, Cultured ; Disease Models, Animal ; Gene Expression Regulation ; Glomerular Filtration Rate/physiology ; Kidney Tubules, Proximal/physiopathology ; Mice ; Mice, Transgenic ; Microvilli/metabolism ; Osmosis ; Protein Transport/physiology ; Random Allocation ; Sensitivity and Specificity ; Time Factors ; Water-Electrolyte Balance/genetics ; Water-Electrolyte Balance/physiology
    Chemical Substances Aqp1 protein, mouse ; Aquaporin 1 (146410-94-8)
    Language English
    Publishing date 2014-09-30
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2014020148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
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  5. Article: Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa).

    Bachmann, Sebastian / Schlichting, Uwe / Geist, Beate / Mutig, Kerim / Petsch, Thomas / Bacic, Desa / Wagner, Carsten A / Kaissling, Brigitte / Biber, Jürg / Murer, Heini / Willnow, Thomas E

    Journal of the American Society of Nephrology : JASN

    2004  Volume 15, Issue 4, Page(s) 892–900

    Abstract: Renal reabsorption of inorganic phosphate is mediated by the type IIa sodium phosphate cotransporter (NaPi-IIa) of the proximal tubule. Changes in renal phosphate handling are mainly attributable to altered NaPi-IIa brush border membrane (BBM) expression. ...

    Abstract Renal reabsorption of inorganic phosphate is mediated by the type IIa sodium phosphate cotransporter (NaPi-IIa) of the proximal tubule. Changes in renal phosphate handling are mainly attributable to altered NaPi-IIa brush border membrane (BBM) expression. Parathyroid hormone (PTH) induces inactivation of NaPi-IIa by endocytic membrane retrieval and degradation. The key elements triggering this process are not clear to date. Megalin serves as a receptor for the endocytosis of multiple ligands and is coexpressed with NaPi-IIa in the proximal tubule. Investigated was the role of megalin in the regulation of NaPi-IIa in steady state and during inactivation. Kidneys and tubular BBM fractions from mice with a renal-specific megalin gene defect and from controls were analyzed by light and electron microscopic histochemical techniques and Western blot test. Steady-state levels of NaPi-IIa in BBM were significantly enhanced, mRNA levels preserved, and phosphaturia reduced in the absence of megalin. Fluid-phase endocytosis was prevented and the apical endocytic apparatus markedly reduced. Systemic administration of PTH resulted in a defective retrieval and impaired degradation of NaPi-IIa. In vitro, the application of various stimuli of the PTH-induced signaling cascade had no effect either. Adequate steady-state expression of NaPi-IIa and the capacity of the proximal tubule cell to react on PTH-driven inactivation of NaPi-IIa by endocytosis and intracellular translocation require the presence of megalin.
    MeSH term(s) Animals ; Kidney/metabolism ; Kidney/ultrastructure ; Low Density Lipoprotein Receptor-Related Protein-2/genetics ; Male ; Mice ; Mice, Knockout ; Parathyroid Hormone/pharmacology ; Sodium-Phosphate Cotransporter Proteins ; Sodium-Phosphate Cotransporter Proteins, Type IIa ; Symporters/drug effects ; Symporters/metabolism
    Chemical Substances Low Density Lipoprotein Receptor-Related Protein-2 ; Parathyroid Hormone ; Slc34a1 protein, mouse ; Sodium-Phosphate Cotransporter Proteins ; Sodium-Phosphate Cotransporter Proteins, Type IIa ; Symporters
    Language English
    Publishing date 2004-03-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1097/01.asn.0000120389.09938.21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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