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  1. Article ; Online: HPV16

    Konstantopoulos, Georgios / Leventakou, Danai / Saltiel, Despoina-Rozi / Zervoudi, Efthalia / Logotheti, Eirini / Pettas, Spyros / Karagianni, Korina / Daiou, Angeliki / Hatzistergos, Konstantinos E / Dafou, Dimitra / Arsenakis, Minas / Kottaridi, Christine

    Viruses

    2024  Volume 16, Issue 1

    Abstract: Human Papillomaviruses have been associated with the occurrence of cervical cancer, the fourth most common cancer that affects women globally, while 70% of cases are caused by infection with the high-risk types HPV16 and HPV18. The integration of these ... ...

    Abstract Human Papillomaviruses have been associated with the occurrence of cervical cancer, the fourth most common cancer that affects women globally, while 70% of cases are caused by infection with the high-risk types HPV16 and HPV18. The integration of these viruses' oncogenes
    MeSH term(s) Female ; Humans ; B7-H1 Antigen/genetics ; Human papillomavirus 16/genetics ; Immune Evasion ; MicroRNAs/genetics ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/virology ; Oncogene Proteins, Viral/genetics
    Chemical Substances B7-H1 Antigen ; MicroRNAs ; MIRN143 microRNA, human ; E6 protein, Human papillomavirus type 16 ; Oncogene Proteins, Viral ; HIF1A protein, human
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16010113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Partial validation of a six-month high-fat diet and fructose-glucose drink combination as a mouse model of nonalcoholic fatty liver disease.

    Makri, Evangelia S / Xanthopoulos, Konstantinos / Mavrommatis Parasidis, Panagiotis / Makri, Eleftheria / Pettas, Spyros / Tsingotjidou, Anastasia / Cheva, Angeliki / Ballaouri, Iris / Gerou, Spyridon / Goulas, Antonis / Polyzos, Stergios A

    Endocrine

    2024  

    Abstract: Purpose: The need to investigate the pathogenesis and treatment of nonalcoholic fatty liver disease (NAFLD) has led to the development of multiple mouse models. The aim of this study was to validate a fast food diet (FFD) mouse model that is introduced ... ...

    Abstract Purpose: The need to investigate the pathogenesis and treatment of nonalcoholic fatty liver disease (NAFLD) has led to the development of multiple mouse models. The aim of this study was to validate a fast food diet (FFD) mouse model that is introduced as being close to the human disease.
    Methods: Eight to nine weeks old male and female C57BL/6 J mice were randomly allocated to a FFD group or to a chow diet (CD) group. Every four weeks, mice were weighed, and blood samples were collected for the measurement of glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglycerides (TGs) and total cholesterol. After 25 weeks, mice were sacrificed, and liver tissue was histologically evaluated.
    Results: FFD mice gained more weight (p = 0.049) and presented a higher liver-to-body weight ratio (p < 0.001) compared to CD mice. FFD group presented with greater steatosis, hepatocellular ballooning and NAFLD activity score (NAS), whereas lobular inflammation and fibrosis were not significantly different compared to CD. When stratified by sex, NAS was different between FFD and CD groups in both male and female mice. Group by time interaction was significant for weight, ALT and cholesterol, but not for glucose, AST and TGs.
    Conclusion: FFD mice presented with morphologic and biochemical features of NAFLD and with greater hepatic steatosis, hepatocellular ballooning and NAS, but not lobular inflammation and fibrosis, compared to CD mice. These results only partly validate the FFD mouse model for NAFLD, at least for a 6-month feeding period.
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-024-03769-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3884: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Αnti-prion effects of anthocyanins.

    Christoudia, Nikoletta / Bekas, Nikolaos / Kanata, Eirini / Chatziefsthathiou, Athanasia / Pettas, Spyros / Karagianni, Korina / Da Silva Correia, Susana Margarida / Schmitz, Matthias / Zerr, Inga / Tsamesidis, Ioannis / Xanthopoulos, Konstantinos / Dafou, Dimitra / Sklaviadis, Theodoros

    Redox biology

    2024  Volume 72, Page(s) 103133

    Abstract: Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), are protein-based neurodegenerative disorders (NDs) affecting humans and animals. They are characterized by the conformational conversion of the normal cellular prion protein, ...

    Abstract Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), are protein-based neurodegenerative disorders (NDs) affecting humans and animals. They are characterized by the conformational conversion of the normal cellular prion protein, PrP
    Language English
    Publishing date 2024-03-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2024.103133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Systematic Review of Common and Brain-Disease-Specific RNA Editing Alterations Providing Novel Insights into Neurological and Neurodegenerative Disease Manifestations.

    Karagianni, Korina / Pettas, Spyros / Christoforidou, Georgia / Kanata, Eirini / Bekas, Nikolaos / Xanthopoulos, Konstantinos / Dafou, Dimitra / Sklaviadis, Theodoros

    Biomolecules

    2022  Volume 12, Issue 3

    Abstract: RNA editing contributes to transcriptome diversification through RNA modifications in relation to genome-encoded information (RNA-DNA differences, RDDs). The deamination of Adenosine (A) to Inosine (I) or Cytidine (C) to Uridine (U) is the most common ... ...

    Abstract RNA editing contributes to transcriptome diversification through RNA modifications in relation to genome-encoded information (RNA-DNA differences, RDDs). The deamination of Adenosine (A) to Inosine (I) or Cytidine (C) to Uridine (U) is the most common type of mammalian RNA editing. It occurs as a nuclear co- and/or post-transcriptional event catalyzed by ADARs (Adenosine deaminases acting on RNA) and APOBECs (apolipoprotein B mRNA editing enzyme catalytic polypeptide-like genes). RNA editing may modify the structure, stability, and processing of a transcript. This review focuses on RNA editing in psychiatric, neurological, neurodegenerative (NDs), and autoimmune brain disorders in humans and rodent models. We discuss targeted studies that focus on RNA editing in specific neuron-enriched transcripts with well-established functions in neuronal activity, and transcriptome-wide studies, enabled by recent technological advances. We provide comparative editome analyses between human disease and corresponding animal models. Data suggest RNA editing to be an emerging mechanism in disease development, displaying common and disease-specific patterns. Commonly edited RNAs represent potential disease-associated targets for therapeutic and diagnostic values. Currently available data are primarily descriptive, calling for additional research to expand global editing profiles and to provide disease mechanistic insights. The potential use of RNA editing events as disease biomarkers and available tools for RNA editing identification, classification, ranking, and functional characterization that are being developed will enable comprehensive analyses for a better understanding of disease(s) pathogenesis and potential cures.
    MeSH term(s) Adenosine/genetics ; Adenosine/metabolism ; Adenosine Deaminase/genetics ; Adenosine Deaminase/metabolism ; Animals ; Brain/metabolism ; Brain Diseases ; Mammals/metabolism ; Neurodegenerative Diseases/genetics ; RNA ; RNA Editing/genetics
    Chemical Substances RNA (63231-63-0) ; Adenosine Deaminase (EC 3.5.4.4) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12030465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Profiling Microglia through Single-Cell RNA Sequencing over the Course of Development, Aging, and Disease.

    Pettas, Spyros / Karagianni, Korina / Kanata, Eirini / Chatziefstathiou, Athanasia / Christoudia, Nikoletta / Xanthopoulos, Konstantinos / Sklaviadis, Theodoros / Dafou, Dimitra

    Cells

    2022  Volume 11, Issue 15

    Abstract: Microglia are macrophages present in the brain that function as the primary and most important source of immune response in the central nervous system (CNS). Regardless of their multitasking role, our knowledge regarding their molecular heterogeneity is ... ...

    Abstract Microglia are macrophages present in the brain that function as the primary and most important source of immune response in the central nervous system (CNS). Regardless of their multitasking role, our knowledge regarding their molecular heterogeneity is limited; due to technical restrictions, it is only possible to measure gene expression in cell populations, not individual cells, with the results reflecting average mRNA levels. Therefore, recent scientific approaches have focused on single-cell techniques such as single-cell RNA sequencing (scRNAseq), a powerful technique that enables the delineation of transcriptomic cell-to-cell differences, revealing subpopulations with distinct molecular and functional characteristics. Here, we summarize recent studies that focused on transcriptomic microglial subpopulation clustering and classify them into three distinct groups based on age, spatial distribution, and disease. Additionally, we cross-compare populations from different studies to identify expressional and functional overlaps between them.
    MeSH term(s) Central Nervous System ; Microglia/metabolism ; Sequence Analysis, RNA ; Transcriptome/genetics
    Language English
    Publishing date 2022-08-02
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11152383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Carnosic Acid and Carnosol Display Antioxidant and Anti-Prion Properties in In Vitro and Cell-Free Models of Prion Diseases.

    Karagianni, Korina / Pettas, Spyros / Kanata, Eirini / Lioulia, Elisavet / Thune, Katrin / Schmitz, Matthias / Tsamesidis, Ioannis / Lymperaki, Evgenia / Xanthopoulos, Konstantinos / Sklaviadis, Theodoros / Dafou, Dimitra

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: Prion diseases are transmissible encephalopathies associated with the conversion of the physiological form of the prion protein ( ... ...

    Abstract Prion diseases are transmissible encephalopathies associated with the conversion of the physiological form of the prion protein (PrP
    Language English
    Publishing date 2022-04-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11040726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: RNA Editing Alterations Define Disease Manifestations in the Progression of Experimental Autoimmune Encephalomyelitis (EAE).

    Dafou, Dimitra / Kanata, Eirini / Pettas, Spyros / Bekas, Nikolaos / Dimitriadis, Athanasios / Kempapidou, Garyfalia / Lagoudaki, Roza / Theotokis, Paschalis / Touloumi, Olga / Delivanoglou, Nikoleta / Kesidou, Evangelia / Xanthopoulos, Konstantinos / Grigoriadis, Nikolaos / Papavasiliou, Fotini Nina / Sklaviadis, Theodoros

    Cells

    2022  Volume 11, Issue 22

    Abstract: RNA editing is an epitranscriptomic modification, leading to targeted changes in RNA transcripts. It is mediated by the action of ADAR (adenosine deaminases acting on double-stranded (ds) RNA and APOBEC (apolipoprotein B mRNA editing enzyme catalytic ... ...

    Abstract RNA editing is an epitranscriptomic modification, leading to targeted changes in RNA transcripts. It is mediated by the action of ADAR (adenosine deaminases acting on double-stranded (ds) RNA and APOBEC (apolipoprotein B mRNA editing enzyme catalytic polypeptide-like) deaminases and appears to play a major role in the pathogenesis of many diseases. Here, we assessed its role in experimental autoimmune encephalomyelitis (EAE), a widely used non-clinical model of autoimmune inflammatory diseases of the central nervous system (CNS), which resembles many aspects of human multiple sclerosis (MS). We have analyzed in silico data from microglia isolated at different timepoints through disease progression to identify the global editing events and validated the selected targets in murine tissue samples. To further evaluate the functional role of RNA editing, we induced EAE in transgenic animals lacking expression of APOBEC-1. We found that RNA-editing events, mediated by the APOBEC and ADAR deaminases, are significantly reduced throughout the course of disease, possibly affecting the protein expression necessary for normal neurological function. Moreover, the severity of the EAE model was significantly higher in APOBEC-1 knock-out mice, compared to wild-type controls. Our results implicate regulatory epitranscriptomic mechanisms in EAE pathogenesis that could be extrapolated to MS and other neurodegenerative disorders (NDs) with common clinical and molecular features.
    MeSH term(s) Humans ; Mice ; Animals ; RNA Editing/genetics ; APOBEC-1 Deaminase/genetics ; Encephalomyelitis, Autoimmune, Experimental/genetics ; RNA, Double-Stranded ; Mutagenesis, Site-Directed ; Mice, Knockout
    Chemical Substances APOBEC-1 Deaminase (EC 3.5.4.36) ; RNA, Double-Stranded
    Language English
    Publishing date 2022-11-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11223582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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