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Article ; Online: Long-term efficacy and impact on quality of life of atrial fibrillation catheter ablation in competitive athletes.

Toso, Elisabetta / Gagliardi, Marco / Peyracchia, Mattia / Angelini, Filippo / Anselmino, Matteo / Ferraris, Federico / Giustetto, Carla / Scaglione, Marco / Gaita, Fiorenzo

The Journal of sports medicine and physical fitness

2021 Volume 62, Issue 9, Page(s) 1266–1271

Abstract: Background: Limited data are available on the efficacy of catheter ablation (CA) for sport-associated atrial fibrillation (AF), in particular at long term follow-up. Moreover, the impact of AF CA on Quality of Life (QoL) in this population remains ... ...

Abstract	Background: Limited data are available on the efficacy of catheter ablation (CA) for sport-associated atrial fibrillation (AF), in particular at long term follow-up. Moreover, the impact of AF CA on Quality of Life (QoL) in this population remains unknown. We aimed to determine AF CA efficacy in athletes, to assess the impact on athletes' QoL (with SF36 score) and on training capabilities in a long-term follow-up (FU). Methods: A total of 1215 AF patients' candidates to CA between January 2007 and December 2012, were retrospectively screened. Athletes were defined as patients performing ≥5 h/week of vigorous sports, achieving a total of ≥1500 h lifetime sport activity, for at least one year before AF first symptomatic episode. Results: Out of 1215 AF patients, 133 were considered competitive athletes and underwent CA. Overall, 43% of our cohort showed typical or atypical atrial flutter, which required a more extensive ablation procedure. Before AF, athletes used to practice for a mean of 8.5±2.7 h/week, while after the first AF episode the mean practice duration decreased to 2.8±2.5 h/week. At 10-year follow-up, 83% of athletes did not present any recurrent event, and training capabilities increased up to 5.6±3.6 h/week after the procedure. Moreover, intense physical activity before AF CA was related to long-term AF recurrence rates (P=0.05). QoL scores significantly improved in each single domain (P<0.05). Conclusions: AF CA represents an effective procedure to maintain sinus rhythm in athletes, with a significant improvement in QoL.
MeSH term(s)	Athletes ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/surgery ; Catheter Ablation/methods ; Humans ; Quality of Life ; Recurrence ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-12-21
Publishing country	Italy
Document type	Journal Article
ZDB-ID	410823-1
ISSN	1827-1928 ; 0022-4707
ISSN (online)	1827-1928
ISSN	0022-4707
DOI	10.23736/S0022-4707.21.13257-8
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Article: Subcutaneous implantable cardioverter-defibrillator implantation assisted by hypnotic communication in a patient with Brugada syndrome.

Scaglione, Marco / Peyracchia, Mattia / Battaglia, Alberto / Di Donna, Paolo / Cerrato, Natascia / Lamanna, Andrea / Caponi, Domenico

HeartRhythm case reports

2019 Volume 6, Issue 4, Page(s) 198–201

Language	English
Publishing date	2019-12-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834871-0
ISSN	2214-0271
ISSN	2214-0271
DOI	10.1016/j.hrcr.2019.12.008
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Article ; Online: Prevalence and predictors of left atrial thrombosis in atrial fibrillation patients treated with non-vitamin K antagonist oral anticoagulants.

Angelini, Filippo / Bocchino, Pier Paolo / Peyracchia, Mattia / Saglietto, Andrea / Magnano, Massimo / Patanè, Nicolò / D'Ascenzo, Fabrizio / Giustetto, Carla / Anselmino, Matteo / Gaita, Fiorenzo / Toso, Elisabetta

Acta cardiologica

2021 Volume 78, Issue 3, Page(s) 290–297

Abstract: Background: Few data are available regarding the prevalence of left atrium (LA) thrombi in atrial fibrillation (AF) patients treated with non-vitamin K antagonist oral anticoagulants (NOACs). Methods: We evaluated the prevalence and predictors of LA/LA ... ...

Abstract	Background: Few data are available regarding the prevalence of left atrium (LA) thrombi in atrial fibrillation (AF) patients treated with non-vitamin K antagonist oral anticoagulants (NOACs). Methods: We evaluated the prevalence and predictors of LA/LA appendage (LAA) thrombi in non-valvular AF patients treated with NOACs referring to a single centre for a scheduled electrical cardioversion (ECV) or catheter ablation (CA). Transesophageal echocardiography (TEE) was performed within 12 h prior to the index procedure. Results: A total of 352 consecutive patients with non-valvular AF treated with NOACs were included in this analysis (ECV group Conclusions: Among real-world patients with non-valvular AF treated with NOACs, we found a high incidence of LA/LAA thrombi compared to previous reports. The main predictors of LA/LAA thrombosis were a CHA
MeSH term(s)	Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Anticoagulants/therapeutic use ; Prevalence ; Administration, Oral ; Retrospective Studies ; Heart Atria/diagnostic imaging ; Atrial Appendage/surgery ; Heart Diseases/drug therapy ; Thrombosis/diagnosis ; Thrombosis/epidemiology ; Thrombosis/etiology ; Obesity/drug therapy ; Echocardiography, Transesophageal
Chemical Substances	Anticoagulants
Language	English
Publishing date	2021-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	390197-x
ISSN	1784-973X ; 0001-5385
ISSN (online)	1784-973X
ISSN	0001-5385
DOI	10.1080/00015385.2021.2005307
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Article ; Online: Prevalence and prognosis of lead masses in patients with cardiac implantable electronic devices without infection.

Golzio, Pier Giorgio / Errigo, Daniele / Peyracchia, Mattia / Gallo, Elisa / Frea, Simone / Castagno, Davide / Budano, Carlo / Giustetto, Carla / Rinaldi, Mauro

Journal of cardiovascular medicine (Hagerstown, Md.)

2019 Volume 20, Issue 6, Page(s) 372–378

Abstract: Background: Finding of intracardiac lead masses in patients with cardiac implantable electronic devices remains controversial, as such masses have been observed in cases of exclusively local infections whereas they have not been recognized in patients ... ...

Abstract	Background: Finding of intracardiac lead masses in patients with cardiac implantable electronic devices remains controversial, as such masses have been observed in cases of exclusively local infections whereas they have not been recognized in patients with positive cultures of intravascular lead fragments. In this study, we aim to describe the prevalence of intracardiac lead masses in true asymptomatic patients with cardiac implantable electronic devices, to identify their predictive factors and to define their prognostic impact at long-term follow-up. Methods: Seventy-eight consecutive patients admitted over a 6-month period for elective generator replacement without clinical evidence of infection were evaluated by transthoracic and transesophageal echocardiography and prospectively followed at in-clinic follow-up visits. Results: Lead masses were found in 10 patients (12.8%). These patients had more frequently right ventricular dysfunction at univariate analysis (OR 2.71, P = 0.010) and after baseline variables adjustment (hazard ratio 6.25, P = 0.012). At 5-year follow-up without any specific therapy, none of the patients suffered from any cardiac device infections, or developed clinical signs of infections. Conclusion: There is an evidence of clinical lead masses in asymptomatic patients with cardiac implantable electronic devices. The value of these findings is still debated for aetiological interpretation and for therapeutic strategy, but they are not necessarily associated with an infection.
MeSH term(s)	Aged ; Aged, 80 and over ; Asymptomatic Diseases ; Cardiac Pacing, Artificial/adverse effects ; Defibrillators, Implantable/adverse effects ; Device Removal ; Echocardiography, Transesophageal ; Electric Countershock/adverse effects ; Electric Countershock/instrumentation ; Female ; Heart Diseases/diagnostic imaging ; Heart Diseases/epidemiology ; Heart Diseases/surgery ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Pacemaker, Artificial/adverse effects ; Prevalence ; Prospective Studies ; Prosthesis-Related Infections/diagnostic imaging ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/surgery ; Time Factors
Language	English
Publishing date	2019-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000000797
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Zs.A 5210: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Impact of chronic kidney disease on mortality in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. A long-term single-center mortality study.

Peyracchia, Mattia / Scacciatella, Paolo / Conrotto, Federico / Meynet, Ilaria / Biava, Lorenza M / Budano, Carlo / Pennone, Mauro / D'Amico, Maurizio / Gaita, Fiorenzo

Minerva cardioangiologica

2018 Volume 66, Issue 1, Page(s) 6–15

Abstract: Background: Chronic kidney disease (CKD) is associated with increased risk of mortality. We examined the impact of moderate and severe CKD at presentation on short- and long-term mortality among unselected patients with ST-segment elevation myocardial ... ...

Abstract	Background: Chronic kidney disease (CKD) is associated with increased risk of mortality. We examined the impact of moderate and severe CKD at presentation on short- and long-term mortality among unselected patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI). Methods: The study cohort consists of 501 patients (pts), enrolled from October 2005 to December 2012. The median follow-up was 46.52±25.58 months (range 8-99). A severe CKD (estimated Glomerular Filtration Rate [eGFR] <30 mL/min/1.73 m2) was detected in 16 pts (3.19%), a moderate CKD (eGFR 30-59 mL/min/1.73 m2) in 110 (21.96%) and a normal kidney function (eGFR >60 mL/min/1.73 m2) in 375 (74.85%). Results: The crude in-hospital mortality rate resulted significantly higher in pts with severe and moderate CKD compared to pts with normal renal function (50% and 19.08% versus 2.93%, P<0.0001), as well as the long-term mortality rate (57.14% and 46.34% versus 8.77%, P<0.0001). After adjustment for confounding variables, severe and moderate CKD resulted the main independent predictors of in-hospital (odds ratio [OR]=21.815, P<0.0001 for severe CKD and OR= 4.203, P=0.002 for moderate CKD) and long-term (hazard ratio [HR]= 5.272, P=0.001; HR= 1.978, P=0.006) mortality. Conclusions: CKD is a frequent condition in patients with STEMI treated with PPCI and it is associated to an excess of mortality, resulting the main independent negative prognostic predictor.
MeSH term(s)	Aged ; Cohort Studies ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention/methods ; Prognosis ; Prospective Studies ; Renal Insufficiency, Chronic/mortality ; Renal Insufficiency, Chronic/physiopathology ; ST Elevation Myocardial Infarction/mortality ; ST Elevation Myocardial Infarction/therapy ; Severity of Illness Index ; Time Factors
Language	English
Publishing date	2018-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123583-7
ISSN	1827-1618 ; 0026-4725
ISSN (online)	1827-1618
ISSN	0026-4725
DOI	10.23736/S0026-4725.17.04506-6
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Article ; Online: Incidence of thromboembolic events following atrial fibrillation catheter ablation and rate control strategies according to the kind of oral anticoagulation: A systematic review and meta-analysis.

Toso, Elisabetta / Peyracchia, Mattia / Matta, Mario / D'Ascenzo, Fabrizio / Gaita, Fiorenzo / Kornej, Jelena / Hindricks, Gerhard / Jared Bunch, Thomas / Saliba, Walid

International journal of cardiology

2018 Volume 270, Page(s) 172–179

Abstract: Introduction: Anticoagulantion therapy (OAT) represents the cornerstone to reduce thromboembolic events for atrial fibrillation (AF). Recent studies suggest that AF catheter ablation on top of OAT may be useful to further reduce the thromboembolic risk ... ...

Abstract	Introduction: Anticoagulantion therapy (OAT) represents the cornerstone to reduce thromboembolic events for atrial fibrillation (AF). Recent studies suggest that AF catheter ablation on top of OAT may be useful to further reduce the thromboembolic risk in AF patients. The aim of the present study is to compare the long-term risk of thromboembolic events and treatment-related complications in patients with AF treated by OAT strategies and catheter ablation. Methods: Pubmed, Cochrane and Google Scholar were searched for studies including >500 patients evaluating AF patients treated with OAT (VKA: vitamin K antagonist or DOAC: Direct oral anticoagulants) and/or AF ablation. Pooled incidence of stroke/year was the primary end point, while that of stroke, of all cause bleeding and of major bleeding the secondary ones. All the analyses were stratified according to the CHADS Results: Overall, 27 studies were selected, including 50,973 patients in the AF catheter ablation group; 281,595 patients in the VKA group; 54,811 patients in the DOAC group. After a mean follow-up of 2.4 (1.5-3.8) years, the overall incidence of stroke and thromboembolic events was 0.63 per 100 patients/year in AF ablation group, 2.09 per 100 patients/year in VKA group and 1.24 per 100 patients/year in DOAC group (p < 0.001). After stratification in 4 groups according to CHADS Conclusion: AF catheter ablation significantly reduces the incidence of long-term thromboembolic events compared to both VKA and DOAC. This reduction is maintained in all CHADS
MeSH term(s)	Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/therapy ; Catheter Ablation/adverse effects ; Catheter Ablation/trends ; Female ; Heart Rate/drug effects ; Heart Rate/physiology ; Humans ; Incidence ; Male ; Thromboembolism/diagnosis ; Thromboembolism/epidemiology
Chemical Substances	Anticoagulants
Language	English
Publishing date	2018-06-19
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2018.06.082
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Article ; Online: Electrocardiographic and clinical predictors for permanent pacemaker requirement after transcatheter aortic valve implantation: a 10-year single center experience.

Errigo, Daniele / Golzio, Pier G / D'Ascenzo, Fabrizio / Ragaglia, Enrico / Bruno, Francesco / Salizzoni, Stefano / Peyracchia, Mattia / Castagno, Davide / Budano, Carlo / D'Amico, Maurizio / Frea, Simone / Baldi, Enrico / Giustetto, Carla / DE Ferrari, Gaetano M

The Journal of cardiovascular surgery

2020 Volume 62, Issue 2, Page(s) 169–174

Abstract: Background: The aim of this study is to identify clinical, electrocardiographic (ECG) and procedural predictors for permanent pacemaker (PPM) requirement after transaortic valve implantation (TAVI).: Methods: All consecutive patients with severe ... ...

Abstract	Background: The aim of this study is to identify clinical, electrocardiographic (ECG) and procedural predictors for permanent pacemaker (PPM) requirement after transaortic valve implantation (TAVI). Methods: All consecutive patients with severe symptomatic aortic stenosis (SSAS) undergoing TAVI at our single center were included in the study and prospectively followed. All patients had standard 12-leads ECGs recordings before and after TAVI and continuous ECG monitoring during hospital stay. Primary endpoint was to identify electrocardiographic predictors of PPM implantation after TAVI; secondary endpoint was to ascertain other clinical or procedure-related predictive factors of PPM need. PPM implantation was further arbitrarily divided into early and late one (beyond the 3 Results: Among the 431 patients undergoing TAVI between 2008 and 2018, 77 (18%) needed PPM implantation; 47 (11%) had an early procedure, and 30 (7%) a late implant. Preoperative right bundle branch block (RBBB) implies more than five-fold increase of the risk of PPM implantation (OR 5.19, CI 1.99-13.56, P=0.001), whereas the use of a self-expandable prosthesis is associated with an almost three-fold increase of the risk (OR 2.60, CI 1.28-5.28, P=0.008). In the late PPM implantation subgroup, only the history of syncope retains a significant association with such an increased risk (OR 2.71, CI 1.09-6.75, P=0.032). Conclusions: The need of a PPM in the individual TAVI patient is hardly predictable. However, the finding of pre-existing RBBB, the use of self-expandable prosthesis and history of syncope can individuate patients at increased risk.
MeSH term(s)	Aged, 80 and over ; Aortic Valve Stenosis/surgery ; Bundle-Branch Block/surgery ; Electrocardiography ; Female ; Humans ; Male ; Pacemaker, Artificial ; Postoperative Complications/surgery ; Risk Factors ; Transcatheter Aortic Valve Replacement
Language	English
Publishing date	2020-09-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	80143-4
ISSN	1827-191X ; 0021-9509
ISSN (online)	1827-191X
ISSN	0021-9509
DOI	10.23736/S0021-9509.20.11342-9
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Article ; Online: Prognostic role of left atrial enlargement in patients with implantable cardioverter defibrillators for primary prevention.

Bissolino, Arianna / Andreis, Alessandro / Magnano, Massimo / Budano, Carlo / Saglietto, Andrea / Angelini, Filippo / Roagna, Edoardo / Mattivi, Simone / Peyracchia, Mattia / Errigo, Daniele / Golzio, Pier Giorgio / Castagno, Davide / Giustetto, Carla / De Ferrari, Gaetano Maria

Acta cardiologica

2020 Volume 77, Issue 1, Page(s) 45–50

Abstract: Purpose: Left atrial volume index (LAVI) is a predictor of heart failure and adverse events, irrespective of left ventricular systolic function. The role of LAVI in the prediction of appropriate implantable cardioverter-defibrillator (ICD) therapies is ... ...

Abstract	Purpose: Left atrial volume index (LAVI) is a predictor of heart failure and adverse events, irrespective of left ventricular systolic function. The role of LAVI in the prediction of appropriate implantable cardioverter-defibrillator (ICD) therapies is currently unclear and was the focus of this study. Methods: Consecutive heart failure patients with ischaemic (ICM) or idiopathic (DCM) aetiology receiving ICD for primary prevention were included. The primary endpoint was the occurrence of appropriate ICD therapies (ATs): shocks or antitachycardia pacing (ATP). Inappropriate ICD shocks were also assessed as secondary endpoint. Results: Among 198 included patients, severe left atrial dilatation (SLAE = LAVI ≥ 60 ml/m Conclusion: In DCM or ICM patients candidate to receive an ICD for primary prevention, a severely enlarged left atrium is a predictive factor for ATs (shocks or ATP). The risk of inappropriate shocks was increased in patients with atrial fibrillation, rather than SLAE.
MeSH term(s)	Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/therapy ; Defibrillators, Implantable/adverse effects ; Heart Failure ; Humans ; Primary Prevention ; Prognosis ; Treatment Outcome
Language	English
Publishing date	2020-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	390197-x
ISSN	1784-973X ; 0001-5385
ISSN (online)	1784-973X
ISSN	0001-5385
DOI	10.1080/00015385.2020.1856491
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Article ; Online: Zero-fluoroscopy atrial fibrillation ablation in the presence of a patent foramen ovale: a multicentre experience.

Scaglione, Marco / Ebrille, Elisa / Caponi, Domenico / Battaglia, Alberto / Di Donna, Paolo / Anselmino, Matteo / Peyracchia, Mattia / Mazzucchi, Paolo / Cerrato, Natascia / Ferraris, Federico / Castagno, Davide / Lamberti, Filippo / Gaita, Fiorenzo

Journal of cardiovascular medicine (Hagerstown, Md.)

2020 Volume 21, Issue 4, Page(s) 292–298

Abstract: Introduction: Atrial fibrillation ablation has historically been guided by fluoroscopy, with the related enhanced risk deriving from radiation. Fluoroscopy exposure may be confined to guide the transseptal puncture. Small sample size study presented a ... ...

Abstract	Introduction: Atrial fibrillation ablation has historically been guided by fluoroscopy, with the related enhanced risk deriving from radiation. Fluoroscopy exposure may be confined to guide the transseptal puncture. Small sample size study presented a new methodology to perform a totally fluoroless atrial fibrillation ablation in the case of a patent foramen ovale (PFO). We evaluated this methodology in a large sample size of patients and a multicentre experience. Methods and results: Two hundred and fifty paroxysmal atrial fibrillation patients referred for first atrial fibrillation ablation with a CARTO3 electroanatomic mapping system were enrolled. In 58 out of 250 patients, a PFO allowed crossing of the interatrial septum, and a completely fluoroless ablation was performed applying the new method (Group A). In the remaining patients, a standard transseptal puncture was performed (Group B). Pulmonary vein isolation was achieved in all patients with comparable procedural and clinical outcomes at short- and long-term follow-up. Conclusion: The presence of a PFO may allow a completely fluoroless well tolerated and effective atrial fibrillation ablation. Probing the fossa ovalis looking for the PFO during the procedure is desirable, as it is not time-consuming and can potentially be done in every patient undergoing atrial fibrillation ablation.
MeSH term(s)	Action Potentials ; Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Electrophysiologic Techniques, Cardiac ; Female ; Foramen Ovale, Patent/diagnostic imaging ; Heart Rate ; Humans ; Italy ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Pulmonary Veins/physiopathology ; Pulmonary Veins/surgery ; Surgery, Computer-Assisted/adverse effects ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2020-02-27
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000000943
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Article ; Online: Beta-blocker therapy reduces mortality in patients with coronary artery disease treated with percutaneous revascularization: a meta-analysis of adjusted results.

Peyracchia, Mattia / Errigo, Daniele / Raposeiras Rubin, Sergio / Conrotto, Federico / DiNicolantonio, James J / Omedè, Pierluigi / Rettegno, Sara / Iannaccone, Mario / Moretti, Claudio / D'Amico, Maurizio / Gaita, Fiorenzo / D'Ascenzo, Fabrizio

Journal of cardiovascular medicine (Hagerstown, Md.)

2018 Volume 19, Issue 7, Page(s) 337–343

Abstract: Aims: The long-term impact of beta blockers on prognosis in patients treated with contemporary therapies for coronary artery disease remains to be defined.: Methods and results: All observational studies evaluating the impact of beta blockers in ... ...

Abstract	Aims: The long-term impact of beta blockers on prognosis in patients treated with contemporary therapies for coronary artery disease remains to be defined. Methods and results: All observational studies evaluating the impact of beta blockers in patients treated with coronary revascularization and contemporary therapies and adjusted with multivariate analysis were included. All-cause death was the primary endpoint, while Major Adverse Cardiac Events (MACE) (composite endpoint of all-cause death or myocardial infarction, MI) and MI were secondary endpoints. A total of 26 studies were included, with 863 335 patients. After 3 (1-4.3) years, long-term risk of all-cause death was lower in patients on beta blockers [odds ratio, OR 0.69 (0.66-0.72)], both for Acute Coronary Syndrome (ACS) [OR 0.60 (0.56-0.65)], and stable angina patients [OR 0.84 (0.78-0.91)], independently from ejection fraction [OR 0.64 (0.42-0.98) for reduced ejection fraction and OR 0.79 (0.69-0.91) for preserved ejection fraction]. The risk of long-term MACE was lower but NS for ACS patients treated with beta blockers [OR 0.83 (0.69-1.00)], as in stable angina. Similarly, risk of MI did not differ between patients treated with beta blockers or without beta blockers [OR 0.99 (0.89-1.09), all 95% confidence intervals]. Using meta-regression analysis, the benefit of beta blockers was increased for those with longer follow-up. The number needed to treat was 52 to avoid one event of all-cause death for ACS patients and 111 for stable patients. Conclusion: Even in percutaneous coronary intervention era, beta blockers reduce mortality in patients with coronary artery disease, confirming their protective effect, which was consistent for both ACS and stable patients indifferently of preserved or reduced ejection fraction.
MeSH term(s)	Acute Coronary Syndrome/mortality ; Adrenergic beta-Antagonists/therapeutic use ; Cause of Death ; Coronary Artery Disease/complications ; Coronary Artery Disease/therapy ; Humans ; Multivariate Analysis ; Myocardial Infarction/mortality ; Observational Studies as Topic ; Percutaneous Coronary Intervention ; Registries ; Stroke Volume ; Treatment Outcome ; Ventricular Dysfunction, Left/complications
Chemical Substances	Adrenergic beta-Antagonists
Language	English
Publishing date	2018-07-27
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000000662
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito