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Article ; Online: Preoperative Albumin-to-Alkaline Phosphatase Ratio as an Independent Predictor of Lymph Node Involvement in Penile Cancer.

Tufano, Antonio / Napolitano, Luigi / Barone, Biagio / Pezone, Gabriele / Alvino, Pierluigi / Cilio, Simone / Buonerba, Carlo / Canciello, Giuseppina / Passaro, Francesco / Perdonà, Sisto

Medicina (Kaunas, Lithuania)

2024 Volume 60, Issue 3

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Alkaline Phosphatase ; Penile Neoplasms/surgery ; Penile Neoplasms/pathology ; Prognosis ; Retrospective Studies ; Lymph Nodes/pathology ; Lymph Node Excision ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Albumins
Chemical Substances	Alkaline Phosphatase (EC 3.1.3.1) ; Albumins
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60030414
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Article: Intra-scrotal epidermoid cyst rupture misdiagnosed as a testicular prosthesis rupture: A case report.

Fraia, Agostino / Di Bello, Francesco / Pezone, Gabriele / Collà Ruvolo, Claudia / Califano, Gianluigi / Longo, Nicola

Urology case reports

2023 Volume 52, Page(s) 102639

Abstract: Testicular cancers represent about 5 % of all urological tumors. Most patients who undergo radical orchiectomy (RO) decide to place a testicular prosthesis, for a cosmetic result and to accept the testicular loss. Among all late complications, a ... ...

Abstract	Testicular cancers represent about 5 % of all urological tumors. Most patients who undergo radical orchiectomy (RO) decide to place a testicular prosthesis, for a cosmetic result and to accept the testicular loss. Among all late complications, a spontaneous prosthesis rupture is a rare event contrary to penile prosthesis. The present study reported the case of a 53-year-old Italian man has presented to our department principally for a suspicious rupture of testicular implant, placed twenty years before after a RO. Despite the findings at scrotal ultrasonography, at final histology, the mass was identified as spontaneously broken intra-scrotal epidermoid cyst.
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	2745459-9
ISSN	2214-4420
ISSN	2214-4420
DOI	10.1016/j.eucr.2023.102639
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Article ; Online: Sexual Outcomes after Conservative Management for Patients with Localized Penile Cancer.

Cilio, Simone / Tufano, Antonio / Pezone, Gabriele / Alvino, Pierluigi / Spena, Gianluca / Pandolfo, Savio Domenico / Del Prete, Paola / Amato, Claudio / Damiano, Rocco / Salonia, Andrea / Autorino, Riccardo / Izzo, Alessandro / Passaro, Francesco / Perdonà, Sisto

Current oncology (Toronto, Ont.)

2023 Volume 30, Issue 12, Page(s) 10501–10508

Abstract: Background: Men with localized invasive penile cancer (PC) can be treated with organ-sparing treatments with different functional and aesthetical outcomes. Thus, the aim of this study is to investigate sexual outcomes in patients with PC confined to the ...

Abstract	Background: Men with localized invasive penile cancer (PC) can be treated with organ-sparing treatments with different functional and aesthetical outcomes. Thus, the aim of this study is to investigate sexual outcomes in patients with PC confined to the glans that underwent wide local excision (WLE) vs. glansectomy with urethral glanduloplasty. Methods: Complete data from 60 patients with PC were analyzed at our institution from 2017 to 2022. Patients were asked for personal habits and clinical features. PC was assessed with a clinical visit and imaging techniques. At the outpatient follow-up visit or phone call, all patients compiled the Changes in Sexual Function Questionnaire (CSFQ) and the International Index of Erectile Function in its short 5-item form (IIEF-5). Erectile function (EF) impairment was categorized using Cappelleri's criteria. Results: Overall, 34 patients with PC confined to the glans (c ≤ T2N0) were included. Of those, 12 underwent WLE and 22 underwent glansectomy with urethral glanduloplasty. Using multivariable logistic regression, glansectomy (OR: 3.49) and diabetes (OR: 2.33) were associated with erectile disfunction (IEEF < 22). Meanwhile, using multivariable linear regression analysis, younger patients (Coeff: -2.41) and those that underwent glansectomy (Coeff: -7.5) had a higher risk of sexual function impairment, according to the CSFQ. Conclusions: Patients with PC ≤ T2N0 that underwent WLE have better outcomes in terms of sexual functioning than the patients who underwent glansectomy and uretheral gladuloplasty. Further research is needed to clarify the outcomes of penile-sparing surgery, to inform patients in pre-surgical counseling more comprehensively, and to meet their post-operative expectations more effectively.
MeSH term(s)	Male ; Humans ; Erectile Dysfunction/psychology ; Penile Neoplasms/surgery ; Penile Erection ; Conservative Treatment ; Penis/surgery
Language	English
Publishing date	2023-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol30120765
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Article ; Online: Incidence and Predicting Factors of Histopathological Features at Robot-Assisted Radical Prostatectomy in the mpMRI Era: Results of a Single Tertiary Referral Center.

Di Mauro, Ernesto / Di Bello, Francesco / Califano, Gianluigi / Morra, Simone / Creta, Massimiliano / Celentano, Giuseppe / Abate, Marco / Fraia, Agostino / Pezone, Gabriele / Marino, Claudio / Cilio, Simone / Capece, Marco / La Rocca, Roberto / Imbimbo, Ciro / Longo, Nicola / Colla' Ruvolo, Claudia

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 3

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Male ; Humans ; Prostate/surgery ; Prostate/pathology ; Robotics ; Multiparametric Magnetic Resonance Imaging ; Incidence ; Tertiary Care Centers ; Prostatectomy/methods ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/surgery ; Prostatic Neoplasms/pathology ; Retrospective Studies ; Neoplasm Grading
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59030625
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Article ; Online: Lower urinary tract symptoms in young-middle aged males with a diagnosis of obstructive sleep apnea syndrome.

Di Bello, Francesco / Pezone, Gabriele / Muzii, Benedetta / Cilio, Simone / Ruvolo, Claudia Collà / Scandurra, Cristiano / Mocini, Edoardo / Creta, Massimiliano / Morra, Simone / Bochicchio, Vincenzo / Salzano, Giovanni / Vaira, Luigi Angelo / Mangiapia, Francesco / Motta, Gaetano / Maldonato, Nelson Mauro / Longo, Nicola / Cantone, Elena / Califano, Gianluigi

Neurourology and urodynamics

2023 Volume 43, Issue 1, Page(s) 144–152

Abstract: Background: The aim of the current study is to measure the prevalence and the potential role of International Prostate Symptom Score (IPSS) score as a predictor of obstructive sleep apnea syndrome (OSAS) in male experienced lower urinary tract symptoms ( ...

Abstract	Background: The aim of the current study is to measure the prevalence and the potential role of International Prostate Symptom Score (IPSS) score as a predictor of obstructive sleep apnea syndrome (OSAS) in male experienced lower urinary tract symptoms (LUTS). Methods: A cross-sectional web-based Italian survey was administered via Google Forms between July 17 and October 31, 2022. The urinary functioning was measured through the IPSS questionnaire. Specifically, we considered symptoms occurring more than "about half the time" (score ≥ 3) as bothering symptoms. Multivariable logistic regression models (LRMs) adjusting for age, body mass index (BMI), International Index of Erectile Function-5, IPSS, and hypertension were fitted to predict OSAS in the cohort of men responding to the survey and experiencing LUTS. Results: Overall, 58 (24.4%) patients had a confirmed diagnosis of OSAS. The overall median IPSS was 5 (inter quartile range [IQR]: 3-8), respectively. According to IPSS items, 24 (10%), 44 (18.4%), 12 (5%), 12 (5%), 12 (5%), 11 (4.6%), 63 (26.4%) patients exhibit incomplete bladder emptying, urinary frequency, intermittency, urgency, weak stream, straining, nocturia with a score ≥ 3, respectively. After multivariable LRMs predicting the developing OSAS, age (odds ratio [OR]: 1.09, p < 0.001), BMI (OR:1.12, p < 0.001) and IPSS total score (OR:1.08, p = 0.02) were independent predicting factors. Conclusion: This analysis revealed that the IPSS total score, age, and BMI are independent predictors of OSAS in males. In this context, the use of IPSS in daily practice could be helpful in assessing the LUTS presence and in supporting physicians to identify a hidden sleep apnea condition.
MeSH term(s)	Humans ; Male ; Middle Aged ; Cross-Sectional Studies ; Lower Urinary Tract Symptoms/diagnosis ; Lower Urinary Tract Symptoms/epidemiology ; Nocturia/diagnosis ; Nocturia/epidemiology ; Nocturia/etiology ; Urination Disorders/epidemiology ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/epidemiology
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.25338
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Article ; Online: The spreading information of YouTube videos on Phosphodiesterase 5 inhibitors: a worrisome picture from one of the most consulted internet source.

Pezone, Gabriele / Collà Ruvolo, Claudia / Cilio, Simone / Fraia, Agostino / Di Mauro, Ernesto / Califano, Gianluigi / Passaro, Francesco / Creta, Massimiliano / Capece, Marco / La Rocca, Roberto / Celentano, Giuseppe / Morra, Simone / Di Bello, Francesco / Palmieri, Alessandro / Imbimbo, Ciro / Longo, Nicola

International journal of impotence research

2023

Abstract: Several previous studies on ... ...

Abstract	Several previous studies on YouTube
Language	English
Publishing date	2023-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1034295-3
ISSN	1476-5489 ; 0955-9930
ISSN (online)	1476-5489
ISSN	0955-9930
DOI	10.1038/s41443-023-00762-w
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Article: Immunotherapy for Urological Tumors on YouTube

Di Bello, Francesco / Di Mauro, Ernesto / Collà Ruvolo, Claudia / Creta, Massimiliano / La Rocca, Roberto / Celentano, Giuseppe / Capece, Marco / Napolitano, Luigi / Fraia, Agostino / Pezone, Gabriele / Morra, Simone / Imbimbo, Ciro / Mirone, Vincenzo / Longo, Nicola / Califano, Gianluigi

Vaccines

2022 Volume 11, Issue 1

Abstract: Background: YouTube: Methods: YouTube: Results: According to the selection criteria, 156 YouTube: Conclusions: ... ...

Abstract	Background: YouTube Methods: YouTube Results: According to the selection criteria, 156 YouTube Conclusions: YouTube
Language	English
Publishing date	2022-12-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11010092
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Article ; Online: A mobile health application for prostate cancer antigen dosage: is it time to say goodbye to classic screening methods?

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

2023 Volume 33, Issue 2, Page(s) 87–94

Abstract: Objective: To evaluate the quality of apps for prostate cancer antigen (PSA) dosage, available for downloading on the iOS and Android platforms, discussing the potential role of mobile health applications (MHAs) in update the screening protocol.: ... ...

Abstract	Objective: To evaluate the quality of apps for prostate cancer antigen (PSA) dosage, available for downloading on the iOS and Android platforms, discussing the potential role of mobile health applications (MHAs) in update the screening protocol. Methods: An observational cross-sectional descriptive study of all smartphone apps for PSA dosage was performed through the most used platforms (iOS and Android). On 10 February 2023, a total of 457 apps were found according to the search criteria. Mobile Application Rating Scale (MARS) was adopted to assess apps' quality. Then, MARS items were analyzed through descriptive statistics and bivariate correlations between study variables with Pearson's coefficient. Results: Of all samples, 24 MHAs were included in the final analysis: 12% (n = 3) from the iTunes App Store and 88% (n = 21) from the Google Play Store. According to the MARS quality assessment, the mean values 2.61, 2.94, 3.11, 2.97, 2.94, and 2.63 were measured for the engagement, functionality, aesthetics, information, overall mean score, and subjective quality, respectively. Conclusion: The MHAs for PSA were under the acceptability threshold and future improvements are required. Moreover, MHAs appropriately developed could play an active role in PSA screening campaign and adherence of follow-up regimens. Finally, the virtual instrument could both reduce the social divide of access to care for patients in rural areas and improve PCA detection, speeding up the active treatment.
MeSH term(s)	Male ; Humans ; Mobile Applications ; Cross-Sectional Studies ; Prostate-Specific Antigen ; Early Detection of Cancer ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/epidemiology ; Telemedicine
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	1137033-6
ISSN	1473-5709 ; 0959-8278
ISSN (online)	1473-5709
ISSN	0959-8278
DOI	10.1097/CEJ.0000000000000845
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Article ; Online: Could YouTubeTM encourage men on prostate checks? A contemporary analysis.

Morra, Simone / Napolitano, Luigi / Collà Ruvolo, Claudia / Celentano, Giuseppe / La Rocca, Roberto / Capece, Marco / Creta, Massimiliano / Passaro, Francesco / Di Bello, Francesco / Cirillo, Luigi / Turco, Carmine / Di Mauro, Ernesto / Pezone, Gabriele / Fraia, Agostino / Mangiapia, Francesco / Fusco, Ferdinando / Mirone, Vincenzo / Califano, Gianluigi / Longo, Nicola

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2022 Volume 94, Issue 3, Page(s) 285–290

Abstract: Objectives: To assess YouTube™ videos' quality on prostate checks, especially on the digital rectal exam (DRE), and to investigate if they can inform patients correctly and eradicate their beliefs and myths.: Methods: A search using as keywords " ... ...

Abstract	Objectives: To assess YouTube™ videos' quality on prostate checks, especially on the digital rectal exam (DRE), and to investigate if they can inform patients correctly and eradicate their beliefs and myths. Methods: A search using as keywords "digital rectal exam for prostate cancer" was performed on the YouTubeTM platform. We selected the ﬁrst 100 videos. To assess video quality content, Patient Education Materials Assessment Tool for audio-visual content (PEMAT A/V) and Misinformation tool were used. Results: Seventy-three videos were suitable for the analyses. The median PEMAT A/V Understandability score and PEMAT A/V Actionability score were 46.2% (interquartile range [IQR]: 30.8-76.9) and 50.0% (IQR: 25.0-75.0), respectively. The medi-an PEMAT A/V Understandability and Actionability scores were 69.2% (IQR: 46.2-88.5) vs 46.2% (IQR: 30.8-61.5) (p = 0.01) and 100.0% (IQR: 87.5-100.0) vs 25.0% (IQR: 25.0-68.8) (p < 0.001), for healthcare workers vs patients, respectively. According to the Misinformation tool, the median misinforma-tion score of the overall videos was 2.2 (IQR:1.7-2.8). According to the target audience, the misinformation score was 2.8 (IQR: 2.4-3.5) vs 2.0 (IQR: 1.5-2.8) (p = 0.02), for healthcare workers vs patients, respectively. Conclusions: Currently, based on our analyses, YouTubeTM videos' quality on DRE resulted unsatisfactory according to the PEMAT A/V score and the Misinformation tool. Videos targeted to healthcare workers got higher quality scores if compared to videos targeted to patients. Therefore, YouTubeTM videos' may not be considered a reliable source of information on DRE for patients.
MeSH term(s)	Health Promotion ; Humans ; Male ; Patient Education as Topic ; Prostate ; Social Media
Language	English
Publishing date	2022-09-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1120-8538 ; 1124-3562
ISSN (online)	2282-4197
ISSN	1120-8538 ; 1124-3562
DOI	10.4081/aiua.2022.3.285
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Article ; Online: Perioperative Red Cell Line Trend following Robot-Assisted Radical Prostatectomy for Prostate Cancer.

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 11

Abstract: Background and Objective: Blood loss represents a long-standing concern of radical prostatectomy (RP). This study aimed to assess how red line cell values changed following robot-assisted radical prostatectomy (RARP) for prostate cancer (PCa). Materials ... ...

Abstract	Background and Objective: Blood loss represents a long-standing concern of radical prostatectomy (RP). This study aimed to assess how red line cell values changed following robot-assisted radical prostatectomy (RARP) for prostate cancer (PCa). Materials and Methods: The blood panels of 453 consecutive PCa patients undergoing RARP at a single tertiary academic referral center, from September 2020 to April 2022, were reviewed. Data from 363 patients with the blood panel available for the following timeframe: within seven days before surgery, six hours after surgery, and the first three postoperative days, were analyzed. Specifically, hemoglobin (Hb, g/dL), red blood cells (RBCs, ×106/μL), and hematocrit (HCT, %) trends were collected. Results: Considering the Hb trend, the median values in the preoperative day, postoperative day (POD) 2, and POD 3 are 14.7 (interquartile range (IQR) = 13.9−15.4), 12.1 (IQR = 11.2−12.9), and 12.2 (IQR = 11.2−13.1), respectively. The ∆ between preoperative day and POD 2 is 2.5 (IQR = 1.8−3.2) (p < 0.001). Considering the RBCs trend, the median values in the preoperative day, POD 2, and POD 3 are 4.9 (IQR = 4.7−5.3), 4.1 (IQR = 3.8−4.4), and 4.1 (IQR = 3.8−4.5), respectively. The ∆ between preoperative day and POD 2 is 0.9 (IQR = 0.6−1.1) (p < 0.001). Considering the HCT trend, the median values in the preoperative day, POD 2, and POD 3 are 44.4 (IQR = 41.7−46.6), 36.4 (IQR = 33.8−38.9), and 36.1 (IQR = 33.5−38.7), respectively. The ∆ between preoperative day and POD 2 is 7.8 (IQR = 5.2−10.5) (p < 0.001). Conclusions: Overall, patients undergoing RARP experience a significant, but clinically limited, decline in red line cell values between the preoperative time and the second day post-surgery. These observations are important to provide physicians with knowledge of the expected postoperative course and, thus, to improve the quality of patient care.
MeSH term(s)	Male ; Humans ; Robotics ; Robotic Surgical Procedures ; Treatment Outcome ; Prostatectomy ; Prostatic Neoplasms/surgery ; Erythrocytes ; Cell Line
Language	English
Publishing date	2022-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58111520
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