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  1. Book ; Online: Biological and Pharmacological Activity of Plant Natural Compounds III

    Pezzani, Raffaele / Vitalini, Sara

    2023  

    Keywords Medicine ; seaweed ; extraction ; vitamin B12 ; central composite design ; curcumin ; antioxidant properties ; ozone ; Ammodaucus leucotrichus ; proximate analysis ; mineral element analysis ; decoction ; alcoholic extract ; essential oil ; secondary metabolites ; ammolactone-A ; R-perillaldehyde ; chemical characterization ; seaweeds ; marine algae ; marine drugs ; fucoidan ; sulfated polysaccharide ; cancer ; adjuvant ; prebiotics ; Candida albicans ; Lavandula angustifolia ; fluconazole ; caspofungin ; time-kill curve ; antioxidative activity ; antimicrobial activity ; Thai edible plant ; microwave-assisted extraction ; ultrasonic-assisted extraction ; quercetin ; antioxidant ; toxipathy ; diabetes mellitus ; advanced glycation end products (AGEs) ; protein cross link formation ; Punica granatum peel ; methylglyoxal ; apocarotenoid ; abiotic stress ; β-carotene ; gene expression ; herb-drug interactions ; Andrographis paniculata ; andrographolide ; glipizide ; superoxide dismutase ; isoflavones ; ion mobility-mass spectrometry ; amyotrophic lateral sclerosis ; aggregation ; bacterial resistance ; combination therapy ; COVID-19 ; medicinal plants ; new drugs ; synergism ; G. tenax ; GC-MS ; anti-spasmodic ; Ca2++ channel blockers ; phosphodiesterase ; artichoke bud ; synchronous extraction ; aqueous two-phase system ; dual-response surface model ; antioxidant activity ; carbohydrates ; polyphenols ; Carica papaya ; in silico ; cytotoxicity ; ethanol extract ; sepsis ; almond [Prunus dulcis (Mill.) DA Webb] hull ; extract ; triterpenoid acids ; hydroxycinnamic acids ; Ajuga integrifolia ; binding energies ; flavonoids ; phenolic acids ; shigellosis ; nephrotoxicity ; cisplatin ; diosmin ; lipid peroxidation ; inflammatory cytokines
    Language English
    Size 1 electronic resource (304 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030376502
    ISBN 9783036570600 ; 3036570608
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Biological and Pharmacological Activity of Plant Natural Compounds II

    Pezzani, Raffaele / Vitalini, Sara

    2022  

    Keywords Medicine ; Pharmacology ; Bergenia species ; botanical description ; traditional uses ; phytochemistry ; pharmacology ; anti-urolithiatic activity ; bergenin ; Flaxseed oil ; linusorb B3 ; anti-cancer ; apoptosis ; actin polymerization ; Src ; glioblastoma ; chlorogenic acid ; coffee ; cyclooxygenase ; espresso ; instant coffee ; platelet aggregation ; Rubia tinctorum L. ; antioxidants ; polyphenols ; ethylene glycol ; urolithiasis ; histophatology ; Saccharomyces cerevisiae ; β-glucan ; antimicrobial and anticancer activities ; detoxification ability ; immunomodulatory effect ; Aquilaria sinensis ; pheophorbide A ; MMP-2 ; MMP-9 ; HT-1080 ; advanced glycation end product (AGE) ; oxidative stress ; epithelial to mesenchymal transition ; AGE-inhibitor ; swertiamarin ; diabetic nephropathy ; astragaloside IV ; Astragalus membranaceus ; huang qi ; Astragali Radix ; liver ; liver regeneration ; 70% partial hepatectomy ; proliferation ; rat ; memory ; object recognition ; Ginkgo biloba ; dorsal hippocampus formation ; brain-derived neurotrophic factor ; Diclofenac ; γ-lactone ; nano-emulsion ; methylcellulose ; Ostrich oil ; Struthio camelus ; Caenorhabditis elegans ; leaf extract ; neuroprotection ; antioxidant activity ; DAF-16 ; Clerodendrum infortunatum ; terpenoids ; phenylpropanoids ; antidiabetic ; breast cancer ; Combretum indicum L. ; antidiabetic activity ; histopathology ; UPLC-QTOF/ESI-MS ; network pharmacology ; Biebersteinia heterostemon ; galegine ; hypotensive ; toxicity ; Sage ; Salvia officinalis ; cytotoxicity ; hepatoprotection ; MDA ; TAOxC ; MCF-7 ; HeLA cells ; HepG-2 cells ; Peganum harmala ; anti-inflammatory activity ; antioxidant ; LC-ESI-MS/MS ; traditional medicine ; rheumatoid arthritis ; rosmanol ; carnosol ; Callicarpa longissima ; TLR4/NF-κB/MAPK ; synergistic effect ; diabetes mellitus ; anti-diabetic drugs ; monoterpenes
    Language 0|e
    Size 1 electronic resource (338 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021609156
    ISBN 9783036535050 ; 3036535055
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Biological and Pharmacological Activity of Plant Natural Compounds

    Pezzani, Raffaele / Vitalini, Sara

    2021  

    Keywords Medicine ; natural products ; phenylpropanoids ; phenolic acids ; plants ; depression ; behavioral disorders ; forced swim test ; tail suspension test ; anti-cancer activities ; multifloroside ; 10-oxyderivatives of oleoside secoiridoids ; structure-activity relationship ; flow cytometry ; epigallocatechin-3-gallate ; EGCG ; catechin ; green tea ; cancer preventive ; pharmacological activities ; Amelanchier alnifolia Nutt ; carriers ; powders ; bioactive compounds ; functional food ; Ageratina havanensis ; flavonoids ; UPLC-ESI-MS/MS ; P-glycoprotein ; antioxidant potential ; nootkatone ; anti-inflammatory ; acute inflammation ; granuloma ; Pharbitis nil ; colorectal cancer ; KRAS ; muscle function ; juglone ; NLRP3 inflammasome ; caspase-1 ; IL-1β ; IL-18 ; plant secondary metabolites ; natural compounds ; biological activity ; phytochemistry ; pharmacological activity ; plant side effects ; Talisia esculenta ; Brosimum gaudichaudii ; Genipa americana ; Bromelia antiacantha ; RA-3 ; nephrotoxicity ; triterpene ; antioxidant ; hyperuricemia ; Hibiscus acetosella ; phenolic compound ; antibacterial ; UPLC ; Tabebuia impetiginosa ; Taheebo ; traditional uses ; immunopharmacology ; immunological disorders ; hesperidin ; new-clean process extraction ; nanocrystals ; anti-ageing ; zingerone ; lipopolysaccharide ; inflammation ; anti-oxidant ; cytokine storm ; procalcitonin ; histopathology ; doxorubicin ; Mahonia aquifolium ; matrix metalloproteinases ; cytotoxicity ; human lung adenocarcinoma ; n/a
    Size 1 electronic resource (296 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044131
    ISBN 9783036503059 ; 3036503056
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Medicinal Chemistry and Natural Plant Products: A Strong Relationship.

    Pezzani, Raffaele

    Current topics in medicinal chemistry

    2022  Volume 22, Issue 11, Page(s) 921

    MeSH term(s) Biological Products/pharmacology ; Chemistry, Pharmaceutical ; Plants
    Chemical Substances Biological Products
    Language English
    Publishing date 2022-07-26
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/156802662211220608163922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A review of the literature on the use of CRISPR/Cas9 gene therapy to treat hepatocellular carcinoma.

    Amjad, Elham / Pezzani, Raffaele / Sokouti, Babak

    Oncology research

    2024  Volume 32, Issue 3, Page(s) 439–461

    Abstract: Noncoding RNAs instruct the Cas9 nuclease to site-specifically cleave DNA in the CRISPR/Cas9 system. Despite the high incidence of hepatocellular carcinoma (HCC), the patient's outcome is poor. As a result of the emergence of therapeutic resistance in ... ...

    Abstract Noncoding RNAs instruct the Cas9 nuclease to site-specifically cleave DNA in the CRISPR/Cas9 system. Despite the high incidence of hepatocellular carcinoma (HCC), the patient's outcome is poor. As a result of the emergence of therapeutic resistance in HCC patients, clinicians have faced difficulties in treating such tumor. In addition, CRISPR/Cas9 screens were used to identify genes that improve the clinical response of HCC patients. It is the objective of this article to summarize the current understanding of the use of the CRISPR/Cas9 system for the treatment of cancer, with a particular emphasis on HCC as part of the current state of knowledge. Thus, in order to locate recent developments in oncology research, we examined both the Scopus database and the PubMed database. The ability to selectively interfere with gene expression in combinatorial CRISPR/Cas9 screening can lead to the discovery of new effective HCC treatment regimens by combining clinically approved drugs. Drug resistance can be overcome with the help of the CRISPR/Cas9 system. HCC signature genes and resistance to treatment have been uncovered by genome-scale CRISPR activation screening, although this method is not without limitations. It has been extensively examined whether CRISPR can be used as a tool for disease research and gene therapy. CRISPR and its applications to tumor research, particularly in HCC, are examined in this study through a review of the literature.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/therapy ; Carcinoma, Hepatocellular/metabolism ; CRISPR-Cas Systems/genetics ; Liver Neoplasms/genetics ; Liver Neoplasms/therapy ; Liver Neoplasms/metabolism ; Genetic Therapy ; Treatment Outcome
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1114699-0
    ISSN 1555-3906 ; 0965-0407
    ISSN (online) 1555-3906
    ISSN 0965-0407
    DOI 10.32604/or.2023.044473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3087: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Adrenocortical carcinoma: current knowledge.

    Pezzani, Raffaele

    Minerva endocrinologica

    2018  Volume 44, Issue 2, Page(s) 232

    MeSH term(s) Adrenal Cortex Neoplasms/diagnosis ; Adrenal Cortex Neoplasms/surgery ; Adrenal Cortex Neoplasms/therapy ; Adrenocortical Carcinoma/diagnosis ; Adrenocortical Carcinoma/surgery ; Adrenocortical Carcinoma/therapy ; Humans
    Language English
    Publishing date 2018-02-13
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 423687-7
    ISSN 1827-1634 ; 0391-1977
    ISSN (online) 1827-1634
    ISSN 0391-1977
    DOI 10.23736/S0391-1977.18.02800-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2105: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: A systematic investigation and network interaction analysis on preventive treatments against HepG2 cancer cells from a genomic-level perspective

    Amjad, Elham / Asnaashari, Solmaz / Pezzani, Raffaele / Sokouti, Babak

    Biochemical Engineering Journal. 2023, p.109040-

    2023  , Page(s) 109040–

    Abstract: Worldwide, the fourth most common malignancy leading to death via cancer transformation is hepatocellular carcinoma (HCC). Notwithstanding various preventive approaches, the incidence and mortality of patients with HCC continue to increase. However, a ... ...

    Abstract Worldwide, the fourth most common malignancy leading to death via cancer transformation is hepatocellular carcinoma (HCC). Notwithstanding various preventive approaches, the incidence and mortality of patients with HCC continue to increase. However, a successful early diagnosis of HCC is beneficial given a potentially curative treatment. We systematically searched the publicly available NCBI microarray database to extract the required information on different preventive treatments and their affected genes and signaling pathways on HCC. Furthermore, the significant genes were analyzed through the Kaplan-Meier tool for overall survival, relapse-free survival, progression-free survival, and disease-specific survival rates. Subsequently, we assessed the protein-protein network interaction analysis and their corresponding drugs and diseases. The thorough screening of the literature microarray gene datasets revealed that various compounds could be implicated in HCC prevention. The results showed that nine genes (i.e., FGA, FGG, TP53, HELLS, CCNA2, MCM10, MCM2, PCTP, and CYP24A1) modulated the four above-mentioned survival rates. Furthermore, the associations between genes, drugs, and related diseases discovered 39 out of 61 medications covered potential anticancer agents. Finally, we demonstrated that numerous signaling pathways were simultaneously modulated in HCC. In conclusion, this work underlines the importance of the genomic-level perspective in studying HCC treatment and development.
    Keywords data collection ; databases ; death ; early diagnosis ; genes ; hepatoma ; microarray technology ; mortality ; Hepatocarcinoma ; herbal medicine ; signaling pathway ; vitamins ; fatty acid
    Language English
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 2012139-8
    ISSN 1369-703X
    ISSN 1369-703X
    DOI 10.1016/j.bej.2023.109040
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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  8. Article ; Online: Editorial to the Special Issue "Biological and Pharmacological Activity of Plant Natural Compounds".

    Pezzani, Raffaele / Vitalini, Sara

    Molecules (Basel, Switzerland)

    2020  Volume 26, Issue 1

    Abstract: Plant natural products are a valuable source of compounds with a healthy potential effect on living organisms, including animals and humans [ ... ]. ...

    Abstract Plant natural products are a valuable source of compounds with a healthy potential effect on living organisms, including animals and humans [...].
    MeSH term(s) Animals ; Biological Products/chemistry ; Biological Products/therapeutic use ; Humans ; Plants/chemistry
    Chemical Substances Biological Products
    Language English
    Publishing date 2020-12-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26010063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  9. Article: A comprehensive review on ethnobotanical, phytochemical and pharmacological aspects of the genus Dorema

    Mottaghipisheh, Javad / Vitalini, Sara / Pezzani, Raffaele / Iriti, Marcello

    Phytochemistry reviews. 2021 Oct., v. 20, no. 5

    2021  

    Abstract: The genus Dorema (Apiaceae) comprises 12 accepted species, mainly growing in Asia and, particularly, in Iran, where D. ammoniacum and D. aucheri are the most used species in cuisine and folk medicine. The Dorema species are traditionally applied in the ... ...

    Abstract The genus Dorema (Apiaceae) comprises 12 accepted species, mainly growing in Asia and, particularly, in Iran, where D. ammoniacum and D. aucheri are the most used species in cuisine and folk medicine. The Dorema species are traditionally applied in the treatment of catarrh, asthma, chronic bronchitis, as carminative, mild diuretic and anthelmintic agents. In general, 42 non-volatile secondary metabolites were isolated from the 6 studied species, namely D. aitchisonii, D. ammoniacum, D. aucheri, D. glabrum, D. hyrcanum, and D. kopetdaghense. Among them, phenolic acid, flavonoid, acetophenone, coumarin, and sesquiterpene derivatives were identified as the predominant phytoconstituents. The leaves are characterized by the highest volatile content, and the sesquiterpenes in both hydrocarbon and oxygenated forms were reported as the most abundant compounds. Most of the studied pharmacological activities were assessed in vivo. Nevertheless, in vitro antiradical and antimicrobial potentials were the main investigated activities. Overall, the evaluation of bioactivities confirmed the ethnopharmacological use of the Dorema species, particularly their anti-inflammatory, antibacterial, and hypolipidemic properties. This study comprehensively overviewed, for the first time, the literature relating to the folk medicinal use and to the available phytochemical and pharmacological data. Considering the genus application and the rare clinical trials, the study of the efficacy and safety of the uninvestigated Dorema species might be an interesting and promising approach for further researches.
    Keywords Dorema ; acetophenones ; anthelmintics ; asthma ; bronchitis ; chemical constituents of plants ; coumarin ; cuisine ; ethnobotany ; flavonoids ; phenolic acids ; secondary metabolites ; sesquiterpenoids ; traditional medicine ; Iran
    Language English
    Dates of publication 2021-10
    Size p. 945-989.
    Publishing place Springer Netherlands
    Document type Article
    Note Review
    ZDB-ID 2065661-0
    ISSN 1572-980X ; 1568-7767
    ISSN (online) 1572-980X
    ISSN 1568-7767
    DOI 10.1007/s11101-020-09727-z
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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  10. Article: Pleiotropic effects of

    Raeisi, Hamideh / Azimirad, Masoumeh / Abdemohamadi, Elham / Pezzani, Raffaele / Zali, Mohammad Reza / Yadegar, Abbas

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1273094

    Abstract: Introduction: The dramatic increase in multidrug-resistance of : Methods: The active phytochemical components of ETOH-ML were detected using GC and HPLC. The antimicrobial properties of the extract were examined against : Results: Based on our ... ...

    Abstract Introduction: The dramatic increase in multidrug-resistance of
    Methods: The active phytochemical components of ETOH-ML were detected using GC and HPLC. The antimicrobial properties of the extract were examined against
    Results: Based on our results, rosmarinic acid was the main phytochemical component of ETOH-ML. The extract showed significant antimicrobial activity against
    Discussion: Our results demonstrated for the first time the antimicrobial, anti-inflammatory, and anti-apoptotic effects of
    Language English
    Publishing date 2023-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1273094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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