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Article ; Online: Probable New Daily Persistent Headache After COVID-19 in Children and Adolescents.

Simmons, Adrienne C / Bonner, Alexandra / Giel, Ashley / Pezzano, Alexandra / Rothner, A David

2022 Volume 132, Page(s) 1–3

Abstract: Introduction: Headache has been cited as both a primary symptom and a sequela of infection with the novel coronavirus. Cases of long coronavirus disease (COVID) headache have already been documented in adults, but literature on similar cases in children ...

Abstract	Introduction: Headache has been cited as both a primary symptom and a sequela of infection with the novel coronavirus. Cases of long coronavirus disease (COVID) headache have already been documented in adults, but literature on similar cases in children and adolescents is scant. Case report: We present three cases of persistent headache after infection with COVID-19 in pediatric patients presenting to a tertiary headache center. Conclusion: Infection has been suggested as a trigger for chronic headaches, specifically those of the new daily persistent headache type. Although the association between new daily persistent headache and COVID-19 remains unclear, these cases highlight the importance of awareness of the neurological sequelae of novel coronavirus infection in children and adolescents.
MeSH term(s)	Adolescent ; Adult ; COVID-19/complications ; Child ; Disease Progression ; Headache/etiology ; Headache Disorders/diagnosis ; Headache Disorders/etiology ; Humans ; SARS-CoV-2
Language	English
Publishing date	2022-04-28
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	639164-3
ISSN	1873-5150 ; 0887-8994
ISSN (online)	1873-5150
ISSN	0887-8994
DOI	10.1016/j.pediatrneurol.2022.04.009
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Article: Can Seismocardiogram Fiducial Points Be Used for the Routine Estimation of Cardiac Time Intervals in Cardiac Patients?

Işilay Zeybek, Zeynep Melike / Racca, Vittorio / Pezzano, Antonio / Tavanelli, Monica / Di Rienzo, Marco

Frontiers in physiology

2022 Volume 13, Page(s) 825918

Abstract: The indexes of cardiac mechanics can be derived from the cardiac time intervals, CTIs, i.e., the timings among the opening and closure of the aortic and mitral valves and the Q wave in the ECG. Traditionally, CTIs are estimated by ultrasound (US) ... ...

Abstract	The indexes of cardiac mechanics can be derived from the cardiac time intervals, CTIs, i.e., the timings among the opening and closure of the aortic and mitral valves and the Q wave in the ECG. Traditionally, CTIs are estimated by ultrasound (US) techniques, but they may also be more easily assessed by the identification of specific fiducial points (FPs) inside the waveform of the seismocardiogram (SCG), i.e., the measure of the thorax micro-accelerations produced by the heart motion. While the correspondence of the FPs with the valve movements has been verified in healthy subjects, less information is available on whether this methodology may be routinely employed in the clinical practice for the monitoring of cardiac patients, in which an SCG waveform distortion is expected because of the heart dysfunction. In this study we checked the SCG shape in 90 patients with myocardial infarction (MI), heart failure (HF), or transplanted heart (TX), referred to our hospital for rehabilitation after an acute event or after surgery. The SCG shapes were classified as traditional (T) or non-traditional (NT) on whether the FPs were visible or not on the basis of nomenclature previously proposed in literature. The T shape was present in 62% of the patients, with a higher ∓ prevalence in MI (79%). No relationship was found between T prevalence and ejection fraction (EF). In 20 patients with T shape, we checked the FPs correspondence with the real valve movements by concomitant SCG and US measures. When compared with reference values in healthy subjects available in the literature, we observed that the Echo vs. FP differences are significantly more dispersed in the patients than in the healthy population with higher differences for the estimation of the mitral valve closure (-17 vs. 4 ms on average). Our results indicate that not every cardiac patient has an SCG waveform suitable for the CTI estimation, thus before starting an SCG-based CTI monitoring a preliminary check by a simultaneous SCG-US measure is advisable to verify the applicability of the methodology.
Language	English
Publishing date	2022-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.825918
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Article ; Online: Evolutionary bioenergetics of ciliates.

Lynch, Michael / Schavemaker, Paul E / Licknack, Timothy J / Hao, Yue / Pezzano, Arianna

The Journal of eukaryotic microbiology

2022 Volume 69, Issue 5, Page(s) e12934

Abstract: Understanding why various organisms evolve alternative ways of living requires information on both the fitness advantages of phenotypic modifications and the costs of constructing and operating cellular features. Although the former has been the subject ... ...

Abstract	Understanding why various organisms evolve alternative ways of living requires information on both the fitness advantages of phenotypic modifications and the costs of constructing and operating cellular features. Although the former has been the subject of a myriad of ecological studies, almost no attention has been given to how organisms allocate resources to alternative structures and functions. We address these matters by capitalizing on an array of observations on diverse ciliate species and from the emerging field of evolutionary bioenergetics. A relatively robust and general estimator for the total cost of a cell per cell cycle (in units of ATP equivalents) is provided, and this is then used to understand how the magnitudes of various investments scale with cell size. Among other things, we examine the costs associated with the large macronuclear genomes of ciliates, as well as ribosomes, various internal membranes, osmoregulation, cilia, and swimming activities. Although a number of uncertainties remain, the general approach taken may serve as blueprint for expanding this line of work to additional traits and phylogenetic lineages.
MeSH term(s)	Cell Cycle ; Cilia ; Ciliophora/genetics ; Energy Metabolism ; Phylogeny
Language	English
Publishing date	2022-07-28
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1147218-2
ISSN	1550-7408 ; 1066-5234
ISSN (online)	1550-7408
ISSN	1066-5234
DOI	10.1111/jeu.12934
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Article: L'insufficienza cardiaca nella cardiopatia ischemica.

Pezzano, A

Italian heart journal : official journal of the Italian Federation of Cardiology

2000 Volume 1 Suppl 2, Page(s) 67–71

Abstract: Heart failure is a major cause of morbidity and mortality and represents an important recognized health problem. Heart (or cardiac) failure is the pathophysiological state in which a myocardial dysfunction is frequently but non always responsible for the ...

Title translation	Cardiac failure in ischemic cardiopathy.
Abstract	Heart failure is a major cause of morbidity and mortality and represents an important recognized health problem. Heart (or cardiac) failure is the pathophysiological state in which a myocardial dysfunction is frequently but non always responsible for the inability of the heart to pump blood at a rate commensurate with tissues metabolic requirements. Ischemic heart disease is the commonest cause of heart failure frequently associated with left ventricular systolic dysfunction, although some patients, particularly the elderly, have diastolic dysfunction. Coronary heart disease is responsible for left ventricular systolic dysfunction (and cardiac failure) in the acute and chronic stage. Myocardial dysfunction is usually a consequence of myocardial infarction that may lead to ventricular remodeling with compensatory dilation and hypertrophy and subsequent systolic and diastolic dysfunction resulting in heart failure. Many patients with heart failure and/or left ventricular dysfunction are unknown. The echocardiographic screening of patients with known or suspected left ventricular dysfunction remains an important topic for future clinical epidemiological research and allows for improvement of therapeutic management of patients with cardiac dysfunction.
MeSH term(s)	Echocardiography ; Heart Failure/diagnostic imaging ; Heart Failure/epidemiology ; Heart Failure/etiology ; Humans ; Myocardial Infarction/complications ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/etiology ; Myocardial Ischemia/complications ; Myocardial Ischemia/diagnostic imaging
Language	Italian
Publishing date	2000-06
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2012387-5
ISSN	1972-6465 ; 1129-471X ; 1129-4728
ISSN (online)	1972-6465
ISSN	1129-471X ; 1129-4728
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Zs.A 5210: Show issues

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Article ; Online: Short- and long-term effects of a cardiac rehabilitation program in patients implanted with a left ventricular assist device.

Scaglione, Anna / Panzarino, Claudia / Modica, Maddalena / Tavanelli, Monica / Pezzano, Antonio / Grati, Paola / Racca, Vittorio / Toccafondi, Anastasia / Bordoni, Bruno / Verde, Alessandro / Cartella, Iside / Castiglioni, Paolo

PloS one

2021 Volume 16, Issue 12, Page(s) e0259927

Abstract: The efficacy of cardiac rehabilitation in heart-failure patients who received a left-ventricular assist device (LVAD) instead of heart transplantation (HTx) is still unclear. This study aims to evaluate whether cardiac rehabilitation is beneficial in ... ...

Abstract	The efficacy of cardiac rehabilitation in heart-failure patients who received a left-ventricular assist device (LVAD) instead of heart transplantation (HTx) is still unclear. This study aims to evaluate whether cardiac rehabilitation is beneficial in LVAD as HTx patients in the short term and whether its effects in LVAD patients persist over time. Twenty-five LVAD patients were evaluated by functional and psychological tests at admission (T0) and discharge (T1) of a 4-week inpatient structured rehabilitation program, and follow-ups 3 (T2), 6 (T3), and 12 months (T4) after discharge. Twenty-five matched HTx patients were also studied from T0 to T1 to compare the improvements in the six-minute walk test (6MWT). The quality-of-life scores substantially improved in LVAD patients and the 6MWT showed the same functional recovery as in HTx patients from T0 to T1. After T1, numerous LVAD patients withdrew from the study. However, the 6MWT outcome increased further from T1 to T3, with a positive trend during the follow-ups. Hemoglobin and the ventilatory performance increased, and the psychological perception of heart-failure symptoms and pain further improved at T2. In conclusion, exercise-based rehabilitation programs provide similar beneficial effects in LVAD and HTx patients, without deterioration in LVAD patients up to 12 months after discharge.
MeSH term(s)	Aged ; Cardiac Surgical Procedures/adverse effects ; Cardiac Surgical Procedures/instrumentation ; Cardiac Surgical Procedures/methods ; Exercise Therapy/methods ; Female ; Heart Failure/rehabilitation ; Heart Failure/surgery ; Heart-Assist Devices ; Humans ; Male ; Middle Aged ; Postoperative Complications/rehabilitation ; Psychotherapy/methods
Language	English
Publishing date	2021-12-01
Publishing country	United States
Document type	Journal Article ; Observational Study
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0259927
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Article: Procoagulant activity during coronary interventions and coronary artery patency.

Visconti, L O / Pezzano, A / Quattrocchi, G / Pezzano, A

International journal of cardiology

1999 Volume 68 Suppl 1, Page(s) S23–7

MeSH term(s)	Abciximab ; Angioplasty, Balloon, Coronary ; Animals ; Antibodies, Monoclonal/therapeutic use ; Anticoagulants/therapeutic use ; Blood Coagulation ; Coronary Disease/physiopathology ; Coronary Disease/therapy ; Immunoglobulin Fab Fragments/therapeutic use ; Platelet Aggregation ; Recurrence ; Thrombin/physiology ; Thromboplastin/physiology
Chemical Substances	Antibodies, Monoclonal ; Anticoagulants ; Immunoglobulin Fab Fragments ; Thromboplastin (9035-58-9) ; Thrombin (EC 3.4.21.5) ; Abciximab (X85G7936GV)
Language	English
Publishing date	1999-04-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/s0167-5273(98)00300-3
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Zs.A 1673: Show issues

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Article ; Online: Heart adaptations to long-term aerobic training in paraplegic subjects: an echocardiographic study.

Maggioni, M A / Ferratini, M / Pezzano, A / Heyman, J E / Agnello, L / Veicsteinas, A / Merati, G

Spinal cord

2012 Volume 50, Issue 7, Page(s) 538–542

Abstract: Study design: Case-control.: Objectives: To execute an echocardiographic comparison between trained and untrained spinal cord injury (SCI) subjects, and to evaluate whether long-term heart adjustments to endurance training are comparable to those ... ...

Abstract	Study design: Case-control. Objectives: To execute an echocardiographic comparison between trained and untrained spinal cord injury (SCI) subjects, and to evaluate whether long-term heart adjustments to endurance training are comparable to those observed in able-bodied (ABL) subjects. Setting: Italy. Methods: We enrolled: (1) 17 male SCI patients (lesion level T1-L3, 34±8 years, body mass index (BMI) 23.0±2.8 kg m(-2)), 10 of whom were aerobically trained for >5 years (SCI(T)); (2) 18 age-, sex- and BMI-matched ABL subjects (35±6 years, BMI 23.6±2.8 kg m(-2)), 10 of whom were aerobically trained for >5 years (ABL(T)). Training frequency and volume were recorded by a dedicated questionnaire. All subjects underwent a trans-thoracic echocardiography; SCI subjects also performed an exhaustive incremental exercise test. Comparisons were made between ABL and SCI groups, between trained and untrained subjects within each group (analysis of variance). Results: Effects of SCI-Compared with ABL subjects, SCI patients showed lower end-diastolic volume (76±21 vs. 113±23 ml, P<0.05) and ejection fraction (61±7% vs. 65±5%, P<0.05). Effects of training-Compared with untrained status, the intra-ventricular septum thickness (SCI, +18%; ABL, +4%), the posterior wall thickness (SCI, +17%; ABL, +2%) and the total normalized heart mass (SCI, +48%; ABL, +5%) were higher in both SCI(T) and in ABL(T). VO2peak was higher in the SCI(T) subgroup compared with the SCI(U) group. Conclusions: Heart seems to positively adapt to long-term endurance training in SCI patients. Regular exercise may therefore increase heart size, septum and posterior wall thickness, which likely contributes to improved VO2peak. These morphological and functional changes may reduce cardiovascular risk in SCI individuals.
MeSH term(s)	Adaptation, Physiological ; Adult ; Echocardiography/methods ; Exercise ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Male ; Paraplegia/etiology ; Paraplegia/physiopathology ; Paraplegia/rehabilitation ; Physical Endurance ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/physiopathology ; Spinal Cord Injuries/rehabilitation ; Stroke Volume ; Ventricular Function, Left
Language	English
Publishing date	2012-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1316161-1
ISSN	1476-5624 ; 1362-4393
ISSN (online)	1476-5624
ISSN	1362-4393
DOI	10.1038/sc.2011.189
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Zs.A 198: Show issues

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Article: La trombolisi nell'anno 2000.

Visconti, L O / Carlà, M / Pezzano, A

Giornale italiano di cardiologia

1999 Volume 29 Suppl 4, Page(s) 59–61

Title translation	Thrombolytic therapy in the year 2000.
MeSH term(s)	Forecasting ; Humans ; Thrombolytic Therapy/trends
Language	Italian
Publishing date	1999
Publishing country	Italy
Document type	Journal Article
ZDB-ID	184670-x
ISSN	0046-5968
ISSN	0046-5968
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Zs.A 761: Show issues

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Article: Carotid intima-media thickness.

Pezzano, Antonio / La Carrubba, Salvatore / Gullace, Giuseppe

Journal of cardiovascular medicine (Hagerstown, Md.)

2006 Volume 7, Issue 7, Page(s) 555–559

Abstract: In advanced countries the incidence of cardiovascular diseases is constantly increasing. During the last century many resources were employed to investigate atherosclerosis in relation to the main risk factors and to modification of lifestyles. ... ...

Abstract	In advanced countries the incidence of cardiovascular diseases is constantly increasing. During the last century many resources were employed to investigate atherosclerosis in relation to the main risk factors and to modification of lifestyles. Technologies have been developed to identify atherosclerosis in the sub-clinical phase. Measurement of the carotid intima-media thickness (IMT) by B-mode ultrasound is a well-validated procedure to detect the early stages of atherosclerosis and to track progression of atherosclerosis whereas other techniques have limited utility because of their invasive nature or limited sensitivity and reproducibility. In comparison with angiography, B-mode ultrasound has greater sensitivity for detecting early atherosclerosis and plaques at risk of rupture. IMT is associated with the severity of atherosclerosis in different vascular districts and has been measured in several clinical studies in order to assess the influence of risk factors, therapies and diet. It is also validated for drug evaluation. In spite of this evidence IMT measurement is not routinely performed in patients with high and middle levels of risk for cardiovascular diseases. Scientific societies and specifically those involved in ultrasonography should promote wider recognition of the diagnostic power of ultrasonic IMT by emphasizing the low costs and low risk of use of the instruments and its major contribution to knowledge, evaluation and monitoring of the progression of atherosclerosis.
MeSH term(s)	Atherosclerosis/diagnostic imaging ; Carotid Arteries/diagnostic imaging ; Carotid Arteries/pathology ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/pathology ; Humans ; Risk Factors ; Tunica Intima/diagnostic imaging ; Tunica Intima/pathology ; Ultrasonography
Language	English
Publishing date	2006-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/01.JCM.0000234774.81077.a6
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Zs.A 5210: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 559: Show issues

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Article: Asymptomatic Left Ventricular Dysfunction and Metabolic Syndrome: Results from an Italian Multicenter Study.

La Carrubba, Salvatore / Todaro, Maria Chiara / Zito, Concetta / Antonini-Canterin, Francesco / Monte, Ines Paola / Caso, Pio / Colonna, Paolo / de Gregorio, Cesare / Pezzano, Antonio / Benedetto, Frank / Salvo, Giovanni Di / Carerj, Scipione / Bello, Vitantonio Di

Journal of cardiovascular echography

2017 Volume 23, Issue 4, Page(s) 96–101

Abstract: Context: Metabolic syndrome (MS) is a cluster of interrelated common clinical disorders, including obesity, insulin resistance, glucose intolerance, hypertension and dyslipidemia, associated with a greater risk of atherosclerotic cardiovascular disease ... ...

Abstract	Context: Metabolic syndrome (MS) is a cluster of interrelated common clinical disorders, including obesity, insulin resistance, glucose intolerance, hypertension and dyslipidemia, associated with a greater risk of atherosclerotic cardiovascular disease than any of its individual components. Although MS is associated with increased cardiovascular risk (CVR), its relationship with heart failure (HF) and left ventricular (LV) dysfunction is not fully understood. Aims: We sought to determine whether MS is associated to LV systolic and diastolic dysfunction in a sample of patients with MS and no symptoms for HF. Subjects and methods: We enrolled 6422 consecutive asymptomatic patients admitted to echo-lab for a routine echocardiogram. We calculated LV systolic and diastolic function, by Simpson biplane method and validated Doppler parameters, respectively. MS was diagnosed if three or more CVR factors were found. Results: LV systolic function was evaluated in 6175 patients (96.2%). In the group of patients without MS ( Conclusions: Our data show that asymptomatic LV systolic and diastolic dysfunction, is correlated with MS and demonstrate that echocardiography is a useful tool to detect patients at high risk for HF. Echocardiography in asymptomatic patients with MS may lead to a therapy initiation at early stages to prevent future cardiovascular events and HF.
Language	English
Publishing date	2017-04-27
Publishing country	India
Document type	Journal Article
ZDB-ID	2734045-4
ISSN	2347-193X ; 2211-4122
ISSN (online)	2347-193X
ISSN	2211-4122
DOI	10.4103/2211-4122.127410
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