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  1. Article ; Online: Development of the Channelized Optical System II for

    Ringham, Mallory / Wang, Zhaohui Aleck / Sonnichsen, Frederick / Lerner, Steven / McDonald, Glenn / Pfeifer, Jonathan

    ACS ES&T water

    2024  Volume 4, Issue 4, Page(s) 1775–1785

    Abstract: This study describes the development of the CHANnelized Optical System II (CHANOS II), an autonomous, ...

    Abstract This study describes the development of the CHANnelized Optical System II (CHANOS II), an autonomous,
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ISSN 2690-0637
    ISSN (online) 2690-0637
    DOI 10.1021/acsestwater.3c00787
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  2. Article ; Online: Measuring Protons with Photons: A Hand-Held, Spectrophotometric pH Analyzer for Ocean Acidification Research, Community Science and Education.

    Pardis, William / Grabb, Kalina C / DeGrandpre, Michael D / Spaulding, Reggie / Beck, James / Pfeifer, Jonathan A / Long, David M

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 20

    Abstract: Ocean Acidification (OA) is negatively affecting the physiological processes of marine organisms, altering biogeochemical cycles, and changing chemical equilibria throughout the world's oceans. It is difficult to measure pH broadly, in large part because ...

    Abstract Ocean Acidification (OA) is negatively affecting the physiological processes of marine organisms, altering biogeochemical cycles, and changing chemical equilibria throughout the world's oceans. It is difficult to measure pH broadly, in large part because accurate pH measurement technology is expensive, bulky, and requires technical training. Here, we present the development and evaluation of a hand-held, affordable, field-durable, and easy-to-use pH instrument, named the pHyter, which is controlled through a smartphone app. We determine the accuracy of pH measurements using the pHyter by comparison with benchtop spectrophotometric seawater pH measurements, measurement of a certified pH standard, and comparison with a proven in situ instrument, the iSAMI-pH. These results show a pHyter pH measurement accuracy of ±0.046 pH or better, which is on par with interlaboratory seawater pH measurement comparison experiments. We also demonstrate the pHyter's ability to conduct both temporal and spatial studies of coastal ecosystems by presenting data from a coral reef and a bay, in which the pHyter was used from a kayak. These studies showcase the instrument's portability, applicability, and potential to be used for community science, STEM education, and outreach, with the goal of empowering people around the world to measure pH in their own backyards.
    MeSH term(s) Seawater/chemistry ; Ecosystem ; Protons ; Hydrogen-Ion Concentration ; Photons ; Oceans and Seas ; Carbon Dioxide/analysis
    Chemical Substances Protons ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2022-10-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22207924
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  3. Article ; Online: Pharmacotherapy of bipolar disorder in children and adolescents: recent progress.

    Pfeifer, Jonathan C / Kowatch, Robert A / DelBello, Melissa P

    CNS drugs

    2010  Volume 24, Issue 7, Page(s) 575–593

    Abstract: Child and adolescent bipolar disorder (BPD) is a serious psychiatric disorder that often causes significant impairment in functioning. Pharmacological intervention is the cornerstone of treatment for bipolar youth, although psychotherapeutic ... ...

    Abstract Child and adolescent bipolar disorder (BPD) is a serious psychiatric disorder that often causes significant impairment in functioning. Pharmacological intervention is the cornerstone of treatment for bipolar youth, although psychotherapeutic interventions may be beneficial as adjunctive treatment. Medications used for the treatment of BPD in adults are still commonly used for bipolar children and adolescents. With the recent US FDA indication of risperidone, aripiprazole, quetiapine and olanzapine for the treatment of bipolar youth, the atypical antipsychotics are rapidly becoming a first-line treatment option. However, these agents are associated with adverse effects such as increased appetite, weight gain and type II diabetes mellitus. Although several evidence-based medications are now available for the treatment of BPD in younger populations, additional studies to evaluate the short- and long-term efficacy and potential for adverse events of these and other medications are needed.
    MeSH term(s) Adolescent ; Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Anticonvulsants/therapeutic use ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Bipolar Disorder/psychology ; Child ; Drug Therapy, Combination ; Humans ; Treatment Outcome
    Chemical Substances Anticonvulsants ; Antipsychotic Agents
    Language English
    Publishing date 2010-05-04
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1203800-3
    ISSN 1179-1934 ; 1172-7047
    ISSN (online) 1179-1934
    ISSN 1172-7047
    DOI 10.2165/11533110-000000000-00000
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4083: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The use of antipsychotics in children and adolescents with bipolar disorders.

    Pfeifer, Jonathan C / Kowatch, Robert A / DelBello, Melissa P

    Expert opinion on pharmacotherapy

    2007  Volume 8, Issue 16, Page(s) 2673–2687

    Abstract: The use of antipsychotics, particularly the atypical antipsychotics, has increased dramatically in child and adolescent populations over the last decade. This class of psychotropics has been used to treat a variety of psychiatric disorders in pediatric ... ...

    Abstract The use of antipsychotics, particularly the atypical antipsychotics, has increased dramatically in child and adolescent populations over the last decade. This class of psychotropics has been used to treat a variety of psychiatric disorders in pediatric populations, including bipolar disorder (BPD). The present clinical guidelines for treating BPD in younger populations closely follow those for managing adult BPD, as reasoning for using the atypicals is many times initially based on the outcomes of adult studies and indications. As in adult populations, metabolic parameters such as body mass index, blood glucose levels and fasting lipid profiles should be routinely monitored throughout the course of treatment. Of the several studies undertaken thus far, it appears that atypical antipsychotics are efficacious in the treatment of pediatric BPD. However, the number of controlled studies demonstrating their efficacy in younger subjects is limited and further investigation is required to evaluate if effectiveness and potential for side effects differ significantly than that for adult populations.
    MeSH term(s) Adolescent ; Animals ; Antipsychotic Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Child ; Humans ; Practice Guidelines as Topic
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2007-09-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1517/14656566.8.16.2673
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5130: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Meta-analysis of amygdala volumes in children and adolescents with bipolar disorder.

    Pfeifer, Jonathan C / Welge, Jeffrey / Strakowski, Stephen M / Adler, Caleb M / DelBello, Melissa P

    Journal of the American Academy of Child and Adolescent Psychiatry

    2008  Volume 47, Issue 11, Page(s) 1289–1298

    Abstract: Objective: The neurophysiological basis of bipolar disorder in youths remains poorly understood. Neurofunctional and neuropathologic studies have implicated the amygdala as a primary brain structure involved in the regulation of emotion. Because one of ... ...

    Abstract Objective: The neurophysiological basis of bipolar disorder in youths remains poorly understood. Neurofunctional and neuropathologic studies have implicated the amygdala as a primary brain structure involved in the regulation of emotion. Because one of the cardinal features of bipolar disorder is mood dysregulation, structural and functional amygdala abnormalities identified with neuroimaging may serve as useful disease and treatment response biomarker. Therefore, we conducted a meta-analysis summarizing the literature examining amygdala size obtained from magnetic resonance imaging in bipolar youths and adults.
    Method: A literature search using the National Institutes of Health's PubMed was conducted to identify published peer-reviewed neuroimaging studies of amygdala size in children, adolescents, and adults with bipolar disorder. Eleven studies that met inclusion and exclusion criteria were identified.
    Results: Smaller amygdala volumes were found in children and adolescents with bipolar disorder compared with the control children and adolescents (standardized mean difference -0.74; 95% confidence interval -1.36 to -0.15). Amygdala volumes in bipolar adults were not significantly different from the control adults (standardized mean difference 0.20; 95% confidence interval -0.31 to 0.73).
    Conclusions: The results of this meta-analysis suggest that structural amygdala abnormalities are present in bipolar youths but that these structural differences do not seem to be present in bipolar adults. Future studies examining whether structural, functional, and neurochemical amygdala differences between bipolar and control youths may be useful as age-specific biomarkers of illness and treatment response are needed.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Amygdala/pathology ; Amygdala/physiopathology ; Bipolar Disorder/diagnosis ; Bipolar Disorder/physiopathology ; Child ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Organ Size/physiology ; Reference Values
    Language English
    Publishing date 2008-11
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1097/CHI.0b013e318185d299
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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.163: Show issues Location:
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  6. Article: Medical management of pediatric mood disorders.

    Singh, Manpreet K / Pfeifer, Jonathan C / Barzman, Drew H / Kowatch, Robert A / DelBello, Melissa P

    Pediatric annals

    2007  Volume 36, Issue 9, Page(s) 552–563

    MeSH term(s) Adolescent ; Drug Therapy/methods ; Genetic Predisposition to Disease ; Humans ; Mood Disorders/drug therapy ; Pediatrics ; United States
    Language English
    Publishing date 2007-10-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195430-1
    ISSN 0090-4481
    ISSN 0090-4481
    DOI 10.3928/0090-4481-20070901-07
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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